AATM_HUMAN
Evidence for PS localization
Functions
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AATM_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 40.9836 | 4 | no |
| GO:0003723 | RNA binding | 14.7541 | 4 | yes |
| GO:0030170 | pyridoxal phosphate binding | 6.5574 | 4 | yes |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | 4.9180 | 5 | yes |
| GO:0008483 | transaminase activity | 4.9180 | 4 | yes |
| GO:0016212 | kynurenine-oxoglutarate transaminase activity | 3.2787 | 6 | yes |
| GO:0036137 | kynurenine aminotransferase activity | 3.2787 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AATM_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 45.9016 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 45.9016 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 42.6230 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.3443 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.4262 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.4262 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.4262 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.4262 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.7869 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.7869 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.7869 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.8689 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.2295 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.2295 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.5902 | 5 | no |
| GO:0022607 | cellular component assembly | 24.5902 | 4 | no |
| GO:0051049 | regulation of transport | 24.5902 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.9508 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.9508 | 5 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 22.9508 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 22.9508 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.9508 | 5 | no |
| GO:0043648 | dicarboxylic acid metabolic process | 21.3115 | 6 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 21.3115 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.3115 | 5 | no |
| GO:0010941 | regulation of cell death | 21.3115 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.3115 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.3115 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.3115 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.3115 | 4 | no |
| GO:0071702 | organic substance transport | 16.3934 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 13.1148 | 4 | yes |
| GO:0006103 | 2-oxoglutarate metabolic process | 11.4754 | 7 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 11.4754 | 5 | yes |
| GO:0016053 | organic acid biosynthetic process | 11.4754 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 11.4754 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 11.4754 | 5 | yes |
| GO:0046395 | carboxylic acid catabolic process | 11.4754 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 11.4754 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 11.4754 | 4 | yes |
| GO:0006536 | glutamate metabolic process | 9.8361 | 6 | yes |
| GO:0009063 | cellular amino acid catabolic process | 9.8361 | 4 | yes |
| GO:0009065 | glutamine family amino acid catabolic process | 9.8361 | 6 | yes |
| GO:0097305 | response to alcohol | 9.8361 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 9.8361 | 5 | yes |
| GO:0006107 | oxaloacetate metabolic process | 8.1967 | 7 | yes |
| GO:0006538 | glutamate catabolic process | 8.1967 | 5 | yes |
| GO:0008652 | cellular amino acid biosynthetic process | 8.1967 | 4 | yes |
| GO:0015849 | organic acid transport | 8.1967 | 5 | yes |
| GO:0043649 | dicarboxylic acid catabolic process | 8.1967 | 6 | yes |
| GO:1901607 | alpha-amino acid biosynthetic process | 8.1967 | 5 | yes |
| GO:0006106 | fumarate metabolic process | 6.5574 | 7 | yes |
| GO:0006869 | lipid transport | 6.5574 | 5 | yes |
| GO:0015908 | fatty acid transport | 6.5574 | 6 | yes |
| GO:0043650 | dicarboxylic acid biosynthetic process | 6.5574 | 6 | yes |
| GO:0006531 | aspartate metabolic process | 4.9180 | 6 | yes |
| GO:0006532 | aspartate biosynthetic process | 4.9180 | 7 | yes |
| GO:0006533 | aspartate catabolic process | 4.9180 | 5 | yes |
| GO:0009066 | aspartate family amino acid metabolic process | 4.9180 | 5 | yes |
| GO:0009067 | aspartate family amino acid biosynthetic process | 4.9180 | 6 | yes |
| GO:0009068 | aspartate family amino acid catabolic process | 4.9180 | 6 | yes |
| GO:0019470 | 4-hydroxyproline catabolic process | 4.9180 | 5 | yes |
| GO:0019471 | 4-hydroxyproline metabolic process | 4.9180 | 4 | yes |
| GO:0019550 | glutamate catabolic process to aspartate | 4.9180 | 6 | yes |
| GO:0019551 | glutamate catabolic process to 2-oxoglutarate | 4.9180 | 6 | yes |
| GO:0042219 | cellular modified amino acid catabolic process | 4.9180 | 4 | yes |
| GO:0045471 | response to ethanol | 4.9180 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AATM_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 3.2787 | 3 | no |
| DOID:10584 | retinitis pigmentosa | 3.2787 | 7 | no |
| DOID:5614 | eye disease | 3.2787 | 4 | no |
| DOID:8466 | retinal degeneration | 3.2787 | 6 | no |
| DOID:9799 | eye degenerative disease | 3.2787 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAMP_HUMAN | [view interactions] | High throughput | no | no |
| CCL21_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| SPRY4_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNA1_HUMAN | [view interactions] | High throughput | no | no |
| 3MG_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CNBP1_HUMAN | [view interactions] | High throughput | no | no |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| ZMY11_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| FAAA_HUMAN | [view interactions] | High throughput | no | no |
| PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NAT8L_HUMAN | [view interactions] | Computational | no | no |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDHA_HUMAN | [view interactions] | Computational | no | yes |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TYRO_HUMAN | [view interactions] | Computational | no | no |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACY2_HUMAN | [view interactions] | Computational | no | no |
| HOGA1_HUMAN | [view interactions] | Computational | no | yes |
| LDH6A_HUMAN | [view interactions] | Computational | no | no |
| CISY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GABT_HUMAN | [view interactions] | Computational | no | yes |
| GGCT_HUMAN | [view interactions] | Computational | no | yes |
| PERT_HUMAN | [view interactions] | Computational | no | no |
| PYR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PEPD_HUMAN | [view interactions] | Computational | no | yes |
| LDH6B_HUMAN | [view interactions] | Computational | no | no |
| LDHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCE2_HUMAN | [view interactions] | Computational | no | yes |
| THTM_HUMAN | [view interactions] | Computational | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NAGS_HUMAN | [view interactions] | Computational | no | no |
| PH4H_HUMAN | [view interactions] | Computational | no | no |
| IDH3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FABPL_HUMAN | [view interactions] | Computational | no | no |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| PYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CATA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LDHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AMPN_HUMAN | [view interactions] | Computational | no | no |
| DCE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ASNS_HUMAN | [view interactions] | Computational | no | yes |
| FABPI_HUMAN | [view interactions] | Computational | no | no |
| FABPH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FABP5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| THTR_HUMAN | [view interactions] | Computational | no | yes |
| PURA2_HUMAN | [view interactions] | Computational | no | yes |
| ASSY_HUMAN | [view interactions] | Computational | no | yes |
| FTCD_HUMAN | [view interactions] | Computational | no | no |
| PCKGM_HUMAN | [view interactions] | Computational | no | no |
| DDC_HUMAN | [view interactions] | Computational | no | no |
| CGL_HUMAN | [view interactions] | Computational | no | yes |
| IDHC_HUMAN | [view interactions] | Computational | no | no |
| CSAD_HUMAN | [view interactions] | Computational | no | yes |
| 3HIDH_HUMAN | [view interactions] | Computational | no | yes |
| ATTY_HUMAN | [view interactions] | Computational | no | no |
| ALAT2_HUMAN | [view interactions] | Computational | no | yes |
| PCKGC_HUMAN | [view interactions] | Computational | no | no |
| GSH0_HUMAN | [view interactions] | Computational | no | yes |
| ASGL1_HUMAN | [view interactions] | Computational | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PPCS_HUMAN | [view interactions] | Computational | no | yes |
| LDHC_HUMAN | [view interactions] | Computational | no | no |
| IRG1_HUMAN | [view interactions] | Computational | no | no |
| FABP4_HUMAN | [view interactions] | Computational | no | no |
| CDO1_HUMAN | [view interactions] | Computational | no | no |
| ASPD_HUMAN | [view interactions] | Computational | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPYA_HUMAN | [view interactions] | Computational | no | no |
| GADL1_HUMAN | [view interactions] | Computational | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| PURA1_HUMAN | [view interactions] | Computational | no | no |
| MIF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KFA_HUMAN | [view interactions] | Computational | no | no |
| TY3H_HUMAN | [view interactions] | Computational | no | no |
| ALAT1_HUMAN | [view interactions] | Computational | no | no |