Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AATM_HUMAN

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AATM_HUMAN
GO:0043169 cation binding 41.3793 4 no
GO:0046872 metal ion binding 39.6552 5 no
GO:0043168 anion binding 31.0345 4 yes
GO:0000166 nucleotide binding 31.0345 4 no
GO:0017076 purine nucleotide binding 29.3103 5 no
GO:0030554 adenyl nucleotide binding 25.8621 6 no
GO:0003723 RNA binding 20.6897 4 yes
GO:0032555 purine ribonucleotide binding 20.6897 4 no
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity 3.4483 5 yes
GO:0008483 transaminase activity 3.4483 4 yes
GO:0016212 kynurenine-oxoglutarate transaminase activity 3.4483 6 yes
GO:0030170 pyridoxal phosphate binding 3.4483 4 yes
GO:0036137 kynurenine aminotransferase activity 3.4483 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AATM_HUMAN
GO:0048522 positive regulation of cellular process 51.7241 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 46.5517 4 no
GO:0051128 regulation of cellular component organization 44.8276 4 no
GO:0031323 regulation of cellular metabolic process 44.8276 4 no
GO:0080090 regulation of primary metabolic process 43.1034 4 no
GO:0006796 phosphate-containing compound metabolic process 43.1034 4 no
GO:0010646 regulation of cell communication 43.1034 4 no
GO:0009893 positive regulation of metabolic process 41.3793 4 no
GO:0022607 cellular component assembly 37.9310 4 no
GO:0009889 regulation of biosynthetic process 37.9310 4 no
GO:0009966 regulation of signal transduction 37.9310 4 no
GO:0010468 regulation of gene expression 36.2069 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.2069 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.2069 5 no
GO:0031326 regulation of cellular biosynthetic process 36.2069 5 no
GO:0006996 organelle organization 34.4828 4 no
GO:0031325 positive regulation of cellular metabolic process 34.4828 5 no
GO:0048584 positive regulation of response to stimulus 31.0345 4 no
GO:1902531 regulation of intracellular signal transduction 31.0345 5 no
GO:0008104 protein localization 31.0345 4 no
GO:0051049 regulation of transport 31.0345 4 no
GO:0043933 protein-containing complex organization 31.0345 4 no
GO:0009892 negative regulation of metabolic process 31.0345 4 no
GO:0036211 protein modification process 31.0345 4 no
GO:0043412 macromolecule modification 31.0345 4 no
GO:0051246 regulation of protein metabolic process 29.3103 5 no
GO:0072521 purine-containing compound metabolic process 29.3103 4 no
GO:0042981 regulation of apoptotic process 29.3103 5 no
GO:0043067 regulation of programmed cell death 29.3103 4 no
GO:0006163 purine nucleotide metabolic process 29.3103 5 no
GO:0006753 nucleoside phosphate metabolic process 29.3103 4 no
GO:0009117 nucleotide metabolic process 29.3103 5 no
GO:0009891 positive regulation of biosynthetic process 29.3103 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.3103 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.5862 5 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0051240 positive regulation of multicellular organismal process 25.8621 4 no
GO:0060341 regulation of cellular localization 25.8621 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.8621 6 no
GO:0019693 ribose phosphate metabolic process 25.8621 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.8621 6 no
GO:0032880 regulation of protein localization 24.1379 5 no
GO:0006355 regulation of DNA-templated transcription 24.1379 7 no
GO:0051252 regulation of RNA metabolic process 24.1379 5 no
GO:2001141 regulation of RNA biosynthetic process 24.1379 6 no
GO:0010648 negative regulation of cell communication 24.1379 5 no
GO:0023057 negative regulation of signaling 24.1379 4 no
GO:0048585 negative regulation of response to stimulus 24.1379 4 no
GO:0071702 organic substance transport 24.1379 4 yes
GO:0007010 cytoskeleton organization 24.1379 5 no
GO:0009150 purine ribonucleotide metabolic process 24.1379 6 no
GO:0009259 ribonucleotide metabolic process 24.1379 5 no
GO:0009967 positive regulation of signal transduction 24.1379 5 no
GO:0010647 positive regulation of cell communication 24.1379 5 no
GO:0023056 positive regulation of signaling 24.1379 4 no
GO:0010243 response to organonitrogen compound 22.4138 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.4138 4 no
GO:0033043 regulation of organelle organization 22.4138 5 no
GO:0019752 carboxylic acid metabolic process 22.4138 5 yes
GO:0043436 oxoacid metabolic process 22.4138 4 yes
GO:1901565 organonitrogen compound catabolic process 22.4138 4 yes
GO:0009141 nucleoside triphosphate metabolic process 22.4138 5 no
GO:0009144 purine nucleoside triphosphate metabolic process 22.4138 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 22.4138 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 22.4138 7 no
GO:0046034 ATP metabolic process 22.4138 7 no
GO:0019220 regulation of phosphate metabolic process 20.6897 6 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0051174 regulation of phosphorus metabolic process 20.6897 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:0071705 nitrogen compound transport 20.6897 4 no
GO:0045595 regulation of cell differentiation 20.6897 4 no
GO:0051094 positive regulation of developmental process 20.6897 4 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:0080134 regulation of response to stress 20.6897 4 no
GO:0009968 negative regulation of signal transduction 20.6897 5 no
GO:0051129 negative regulation of cellular component organization 20.6897 5 no
GO:0009890 negative regulation of biosynthetic process 20.6897 5 no
GO:0009894 regulation of catabolic process 20.6897 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.6897 6 no
GO:0031327 negative regulation of cellular biosynthetic process 20.6897 6 no
GO:1901361 organic cyclic compound catabolic process 17.2414 4 yes
GO:1901566 organonitrogen compound biosynthetic process 17.2414 4 yes
GO:0097305 response to alcohol 12.0690 4 yes
GO:0015711 organic anion transport 6.8966 5 yes
GO:0015849 organic acid transport 6.8966 5 yes
GO:0016054 organic acid catabolic process 6.8966 4 yes
GO:0043648 dicarboxylic acid metabolic process 6.8966 6 yes
GO:0046395 carboxylic acid catabolic process 6.8966 5 yes
GO:0046942 carboxylic acid transport 6.8966 6 yes
GO:0006107 oxaloacetate metabolic process 5.1724 7 yes
GO:0006536 glutamate metabolic process 5.1724 6 yes
GO:0006869 lipid transport 5.1724 5 yes
GO:0009063 amino acid catabolic process 5.1724 4 yes
GO:0009064 glutamine family amino acid metabolic process 5.1724 5 yes
GO:0009065 glutamine family amino acid catabolic process 5.1724 6 yes
GO:0015718 monocarboxylic acid transport 5.1724 7 yes
GO:0015908 fatty acid transport 5.1724 6 yes
GO:0016053 organic acid biosynthetic process 5.1724 4 yes
GO:0019470 4-hydroxyproline catabolic process 5.1724 5 yes
GO:0019471 4-hydroxyproline metabolic process 5.1724 4 yes
GO:0042219 cellular modified amino acid catabolic process 5.1724 4 yes
GO:0045471 response to ethanol 5.1724 5 yes
GO:0046394 carboxylic acid biosynthetic process 5.1724 5 yes
GO:0170033 L-amino acid metabolic process 5.1724 5 yes
GO:0170035 L-amino acid catabolic process 5.1724 6 yes
GO:0170039 proteinogenic amino acid metabolic process 5.1724 4 yes
GO:0170040 proteinogenic amino acid catabolic process 5.1724 5 yes
GO:0170041 non-proteinogenic amino acid metabolic process 5.1724 4 yes
GO:0170044 non-proteinogenic amino acid catabolic process 5.1724 5 yes
GO:1901605 alpha-amino acid metabolic process 5.1724 4 yes
GO:1901606 alpha-amino acid catabolic process 5.1724 5 yes
GO:0006103 2-oxoglutarate metabolic process 3.4483 7 yes
GO:0006106 fumarate metabolic process 3.4483 7 yes
GO:0006531 aspartate metabolic process 3.4483 6 yes
GO:0006532 aspartate biosynthetic process 3.4483 7 yes
GO:0006533 aspartate catabolic process 3.4483 7 yes
GO:0006538 glutamate catabolic process 3.4483 7 yes
GO:0008652 amino acid biosynthetic process 3.4483 4 yes
GO:0009066 aspartate family amino acid metabolic process 3.4483 5 yes
GO:0009067 aspartate family amino acid biosynthetic process 3.4483 6 yes
GO:0009068 aspartate family amino acid catabolic process 3.4483 6 yes
GO:0019550 glutamate catabolic process to aspartate 3.4483 7 yes
GO:0019551 glutamate catabolic process to 2-oxoglutarate 3.4483 8 yes
GO:0043649 dicarboxylic acid catabolic process 3.4483 6 yes
GO:0043650 dicarboxylic acid biosynthetic process 3.4483 6 yes
GO:0170034 L-amino acid biosynthetic process 3.4483 6 yes
GO:0170038 proteinogenic amino acid biosynthetic process 3.4483 5 yes
GO:1901607 alpha-amino acid biosynthetic process 3.4483 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AATM_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUA3_HUMAN [view interactions] High throughput no yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
SDHB_HUMAN [view interactions] High throughput no yes
S14L2_HUMAN [view entry] [view interactions] High throughput yes yes
MYG_HUMAN [view interactions] High throughput no no
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ADHX_HUMAN [view interactions] High throughput no yes
NQO1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
AL4A1_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
GABT_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
THEM4_HUMAN [view interactions] High throughput no no
LYPL1_HUMAN [view interactions] High throughput no yes
RIFK_HUMAN [view interactions] High throughput no yes
MYDGF_HUMAN [view interactions] High throughput no yes
NIT2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
SAMP_HUMAN [view interactions] High throughput no no
CCL21_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
GLRX1_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
SPRY4_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
SOST_HUMAN [view interactions] High throughput no no
PHOP1_HUMAN [view interactions] High throughput no no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TENS3_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
KPCD2_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TRM7_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
EIF1B_HUMAN [view interactions] High throughput no no
PACN3_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
HLAC_HUMAN [view interactions] High throughput no no
CRCM_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
CCNA1_HUMAN [view interactions] High throughput no no
3MG_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
CNBP1_HUMAN [view interactions] High throughput no no
BCAR3_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
AAKB1_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
THOC7_HUMAN [view interactions] High throughput no yes
ZDHC6_HUMAN [view interactions] High throughput no no
CK068_HUMAN [view interactions] High throughput no yes
ZMY11_HUMAN [view interactions] High throughput no no
SNF5_HUMAN [view interactions] High throughput no yes
PSMD4_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PPCEL_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
TADBP_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
NFIX_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
SEPT9_HUMAN [view interactions] High throughput no no
FGD5_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
BCL6_HUMAN [view interactions] High throughput no no
BACH_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
UBP53_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
KAT3_HUMAN [view interactions] High throughput no yes
FAAA_HUMAN [view interactions] High throughput no no
PTGR1_HUMAN [view interactions] High throughput no yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
GLYG_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
COF1_HUMAN [view entry] [view interactions] High throughput yes no
COX17_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
THIO_HUMAN [view interactions] High throughput no yes
TXD12_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
PYRD_HUMAN [view interactions] High throughput no yes