AATM_HUMAN
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AATM_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 41.3793 | 4 | no |
GO:0046872 | metal ion binding | 39.6552 | 5 | no |
GO:0043168 | anion binding | 31.0345 | 4 | yes |
GO:0000166 | nucleotide binding | 31.0345 | 4 | no |
GO:0017076 | purine nucleotide binding | 29.3103 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 25.8621 | 6 | no |
GO:0003723 | RNA binding | 20.6897 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 20.6897 | 4 | no |
GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | 3.4483 | 5 | yes |
GO:0008483 | transaminase activity | 3.4483 | 4 | yes |
GO:0016212 | kynurenine-oxoglutarate transaminase activity | 3.4483 | 6 | yes |
GO:0030170 | pyridoxal phosphate binding | 3.4483 | 4 | yes |
GO:0036137 | kynurenine aminotransferase activity | 3.4483 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AATM_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 51.7241 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 46.5517 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 44.8276 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 43.1034 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 43.1034 | 4 | no |
GO:0010646 | regulation of cell communication | 43.1034 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 41.3793 | 4 | no |
GO:0022607 | cellular component assembly | 37.9310 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 37.9310 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.9310 | 4 | no |
GO:0010468 | regulation of gene expression | 36.2069 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.2069 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.2069 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.2069 | 5 | no |
GO:0006996 | organelle organization | 34.4828 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.4828 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 31.0345 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.0345 | 5 | no |
GO:0008104 | protein localization | 31.0345 | 4 | no |
GO:0051049 | regulation of transport | 31.0345 | 4 | no |
GO:0043933 | protein-containing complex organization | 31.0345 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 31.0345 | 4 | no |
GO:0036211 | protein modification process | 31.0345 | 4 | no |
GO:0043412 | macromolecule modification | 31.0345 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 29.3103 | 5 | no |
GO:0072521 | purine-containing compound metabolic process | 29.3103 | 4 | no |
GO:0042981 | regulation of apoptotic process | 29.3103 | 5 | no |
GO:0043067 | regulation of programmed cell death | 29.3103 | 4 | no |
GO:0006163 | purine nucleotide metabolic process | 29.3103 | 5 | no |
GO:0006753 | nucleoside phosphate metabolic process | 29.3103 | 4 | no |
GO:0009117 | nucleotide metabolic process | 29.3103 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 29.3103 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.3103 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.5862 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 27.5862 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.8621 | 4 | no |
GO:0060341 | regulation of cellular localization | 25.8621 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
GO:0019693 | ribose phosphate metabolic process | 25.8621 | 4 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.8621 | 6 | no |
GO:0032880 | regulation of protein localization | 24.1379 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 24.1379 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 24.1379 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.1379 | 6 | no |
GO:0010648 | negative regulation of cell communication | 24.1379 | 5 | no |
GO:0023057 | negative regulation of signaling | 24.1379 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 24.1379 | 4 | no |
GO:0071702 | organic substance transport | 24.1379 | 4 | yes |
GO:0007010 | cytoskeleton organization | 24.1379 | 5 | no |
GO:0009150 | purine ribonucleotide metabolic process | 24.1379 | 6 | no |
GO:0009259 | ribonucleotide metabolic process | 24.1379 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 24.1379 | 5 | no |
GO:0010647 | positive regulation of cell communication | 24.1379 | 5 | no |
GO:0023056 | positive regulation of signaling | 24.1379 | 4 | no |
GO:0010243 | response to organonitrogen compound | 22.4138 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.4138 | 4 | no |
GO:0033043 | regulation of organelle organization | 22.4138 | 5 | no |
GO:0019752 | carboxylic acid metabolic process | 22.4138 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 22.4138 | 4 | yes |
GO:1901565 | organonitrogen compound catabolic process | 22.4138 | 4 | yes |
GO:0009141 | nucleoside triphosphate metabolic process | 22.4138 | 5 | no |
GO:0009144 | purine nucleoside triphosphate metabolic process | 22.4138 | 6 | no |
GO:0009199 | ribonucleoside triphosphate metabolic process | 22.4138 | 6 | no |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 22.4138 | 7 | no |
GO:0046034 | ATP metabolic process | 22.4138 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 20.6897 | 6 | no |
GO:0031344 | regulation of cell projection organization | 20.6897 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 20.6897 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6897 | 6 | no |
GO:0071705 | nitrogen compound transport | 20.6897 | 4 | no |
GO:0045595 | regulation of cell differentiation | 20.6897 | 4 | no |
GO:0051094 | positive regulation of developmental process | 20.6897 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 20.6897 | 5 | no |
GO:0080134 | regulation of response to stress | 20.6897 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 20.6897 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 20.6897 | 5 | no |
GO:0009894 | regulation of catabolic process | 20.6897 | 4 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.6897 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 20.6897 | 6 | no |
GO:1901361 | organic cyclic compound catabolic process | 17.2414 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 17.2414 | 4 | yes |
GO:0097305 | response to alcohol | 12.0690 | 4 | yes |
GO:0015711 | organic anion transport | 6.8966 | 5 | yes |
GO:0015849 | organic acid transport | 6.8966 | 5 | yes |
GO:0016054 | organic acid catabolic process | 6.8966 | 4 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 6.8966 | 6 | yes |
GO:0046395 | carboxylic acid catabolic process | 6.8966 | 5 | yes |
GO:0046942 | carboxylic acid transport | 6.8966 | 6 | yes |
GO:0006107 | oxaloacetate metabolic process | 5.1724 | 7 | yes |
GO:0006536 | glutamate metabolic process | 5.1724 | 6 | yes |
GO:0006869 | lipid transport | 5.1724 | 5 | yes |
GO:0009063 | amino acid catabolic process | 5.1724 | 4 | yes |
GO:0009064 | glutamine family amino acid metabolic process | 5.1724 | 5 | yes |
GO:0009065 | glutamine family amino acid catabolic process | 5.1724 | 6 | yes |
GO:0015718 | monocarboxylic acid transport | 5.1724 | 7 | yes |
GO:0015908 | fatty acid transport | 5.1724 | 6 | yes |
GO:0016053 | organic acid biosynthetic process | 5.1724 | 4 | yes |
GO:0019470 | 4-hydroxyproline catabolic process | 5.1724 | 5 | yes |
GO:0019471 | 4-hydroxyproline metabolic process | 5.1724 | 4 | yes |
GO:0042219 | cellular modified amino acid catabolic process | 5.1724 | 4 | yes |
GO:0045471 | response to ethanol | 5.1724 | 5 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 5.1724 | 5 | yes |
GO:0170033 | L-amino acid metabolic process | 5.1724 | 5 | yes |
GO:0170035 | L-amino acid catabolic process | 5.1724 | 6 | yes |
GO:0170039 | proteinogenic amino acid metabolic process | 5.1724 | 4 | yes |
GO:0170040 | proteinogenic amino acid catabolic process | 5.1724 | 5 | yes |
GO:0170041 | non-proteinogenic amino acid metabolic process | 5.1724 | 4 | yes |
GO:0170044 | non-proteinogenic amino acid catabolic process | 5.1724 | 5 | yes |
GO:1901605 | alpha-amino acid metabolic process | 5.1724 | 4 | yes |
GO:1901606 | alpha-amino acid catabolic process | 5.1724 | 5 | yes |
GO:0006103 | 2-oxoglutarate metabolic process | 3.4483 | 7 | yes |
GO:0006106 | fumarate metabolic process | 3.4483 | 7 | yes |
GO:0006531 | aspartate metabolic process | 3.4483 | 6 | yes |
GO:0006532 | aspartate biosynthetic process | 3.4483 | 7 | yes |
GO:0006533 | aspartate catabolic process | 3.4483 | 7 | yes |
GO:0006538 | glutamate catabolic process | 3.4483 | 7 | yes |
GO:0008652 | amino acid biosynthetic process | 3.4483 | 4 | yes |
GO:0009066 | aspartate family amino acid metabolic process | 3.4483 | 5 | yes |
GO:0009067 | aspartate family amino acid biosynthetic process | 3.4483 | 6 | yes |
GO:0009068 | aspartate family amino acid catabolic process | 3.4483 | 6 | yes |
GO:0019550 | glutamate catabolic process to aspartate | 3.4483 | 7 | yes |
GO:0019551 | glutamate catabolic process to 2-oxoglutarate | 3.4483 | 8 | yes |
GO:0043649 | dicarboxylic acid catabolic process | 3.4483 | 6 | yes |
GO:0043650 | dicarboxylic acid biosynthetic process | 3.4483 | 6 | yes |
GO:0170034 | L-amino acid biosynthetic process | 3.4483 | 6 | yes |
GO:0170038 | proteinogenic amino acid biosynthetic process | 3.4483 | 5 | yes |
GO:1901607 | alpha-amino acid biosynthetic process | 3.4483 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AATM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
S14L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYG_HUMAN | [view interactions] | High throughput | no | no |
ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADHX_HUMAN | [view interactions] | High throughput | no | yes |
NQO1_HUMAN | [view interactions] | High throughput | no | no |
CATS_HUMAN | [view interactions] | High throughput | no | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GABT_HUMAN | [view interactions] | High throughput | no | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THEM4_HUMAN | [view interactions] | High throughput | no | no |
LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
RIFK_HUMAN | [view interactions] | High throughput | no | yes |
MYDGF_HUMAN | [view interactions] | High throughput | no | yes |
NIT2_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA4_HUMAN | [view interactions] | High throughput | no | yes |
SAMP_HUMAN | [view interactions] | High throughput | no | no |
CCL21_HUMAN | [view interactions] | High throughput | no | no |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLRX1_HUMAN | [view interactions] | High throughput | no | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
SPRY4_HUMAN | [view interactions] | High throughput | no | yes |
MET14_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SOST_HUMAN | [view interactions] | High throughput | no | no |
PHOP1_HUMAN | [view interactions] | High throughput | no | no |
APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
TENS3_HUMAN | [view interactions] | High throughput | no | no |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRM7_HUMAN | [view interactions] | High throughput | no | yes |
ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
PACN3_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HLAC_HUMAN | [view interactions] | High throughput | no | no |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCNA1_HUMAN | [view interactions] | High throughput | no | no |
3MG_HUMAN | [view interactions] | High throughput | no | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
CNBP1_HUMAN | [view interactions] | High throughput | no | no |
BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
SOMA_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
CP135_HUMAN | [view interactions] | High throughput | no | no |
THOC7_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC6_HUMAN | [view interactions] | High throughput | no | no |
CK068_HUMAN | [view interactions] | High throughput | no | yes |
ZMY11_HUMAN | [view interactions] | High throughput | no | no |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TADBP_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
NFIX_HUMAN | [view interactions] | High throughput | no | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
SEPT9_HUMAN | [view interactions] | High throughput | no | no |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
BCL6_HUMAN | [view interactions] | High throughput | no | no |
BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F4_HUMAN | [view interactions] | High throughput | no | no |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
UBP53_HUMAN | [view interactions] | High throughput | no | yes |
LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAT3_HUMAN | [view interactions] | High throughput | no | yes |
FAAA_HUMAN | [view interactions] | High throughput | no | no |
PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLYG_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COX17_HUMAN | [view interactions] | High throughput | no | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
TXD12_HUMAN | [view interactions] | High throughput | no | no |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PYRD_HUMAN | [view interactions] | High throughput | no | yes |