S14L2_HUMAN
Evidence for PS localization
Functions
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S14L2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 50.0000 | 4 | no |
| GO:0043168 | anion binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S14L2_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 40.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 40.0000 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 30.0000 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 30.0000 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 30.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.0000 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 20.0000 | 6 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 20.0000 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PPM1L_HUMAN | [view interactions] | Low throughput | no | yes |
| S14L3_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPXN2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| PMM2_HUMAN | [view interactions] | High throughput | no | no |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIDA_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RIFK_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |