S14L2_HUMAN
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
No data found.
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in S14L2_HUMAN |
---|---|---|---|---|
GO:0010468 | regulation of gene expression | 100.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 100.0000 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 100.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 100.0000 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 100.0000 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 100.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 100.0000 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PPM1L_HUMAN | [view interactions] | Low throughput | no | yes |
S14L3_HUMAN | [view interactions] | High throughput | no | no |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPXN2_HUMAN | [view interactions] | High throughput | no | no |
GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |