AL4A1_HUMAN
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AL4A1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 29.1667 | 4 | no |
GO:0003723 | RNA binding | 20.8333 | 4 | no |
GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 12.5000 | 4 | yes |
GO:0004029 | aldehyde dehydrogenase (NAD+) activity | 10.4167 | 6 | yes |
GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | 10.4167 | 5 | yes |
GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity | 4.1667 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AL4A1_HUMAN |
---|---|---|---|---|
GO:0043436 | oxoacid metabolic process | 54.1667 | 4 | yes |
GO:0019752 | carboxylic acid metabolic process | 54.1667 | 5 | yes |
GO:0048522 | positive regulation of cellular process | 35.4167 | 4 | no |
GO:1901565 | organonitrogen compound catabolic process | 31.2500 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 27.0833 | 5 | yes |
GO:1901605 | alpha-amino acid metabolic process | 27.0833 | 4 | yes |
GO:0010941 | regulation of cell death | 27.0833 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 27.0833 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 27.0833 | 4 | no |
GO:0009063 | cellular amino acid catabolic process | 27.0833 | 4 | yes |
GO:0016054 | organic acid catabolic process | 27.0833 | 4 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 25.0000 | 6 | yes |
GO:1901606 | alpha-amino acid catabolic process | 25.0000 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.9167 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 22.9167 | 4 | no |
GO:0043067 | regulation of programmed cell death | 22.9167 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 22.9167 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 22.9167 | 4 | no |
GO:0010646 | regulation of cell communication | 22.9167 | 4 | no |
GO:0009064 | glutamine family amino acid metabolic process | 22.9167 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 20.8333 | 6 | no |
GO:0010468 | regulation of gene expression | 20.8333 | 5 | no |
GO:0042981 | regulation of apoptotic process | 20.8333 | 6 | no |
GO:0043933 | protein-containing complex organization | 20.8333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 20.8333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.8333 | 5 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 20.8333 | 4 | no |
GO:0006536 | glutamate metabolic process | 20.8333 | 6 | yes |
GO:0009065 | glutamine family amino acid catabolic process | 20.8333 | 6 | yes |
GO:0006560 | proline metabolic process | 8.3333 | 6 | yes |
GO:0019470 | 4-hydroxyproline catabolic process | 8.3333 | 5 | yes |
GO:0019471 | 4-hydroxyproline metabolic process | 8.3333 | 4 | yes |
GO:0042219 | cellular modified amino acid catabolic process | 8.3333 | 4 | yes |
GO:0006562 | proline catabolic process | 6.2500 | 5 | yes |
GO:0010133 | proline catabolic process to glutamate | 6.2500 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AL4A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARGI1_HUMAN | [view interactions] | High throughput | no | no |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
T184A_HUMAN | [view interactions] | High throughput | no | no |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
TR61B_HUMAN | [view interactions] | High throughput | no | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
OR2A4_HUMAN | [view interactions] | High throughput | no | no |
MRM2_HUMAN | [view interactions] | High throughput | no | yes |
P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
STK16_HUMAN | [view interactions] | High throughput | no | no |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
RB33A_HUMAN | [view interactions] | High throughput | no | no |
LRC46_HUMAN | [view interactions] | High throughput | no | no |
ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
KAD4_HUMAN | [view interactions] | High throughput | no | yes |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
MASU1_HUMAN | [view interactions] | High throughput | no | yes |
FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
OIT3_HUMAN | [view interactions] | High throughput | no | no |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADHX_HUMAN | [view interactions] | High throughput | no | yes |
MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDH6A_HUMAN | [view interactions] | High throughput | no | no |
LDH6B_HUMAN | [view interactions] | High throughput | no | no |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESTD_HUMAN | [view interactions] | High throughput | no | yes |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGM2_HUMAN | [view interactions] | High throughput | no | no |
FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INHBA_HUMAN | [view interactions] | High throughput | no | no |
FRDA_HUMAN | [view interactions] | High throughput | no | yes |
MPPA_HUMAN | [view interactions] | High throughput | no | yes |
CLIC4_HUMAN | [view interactions] | High throughput | no | no |
HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
TBCA_HUMAN | [view interactions] | High throughput | no | yes |
PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
MTPN_HUMAN | [view interactions] | High throughput | no | yes |
CLIC1_HUMAN | [view interactions] | High throughput | no | no |
GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THTR_HUMAN | [view interactions] | High throughput | no | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
MSRB2_HUMAN | [view interactions] | High throughput | no | no |
THTM_HUMAN | [view interactions] | High throughput | no | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRES1_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HINT2_HUMAN | [view interactions] | High throughput | no | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET17_HUMAN | [view interactions] | High throughput | no | yes |
RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
MPPB_HUMAN | [view interactions] | High throughput | no | yes |
SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TACO1_HUMAN | [view interactions] | High throughput | no | yes |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
EFTS_HUMAN | [view interactions] | High throughput | no | no |
EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCST_HUMAN | [view interactions] | Computational | no | yes |
GLNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GATM_HUMAN | [view interactions] | Computational | no | no |
DLDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GGT1_HUMAN | [view interactions] | Computational | no | no |
GLSL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GGT7_HUMAN | [view interactions] | Computational | no | yes |
AL9A1_HUMAN | [view interactions] | Computational | no | yes |
L2HDH_HUMAN | [view interactions] | Computational | no | yes |
AL1B1_HUMAN | [view interactions] | Computational | no | yes |
CNDP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNDP1_HUMAN | [view interactions] | Computational | no | yes |
GCSH_HUMAN | [view interactions] | Computational | no | yes |
OPLA_HUMAN | [view interactions] | Computational | no | no |
GSH0_HUMAN | [view interactions] | Computational | no | yes |
AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GGT5_HUMAN | [view interactions] | Computational | no | yes |
SYEP_HUMAN | [view interactions] | Computational | no | yes |
FTCD_HUMAN | [view interactions] | Computational | no | no |
DCE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
P5CS_HUMAN | [view interactions] | Computational | no | yes |
AL7A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
P5CR2_HUMAN | [view interactions] | Computational | no | yes |
AATC2_HUMAN | [view interactions] | Computational | no | no |
ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DCE2_HUMAN | [view interactions] | Computational | no | yes |
HYPDH_HUMAN | [view interactions] | Computational | no | no |
ACY2_HUMAN | [view interactions] | Computational | no | no |
GLSK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GCSP_HUMAN | [view interactions] | Computational | no | yes |
CRNS1_HUMAN | [view interactions] | Computational | no | no |
PROD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DHE4_HUMAN | [view interactions] | Computational | no | yes |
SYEM_HUMAN | [view interactions] | Computational | no | yes |
OAT_HUMAN | [view interactions] | Computational | no | yes |