AL4A1_HUMAN
Evidence for PS localization
Functions
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AL4A1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 33.3333 | 5 | no |
| GO:0003723 | RNA binding | 26.1905 | 4 | no |
| GO:0043168 | anion binding | 21.4286 | 4 | no |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 9.5238 | 4 | yes |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity | 7.1429 | 6 | yes |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | 7.1429 | 5 | yes |
| GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AL4A1_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 42.8571 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 42.8571 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 38.0952 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.9524 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.9524 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.9524 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9524 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 30.9524 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.9524 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.9524 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 30.9524 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.1905 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.1905 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.1905 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 26.1905 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.8095 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.8095 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 23.8095 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 7 | no |
| GO:0006996 | organelle organization | 21.4286 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.4286 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
| GO:0006163 | purine nucleotide metabolic process | 21.4286 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.4286 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.4286 | 5 | no |
| GO:0019362 | pyridine nucleotide metabolic process | 21.4286 | 5 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 21.4286 | 6 | no |
| GO:0046496 | nicotinamide nucleotide metabolic process | 21.4286 | 6 | no |
| GO:0072521 | purine-containing compound metabolic process | 21.4286 | 4 | no |
| GO:0072524 | pyridine-containing compound metabolic process | 21.4286 | 4 | no |
| GO:1901361 | organic cyclic compound catabolic process | 19.0476 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 16.6667 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 14.2857 | 5 | yes |
| GO:0009063 | amino acid catabolic process | 14.2857 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 14.2857 | 4 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 14.2857 | 6 | yes |
| GO:0046395 | carboxylic acid catabolic process | 14.2857 | 5 | yes |
| GO:0170033 | L-amino acid metabolic process | 14.2857 | 5 | yes |
| GO:0170039 | proteinogenic amino acid metabolic process | 14.2857 | 4 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 11.9048 | 5 | yes |
| GO:0170035 | L-amino acid catabolic process | 11.9048 | 6 | yes |
| GO:0170040 | proteinogenic amino acid catabolic process | 11.9048 | 5 | yes |
| GO:0006536 | glutamate metabolic process | 9.5238 | 6 | yes |
| GO:0009065 | glutamine family amino acid catabolic process | 9.5238 | 6 | yes |
| GO:0006560 | proline metabolic process | 7.1429 | 6 | yes |
| GO:0019470 | 4-hydroxyproline catabolic process | 7.1429 | 5 | yes |
| GO:0019471 | 4-hydroxyproline metabolic process | 7.1429 | 4 | yes |
| GO:0042219 | cellular modified amino acid catabolic process | 7.1429 | 4 | yes |
| GO:0170041 | non-proteinogenic amino acid metabolic process | 7.1429 | 4 | yes |
| GO:0170044 | non-proteinogenic amino acid catabolic process | 7.1429 | 5 | yes |
| GO:0006562 | proline catabolic process | 4.7619 | 7 | yes |
| GO:0010133 | proline catabolic process to glutamate | 4.7619 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AL4A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARGI1_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| GATA_HUMAN | [view interactions] | High throughput | no | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| LRC46_HUMAN | [view interactions] | High throughput | no | no |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADHX_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM2_HUMAN | [view interactions] | High throughput | no | no |
| FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INHBA_HUMAN | [view interactions] | High throughput | no | no |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMM2_HUMAN | [view interactions] | High throughput | no | no |
| S14L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIDA_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| DCXR_HUMAN | [view interactions] | High throughput | no | no |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |