GPDM_HUMAN
Evidence for PS localization
Functions
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPDM_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.8571 | 4 | yes |
| GO:0005509 | calcium ion binding | 8.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPDM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.1429 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.1429 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.2857 | 4 | no |
| GO:0006996 | organelle organization | 31.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.4286 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.4286 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | yes |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.5714 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 28.5714 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.7143 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.7143 | 4 | no |
| GO:0022607 | cellular component assembly | 25.7143 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.8571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.8571 | 5 | no |
| GO:0010941 | regulation of cell death | 22.8571 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.8571 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.8571 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.8571 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 22.8571 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.8571 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.8571 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.8571 | 4 | no |
| GO:0008104 | protein localization | 22.8571 | 4 | no |
| GO:0051049 | regulation of transport | 22.8571 | 4 | no |
| GO:0016052 | carbohydrate catabolic process | 8.5714 | 4 | yes |
| GO:0046164 | alcohol catabolic process | 8.5714 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 8.5714 | 4 | yes |
| GO:0006071 | glycerol metabolic process | 5.7143 | 5 | yes |
| GO:0006072 | glycerol-3-phosphate metabolic process | 5.7143 | 5 | yes |
| GO:0019400 | alditol metabolic process | 5.7143 | 4 | yes |
| GO:0019405 | alditol catabolic process | 5.7143 | 5 | yes |
| GO:0019563 | glycerol catabolic process | 5.7143 | 6 | yes |
| GO:0019751 | polyol metabolic process | 5.7143 | 4 | yes |
| GO:0034308 | primary alcohol metabolic process | 5.7143 | 4 | yes |
| GO:0044275 | cellular carbohydrate catabolic process | 5.7143 | 4 | yes |
| GO:0046174 | polyol catabolic process | 5.7143 | 5 | yes |
| GO:0052646 | alditol phosphate metabolic process | 5.7143 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GPDM_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 5.7143 | 6 | no |
| DOID:440 | neuromuscular disease | 5.7143 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.7143 | 3 | no |
| DOID:870 | neuropathy | 5.7143 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| DUS29_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| NAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| WDFY2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| S39A8_HUMAN | [view interactions] | High throughput | no | yes |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| HDA10_HUMAN | [view interactions] | High throughput | no | yes |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GHRL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAC9_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| LIX1L_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| DHB1_HUMAN | [view interactions] | High throughput | no | no |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| FLOWR_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACO11_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPIN2_HUMAN | [view interactions] | Computational | no | yes |
| GPAT1_HUMAN | [view interactions] | Computational | no | no |
| PLCC_HUMAN | [view interactions] | Computational | no | no |
| GPAT4_HUMAN | [view interactions] | Computational | no | yes |
| LPIN1_HUMAN | [view interactions] | Computational | no | no |
| ADPRM_HUMAN | [view interactions] | Computational | no | yes |
| GPAT3_HUMAN | [view interactions] | Computational | no | yes |
| PLCB_HUMAN | [view interactions] | Computational | no | yes |
| GLPK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LCLT1_HUMAN | [view interactions] | Computational | no | no |
| TKFC_HUMAN | [view interactions] | Computational | no | no |
| PLCD_HUMAN | [view interactions] | Computational | no | yes |
| PLPP3_HUMAN | [view interactions] | Computational | no | no |
| GLPK2_HUMAN | [view interactions] | Computational | no | no |
| MBOA2_HUMAN | [view interactions] | Computational | no | yes |
| PLPP2_HUMAN | [view interactions] | Computational | no | yes |
| PLCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GPDA_HUMAN | [view interactions] | Computational | no | yes |
| PLPP4_HUMAN | [view interactions] | Computational | no | yes |
| PLCA_HUMAN | [view interactions] | Computational | no | yes |
| MBOA1_HUMAN | [view interactions] | Computational | no | no |
| PLPP5_HUMAN | [view interactions] | Computational | no | no |
| GPAT2_HUMAN | [view interactions] | Computational | no | no |
| GNPAT_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LPIN3_HUMAN | [view interactions] | Computational | no | yes |
| GPD1L_HUMAN | [view interactions] | Computational | no | no |