GPDM_HUMAN
Evidence for PS localization
Functions
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPDM_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0005509 | calcium ion binding | 8.3333 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPDM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 41.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.1111 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.5556 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.5556 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.5556 | 4 | no |
| GO:0008104 | protein localization | 30.5556 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.5556 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0033365 | protein localization to organelle | 22.2222 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 22.2222 | 4 | no |
| GO:0007005 | mitochondrion organization | 22.2222 | 5 | no |
| GO:0006163 | purine nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 16.6667 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 5.5556 | 4 | yes |
| GO:0018958 | phenol-containing compound metabolic process | 5.5556 | 4 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 5.5556 | 5 | yes |
| GO:0046164 | alcohol catabolic process | 5.5556 | 4 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 5.5556 | 6 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 5.5556 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 5.5556 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| DUS29_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| NAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| WDFY2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| S39A8_HUMAN | [view interactions] | High throughput | no | yes |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| HDA10_HUMAN | [view interactions] | High throughput | no | yes |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GHRL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAC9_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| LIX1L_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| DHB1_HUMAN | [view interactions] | High throughput | no | no |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| FLOWR_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACO11_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |