GHRL_HUMAN
Evidence for PS localization
Functions
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GHRL_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 41.6667 | 4 | no |
| GO:0046872 | metal ion binding | 41.6667 | 5 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 25.0000 | 4 | yes |
| GO:0003924 | GTPase activity | 25.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GHRL_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 41.6667 | 4 | yes |
| GO:0033993 | response to lipid | 41.6667 | 4 | no |
| GO:0071310 | cellular response to organic substance | 41.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 33.3333 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 33.3333 | 4 | no |
| GO:0071396 | cellular response to lipid | 33.3333 | 5 | no |
| GO:1901654 | response to ketone | 33.3333 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 33.3333 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | yes |
| GO:0032870 | cellular response to hormone stimulus | 25.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
| GO:0097305 | response to alcohol | 25.0000 | 4 | no |
| GO:0097306 | cellular response to alcohol | 25.0000 | 5 | no |
| GO:1901655 | cellular response to ketone | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | yes |
| GO:0032715 | negative regulation of interleukin-6 production | 16.6667 | 6 | yes |
| GO:0032720 | negative regulation of tumor necrosis factor production | 16.6667 | 7 | yes |
| GO:0034329 | cell junction assembly | 16.6667 | 5 | yes |
| GO:0034330 | cell junction organization | 16.6667 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 16.6667 | 4 | yes |
| GO:0040014 | regulation of multicellular organism growth | 16.6667 | 4 | yes |
| GO:0040018 | positive regulation of multicellular organism growth | 16.6667 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 16.6667 | 4 | yes |
| GO:0042886 | amide transport | 16.6667 | 5 | yes |
| GO:0044057 | regulation of system process | 16.6667 | 4 | yes |
| GO:0044058 | regulation of digestive system process | 16.6667 | 5 | yes |
| GO:0045765 | regulation of angiogenesis | 16.6667 | 5 | yes |
| GO:0045766 | positive regulation of angiogenesis | 16.6667 | 6 | yes |
| GO:0045927 | positive regulation of growth | 16.6667 | 4 | yes |
| GO:0045933 | positive regulation of muscle contraction | 16.6667 | 5 | yes |
| GO:0045987 | positive regulation of smooth muscle contraction | 16.6667 | 6 | yes |
| GO:0046676 | negative regulation of insulin secretion | 16.6667 | 7 | yes |
| GO:0046879 | hormone secretion | 16.6667 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 16.6667 | 4 | yes |
| GO:0046888 | negative regulation of hormone secretion | 16.6667 | 5 | yes |
| GO:0046903 | secretion | 16.6667 | 4 | yes |
| GO:0048520 | positive regulation of behavior | 16.6667 | 5 | yes |
| GO:0048521 | negative regulation of behavior | 16.6667 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 16.6667 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 16.6667 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 16.6667 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 16.6667 | 5 | yes |
| GO:0050679 | positive regulation of epithelial cell proliferation | 16.6667 | 6 | yes |
| GO:0050708 | regulation of protein secretion | 16.6667 | 5 | yes |
| GO:0050709 | negative regulation of protein secretion | 16.6667 | 6 | yes |
| GO:0050727 | regulation of inflammatory response | 16.6667 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 16.6667 | 6 | yes |
| GO:0050795 | regulation of behavior | 16.6667 | 4 | yes |
| GO:0050796 | regulation of insulin secretion | 16.6667 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 16.6667 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 16.6667 | 5 | yes |
| GO:0050808 | synapse organization | 16.6667 | 5 | yes |
| GO:0051046 | regulation of secretion | 16.6667 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 16.6667 | 5 | yes |
| GO:0051049 | regulation of transport | 16.6667 | 4 | yes |
| GO:0051051 | negative regulation of transport | 16.6667 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 16.6667 | 4 | yes |
| GO:0051223 | regulation of protein transport | 16.6667 | 5 | yes |
| GO:0051224 | negative regulation of protein transport | 16.6667 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 16.6667 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 16.6667 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 16.6667 | 6 | yes |
| GO:0051969 | regulation of transmission of nerve impulse | 16.6667 | 5 | yes |
| GO:0060123 | regulation of growth hormone secretion | 16.6667 | 6 | yes |
| GO:0060259 | regulation of feeding behavior | 16.6667 | 5 | yes |
| GO:0060456 | positive regulation of digestive system process | 16.6667 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 16.6667 | 6 | yes |
| GO:0090087 | regulation of peptide transport | 16.6667 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 16.6667 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 16.6667 | 5 | yes |
| GO:0090278 | negative regulation of peptide hormone secretion | 16.6667 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 16.6667 | 4 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 16.6667 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 16.6667 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 16.6667 | 4 | yes |
| GO:0120057 | regulation of small intestinal transit | 16.6667 | 6 | yes |
| GO:0120058 | positive regulation of small intestinal transit | 16.6667 | 6 | yes |
| GO:1901342 | regulation of vasculature development | 16.6667 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 16.6667 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 16.6667 | 4 | yes |
| GO:1903531 | negative regulation of secretion by cell | 16.6667 | 5 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 16.6667 | 5 | yes |
| GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production | 16.6667 | 6 | yes |
| GO:1903670 | regulation of sprouting angiogenesis | 16.6667 | 6 | yes |
| GO:1903672 | positive regulation of sprouting angiogenesis | 16.6667 | 7 | yes |
| GO:1903828 | negative regulation of protein localization | 16.6667 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 16.6667 | 5 | yes |
| GO:1903998 | regulation of eating behavior | 16.6667 | 6 | yes |
| GO:1904000 | positive regulation of eating behavior | 16.6667 | 7 | yes |
| GO:1904018 | positive regulation of vasculature development | 16.6667 | 5 | yes |
| GO:1904304 | regulation of gastro-intestinal system smooth muscle contraction | 16.6667 | 8 | yes |
| GO:1904306 | positive regulation of gastro-intestinal system smooth muscle contraction | 16.6667 | 7 | yes |
| GO:1904347 | regulation of small intestine smooth muscle contraction | 16.6667 | 9 | yes |
| GO:1904349 | positive regulation of small intestine smooth muscle contraction | 16.6667 | 8 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 16.6667 | 6 | yes |
| GO:1905333 | regulation of gastric motility | 16.6667 | 6 | yes |
| GO:1905562 | regulation of vascular endothelial cell proliferation | 16.6667 | 7 | yes |
| GO:1905564 | positive regulation of vascular endothelial cell proliferation | 16.6667 | 8 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.6667 | 4 | yes |
| GO:2000253 | positive regulation of feeding behavior | 16.6667 | 6 | yes |
| GO:0001817 | regulation of cytokine production | 16.6667 | 4 | yes |
| GO:0001818 | negative regulation of cytokine production | 16.6667 | 5 | yes |
| GO:0001936 | regulation of endothelial cell proliferation | 16.6667 | 6 | yes |
| GO:0001938 | positive regulation of endothelial cell proliferation | 16.6667 | 7 | yes |
| GO:0002790 | peptide secretion | 16.6667 | 5 | yes |
| GO:0002791 | regulation of peptide secretion | 16.6667 | 6 | yes |
| GO:0002792 | negative regulation of peptide secretion | 16.6667 | 6 | yes |
| GO:0006869 | lipid transport | 16.6667 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 16.6667 | 6 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 16.6667 | 7 | yes |
| GO:0007015 | actin filament organization | 16.6667 | 5 | yes |
| GO:0007416 | synapse assembly | 16.6667 | 6 | yes |
| GO:0008154 | actin polymerization or depolymerization | 16.6667 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 16.6667 | 5 | yes |
| GO:0008343 | adult feeding behavior | 16.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 16.6667 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 16.6667 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 16.6667 | 4 | yes |
| GO:0009914 | hormone transport | 16.6667 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 16.6667 | 5 | yes |
| GO:0010468 | regulation of gene expression | 16.6667 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 16.6667 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 16.6667 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 16.6667 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 16.6667 | 7 | yes |
| GO:0010647 | positive regulation of cell communication | 16.6667 | 5 | yes |
| GO:0015833 | peptide transport | 16.6667 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 16.6667 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 16.6667 | 4 | yes |
| GO:0023061 | signal release | 16.6667 | 4 | yes |
| GO:0030072 | peptide hormone secretion | 16.6667 | 6 | yes |
| GO:0030252 | growth hormone secretion | 16.6667 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 16.6667 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 16.6667 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 16.6667 | 6 | yes |
| GO:0031347 | regulation of defense response | 16.6667 | 5 | yes |
| GO:0031348 | negative regulation of defense response | 16.6667 | 5 | yes |
| GO:0031644 | regulation of nervous system process | 16.6667 | 5 | yes |
| GO:0032095 | regulation of response to food | 16.6667 | 5 | yes |
| GO:0032097 | positive regulation of response to food | 16.6667 | 6 | yes |
| GO:0032100 | positive regulation of appetite | 16.6667 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 16.6667 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 16.6667 | 5 | yes |
| GO:0032107 | regulation of response to nutrient levels | 16.6667 | 4 | yes |
| GO:0032109 | positive regulation of response to nutrient levels | 16.6667 | 5 | yes |
| GO:0032651 | regulation of interleukin-1 beta production | 16.6667 | 6 | yes |
| GO:0032652 | regulation of interleukin-1 production | 16.6667 | 5 | yes |
| GO:0032675 | regulation of interleukin-6 production | 16.6667 | 5 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 16.6667 | 6 | yes |
| GO:0032691 | negative regulation of interleukin-1 beta production | 16.6667 | 7 | yes |
| GO:0032692 | negative regulation of interleukin-1 production | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GHSR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PI2R_HUMAN | [view interactions] | Low throughput | no | no |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| PE2R3_HUMAN | [view interactions] | Low throughput | no | no |
| MTLR_HUMAN | [view interactions] | Low throughput | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR5_HUMAN | [view interactions] | High throughput | no | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| GNPAT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP6_HUMAN | [view interactions] | High throughput | no | yes |