Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GHRL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GHRL_HUMAN
GO:0046872 metal ion binding 33.3333 4 no
GO:0017076 purine nucleotide binding 26.6667 4 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.6667 4 no
GO:0016462 pyrophosphatase activity 26.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.6667 6 no
GO:0001664 G protein-coupled receptor binding 20.0000 4 yes
GO:0005179 hormone activity 20.0000 5 yes
GO:0048018 receptor ligand activity 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GHRL_HUMAN
GO:0010243 response to organonitrogen compound 53.3333 4 no
GO:0014070 response to organic cyclic compound 46.6667 4 no
GO:0048522 positive regulation of cellular process 40.0000 4 yes
GO:0048523 negative regulation of cellular process 40.0000 4 yes
GO:0051128 regulation of cellular component organization 40.0000 4 yes
GO:0071702 organic substance transport 40.0000 4 yes
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 40.0000 4 no
GO:0033993 response to lipid 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 yes
GO:0010646 regulation of cell communication 40.0000 4 yes
GO:0010941 regulation of cell death 40.0000 4 yes
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 yes
GO:0060341 regulation of cellular localization 33.3333 4 yes
GO:0060548 negative regulation of cell death 33.3333 5 yes
GO:0080134 regulation of response to stress 33.3333 4 yes
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0040014 regulation of multicellular organism growth 26.6667 4 yes
GO:0043066 negative regulation of apoptotic process 26.6667 7 yes
GO:0043069 negative regulation of programmed cell death 26.6667 6 yes
GO:0044057 regulation of system process 26.6667 4 yes
GO:0045927 positive regulation of growth 26.6667 4 yes
GO:0048584 positive regulation of response to stimulus 26.6667 4 yes
GO:0048638 regulation of developmental growth 26.6667 4 yes
GO:0048639 positive regulation of developmental growth 26.6667 5 yes
GO:0050708 regulation of protein secretion 26.6667 5 yes
GO:0051046 regulation of secretion 26.6667 5 yes
GO:0051049 regulation of transport 26.6667 4 yes
GO:0051094 positive regulation of developmental process 26.6667 4 yes
GO:0051130 positive regulation of cellular component organization 26.6667 5 yes
GO:0051223 regulation of protein transport 26.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 26.6667 4 yes
GO:0051241 negative regulation of multicellular organismal process 26.6667 4 yes
GO:0070201 regulation of establishment of protein localization 26.6667 6 yes
GO:0071705 nitrogen compound transport 26.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 26.6667 5 yes
GO:1903530 regulation of secretion by cell 26.6667 4 yes
GO:2000026 regulation of multicellular organismal development 26.6667 4 yes
GO:0030334 regulation of cell migration 26.6667 5 no
GO:0031325 positive regulation of cellular metabolic process 26.6667 5 no
GO:2000145 regulation of cell motility 26.6667 4 no
GO:0071396 cellular response to lipid 26.6667 5 no
GO:0071407 cellular response to organic cyclic compound 26.6667 5 no
GO:1901654 response to ketone 26.6667 4 no
GO:0022607 cellular component assembly 26.6667 4 no
GO:0031667 response to nutrient levels 26.6667 4 no
GO:0001817 regulation of cytokine production 26.6667 4 yes
GO:0008284 positive regulation of cell population proliferation 26.6667 5 yes
GO:0009892 negative regulation of metabolic process 26.6667 4 yes
GO:0009967 positive regulation of signal transduction 26.6667 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 yes
GO:0010647 positive regulation of cell communication 26.6667 5 yes
GO:0023056 positive regulation of signaling 26.6667 4 yes
GO:0031347 regulation of defense response 26.6667 5 yes
GO:0031348 negative regulation of defense response 26.6667 5 yes
GO:0032101 regulation of response to external stimulus 26.6667 4 yes
GO:0032102 negative regulation of response to external stimulus 26.6667 5 yes
GO:0032720 negative regulation of tumor necrosis factor production 20.0000 7 yes
GO:0040013 negative regulation of locomotion 20.0000 4 yes
GO:0040018 positive regulation of multicellular organism growth 20.0000 5 yes
GO:0043408 regulation of MAPK cascade 20.0000 6 yes
GO:0043410 positive regulation of MAPK cascade 20.0000 7 yes
GO:0044087 regulation of cellular component biogenesis 20.0000 4 yes
GO:0046676 negative regulation of insulin secretion 20.0000 7 yes
GO:0046883 regulation of hormone secretion 20.0000 4 yes
GO:0046888 negative regulation of hormone secretion 20.0000 5 yes
GO:0046903 secretion 20.0000 4 yes
GO:0048521 negative regulation of behavior 20.0000 5 yes
GO:0050678 regulation of epithelial cell proliferation 20.0000 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 20.0000 6 yes
GO:0050709 negative regulation of protein secretion 20.0000 6 yes
GO:0050727 regulation of inflammatory response 20.0000 5 yes
GO:0050728 negative regulation of inflammatory response 20.0000 6 yes
GO:0050795 regulation of behavior 20.0000 4 yes
GO:0050796 regulation of insulin secretion 20.0000 6 yes
GO:0050804 modulation of chemical synaptic transmission 20.0000 5 yes
GO:0050807 regulation of synapse organization 20.0000 5 yes
GO:0051047 positive regulation of secretion 20.0000 5 yes
GO:0051048 negative regulation of secretion 20.0000 5 yes
GO:0051050 positive regulation of transport 20.0000 4 yes
GO:0051051 negative regulation of transport 20.0000 4 yes
GO:0051224 negative regulation of protein transport 20.0000 5 yes
GO:0060123 regulation of growth hormone secretion 20.0000 6 yes
GO:0090087 regulation of peptide transport 20.0000 5 yes
GO:0090257 regulation of muscle system process 20.0000 5 yes
GO:0090276 regulation of peptide hormone secretion 20.0000 5 yes
GO:0090278 negative regulation of peptide hormone secretion 20.0000 6 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 20.0000 6 yes
GO:0099177 regulation of trans-synaptic signaling 20.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 20.0000 6 yes
GO:1903531 negative regulation of secretion by cell 20.0000 5 yes
GO:1903532 positive regulation of secretion by cell 20.0000 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 20.0000 5 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 20.0000 6 yes
GO:1903828 negative regulation of protein localization 20.0000 5 yes
GO:1903829 positive regulation of protein localization 20.0000 5 yes
GO:1904950 negative regulation of establishment of protein localization 20.0000 6 yes
GO:0001818 negative regulation of cytokine production 20.0000 5 yes
GO:0002791 regulation of peptide secretion 20.0000 6 yes
GO:0002792 negative regulation of peptide secretion 20.0000 6 yes
GO:0006869 lipid transport 20.0000 5 yes
GO:0008285 negative regulation of cell population proliferation 20.0000 5 yes
GO:0010629 negative regulation of gene expression 20.0000 6 yes
GO:0032651 regulation of interleukin-1 beta production 20.0000 6 yes
GO:0032652 regulation of interleukin-1 production 20.0000 5 yes
GO:0032680 regulation of tumor necrosis factor production 20.0000 6 yes
GO:0032691 negative regulation of interleukin-1 beta production 20.0000 7 yes
GO:0032692 negative regulation of interleukin-1 production 20.0000 6 yes
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep 13.3333 5 yes
GO:0042749 regulation of circadian sleep/wake cycle 13.3333 4 yes
GO:0042754 negative regulation of circadian rhythm 13.3333 4 yes
GO:0042886 amide transport 13.3333 5 yes
GO:0044058 regulation of digestive system process 13.3333 5 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 13.3333 5 yes
GO:0045765 regulation of angiogenesis 13.3333 5 yes
GO:0045766 positive regulation of angiogenesis 13.3333 6 yes
GO:0045933 positive regulation of muscle contraction 13.3333 5 yes
GO:0045987 positive regulation of smooth muscle contraction 13.3333 6 yes
GO:0046717 acid secretion 13.3333 5 yes
GO:0046879 hormone secretion 13.3333 5 yes
GO:0046887 positive regulation of hormone secretion 13.3333 5 yes
GO:0048520 positive regulation of behavior 13.3333 5 yes
GO:0050714 positive regulation of protein secretion 13.3333 6 yes
GO:0051093 negative regulation of developmental process 13.3333 4 yes
GO:0051222 positive regulation of protein transport 13.3333 5 yes
GO:0051960 regulation of nervous system development 13.3333 5 yes
GO:0051962 positive regulation of nervous system development 13.3333 5 yes
GO:0051963 regulation of synapse assembly 13.3333 6 yes
GO:0051969 regulation of transmission of nerve impulse 13.3333 4 yes
GO:0060078 regulation of postsynaptic membrane potential 13.3333 4 yes
GO:0060079 excitatory postsynaptic potential 13.3333 5 yes
GO:0060124 positive regulation of growth hormone secretion 13.3333 7 yes
GO:0060259 regulation of feeding behavior 13.3333 5 yes
GO:0060456 positive regulation of digestive system process 13.3333 5 yes
GO:0090277 positive regulation of peptide hormone secretion 13.3333 6 yes
GO:0097435 supramolecular fiber organization 13.3333 4 yes
GO:0099175 regulation of postsynapse organization 13.3333 6 yes
GO:0120057 regulation of small intestinal transit 13.3333 6 yes
GO:0120058 positive regulation of small intestinal transit 13.3333 6 yes
GO:1901342 regulation of vasculature development 13.3333 5 yes
GO:1901888 regulation of cell junction assembly 13.3333 5 yes
GO:1903522 regulation of blood circulation 13.3333 5 yes
GO:1903670 regulation of sprouting angiogenesis 13.3333 6 yes
GO:1903672 positive regulation of sprouting angiogenesis 13.3333 7 yes
GO:1903998 regulation of eating behavior 13.3333 6 yes
GO:1904000 positive regulation of eating behavior 13.3333 7 yes
GO:1904018 positive regulation of vasculature development 13.3333 5 yes
GO:1904304 regulation of gastro-intestinal system smooth muscle contraction 13.3333 8 yes
GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction 13.3333 7 yes
GO:1904347 regulation of small intestine smooth muscle contraction 13.3333 9 yes
GO:1904349 positive regulation of small intestine smooth muscle contraction 13.3333 8 yes
GO:1904951 positive regulation of establishment of protein localization 13.3333 6 yes
GO:1905333 regulation of gastric motility 13.3333 6 yes
GO:1905562 regulation of vascular endothelial cell proliferation 13.3333 7 yes
GO:1905564 positive regulation of vascular endothelial cell proliferation 13.3333 8 yes
GO:2000253 positive regulation of feeding behavior 13.3333 6 yes
GO:0001936 regulation of endothelial cell proliferation 13.3333 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 13.3333 7 yes
GO:0002790 peptide secretion 13.3333 5 yes
GO:0002793 positive regulation of peptide secretion 13.3333 6 yes
GO:0006937 regulation of muscle contraction 13.3333 6 yes
GO:0006940 regulation of smooth muscle contraction 13.3333 7 yes
GO:0007015 actin filament organization 13.3333 5 yes
GO:0008154 actin polymerization or depolymerization 13.3333 6 yes
GO:0008343 adult feeding behavior 13.3333 4 yes
GO:0009914 hormone transport 13.3333 4 yes
GO:0015833 peptide transport 13.3333 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 13.3333 4 yes
GO:0023061 signal release 13.3333 4 yes
GO:0030030 cell projection organization 13.3333 4 yes
GO:0030072 peptide hormone secretion 13.3333 6 yes
GO:0030252 growth hormone secretion 13.3333 7 yes
GO:0031644 regulation of nervous system process 13.3333 5 yes
GO:0032095 regulation of response to food 13.3333 7 yes
GO:0032097 positive regulation of response to food 13.3333 8 yes
GO:0032100 positive regulation of appetite 13.3333 4 yes
GO:0032103 positive regulation of response to external stimulus 13.3333 5 yes
GO:0032104 regulation of response to extracellular stimulus 13.3333 5 yes
GO:0032106 positive regulation of response to extracellular stimulus 13.3333 6 yes
GO:0032107 regulation of response to nutrient levels 13.3333 6 yes
GO:0032109 positive regulation of response to nutrient levels 13.3333 7 yes
GO:0032675 regulation of interleukin-6 production 13.3333 5 yes
GO:0032715 negative regulation of interleukin-6 production 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
SGMR1_HUMAN [view entry] [view interactions] Low throughput yes yes
PI2R_HUMAN [view interactions] Low throughput no no
TA2R_HUMAN [view interactions] Low throughput no no
PE2R3_HUMAN [view interactions] Low throughput no no
MTLR_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
UBQL1_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
SYFB_HUMAN [view entry] [view interactions] High throughput yes yes
SIR5_HUMAN [view interactions] High throughput no yes
WDCP_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
GNPAT_HUMAN [view entry] [view interactions] High throughput yes no
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
NECP2_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
UTP6_HUMAN [view interactions] High throughput no yes
NPY_HUMAN [view interactions] Computational no yes
IGF1_HUMAN [view entry] [view interactions] Computational yes no
GLUC_HUMAN [view interactions] Computational no no
SOMA_HUMAN [view interactions] Computational no no
NEUT_HUMAN [view interactions] Computational no no
GIP_HUMAN [view interactions] Computational no no
TRH_HUMAN [view interactions] Computational no no
GPR39_HUMAN [view interactions] Computational no yes
GRP_HUMAN [view interactions] Computational no no
NEU1_HUMAN [view interactions] Computational no no
SC11C_HUMAN [view interactions] Computational no no
KLF4_HUMAN [view interactions] Computational no no
UCN1_HUMAN [view interactions] Computational no yes
GAST_HUMAN [view interactions] Computational no no
CCKN_HUMAN [view interactions] Computational no yes
MBOA4_HUMAN [view interactions] Computational no no
SLIB_HUMAN [view interactions] Computational no no
SC11A_HUMAN [view interactions] Computational no no
PAFA_HUMAN [view interactions] Computational no no
OREX_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
PYY_HUMAN [view interactions] Computational no no
SMS_HUMAN [view entry] [view interactions] Computational yes no
SPCS3_HUMAN [view interactions] Computational no yes
DRD2_HUMAN [view entry] [view interactions] Computational yes no
CHLE_HUMAN [view interactions] Computational no no
MOTI_HUMAN [view interactions] Computational no no
AGRP_HUMAN [view interactions] Computational no no
LEP_HUMAN [view interactions] Computational no no
NPY1R_HUMAN [view interactions] Computational no no
ACES_HUMAN [view interactions] Computational no no
PAHO_HUMAN [view interactions] Computational no no
NEC1_HUMAN [view interactions] Computational no yes
COLI_HUMAN [view interactions] Computational no no
SPCS2_HUMAN [view interactions] Computational no yes
ADIPO_HUMAN [view interactions] Computational no no
CRFR2_HUMAN [view interactions] Computational no no