Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GHSR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
204 Ala Glu Growthhormonedeficiency,isolatedpartial(GHDP) -
237 Arg Trp Growthhormonedeficiency,isolatedpartial(GHDP) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GHSR_HUMAN
GO:0017076 purine nucleotide binding 38.4615 4 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 no
GO:0046872 metal ion binding 38.4615 4 no
GO:0003924 GTPase activity 38.4615 7 no
GO:0016462 pyrophosphatase activity 38.4615 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 38.4615 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 38.4615 6 no
GO:0001664 G protein-coupled receptor binding 38.4615 4 no
GO:0004930 G protein-coupled receptor activity 30.7692 4 yes
GO:0005525 GTP binding 30.7692 5 no
GO:0019001 guanyl nucleotide binding 30.7692 5 no
GO:0032561 guanyl ribonucleotide binding 30.7692 5 no
GO:0001616 growth hormone secretagogue receptor activity 15.3846 5 yes
GO:0016520 growth hormone-releasing hormone receptor activity 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GHSR_HUMAN
GO:0010243 response to organonitrogen compound 61.5385 4 yes
GO:0048523 negative regulation of cellular process 53.8462 4 yes
GO:0071310 cellular response to organic substance 53.8462 4 yes
GO:1901701 cellular response to oxygen-containing compound 53.8462 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 53.8462 4 no
GO:0014070 response to organic cyclic compound 53.8462 4 yes
GO:0033993 response to lipid 46.1538 4 yes
GO:0048522 positive regulation of cellular process 46.1538 4 yes
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 yes
GO:0071417 cellular response to organonitrogen compound 46.1538 4 yes
GO:0071702 organic substance transport 46.1538 4 yes
GO:1901699 cellular response to nitrogen compound 46.1538 4 yes
GO:0010646 regulation of cell communication 46.1538 4 yes
GO:0031323 regulation of cellular metabolic process 38.4615 4 yes
GO:0032870 cellular response to hormone stimulus 38.4615 4 yes
GO:0032880 regulation of protein localization 38.4615 5 yes
GO:0042127 regulation of cell population proliferation 38.4615 4 yes
GO:0042981 regulation of apoptotic process 38.4615 6 yes
GO:0043067 regulation of programmed cell death 38.4615 5 yes
GO:0051049 regulation of transport 38.4615 4 yes
GO:0051128 regulation of cellular component organization 38.4615 4 yes
GO:0060341 regulation of cellular localization 38.4615 4 yes
GO:0071396 cellular response to lipid 38.4615 5 yes
GO:0071705 nitrogen compound transport 38.4615 4 yes
GO:0080090 regulation of primary metabolic process 38.4615 4 yes
GO:1901654 response to ketone 38.4615 4 yes
GO:0009893 positive regulation of metabolic process 38.4615 4 yes
GO:0009966 regulation of signal transduction 38.4615 4 yes
GO:0010468 regulation of gene expression 38.4615 5 yes
GO:0010941 regulation of cell death 38.4615 4 yes
GO:0023056 positive regulation of signaling 30.7692 4 yes
GO:0023057 negative regulation of signaling 30.7692 4 yes
GO:0032101 regulation of response to external stimulus 30.7692 4 yes
GO:0032102 negative regulation of response to external stimulus 30.7692 5 yes
GO:0043066 negative regulation of apoptotic process 30.7692 7 yes
GO:0043069 negative regulation of programmed cell death 30.7692 6 yes
GO:0043434 response to peptide hormone 30.7692 4 yes
GO:0048585 negative regulation of response to stimulus 30.7692 4 yes
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 yes
GO:0051046 regulation of secretion 30.7692 5 yes
GO:0051051 negative regulation of transport 30.7692 4 yes
GO:0051223 regulation of protein transport 30.7692 5 yes
GO:0060548 negative regulation of cell death 30.7692 5 yes
GO:0070201 regulation of establishment of protein localization 30.7692 6 yes
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 yes
GO:1901652 response to peptide 30.7692 4 yes
GO:1903530 regulation of secretion by cell 30.7692 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 30.7692 5 no
GO:0071407 cellular response to organic cyclic compound 30.7692 5 no
GO:0009416 response to light stimulus 30.7692 4 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 yes
GO:0009892 negative regulation of metabolic process 30.7692 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 yes
GO:0010647 positive regulation of cell communication 30.7692 5 yes
GO:0010648 negative regulation of cell communication 30.7692 5 yes
GO:0015833 peptide transport 23.0769 5 yes
GO:0019216 regulation of lipid metabolic process 23.0769 5 yes
GO:0019217 regulation of fatty acid metabolic process 23.0769 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 yes
GO:0023061 signal release 23.0769 4 yes
GO:0030072 peptide hormone secretion 23.0769 6 yes
GO:0030252 growth hormone secretion 23.0769 7 yes
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 yes
GO:0031347 regulation of defense response 23.0769 5 yes
GO:0031348 negative regulation of defense response 23.0769 5 yes
GO:0031644 regulation of nervous system process 23.0769 5 yes
GO:0031667 response to nutrient levels 23.0769 4 yes
GO:0032095 regulation of response to food 23.0769 7 yes
GO:0032097 positive regulation of response to food 23.0769 8 yes
GO:0032100 positive regulation of appetite 23.0769 4 yes
GO:0032103 positive regulation of response to external stimulus 23.0769 5 yes
GO:0032104 regulation of response to extracellular stimulus 23.0769 5 yes
GO:0032106 positive regulation of response to extracellular stimulus 23.0769 6 yes
GO:0032107 regulation of response to nutrient levels 23.0769 6 yes
GO:0032109 positive regulation of response to nutrient levels 23.0769 7 yes
GO:0032651 regulation of interleukin-1 beta production 23.0769 6 yes
GO:0032652 regulation of interleukin-1 production 23.0769 5 yes
GO:0032675 regulation of interleukin-6 production 23.0769 5 yes
GO:0032680 regulation of tumor necrosis factor production 23.0769 6 yes
GO:0032691 negative regulation of interleukin-1 beta production 23.0769 7 yes
GO:0032692 negative regulation of interleukin-1 production 23.0769 6 yes
GO:0032715 negative regulation of interleukin-6 production 23.0769 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 23.0769 7 yes
GO:0032868 response to insulin 23.0769 5 yes
GO:0032869 cellular response to insulin stimulus 23.0769 6 yes
GO:0040013 negative regulation of locomotion 23.0769 4 yes
GO:0040014 regulation of multicellular organism growth 23.0769 4 yes
GO:0040018 positive regulation of multicellular organism growth 23.0769 5 yes
GO:0042886 amide transport 23.0769 5 yes
GO:0043269 regulation of ion transport 23.0769 5 yes
GO:0044057 regulation of system process 23.0769 4 yes
GO:0044058 regulation of digestive system process 23.0769 5 yes
GO:0044087 regulation of cellular component biogenesis 23.0769 4 yes
GO:0045765 regulation of angiogenesis 23.0769 5 yes
GO:0045766 positive regulation of angiogenesis 23.0769 6 yes
GO:0045834 positive regulation of lipid metabolic process 23.0769 5 yes
GO:0045923 positive regulation of fatty acid metabolic process 23.0769 6 yes
GO:0045927 positive regulation of growth 23.0769 4 yes
GO:0045933 positive regulation of muscle contraction 23.0769 5 yes
GO:0045987 positive regulation of smooth muscle contraction 23.0769 6 yes
GO:0046676 negative regulation of insulin secretion 23.0769 7 yes
GO:0046879 hormone secretion 23.0769 5 yes
GO:0046883 regulation of hormone secretion 23.0769 4 yes
GO:0046888 negative regulation of hormone secretion 23.0769 5 yes
GO:0046903 secretion 23.0769 4 yes
GO:0048520 positive regulation of behavior 23.0769 5 yes
GO:0048521 negative regulation of behavior 23.0769 5 yes
GO:0048545 response to steroid hormone 23.0769 4 yes
GO:0048584 positive regulation of response to stimulus 23.0769 4 yes
GO:0048638 regulation of developmental growth 23.0769 4 yes
GO:0048639 positive regulation of developmental growth 23.0769 5 yes
GO:0050678 regulation of epithelial cell proliferation 23.0769 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 23.0769 6 yes
GO:0050708 regulation of protein secretion 23.0769 5 yes
GO:0050709 negative regulation of protein secretion 23.0769 6 yes
GO:0050727 regulation of inflammatory response 23.0769 5 yes
GO:0050728 negative regulation of inflammatory response 23.0769 6 yes
GO:0050795 regulation of behavior 23.0769 4 yes
GO:0050796 regulation of insulin secretion 23.0769 6 yes
GO:0050807 regulation of synapse organization 23.0769 5 yes
GO:0050890 cognition 23.0769 4 yes
GO:0051048 negative regulation of secretion 23.0769 5 yes
GO:0051094 positive regulation of developmental process 23.0769 4 yes
GO:0051224 negative regulation of protein transport 23.0769 5 yes
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 yes
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 yes
GO:0051952 regulation of amine transport 23.0769 5 yes
GO:0051963 regulation of synapse assembly 23.0769 6 yes
GO:0051969 regulation of transmission of nerve impulse 23.0769 4 yes
GO:0060123 regulation of growth hormone secretion 23.0769 6 yes
GO:0060259 regulation of feeding behavior 23.0769 5 yes
GO:0060456 positive regulation of digestive system process 23.0769 5 yes
GO:0062012 regulation of small molecule metabolic process 23.0769 4 yes
GO:0062013 positive regulation of small molecule metabolic process 23.0769 5 yes
GO:0071375 cellular response to peptide hormone stimulus 23.0769 5 yes
GO:0080134 regulation of response to stress 23.0769 4 yes
GO:0090087 regulation of peptide transport 23.0769 5 yes
GO:0090257 regulation of muscle system process 23.0769 5 yes
GO:0090276 regulation of peptide hormone secretion 23.0769 5 yes
GO:0090278 negative regulation of peptide hormone secretion 23.0769 6 yes
GO:0097435 supramolecular fiber organization 23.0769 4 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 23.0769 6 yes
GO:0099175 regulation of postsynapse organization 23.0769 6 yes
GO:0120057 regulation of small intestinal transit 23.0769 6 yes
GO:0120058 positive regulation of small intestinal transit 23.0769 6 yes
GO:1901342 regulation of vasculature development 23.0769 5 yes
GO:1901653 cellular response to peptide 23.0769 5 yes
GO:1901888 regulation of cell junction assembly 23.0769 5 yes
GO:1903531 negative regulation of secretion by cell 23.0769 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 23.0769 5 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 23.0769 6 yes
GO:1903670 regulation of sprouting angiogenesis 23.0769 6 yes
GO:1903672 positive regulation of sprouting angiogenesis 23.0769 7 yes
GO:1903828 negative regulation of protein localization 23.0769 5 yes
GO:1903998 regulation of eating behavior 23.0769 6 yes
GO:1904000 positive regulation of eating behavior 23.0769 7 yes
GO:1904018 positive regulation of vasculature development 23.0769 5 yes
GO:1904304 regulation of gastro-intestinal system smooth muscle contraction 23.0769 8 yes
GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction 23.0769 7 yes
GO:1904347 regulation of small intestine smooth muscle contraction 23.0769 9 yes
GO:1904349 positive regulation of small intestine smooth muscle contraction 23.0769 8 yes
GO:1904375 regulation of protein localization to cell periphery 23.0769 6 yes
GO:1904950 negative regulation of establishment of protein localization 23.0769 6 yes
GO:1905333 regulation of gastric motility 23.0769 6 yes
GO:1905475 regulation of protein localization to membrane 23.0769 6 yes
GO:1905562 regulation of vascular endothelial cell proliferation 23.0769 7 yes
GO:1905564 positive regulation of vascular endothelial cell proliferation 23.0769 8 yes
GO:2000026 regulation of multicellular organismal development 23.0769 4 yes
GO:2000253 positive regulation of feeding behavior 23.0769 6 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 23.0769 4 no
GO:0071867 response to monoamine 23.0769 5 no
GO:0071868 cellular response to monoamine stimulus 23.0769 5 no
GO:0071869 response to catecholamine 23.0769 4 no
GO:0071870 cellular response to catecholamine stimulus 23.0769 5 no
GO:0097305 response to alcohol 23.0769 4 no
GO:0097306 cellular response to alcohol 23.0769 5 no
GO:1901655 cellular response to ketone 23.0769 5 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0030334 regulation of cell migration 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051171 regulation of nitrogen compound metabolic process 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:2000145 regulation of cell motility 23.0769 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 23.0769 4 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 23.0769 4 no
GO:0095500 acetylcholine receptor signaling pathway 23.0769 4 no
GO:0001508 action potential 23.0769 4 no
GO:0001817 regulation of cytokine production 23.0769 4 yes
GO:0001818 negative regulation of cytokine production 23.0769 5 yes
GO:0001936 regulation of endothelial cell proliferation 23.0769 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 23.0769 7 yes
GO:0002790 peptide secretion 23.0769 5 yes
GO:0002791 regulation of peptide secretion 23.0769 6 yes
GO:0002792 negative regulation of peptide secretion 23.0769 6 yes
GO:0006937 regulation of muscle contraction 23.0769 6 yes
GO:0006940 regulation of smooth muscle contraction 23.0769 7 yes
GO:0007015 actin filament organization 23.0769 5 yes
GO:0008154 actin polymerization or depolymerization 23.0769 6 yes
GO:0008343 adult feeding behavior 23.0769 4 yes
GO:0009914 hormone transport 23.0769 4 yes
GO:0009967 positive regulation of signal transduction 23.0769 5 yes
GO:0010565 regulation of cellular ketone metabolic process 23.0769 5 yes
GO:0010629 negative regulation of gene expression 23.0769 6 yes
GO:0031960 response to corticosteroid 15.3846 5 yes
GO:0032096 negative regulation of response to food 15.3846 8 yes
GO:0032099 negative regulation of appetite 15.3846 4 yes
GO:0032105 negative regulation of response to extracellular stimulus 15.3846 6 yes
GO:0032108 negative regulation of response to nutrient levels 15.3846 7 yes
GO:0032354 response to follicle-stimulating hormone 15.3846 5 yes
GO:0032355 response to estradiol 15.3846 4 yes
GO:0032496 response to lipopolysaccharide 15.3846 4 yes
GO:0033032 regulation of myeloid cell apoptotic process 15.3846 7 yes
GO:0033033 negative regulation of myeloid cell apoptotic process 15.3846 8 yes
GO:0033604 negative regulation of catecholamine secretion 15.3846 6 yes
GO:0034698 response to gonadotropin 15.3846 4 yes
GO:0036321 ghrelin secretion 15.3846 7 yes
GO:0043134 regulation of hindgut contraction 15.3846 6 yes
GO:0043271 negative regulation of ion transport 15.3846 5 yes
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 15.3846 5 yes
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 15.3846 6 yes
GO:0048232 male gamete generation 15.3846 4 yes
GO:0050433 regulation of catecholamine secretion 15.3846 5 yes
GO:0051384 response to glucocorticoid 15.3846 6 yes
GO:0051953 negative regulation of amine transport 15.3846 5 yes
GO:0060416 response to growth hormone 15.3846 5 yes
GO:0071219 cellular response to molecule of bacterial origin 15.3846 4 yes
GO:0071222 cellular response to lipopolysaccharide 15.3846 5 yes
GO:0071548 response to dexamethasone 15.3846 5 yes
GO:0090325 regulation of locomotion involved in locomotory behavior 15.3846 4 yes
GO:0090327 negative regulation of locomotion involved in locomotory behavior 15.3846 5 yes
GO:0097066 response to thyroid hormone 15.3846 4 yes
GO:0097067 cellular response to thyroid hormone stimulus 15.3846 5 yes
GO:1902473 regulation of protein localization to synapse 15.3846 6 yes
GO:1902683 regulation of receptor localization to synapse 15.3846 4 yes
GO:1904008 response to monosodium glutamate 15.3846 4 yes
GO:1990314 cellular response to insulin-like growth factor stimulus 15.3846 6 yes
GO:2000106 regulation of leukocyte apoptotic process 15.3846 7 yes
GO:2000107 negative regulation of leukocyte apoptotic process 15.3846 8 yes
GO:2000109 regulation of macrophage apoptotic process 15.3846 8 yes
GO:2000110 negative regulation of macrophage apoptotic process 15.3846 9 yes
GO:0002237 response to molecule of bacterial origin 15.3846 4 yes
GO:0010700 negative regulation of norepinephrine secretion 15.3846 6 yes
GO:0014061 regulation of norepinephrine secretion 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GHRL_HUMAN [view entry] [view interactions] Low throughput yes no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT2C_HUMAN [view interactions] Low throughput no no
OXYR_HUMAN [view interactions] Low throughput no no
SGMR1_HUMAN [view entry] [view interactions] Low throughput yes yes
LEPR_HUMAN [view interactions] Low throughput no no
OX1R_HUMAN [view interactions] Low throughput no yes
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
KSR1_HUMAN [view interactions] High throughput no yes
CLK3_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UCK2_HUMAN [view interactions] High throughput no no
NPY_HUMAN [view interactions] Computational no yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
MBOA4_HUMAN [view interactions] Computational no no
SLIB_HUMAN [view interactions] Computational no no
MC3R_HUMAN [view interactions] Computational no no
SMS_HUMAN [view entry] [view interactions] Computational yes no
AGRP_HUMAN [view interactions] Computational no no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
CORT_HUMAN [view interactions] Computational no no