AKT2_HUMAN
One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on Ser-197 during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on Thr-343. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
17 | Glu | Lys | Hypoinsulinemichypoglycemiawithhemihypertrophy(HIHGHH) | - |
274 | Arg | His | Diabetesmellitus,non-insulin-dependent(NIDDM) | - |
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001633 | DOC_AGCK_PIF_1 | DOC | 470 | 475 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AKT2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 45.3333 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 45.3333 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 45.3333 | 4 | yes |
GO:0005524 | ATP binding | 36.0000 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 36.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 36.0000 | 5 | yes |
GO:0016301 | kinase activity | 22.6667 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 22.6667 | 4 | yes |
GO:0019900 | kinase binding | 22.6667 | 4 | no |
GO:0019901 | protein kinase binding | 22.6667 | 5 | no |
GO:0016462 | pyrophosphatase activity | 22.6667 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.6667 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.6667 | 6 | no |
GO:0003723 | RNA binding | 21.3333 | 4 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 20.0000 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 18.6667 | 4 | yes |
GO:0046872 | metal ion binding | 18.6667 | 4 | yes |
GO:0106310 | protein serine kinase activity | 18.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AKT2_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 74.6667 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 73.3333 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 72.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 70.6667 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 69.3333 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 62.6667 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 61.3333 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 60.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 58.6667 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 58.6667 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 57.3333 | 5 | yes |
GO:0009966 | regulation of signal transduction | 56.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 52.0000 | 5 | yes |
GO:0071310 | cellular response to organic substance | 52.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 52.0000 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 52.0000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 50.6667 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 49.3333 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 48.0000 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 48.0000 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 48.0000 | 6 | yes |
GO:0031399 | regulation of protein modification process | 48.0000 | 6 | yes |
GO:1902531 | regulation of intracellular signal transduction | 46.6667 | 5 | no |
GO:0010941 | regulation of cell death | 45.3333 | 4 | yes |
GO:0043412 | macromolecule modification | 44.0000 | 4 | yes |
GO:0036211 | protein modification process | 44.0000 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 44.0000 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 42.6667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 42.6667 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 42.6667 | 6 | yes |
GO:0051049 | regulation of transport | 41.3333 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 41.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.3333 | 5 | no |
GO:0042325 | regulation of phosphorylation | 41.3333 | 7 | yes |
GO:0010243 | response to organonitrogen compound | 40.0000 | 4 | yes |
GO:0006996 | organelle organization | 38.6667 | 4 | no |
GO:0010648 | negative regulation of cell communication | 37.3333 | 5 | no |
GO:0023057 | negative regulation of signaling | 37.3333 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 37.3333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 37.3333 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 37.3333 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 36.0000 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 36.0000 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 36.0000 | 7 | yes |
GO:0031401 | positive regulation of protein modification process | 36.0000 | 7 | yes |
GO:0060548 | negative regulation of cell death | 34.6667 | 5 | yes |
GO:0071702 | organic substance transport | 34.6667 | 4 | yes |
GO:0009894 | regulation of catabolic process | 34.6667 | 4 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | yes |
GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 6 | no |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 33.3333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | yes |
GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | yes |
GO:0060341 | regulation of cellular localization | 32.0000 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 32.0000 | 5 | no |
GO:0045595 | regulation of cell differentiation | 32.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 32.0000 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 32.0000 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 32.0000 | 6 | yes |
GO:0071417 | cellular response to organonitrogen compound | 30.6667 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 30.6667 | 4 | yes |
GO:0008104 | protein localization | 30.6667 | 4 | yes |
GO:0031329 | regulation of cellular catabolic process | 30.6667 | 5 | yes |
GO:0042327 | positive regulation of phosphorylation | 30.6667 | 8 | yes |
GO:0043066 | negative regulation of apoptotic process | 30.6667 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 30.6667 | 6 | yes |
GO:0051130 | positive regulation of cellular component organization | 29.3333 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 29.3333 | 6 | no |
GO:0080134 | regulation of response to stress | 29.3333 | 4 | no |
GO:0010628 | positive regulation of gene expression | 29.3333 | 6 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 29.3333 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 28.0000 | 4 | yes |
GO:0051338 | regulation of transferase activity | 28.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 28.0000 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 28.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 28.0000 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 28.0000 | 8 | yes |
GO:0016310 | phosphorylation | 28.0000 | 5 | yes |
GO:0032880 | regulation of protein localization | 28.0000 | 5 | yes |
GO:0033043 | regulation of organelle organization | 28.0000 | 5 | yes |
GO:0051726 | regulation of cell cycle | 26.6667 | 4 | yes |
GO:1901652 | response to peptide | 26.6667 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 26.6667 | 5 | no |
GO:0006915 | apoptotic process | 26.6667 | 4 | yes |
GO:0015031 | protein transport | 26.6667 | 4 | yes |
GO:0051050 | positive regulation of transport | 25.3333 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.3333 | 6 | no |
GO:0014070 | response to organic cyclic compound | 25.3333 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.3333 | 6 | no |
GO:0018193 | peptidyl-amino acid modification | 25.3333 | 5 | yes |
GO:0031400 | negative regulation of protein modification process | 22.6667 | 7 | no |
GO:0043549 | regulation of kinase activity | 22.6667 | 5 | no |
GO:0033993 | response to lipid | 22.6667 | 4 | no |
GO:0045597 | positive regulation of cell differentiation | 22.6667 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 22.6667 | 4 | no |
GO:0006468 | protein phosphorylation | 22.6667 | 5 | yes |
GO:0008284 | positive regulation of cell population proliferation | 22.6667 | 5 | yes |
GO:1901653 | cellular response to peptide | 21.3333 | 5 | yes |
GO:2000145 | regulation of cell motility | 21.3333 | 4 | yes |
GO:0051347 | positive regulation of transferase activity | 21.3333 | 5 | no |
GO:0030162 | regulation of proteolysis | 21.3333 | 6 | no |
GO:0080135 | regulation of cellular response to stress | 21.3333 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 21.3333 | 4 | no |
GO:0032870 | cellular response to hormone stimulus | 21.3333 | 4 | yes |
GO:0043434 | response to peptide hormone | 20.0000 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 20.0000 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 20.0000 | 6 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.0000 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 20.0000 | 5 | yes |
GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
GO:0032868 | response to insulin | 20.0000 | 5 | yes |
GO:0006886 | intracellular protein transport | 18.6667 | 4 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 18.6667 | 6 | yes |
GO:0051223 | regulation of protein transport | 17.3333 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 17.3333 | 6 | yes |
GO:1903829 | positive regulation of protein localization | 17.3333 | 5 | yes |
GO:0010638 | positive regulation of organelle organization | 17.3333 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 17.3333 | 4 | yes |
GO:0006417 | regulation of translation | 16.0000 | 6 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 16.0000 | 5 | yes |
GO:0010608 | post-transcriptional regulation of gene expression | 16.0000 | 6 | yes |
GO:0018209 | peptidyl-serine modification | 16.0000 | 6 | yes |
GO:0034248 | regulation of cellular amide metabolic process | 16.0000 | 5 | yes |
GO:0061024 | membrane organization | 14.6667 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 14.6667 | 4 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 14.6667 | 5 | yes |
GO:2000147 | positive regulation of cell motility | 14.6667 | 5 | yes |
GO:0018105 | peptidyl-serine phosphorylation | 14.6667 | 6 | yes |
GO:0030335 | positive regulation of cell migration | 14.6667 | 6 | yes |
GO:0032869 | cellular response to insulin stimulus | 14.6667 | 6 | yes |
GO:0040017 | positive regulation of locomotion | 14.6667 | 4 | yes |
GO:0051051 | negative regulation of transport | 13.3333 | 4 | yes |
GO:0009059 | macromolecule biosynthetic process | 13.3333 | 4 | yes |
GO:0034764 | positive regulation of transmembrane transport | 13.3333 | 5 | yes |
GO:0051222 | positive regulation of protein transport | 12.0000 | 5 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 12.0000 | 6 | yes |
GO:1905475 | regulation of protein localization to membrane | 12.0000 | 6 | yes |
GO:0006006 | glucose metabolic process | 12.0000 | 5 | yes |
GO:0019318 | hexose metabolic process | 12.0000 | 4 | yes |
GO:0043467 | regulation of generation of precursor metabolites and energy | 10.6667 | 5 | yes |
GO:0045834 | positive regulation of lipid metabolic process | 10.6667 | 5 | yes |
GO:0062013 | positive regulation of small molecule metabolic process | 10.6667 | 5 | yes |
GO:0006109 | regulation of carbohydrate metabolic process | 10.6667 | 5 | yes |
GO:0019216 | regulation of lipid metabolic process | 10.6667 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 10.6667 | 5 | yes |
GO:0043087 | regulation of GTPase activity | 10.6667 | 5 | yes |
GO:0072657 | protein localization to membrane | 9.3333 | 4 | yes |
GO:0008286 | insulin receptor signaling pathway | 9.3333 | 6 | yes |
GO:0009416 | response to light stimulus | 9.3333 | 4 | yes |
GO:0010675 | regulation of cellular carbohydrate metabolic process | 9.3333 | 5 | yes |
GO:0010827 | regulation of glucose transmembrane transport | 9.3333 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 8.0000 | 6 | yes |
GO:0046324 | regulation of glucose import | 8.0000 | 6 | yes |
GO:0051402 | neuron apoptotic process | 8.0000 | 4 | yes |
GO:0051881 | regulation of mitochondrial membrane potential | 8.0000 | 4 | yes |
GO:0090316 | positive regulation of intracellular protein transport | 8.0000 | 6 | yes |
GO:1905477 | positive regulation of protein localization to membrane | 8.0000 | 6 | yes |
GO:0010828 | positive regulation of glucose transmembrane transport | 8.0000 | 6 | yes |
GO:0010906 | regulation of glucose metabolic process | 8.0000 | 5 | yes |
GO:0032388 | positive regulation of intracellular transport | 8.0000 | 5 | yes |
GO:0033157 | regulation of intracellular protein transport | 8.0000 | 6 | yes |
GO:0043255 | regulation of carbohydrate biosynthetic process | 8.0000 | 5 | yes |
GO:0045913 | positive regulation of carbohydrate metabolic process | 6.6667 | 5 | yes |
GO:0046326 | positive regulation of glucose import | 6.6667 | 7 | yes |
GO:0070873 | regulation of glycogen metabolic process | 6.6667 | 6 | yes |
GO:0005979 | regulation of glycogen biosynthetic process | 6.6667 | 7 | yes |
GO:0006112 | energy reserve metabolic process | 6.6667 | 5 | yes |
GO:0010565 | regulation of cellular ketone metabolic process | 6.6667 | 5 | yes |
GO:0010962 | regulation of glucan biosynthetic process | 6.6667 | 6 | yes |
GO:0015980 | energy derivation by oxidation of organic compounds | 6.6667 | 4 | yes |
GO:0019217 | regulation of fatty acid metabolic process | 6.6667 | 6 | yes |
GO:0032881 | regulation of polysaccharide metabolic process | 6.6667 | 5 | yes |
GO:0032885 | regulation of polysaccharide biosynthetic process | 6.6667 | 6 | yes |
GO:0034645 | cellular macromolecule biosynthetic process | 6.6667 | 4 | yes |
GO:0044042 | glucan metabolic process | 5.3333 | 5 | yes |
GO:0044264 | cellular polysaccharide metabolic process | 5.3333 | 4 | yes |
GO:0045725 | positive regulation of glycogen biosynthetic process | 5.3333 | 7 | yes |
GO:0045838 | positive regulation of membrane potential | 5.3333 | 4 | yes |
GO:0045923 | positive regulation of fatty acid metabolic process | 5.3333 | 6 | yes |
GO:0046320 | regulation of fatty acid oxidation | 5.3333 | 7 | yes |
GO:0050994 | regulation of lipid catabolic process | 5.3333 | 5 | yes |
GO:0070875 | positive regulation of glycogen metabolic process | 5.3333 | 6 | yes |
GO:0071478 | cellular response to radiation | 5.3333 | 4 | yes |
GO:0072659 | protein localization to plasma membrane | 5.3333 | 5 | yes |
GO:1903533 | regulation of protein targeting | 5.3333 | 7 | yes |
GO:1990778 | protein localization to cell periphery | 5.3333 | 5 | yes |
GO:0005976 | polysaccharide metabolic process | 5.3333 | 4 | yes |
GO:0005977 | glycogen metabolic process | 5.3333 | 6 | yes |
GO:0006073 | cellular glucan metabolic process | 5.3333 | 5 | yes |
GO:0007009 | plasma membrane organization | 5.3333 | 5 | yes |
GO:0008643 | carbohydrate transport | 5.3333 | 5 | yes |
GO:0010676 | positive regulation of cellular carbohydrate metabolic process | 5.3333 | 6 | yes |
GO:0010907 | positive regulation of glucose metabolic process | 5.3333 | 6 | yes |
GO:0010918 | positive regulation of mitochondrial membrane potential | 5.3333 | 5 | yes |
GO:0030855 | epithelial cell differentiation | 5.3333 | 4 | yes |
GO:0031998 | regulation of fatty acid beta-oxidation | 5.3333 | 6 | yes |
GO:0032890 | regulation of organic acid transport | 5.3333 | 5 | yes |
GO:0034763 | negative regulation of transmembrane transport | 5.3333 | 5 | yes |
GO:0043217 | myelin maintenance | 5.3333 | 6 | yes |
GO:0045444 | fat cell differentiation | 4.0000 | 4 | yes |
GO:0046321 | positive regulation of fatty acid oxidation | 4.0000 | 7 | yes |
GO:0050996 | positive regulation of lipid catabolic process | 4.0000 | 6 | yes |
GO:0060644 | mammary gland epithelial cell differentiation | 4.0000 | 5 | yes |
GO:0065002 | intracellular protein transmembrane transport | 4.0000 | 4 | yes |
GO:0071482 | cellular response to light stimulus | 4.0000 | 5 | yes |
GO:0090313 | regulation of protein targeting to membrane | 4.0000 | 7 | yes |
GO:0090314 | positive regulation of protein targeting to membrane | 4.0000 | 7 | yes |
GO:0090630 | activation of GTPase activity | 4.0000 | 7 | yes |
GO:0140212 | regulation of long-chain fatty acid import into cell | 4.0000 | 7 | yes |
GO:0140213 | negative regulation of long-chain fatty acid import into cell | 4.0000 | 7 | yes |
GO:1905952 | regulation of lipid localization | 4.0000 | 4 | yes |
GO:1905953 | negative regulation of lipid localization | 4.0000 | 4 | yes |
GO:2000191 | regulation of fatty acid transport | 4.0000 | 6 | yes |
GO:2000192 | negative regulation of fatty acid transport | 4.0000 | 6 | yes |
GO:0000271 | polysaccharide biosynthetic process | 4.0000 | 5 | yes |
GO:0005978 | glycogen biosynthetic process | 4.0000 | 7 | yes |
GO:0009250 | glucan biosynthetic process | 4.0000 | 6 | yes |
GO:0010746 | regulation of long-chain fatty acid import across plasma membrane | 4.0000 | 5 | yes |
GO:0010748 | negative regulation of long-chain fatty acid import across plasma membrane | 4.0000 | 6 | yes |
GO:0016051 | carbohydrate biosynthetic process | 4.0000 | 4 | yes |
GO:0032000 | positive regulation of fatty acid beta-oxidation | 4.0000 | 7 | yes |
GO:0032287 | peripheral nervous system myelin maintenance | 4.0000 | 7 | yes |
GO:0032368 | regulation of lipid transport | 4.0000 | 5 | yes |
GO:0032369 | negative regulation of lipid transport | 4.0000 | 5 | yes |
GO:0032891 | negative regulation of organic acid transport | 4.0000 | 5 | yes |
GO:0033692 | cellular polysaccharide biosynthetic process | 4.0000 | 5 | yes |
GO:0034637 | cellular carbohydrate biosynthetic process | 4.0000 | 4 | yes |
GO:0071484 | cellular response to light intensity | 2.6667 | 6 | yes |
GO:0071486 | cellular response to high light intensity | 2.6667 | 7 | yes |
GO:0097473 | retinal rod cell apoptotic process | 2.6667 | 5 | yes |
GO:1990009 | retinal cell apoptotic process | 2.6667 | 5 | yes |
GO:0009642 | response to light intensity | 2.6667 | 5 | yes |
GO:0009644 | response to high light intensity | 2.6667 | 6 | yes |
GO:0031338 | regulation of vesicle fusion | 2.6667 | 5 | yes |
GO:0031340 | positive regulation of vesicle fusion | 2.6667 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in AKT2_HUMAN |
---|---|---|---|---|
DOID:0081062 | diabetes | 4.0000 | 5 | yes |
DOID:2978 | carbohydrate metabolic disorder | 4.0000 | 3 | yes |
DOID:4194 | glucose metabolism disease | 4.0000 | 4 | yes |
DOID:9351 | diabetes mellitus | 4.0000 | 6 | yes |
DOID:9352 | type 2 diabetes mellitus | 4.0000 | 7 | yes |
DOID:0050686 | organ system cancer | 4.0000 | 3 | no |
DOID:0112263 | hypoinsulinemic hypoglycemia with hemihypertrophy | 2.6667 | 3 | yes |
DOID:6457 | Cowden syndrome | 2.6667 | 3 | no |
DOID:10780 | primary polycythemia | 2.6667 | 5 | no |
DOID:4961 | bone marrow disease | 2.6667 | 3 | no |
DOID:8432 | polycythemia | 2.6667 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AKT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TTC3_HUMAN | [view interactions] | Low throughput | no | yes |
SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
PREX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
CDC37_HUMAN | [view interactions] | Low throughput | no | yes |
UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SH3R1_HUMAN | [view interactions] | Low throughput | no | yes |
PDK1_HUMAN | [view interactions] | Low throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
G3P_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ENOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CASP3_HUMAN | [view interactions] | Low throughput | no | yes |
DP13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TCL1A_HUMAN | [view interactions] | Low throughput | no | no |
TCL1B_HUMAN | [view interactions] | Low throughput | no | no |
MTCP1_HUMAN | [view interactions] | Low throughput | no | no |
GRDN_HUMAN | [view interactions] | Low throughput | no | no |
ESR1_HUMAN | [view interactions] | Low throughput | no | no |
BTBDA_HUMAN | [view interactions] | Low throughput | no | no |
SKI_HUMAN | [view interactions] | Low throughput | no | yes |
FSHR_HUMAN | [view interactions] | Low throughput | no | no |
KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CLIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PKHO1_HUMAN | [view interactions] | Low throughput | no | no |
SNAI1_HUMAN | [view interactions] | Low throughput | no | yes |
CDN1A_HUMAN | [view interactions] | Low throughput | no | no |
VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
WDR26_HUMAN | [view interactions] | Low throughput | no | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PFKAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
PRKDC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCD20_HUMAN | [view interactions] | Low throughput | no | yes |
BIEA_HUMAN | [view interactions] | Low throughput | no | yes |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB3D_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
COIL_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPOT_HUMAN | [view interactions] | High throughput | no | no |
APOA1_HUMAN | [view interactions] | High throughput | no | no |
APOB_HUMAN | [view interactions] | High throughput | no | no |
CCL14_HUMAN | [view interactions] | High throughput | no | no |
SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPR2A_HUMAN | [view interactions] | High throughput | no | no |
NAMPT_HUMAN | [view interactions] | High throughput | no | no |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
OFUT1_HUMAN | [view interactions] | High throughput | no | yes |
STEA4_HUMAN | [view interactions] | High throughput | no | no |
RPA2_HUMAN | [view interactions] | High throughput | no | no |
AP2C_HUMAN | [view interactions] | High throughput | no | no |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGAP1_HUMAN | [view interactions] | High throughput | no | no |
TISD_HUMAN | [view interactions] | High throughput | no | no |
AP4M1_HUMAN | [view interactions] | High throughput | no | yes |
COT2_HUMAN | [view interactions] | High throughput | no | no |
NSE4A_HUMAN | [view interactions] | High throughput | no | yes |
UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
USP9Y_HUMAN | [view interactions] | High throughput | no | no |
CDK3_HUMAN | [view interactions] | High throughput | no | no |
LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABCG8_HUMAN | [view interactions] | High throughput | no | yes |
PLPL3_HUMAN | [view interactions] | High throughput | no | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB1_HUMAN | [view interactions] | High throughput | no | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
REL_HUMAN | [view interactions] | High throughput | no | yes |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
BRNP1_HUMAN | [view interactions] | High throughput | no | yes |
DRC1_HUMAN | [view interactions] | High throughput | no | no |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAT3_HUMAN | [view interactions] | High throughput | no | no |
EGLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
AKTS1_HUMAN | [view interactions] | High throughput | no | yes |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJB13_HUMAN | [view interactions] | High throughput | no | no |
ZN363_HUMAN | [view interactions] | High throughput | no | yes |
XAF1_HUMAN | [view interactions] | High throughput | no | yes |
KCNQ3_HUMAN | [view interactions] | High throughput | no | no |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMDH_HUMAN | [view interactions] | High throughput | no | yes |
CDK12_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GHSR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGA1_HUMAN | [view interactions] | High throughput | no | yes |
PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
PK3CD_HUMAN | [view interactions] | High throughput | no | no |
RPE_HUMAN | [view interactions] | High throughput | no | yes |
PHLP2_HUMAN | [view interactions] | Computational | no | yes |
BRPF1_HUMAN | [view interactions] | Computational | no | yes |
2A5E_HUMAN | [view interactions] | Computational | no | yes |
NOS3_HUMAN | [view interactions] | Computational | no | no |
BAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
2AAA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
2A5G_HUMAN | [view interactions] | Computational | no | yes |
PI3R6_HUMAN | [view interactions] | Computational | no | yes |
FOXO4_HUMAN | [view interactions] | Computational | no | no |
PHF20_HUMAN | [view interactions] | Computational | no | yes |
PEBB_HUMAN | [view interactions] | Computational | no | no |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
GLUT4_HUMAN | [view interactions] | Computational | no | no |
NKX31_HUMAN | [view interactions] | Computational | no | no |
PDE3B_HUMAN | [view interactions] | Computational | no | no |
IKKA_HUMAN | [view interactions] | Computational | no | yes |
FOXO1_HUMAN | [view interactions] | Computational | no | yes |
M3K5_HUMAN | [view interactions] | Computational | no | yes |
SIR1_HUMAN | [view interactions] | Computational | no | yes |
NEMO_HUMAN | [view interactions] | Computational | no | yes |
LYRIC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MKRN1_HUMAN | [view interactions] | Computational | no | no |
F262_HUMAN | [view interactions] | Computational | no | no |
RAF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
2A5D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
P53_HUMAN | [view interactions] | Computational | no | no |
MDM2_HUMAN | [view interactions] | Computational | no | yes |
M3K8_HUMAN | [view interactions] | Computational | no | yes |
BRCA1_HUMAN | [view interactions] | Computational | no | yes |
P55G_HUMAN | [view interactions] | Computational | no | yes |
RICTR_HUMAN | [view interactions] | Computational | no | yes |
ILK_HUMAN | [view interactions] | Computational | no | no |
PML_HUMAN | [view interactions] | Computational | no | yes |
PRR5_HUMAN | [view interactions] | Computational | no | yes |
KAT6A_HUMAN | [view interactions] | Computational | no | yes |
ASXL2_HUMAN | [view interactions] | Computational | no | no |
CREB1_HUMAN | [view interactions] | Computational | no | yes |
SIN1_HUMAN | [view interactions] | Computational | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGPA2_HUMAN | [view interactions] | Computational | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GON1_HUMAN | [view interactions] | Computational | no | yes |
TBCD4_HUMAN | [view interactions] | Computational | no | yes |
NOS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DEN1A_HUMAN | [view interactions] | Computational | no | no |
PK3CG_HUMAN | [view interactions] | Computational | no | yes |
JUN_HUMAN | [view interactions] | Computational | no | yes |
P85A_HUMAN | [view interactions] | Computational | no | yes |
MP2K4_HUMAN | [view interactions] | Computational | no | yes |
PP2AB_HUMAN | [view interactions] | Computational | no | yes |
2A5B_HUMAN | [view interactions] | Computational | no | yes |
2AAB_HUMAN | [view interactions] | Computational | no | yes |
BCL2_HUMAN | [view interactions] | Computational | no | no |
DEN1B_HUMAN | [view interactions] | Computational | no | yes |
IRS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KS6B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RLGPB_HUMAN | [view interactions] | Computational | no | yes |
P85B_HUMAN | [view interactions] | Computational | no | yes |
RUNX2_HUMAN | [view interactions] | Computational | no | no |
BRPF3_HUMAN | [view interactions] | Computational | no | yes |
IKKB_HUMAN | [view interactions] | Computational | no | yes |
C2CD5_HUMAN | [view interactions] | Computational | no | yes |
ING5_HUMAN | [view interactions] | Computational | no | yes |
UBP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CDN1B_HUMAN | [view interactions] | Computational | no | yes |
TSC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBCD7_HUMAN | [view interactions] | Computational | no | no |
DPTOR_HUMAN | [view interactions] | Computational | no | no |
LST8_HUMAN | [view interactions] | Computational | no | yes |
THEM4_HUMAN | [view interactions] | Computational | no | no |
OGT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LCAP_HUMAN | [view interactions] | Computational | no | yes |
PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRB14_HUMAN | [view interactions] | Computational | no | yes |
NOS2_HUMAN | [view interactions] | Computational | no | yes |
BRD1_HUMAN | [view interactions] | Computational | no | yes |
PHLP1_HUMAN | [view interactions] | Computational | no | yes |
B2CL1_HUMAN | [view interactions] | Computational | no | yes |
MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
INS_HUMAN | [view interactions] | Computational | no | no |
CRTC2_HUMAN | [view interactions] | Computational | no | yes |
INSR_HUMAN | [view interactions] | Computational | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EAF6_HUMAN | [view interactions] | Computational | no | no |
RPTOR_HUMAN | [view interactions] | Computational | no | yes |
GON2_HUMAN | [view interactions] | Computational | no | no |
CASP9_HUMAN | [view interactions] | Computational | no | yes |
KS6B2_HUMAN | [view interactions] | Computational | no | yes |
2A5A_HUMAN | [view interactions] | Computational | no | yes |
PI3R5_HUMAN | [view interactions] | Computational | no | no |