Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CLIP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CLIP3_HUMAN
GO:0003723 RNA binding 33.3333 4 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0046872 metal ion binding 26.6667 4 no
GO:0008017 microtubule binding 20.0000 5 yes
GO:0015631 tubulin binding 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CLIP3_HUMAN
GO:0060255 regulation of macromolecule metabolic process 73.3333 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0036211 protein modification process 60.0000 4 yes
GO:0043412 macromolecule modification 60.0000 4 yes
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0051246 regulation of protein metabolic process 53.3333 5 yes
GO:0010468 regulation of gene expression 53.3333 5 no
GO:0031399 regulation of protein modification process 53.3333 6 yes
GO:0042981 regulation of apoptotic process 46.6667 6 yes
GO:0043067 regulation of programmed cell death 46.6667 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 46.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 46.6667 6 yes
GO:0071702 organic substance transport 46.6667 4 yes
GO:0071705 nitrogen compound transport 46.6667 4 yes
GO:0009057 macromolecule catabolic process 46.6667 4 no
GO:0009889 regulation of biosynthetic process 46.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 46.6667 5 no
GO:0010646 regulation of cell communication 46.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 46.6667 5 no
GO:0010941 regulation of cell death 46.6667 4 yes
GO:0031401 positive regulation of protein modification process 46.6667 7 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0051050 positive regulation of transport 40.0000 4 yes
GO:0006508 proteolysis 40.0000 4 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010648 negative regulation of cell communication 40.0000 5 no
GO:0019941 modification-dependent protein catabolic process 40.0000 6 no
GO:0023057 negative regulation of signaling 40.0000 4 no
GO:0043632 modification-dependent macromolecule catabolic process 40.0000 5 no
GO:0044265 cellular macromolecule catabolic process 40.0000 4 no
GO:0051603 proteolysis involved in protein catabolic process 40.0000 5 no
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0070647 protein modification by small protein conjugation or removal 40.0000 5 no
GO:0042325 regulation of phosphorylation 33.3333 7 yes
GO:0051128 regulation of cellular component organization 33.3333 4 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0080135 regulation of cellular response to stress 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:2001233 regulation of apoptotic signaling pathway 33.3333 5 no
GO:2001242 regulation of intrinsic apoptotic signaling pathway 33.3333 6 no
GO:0016567 protein ubiquitination 33.3333 7 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0032446 protein modification by small protein conjugation 33.3333 6 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 yes
GO:0042327 positive regulation of phosphorylation 26.6667 8 yes
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 yes
GO:0009968 negative regulation of signal transduction 26.6667 5 no
GO:0010243 response to organonitrogen compound 26.6667 4 no
GO:0043066 negative regulation of apoptotic process 26.6667 7 no
GO:0043069 negative regulation of programmed cell death 26.6667 6 no
GO:0043269 regulation of ion transport 26.6667 5 no
GO:0048585 negative regulation of response to stimulus 26.6667 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.6667 5 no
GO:0060548 negative regulation of cell death 26.6667 5 no
GO:1902532 negative regulation of intracellular signal transduction 26.6667 6 no
GO:0006417 regulation of translation 26.6667 6 no
GO:0009059 macromolecule biosynthetic process 26.6667 4 no
GO:0009891 positive regulation of biosynthetic process 26.6667 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0010608 post-transcriptional regulation of gene expression 26.6667 6 no
GO:0010628 positive regulation of gene expression 26.6667 6 no
GO:0031328 positive regulation of cellular biosynthetic process 26.6667 6 no
GO:0034248 regulation of cellular amide metabolic process 26.6667 5 no
GO:0034645 cellular macromolecule biosynthetic process 26.6667 4 no
GO:0051726 regulation of cell cycle 26.6667 4 no
GO:0071310 cellular response to organic substance 26.6667 4 no
GO:1901699 cellular response to nitrogen compound 26.6667 4 no
GO:0048584 positive regulation of response to stimulus 26.6667 4 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 yes
GO:0006886 intracellular protein transport 26.6667 4 yes
GO:0006996 organelle organization 26.6667 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 yes
GO:0033043 regulation of organelle organization 26.6667 5 yes
GO:0034762 regulation of transmembrane transport 26.6667 4 yes
GO:0043065 positive regulation of apoptotic process 20.0000 7 yes
GO:0043068 positive regulation of programmed cell death 20.0000 6 yes
GO:0044087 regulation of cellular component biogenesis 20.0000 4 yes
GO:0051130 positive regulation of cellular component organization 20.0000 5 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 20.0000 4 yes
GO:0099111 microtubule-based transport 20.0000 4 yes
GO:1903829 positive regulation of protein localization 20.0000 5 yes
GO:1905475 regulation of protein localization to membrane 20.0000 6 yes
GO:1905477 positive regulation of protein localization to membrane 20.0000 6 yes
GO:0010827 regulation of glucose transmembrane transport 20.0000 5 yes
GO:0010828 positive regulation of glucose transmembrane transport 20.0000 6 yes
GO:0010942 positive regulation of cell death 20.0000 5 yes
GO:0010970 transport along microtubule 20.0000 4 yes
GO:0018193 peptidyl-amino acid modification 20.0000 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 20.0000 4 yes
GO:0032880 regulation of protein localization 20.0000 5 yes
GO:0034764 positive regulation of transmembrane transport 20.0000 5 yes
GO:0045444 fat cell differentiation 13.3333 4 yes
GO:0045807 positive regulation of endocytosis 13.3333 5 yes
GO:0051129 negative regulation of cellular component organization 13.3333 5 yes
GO:0051493 regulation of cytoskeleton organization 13.3333 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 13.3333 5 yes
GO:0097435 supramolecular fiber organization 13.3333 4 yes
GO:0098840 protein transport along microtubule 13.3333 4 yes
GO:1903076 regulation of protein localization to plasma membrane 13.3333 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 13.3333 7 yes
GO:1904375 regulation of protein localization to cell periphery 13.3333 6 yes
GO:1904377 positive regulation of protein localization to cell periphery 13.3333 6 yes
GO:0007010 cytoskeleton organization 13.3333 5 yes
GO:0010639 negative regulation of organelle organization 13.3333 6 yes
GO:0030100 regulation of endocytosis 13.3333 5 yes
GO:0032886 regulation of microtubule-based process 13.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNR1A_HUMAN [view interactions] Low throughput no yes
TNR21_HUMAN [view interactions] Low throughput no yes
FADD_HUMAN [view interactions] Low throughput no yes
CASP8_HUMAN [view interactions] Low throughput no yes
RIPK1_HUMAN [view interactions] Low throughput no yes
CYLD_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT2_HUMAN [view entry] [view interactions] Low throughput yes yes
SPDYA_HUMAN [view interactions] Low throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GRN_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF11_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TLE5_HUMAN [view interactions] High throughput no no
CEP83_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
FBX7_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
ELMO2_HUMAN [view entry] [view interactions] Computational yes no