PREX1_HUMAN
Evidence for PS localization
Functions
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PREX1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 41.9355 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 41.9355 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 41.9355 | 4 | no |
| GO:0019900 | kinase binding | 32.2581 | 4 | no |
| GO:0019901 | protein kinase binding | 32.2581 | 5 | no |
| GO:0046872 | metal ion binding | 25.8065 | 4 | no |
| GO:0003924 | GTPase activity | 25.8065 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 25.8065 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.8065 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.8065 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 25.8065 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.8065 | 5 | no |
| GO:0005525 | GTP binding | 22.5806 | 5 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 12.9032 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 12.9032 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PREX1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.2903 | 4 | yes |
| GO:0006996 | organelle organization | 51.6129 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.3871 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.3871 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.1613 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.1613 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.1613 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.1613 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.1613 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.7097 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.7097 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.7097 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.7097 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.7097 | 5 | no |
| GO:0033043 | regulation of organelle organization | 38.7097 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.7097 | 5 | no |
| GO:0022607 | cellular component assembly | 35.4839 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 35.4839 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 35.4839 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 35.4839 | 4 | no |
| GO:0010941 | regulation of cell death | 35.4839 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 35.4839 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 35.4839 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 35.4839 | 5 | no |
| GO:0030030 | cell projection organization | 35.4839 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 32.2581 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 32.2581 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.2581 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.2581 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.2581 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.2581 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.2581 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 32.2581 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.0323 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 29.0323 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 29.0323 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 29.0323 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 29.0323 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.0323 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 29.0323 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.0323 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.0323 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 29.0323 | 5 | no |
| GO:0036211 | protein modification process | 29.0323 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 29.0323 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 29.0323 | 8 | no |
| GO:0043412 | macromolecule modification | 29.0323 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 29.0323 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.0323 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.0323 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.0323 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.0323 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 25.8065 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 25.8065 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 25.8065 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 25.8065 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.8065 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.8065 | 8 | no |
| GO:0031399 | regulation of protein modification process | 25.8065 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.8065 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.8065 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 25.8065 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.8065 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.8065 | 6 | no |
| GO:0007264 | small GTPase mediated signal transduction | 25.8065 | 4 | no |
| GO:0007015 | actin filament organization | 22.5806 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 22.5806 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 22.5806 | 5 | yes |
| GO:0060284 | regulation of cell development | 22.5806 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 22.5806 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 22.5806 | 4 | no |
| GO:0033993 | response to lipid | 22.5806 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 22.5806 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.5806 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5806 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.5806 | 6 | no |
| GO:0016310 | phosphorylation | 22.5806 | 5 | no |
| GO:0030334 | regulation of cell migration | 22.5806 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 22.5806 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.5806 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.5806 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.5806 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.5806 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.5806 | 6 | no |
| GO:0051049 | regulation of transport | 22.5806 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0060548 | negative regulation of cell death | 22.5806 | 5 | no |
| GO:2000145 | regulation of cell motility | 22.5806 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 22.5806 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.5806 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 22.5806 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 22.5806 | 5 | no |
| GO:0010720 | positive regulation of cell development | 19.3548 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 19.3548 | 4 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 16.1290 | 6 | yes |
| GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 16.1290 | 7 | yes |
| GO:0010811 | positive regulation of cell-substrate adhesion | 16.1290 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 16.1290 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 16.1290 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 16.1290 | 5 | yes |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 16.1290 | 6 | yes |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 16.1290 | 7 | yes |
| GO:0008154 | actin polymerization or depolymerization | 9.6774 | 6 | yes |
| GO:0043547 | positive regulation of GTPase activity | 9.6774 | 6 | yes |
| GO:0002521 | leukocyte differentiation | 6.4516 | 4 | yes |
| GO:0030041 | actin filament polymerization | 6.4516 | 7 | yes |
| GO:0030593 | neutrophil chemotaxis | 6.4516 | 5 | yes |
| GO:0051258 | protein polymerization | 6.4516 | 6 | yes |
| GO:0060326 | cell chemotaxis | 6.4516 | 4 | yes |
| GO:0071621 | granulocyte chemotaxis | 6.4516 | 4 | yes |
| GO:0097530 | granulocyte migration | 6.4516 | 4 | yes |
| GO:1990266 | neutrophil migration | 6.4516 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | Low throughput | no | yes |
| RICTR_HUMAN | [view interactions] | Low throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| C1TC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCDN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| GID8_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| SPF30_HUMAN | [view interactions] | High throughput | no | no |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB36_HUMAN | [view interactions] | High throughput | no | no |
| RB40C_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| QPCTL_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PREX2_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85B_HUMAN | [view interactions] | Computational | no | yes |
| PK3CD_HUMAN | [view interactions] | Computational | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CB_HUMAN | [view interactions] | Computational | no | yes |
| P55G_HUMAN | [view interactions] | Computational | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |