Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PREX1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PREX1_HUMAN
GO:0043168 anion binding 42.3077 4 no
GO:0000166 nucleotide binding 38.4615 4 no
GO:0017076 purine nucleotide binding 38.4615 5 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 no
GO:0043169 cation binding 30.7692 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0019001 guanyl nucleotide binding 23.0769 6 no
GO:0032561 guanyl ribonucleotide binding 23.0769 5 no
GO:0005085 guanyl-nucleotide exchange factor activity 15.3846 5 yes
GO:0030695 GTPase regulator activity 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PREX1_HUMAN
GO:0048522 positive regulation of cellular process 69.2308 4 yes
GO:0006996 organelle organization 53.8462 4 no
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.1538 5 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0042981 regulation of apoptotic process 46.1538 5 no
GO:0043067 regulation of programmed cell death 46.1538 4 no
GO:0009966 regulation of signal transduction 42.3077 4 yes
GO:0009889 regulation of biosynthetic process 42.3077 4 no
GO:0010468 regulation of gene expression 42.3077 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.3077 5 no
GO:0031326 regulation of cellular biosynthetic process 42.3077 5 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 yes
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0042127 regulation of cell population proliferation 38.4615 4 no
GO:0022607 cellular component assembly 34.6154 4 yes
GO:0031344 regulation of cell projection organization 34.6154 5 yes
GO:0033043 regulation of organelle organization 34.6154 5 yes
GO:0044087 regulation of cellular component biogenesis 34.6154 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.6154 6 yes
GO:0010647 positive regulation of cell communication 34.6154 5 no
GO:0023056 positive regulation of signaling 34.6154 4 no
GO:0071310 cellular response to organic substance 34.6154 4 no
GO:0030334 regulation of cell migration 30.7692 5 yes
GO:0030335 positive regulation of cell migration 30.7692 6 yes
GO:0040017 positive regulation of locomotion 30.7692 4 yes
GO:0043933 protein-containing complex organization 30.7692 4 yes
GO:2000145 regulation of cell motility 30.7692 4 yes
GO:2000147 positive regulation of cell motility 30.7692 5 yes
GO:0007010 cytoskeleton organization 30.7692 5 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0141124 intracellular signaling cassette 30.7692 4 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 no
GO:0030155 regulation of cell adhesion 26.9231 4 yes
GO:0043254 regulation of protein-containing complex assembly 26.9231 5 yes
GO:0045785 positive regulation of cell adhesion 26.9231 5 yes
GO:0030030 cell projection organization 26.9231 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.9231 5 no
GO:0001932 regulation of protein phosphorylation 26.9231 7 no
GO:0001934 positive regulation of protein phosphorylation 26.9231 8 no
GO:0006915 apoptotic process 26.9231 4 no
GO:0009891 positive regulation of biosynthetic process 26.9231 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.9231 6 no
GO:0010562 positive regulation of phosphorus metabolic process 26.9231 6 no
GO:0019220 regulation of phosphate metabolic process 26.9231 6 no
GO:0031328 positive regulation of cellular biosynthetic process 26.9231 6 no
GO:0031399 regulation of protein modification process 26.9231 6 no
GO:0031401 positive regulation of protein modification process 26.9231 7 no
GO:0042325 regulation of phosphorylation 26.9231 7 no
GO:0042327 positive regulation of phosphorylation 26.9231 8 no
GO:0043066 negative regulation of apoptotic process 26.9231 6 no
GO:0043069 negative regulation of programmed cell death 26.9231 5 no
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.9231 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.9231 7 no
GO:0051094 positive regulation of developmental process 26.9231 4 no
GO:0051130 positive regulation of cellular component organization 26.9231 5 no
GO:0051174 regulation of phosphorus metabolic process 26.9231 5 no
GO:0051240 positive regulation of multicellular organismal process 26.9231 4 no
GO:0051247 positive regulation of protein metabolic process 26.9231 6 no
GO:1902533 positive regulation of intracellular signal transduction 26.9231 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 yes
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 yes
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0043467 regulation of generation of precursor metabolites and energy 23.0769 5 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0007264 small GTPase-mediated signal transduction 23.0769 5 no
GO:0008104 protein localization 23.0769 4 no
GO:0034097 response to cytokine 23.0769 4 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0007015 actin filament organization 19.2308 5 yes
GO:0010810 regulation of cell-substrate adhesion 19.2308 5 yes
GO:0010975 regulation of neuron projection development 19.2308 7 yes
GO:0032535 regulation of cellular component size 19.2308 4 yes
GO:0032956 regulation of actin cytoskeleton organization 19.2308 5 yes
GO:0032970 regulation of actin filament-based process 19.2308 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 19.2308 6 yes
GO:0065003 protein-containing complex assembly 19.2308 5 yes
GO:0097435 supramolecular fiber organization 19.2308 4 yes
GO:0110053 regulation of actin filament organization 19.2308 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 15.3846 6 yes
GO:0032271 regulation of protein polymerization 15.3846 6 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 15.3846 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 15.3846 7 yes
GO:0002521 leukocyte differentiation 11.5385 4 yes
GO:0008154 actin polymerization or depolymerization 11.5385 6 yes
GO:0060326 cell chemotaxis 11.5385 4 yes
GO:1903131 mononuclear cell differentiation 11.5385 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 7.6923 6 yes
GO:0030041 actin filament polymerization 7.6923 7 yes
GO:0030593 neutrophil chemotaxis 7.6923 5 yes
GO:0030832 regulation of actin filament length 7.6923 5 yes
GO:0030833 regulation of actin filament polymerization 7.6923 7 yes
GO:0051258 protein polymerization 7.6923 6 yes
GO:0071621 granulocyte chemotaxis 7.6923 4 yes
GO:0097530 granulocyte migration 7.6923 4 yes
GO:1990266 neutrophil migration 7.6923 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
RICTR_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT2_HUMAN [view entry] [view interactions] Low throughput yes yes
MET_HUMAN [view interactions] Low throughput no yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
C1TC_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] Low throughput yes yes
NCDN_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3B2_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
NHLC1_HUMAN [view interactions] Low throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
P5CS_HUMAN [view interactions] High throughput no yes
GID8_HUMAN [view interactions] High throughput no yes
CBS_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
PSMD7_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
SPF30_HUMAN [view interactions] High throughput no no
5MP2_HUMAN [view interactions] High throughput no yes
RAB36_HUMAN [view interactions] High throughput no no
RB40C_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
SIM2_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL2_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
MYCBP_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
PSB1_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
QPCTL_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
UTP25_HUMAN [view interactions] High throughput no yes
ASPC1_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
DNMBP_HUMAN [view interactions] High throughput no no
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PREX2_HUMAN [view interactions] High throughput no no
ODBA_HUMAN [view interactions] High throughput no yes
TGM2_HUMAN [view interactions] High throughput no no
RFC4_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
DCA17_HUMAN [view interactions] High throughput no no
DTL_HUMAN [view interactions] High throughput no no
NLE1_HUMAN [view interactions] High throughput no yes
WDR59_HUMAN [view interactions] High throughput no yes
WSB2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes