NCDN_HUMAN
Evidence for PS localization
Functions
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling . Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 478 | Arg | Gln | Neurodevelopmentaldisorderwithinfantileepilepticspasms(NEDIES) | - |
| 498 | Trp | Arg | Neurodevelopmentaldisorderwithinfantileepilepticspasms(NEDIES) | - |
| 652 | Pro | Leu | Neurodevelopmentaldisorderwithinfantileepilepticspasms(NEDIES) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NCDN_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 23.5294 | 4 | no |
| GO:0046872 | metal ion binding | 23.5294 | 5 | no |
| GO:0003723 | RNA binding | 20.5882 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NCDN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.1176 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.1176 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.1176 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.1765 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.1765 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.3529 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 32.3529 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.4118 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.4118 | 4 | no |
| GO:0022607 | cellular component assembly | 29.4118 | 4 | no |
| GO:0030030 | cell projection organization | 26.4706 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.4706 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.4706 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.4706 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.4706 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.4706 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.4706 | 6 | no |
| GO:0008104 | protein localization | 26.4706 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.4706 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.4706 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.4706 | 4 | no |
| GO:0050890 | cognition | 26.4706 | 4 | no |
| GO:0051049 | regulation of transport | 26.4706 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.4706 | 4 | no |
| GO:0031175 | neuron projection development | 23.5294 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:0006996 | organelle organization | 23.5294 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5882 | 7 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.5882 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.5882 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0071702 | organic substance transport | 20.5882 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.5882 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 14.7059 | 4 | yes |
| GO:0001894 | tissue homeostasis | 5.8824 | 4 | yes |
| GO:0045453 | bone resorption | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PREX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| ZN398_HUMAN | [view interactions] | High throughput | no | no |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LYST_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| TTC27_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRN_HUMAN | [view interactions] | High throughput | no | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| EAPP_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| CLP1L_HUMAN | [view interactions] | High throughput | no | yes |
| COA1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| NCDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| TSSC4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNHI2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC17_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| LRIT3_HUMAN | [view interactions] | High throughput | no | no |
| K1143_HUMAN | [view interactions] | High throughput | no | yes |
| NT5C_HUMAN | [view interactions] | High throughput | no | yes |
| GGT1_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| KLH34_HUMAN | [view interactions] | High throughput | no | no |
| LEUK_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| CIB2_HUMAN | [view interactions] | High throughput | no | yes |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| SNR40_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| FA50A_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ARLY_HUMAN | [view interactions] | High throughput | no | no |
| SLD5_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| IPP2B_HUMAN | [view interactions] | High throughput | no | no |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP9_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| PROP1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |