Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ESYT1_HUMAN

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport . Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

ELM instance Name Type Start End Partner
ELMI003225 MOD_CDK_SPxxK_3 MOD 321 328 -

Molecular function

Term Name % Distance from the top of the tree Annotated in ESYT1_HUMAN
GO:0017076 purine nucleotide binding 42.3077 4 no
GO:0032555 purine ribonucleotide binding 42.3077 4 no
GO:0035639 purine ribonucleoside triphosphate binding 42.3077 4 no
GO:0019001 guanyl nucleotide binding 28.2051 5 no
GO:0032561 guanyl ribonucleotide binding 28.2051 5 no
GO:0003924 GTPase activity 26.9231 7 no
GO:0005525 GTP binding 26.9231 5 no
GO:0016462 pyrophosphatase activity 26.9231 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.9231 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.9231 6 no
GO:0046872 metal ion binding 16.6667 4 yes
GO:0005509 calcium ion binding 8.9744 5 yes
GO:0035091 phosphatidylinositol binding 6.4103 4 yes
GO:0005544 calcium-dependent phospholipid binding 3.8462 4 yes
GO:0008429 phosphatidylethanolamine binding 3.8462 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ESYT1_HUMAN
GO:0048522 positive regulation of cellular process 52.5641 4 no
GO:0010646 regulation of cell communication 42.3077 4 no
GO:0071702 organic substance transport 41.0256 4 yes
GO:0006996 organelle organization 41.0256 4 no
GO:0051128 regulation of cellular component organization 39.7436 4 no
GO:0008104 protein localization 38.4615 4 no
GO:0071705 nitrogen compound transport 37.1795 4 no
GO:0048523 negative regulation of cellular process 37.1795 4 no
GO:0060255 regulation of macromolecule metabolic process 37.1795 4 no
GO:0031323 regulation of cellular metabolic process 35.8974 4 no
GO:0051049 regulation of transport 34.6154 4 no
GO:0009966 regulation of signal transduction 34.6154 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0015031 protein transport 30.7692 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0016192 vesicle-mediated transport 29.4872 4 no
GO:0010647 positive regulation of cell communication 28.2051 5 no
GO:0023056 positive regulation of signaling 28.2051 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.9231 5 no
GO:0030030 cell projection organization 26.9231 4 no
GO:0006886 intracellular protein transport 25.6410 4 no
GO:0051246 regulation of protein metabolic process 25.6410 5 no
GO:0060341 regulation of cellular localization 25.6410 4 no
GO:0009892 negative regulation of metabolic process 25.6410 4 no
GO:0009967 positive regulation of signal transduction 25.6410 5 no
GO:1902531 regulation of intracellular signal transduction 25.6410 5 no
GO:0042127 regulation of cell population proliferation 24.3590 4 no
GO:0010468 regulation of gene expression 24.3590 5 no
GO:0030334 regulation of cell migration 24.3590 5 no
GO:0120036 plasma membrane bounded cell projection organization 24.3590 5 no
GO:2000145 regulation of cell motility 24.3590 4 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0010941 regulation of cell death 23.0769 4 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0061024 membrane organization 23.0769 4 no
GO:0031325 positive regulation of cellular metabolic process 21.7949 5 no
GO:0031344 regulation of cell projection organization 21.7949 5 no
GO:0033043 regulation of organelle organization 21.7949 5 no
GO:0045595 regulation of cell differentiation 21.7949 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.7949 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.7949 6 no
GO:0071310 cellular response to organic substance 20.5128 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.5128 5 no
GO:0031324 negative regulation of cellular metabolic process 20.5128 5 no
GO:0042981 regulation of apoptotic process 20.5128 6 no
GO:0043067 regulation of programmed cell death 20.5128 5 no
GO:0006869 lipid transport 5.1282 5 yes
GO:0061817 endoplasmic reticulum-plasma membrane tethering 5.1282 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GLUT4_HUMAN [view interactions] Low throughput no no
ESYT2_HUMAN [view entry] [view interactions] Low throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ESYT3_HUMAN [view interactions] Low throughput no no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
SEGN_HUMAN [view interactions] High throughput no no
BT2A1_HUMAN [view interactions] High throughput no yes
TRML2_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
ATLA3_HUMAN [view interactions] High throughput no no
FOXL1_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
TSN11_HUMAN [view interactions] High throughput no no
UD19_HUMAN [view interactions] High throughput no no
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
DUS23_HUMAN [view interactions] High throughput no yes
MGDP1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PAQR9_HUMAN [view interactions] High throughput no no
EMC2_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF23_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
UBP1_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
TM129_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
UD11_HUMAN [view interactions] High throughput no no
UD17_HUMAN [view interactions] High throughput no no
KCMB3_HUMAN [view interactions] High throughput no no
UD15_HUMAN [view interactions] High throughput no no
F241A_HUMAN [view interactions] High throughput no yes
OR6T1_HUMAN [view interactions] High throughput no no
ZNT2_HUMAN [view interactions] High throughput no no
CNGA3_HUMAN [view interactions] High throughput no no
ANR22_HUMAN [view interactions] High throughput no no
PIGH_HUMAN [view interactions] High throughput no yes
ZDH12_HUMAN [view interactions] High throughput no yes
GPM6B_HUMAN [view interactions] High throughput no yes
CP26B_HUMAN [view interactions] High throughput no yes
CP2CI_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
RTN3_HUMAN [view entry] [view interactions] High throughput yes yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
CP19A_HUMAN [view interactions] High throughput no no
TMM9B_HUMAN [view interactions] High throughput no yes
PCDB3_HUMAN [view interactions] High throughput no no
ASB14_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
ANTR1_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RHG15_HUMAN [view interactions] High throughput no no
AR6P1_HUMAN [view interactions] High throughput no yes
ATLA2_HUMAN [view entry] [view interactions] High throughput yes yes
BAP31_HUMAN [view interactions] High throughput no yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
DHRS7_HUMAN [view interactions] High throughput no yes
ATLA1_HUMAN [view entry] [view interactions] High throughput yes yes
SCD_HUMAN [view entry] [view interactions] High throughput yes yes
HYEP_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
NSDHL_HUMAN [view interactions] High throughput no yes
OSBP1_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF5_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMX3_HUMAN [view interactions] High throughput no no
TOM6_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
TOM5_HUMAN [view interactions] High throughput no yes
NUP35_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
PTH2_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
RHBL4_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
OTULL_HUMAN [view interactions] High throughput no no
SYVN1_HUMAN [view interactions] High throughput no yes
ST7_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DJC16_HUMAN [view interactions] High throughput no no
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
CP2C9_HUMAN [view interactions] High throughput no no
DYR2_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
ERGI2_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LMAN1_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
MET7A_HUMAN [view interactions] High throughput no no
NU155_HUMAN [view interactions] High throughput no yes
PANX1_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
STIM1_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CLC4E_HUMAN [view interactions] High throughput no no
CD3Z_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
CDN1A_HUMAN [view interactions] High throughput no no
RNF43_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
EDEM1_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
PRAF3_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
DERL2_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
AAPK2_HUMAN [view interactions] High throughput no yes
ADCK2_HUMAN [view interactions] High throughput no yes
COQ8A_HUMAN [view interactions] High throughput no no
PHAG1_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
ROS1_HUMAN [view interactions] High throughput no no
CD177_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TECT3_HUMAN [view interactions] High throughput no yes
LBN_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
PLRKT_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA5_HUMAN [view interactions] High throughput no no
EPHA8_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
RET_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
RDH11_HUMAN [view interactions] High throughput no no
COMT_HUMAN [view entry] [view interactions] High throughput yes yes
GLCM_HUMAN [view interactions] High throughput no yes
CCHL_HUMAN [view interactions] High throughput no yes
TMX1_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ZC3HA_HUMAN [view interactions] Computational no yes