PLD3_HUMAN
Evidence for PS localization
Functions
5->3 DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 . May be important in myotube formation (PubMed). Plays a role in lysosomal homeostasis (PubMed). Involved in the regulation of endosomal protein sorting (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLD3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.0952 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 38.0952 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.0952 | 4 | no |
| GO:0046872 | metal ion binding | 28.5714 | 4 | no |
| GO:0003723 | RNA binding | 23.8095 | 4 | no |
| GO:0042578 | phosphoric ester hydrolase activity | 9.5238 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLD3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | yes |
| GO:0010646 | regulation of cell communication | 57.1429 | 4 | no |
| GO:0010468 | regulation of gene expression | 52.3810 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 52.3810 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 52.3810 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 47.6190 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 47.6190 | 5 | no |
| GO:0051049 | regulation of transport | 42.8571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 38.0952 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 38.0952 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.0952 | 4 | no |
| GO:0031399 | regulation of protein modification process | 38.0952 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.0952 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 38.0952 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 38.0952 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 33.3333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0008285 | negative regulation of cell population proliferation | 28.5714 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.5714 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
| GO:0016192 | vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0010941 | regulation of cell death | 28.5714 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 28.5714 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | no |
| GO:0015031 | protein transport | 23.8095 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.8095 | 6 | no |
| GO:0051046 | regulation of secretion | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 23.8095 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.8095 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 23.8095 | 6 | no |
| GO:0051338 | regulation of transferase activity | 23.8095 | 4 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.8095 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.8095 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 23.8095 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.8095 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.8095 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.8095 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.8095 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.8095 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.8095 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.8095 | 6 | no |
| GO:0006954 | inflammatory response | 14.2857 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 9.5238 | 4 | yes |
| GO:0042692 | muscle cell differentiation | 9.5238 | 4 | yes |
| GO:0051146 | striated muscle cell differentiation | 9.5238 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| CNIH3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCO4_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| LBN_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| LSME2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEPT1_HUMAN | [view interactions] | Computational | no | no |
| LCAT_HUMAN | [view interactions] | Computational | no | no |
| PTSS2_HUMAN | [view interactions] | Computational | no | yes |
| PISD_HUMAN | [view interactions] | Computational | no | yes |
| LPCT4_HUMAN | [view interactions] | Computational | no | yes |
| PLD2_HUMAN | [view interactions] | Computational | no | yes |
| CDS1_HUMAN | [view interactions] | Computational | no | yes |
| EPT1_HUMAN | [view interactions] | Computational | no | yes |
| CHDH_HUMAN | [view interactions] | Computational | no | yes |
| PLPP5_HUMAN | [view interactions] | Computational | no | no |
| PLAT3_HUMAN | [view interactions] | Computational | no | yes |
| PLD1_HUMAN | [view interactions] | Computational | no | no |
| PTSS1_HUMAN | [view interactions] | Computational | no | no |
| PEMT_HUMAN | [view interactions] | Computational | no | yes |
| PDES1_HUMAN | [view interactions] | Computational | no | no |
| PLD6_HUMAN | [view interactions] | Computational | no | yes |
| PLD4_HUMAN | [view interactions] | Computational | no | yes |
| PLPP4_HUMAN | [view interactions] | Computational | no | yes |
| CDS2_HUMAN | [view interactions] | Computational | no | yes |
| HIPK4_HUMAN | [view interactions] | Computational | no | no |
| CHPT1_HUMAN | [view interactions] | Computational | no | yes |