Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLD3_HUMAN

5->3 DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 . May be important in myotube formation (PubMed). Plays a role in lysosomal homeostasis (PubMed). Involved in the regulation of endosomal protein sorting (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PLD3_HUMAN
GO:0043169 cation binding 39.6552 4 no
GO:0046872 metal ion binding 39.6552 5 no
GO:0043168 anion binding 36.2069 4 no
GO:0000166 nucleotide binding 34.4828 4 no
GO:0017076 purine nucleotide binding 34.4828 5 no
GO:0032555 purine ribonucleotide binding 32.7586 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.0345 4 no
GO:0030554 adenyl nucleotide binding 25.8621 6 no
GO:0003723 RNA binding 24.1379 4 no
GO:0032559 adenyl ribonucleotide binding 24.1379 5 no
GO:0005524 ATP binding 22.4138 5 no
GO:0016462 pyrophosphatase activity 22.4138 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.4138 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.4138 6 no
GO:0004620 phospholipase activity 6.8966 5 yes
GO:0016298 lipase activity 6.8966 4 yes
GO:0042578 phosphoric ester hydrolase activity 6.8966 4 yes
GO:0008081 phosphoric diester hydrolase activity 5.1724 5 yes
GO:0004518 nuclease activity 3.4483 4 yes
GO:0004527 exonuclease activity 3.4483 5 yes
GO:0004529 DNA exonuclease activity 3.4483 5 yes
GO:0004536 DNA nuclease activity 3.4483 4 yes
GO:0004630 phospholipase D activity 3.4483 6 yes
GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3.4483 7 yes
GO:0008409 5-3 exonuclease activity 3.4483 6 yes
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5-phosphomonoesters 3.4483 6 yes
GO:0016895 DNA exonuclease activity, producing 5-phosphomonoesters 3.4483 6 yes
GO:0035312 5-3 DNA exonuclease activity 3.4483 7 yes
GO:0045145 single-stranded DNA 5-3 DNA exonuclease activity 3.4483 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLD3_HUMAN
GO:0048522 positive regulation of cellular process 56.8966 4 no
GO:0010646 regulation of cell communication 48.2759 4 no
GO:0031323 regulation of cellular metabolic process 44.8276 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.8276 4 yes
GO:0009889 regulation of biosynthetic process 43.1034 4 yes
GO:0009966 regulation of signal transduction 41.3793 4 no
GO:0010468 regulation of gene expression 39.6552 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 39.6552 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.6552 5 yes
GO:0048523 negative regulation of cellular process 39.6552 4 no
GO:0080090 regulation of primary metabolic process 37.9310 4 no
GO:0009893 positive regulation of metabolic process 37.9310 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.4828 5 no
GO:0051246 regulation of protein metabolic process 32.7586 5 no
GO:0006996 organelle organization 32.7586 4 no
GO:0051128 regulation of cellular component organization 32.7586 4 no
GO:0042127 regulation of cell population proliferation 32.7586 4 no
GO:0008104 protein localization 31.0345 4 no
GO:0043067 regulation of programmed cell death 31.0345 4 no
GO:0010647 positive regulation of cell communication 31.0345 5 no
GO:0023056 positive regulation of signaling 31.0345 4 no
GO:0031325 positive regulation of cellular metabolic process 31.0345 5 no
GO:0048584 positive regulation of response to stimulus 31.0345 4 no
GO:0031399 regulation of protein modification process 29.3103 6 no
GO:0042981 regulation of apoptotic process 29.3103 5 no
GO:0060341 regulation of cellular localization 29.3103 4 no
GO:1902531 regulation of intracellular signal transduction 29.3103 5 no
GO:0009892 negative regulation of metabolic process 27.5862 4 no
GO:0009891 positive regulation of biosynthetic process 27.5862 5 no
GO:0009967 positive regulation of signal transduction 27.5862 5 no
GO:0022607 cellular component assembly 25.8621 4 no
GO:0071702 organic substance transport 25.8621 4 no
GO:0032880 regulation of protein localization 25.8621 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.8621 5 no
GO:0010648 negative regulation of cell communication 25.8621 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.8621 5 no
GO:0023057 negative regulation of signaling 25.8621 4 no
GO:0051247 positive regulation of protein metabolic process 25.8621 6 no
GO:0051049 regulation of transport 25.8621 4 no
GO:0071310 cellular response to organic substance 24.1379 4 no
GO:0009890 negative regulation of biosynthetic process 24.1379 5 no
GO:0009968 negative regulation of signal transduction 24.1379 5 no
GO:0048585 negative regulation of response to stimulus 24.1379 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.1379 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.1379 6 no
GO:0019220 regulation of phosphate metabolic process 22.4138 6 no
GO:0051174 regulation of phosphorus metabolic process 22.4138 5 no
GO:0071705 nitrogen compound transport 22.4138 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.4138 6 no
GO:0031324 negative regulation of cellular metabolic process 22.4138 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.4138 6 no
GO:0043085 positive regulation of catalytic activity 22.4138 4 no
GO:0051240 positive regulation of multicellular organismal process 22.4138 4 no
GO:0051252 regulation of RNA metabolic process 22.4138 5 no
GO:0043933 protein-containing complex organization 22.4138 4 no
GO:0010628 positive regulation of gene expression 22.4138 7 no
GO:0043066 negative regulation of apoptotic process 20.6897 6 no
GO:0043069 negative regulation of programmed cell death 20.6897 5 no
GO:0006355 regulation of DNA-templated transcription 20.6897 7 no
GO:0008284 positive regulation of cell population proliferation 20.6897 5 no
GO:0008285 negative regulation of cell population proliferation 20.6897 5 no
GO:0031401 positive regulation of protein modification process 20.6897 7 no
GO:0080134 regulation of response to stress 20.6897 4 no
GO:2001141 regulation of RNA biosynthetic process 20.6897 6 no
GO:1902533 positive regulation of intracellular signal transduction 20.6897 6 no
GO:0001817 regulation of cytokine production 15.5172 4 yes
GO:0006954 inflammatory response 8.6207 4 yes
GO:0042692 muscle cell differentiation 6.8966 4 yes
GO:0051146 striated muscle cell differentiation 6.8966 5 yes
GO:0014902 myotube differentiation 3.4483 6 yes
GO:1900015 regulation of cytokine production involved in inflammatory response 3.4483 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLD3_HUMAN [view entry] [view interactions] Low throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
CNIH3_HUMAN [view entry] [view interactions] High throughput yes no
SMCO4_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
CLTR2_HUMAN [view interactions] High throughput no no
LBN_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
YMEL1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
UFO_HUMAN [view interactions] High throughput no no
OSTP_HUMAN [view interactions] High throughput no yes
SOX4_HUMAN [view interactions] High throughput no yes
OPRM_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ARRD3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
S15A3_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
FA20C_HUMAN [view interactions] High throughput no no
LSME2_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RND1_HUMAN [view interactions] High throughput no no
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PLD1_HUMAN [view interactions] High throughput no no
PLD2_HUMAN [view interactions] High throughput no yes
PLD4_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
PDIA1_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
TM9S1_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
UGGG1_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
HACD3_HUMAN [view interactions] High throughput no yes
SRPRA_HUMAN [view interactions] High throughput no no
MA1B1_HUMAN [view interactions] High throughput no yes
GLU2B_HUMAN [view interactions] High throughput no yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
CLCC1_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
MANEA_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
ADA15_HUMAN [view interactions] High throughput no yes
EXTL3_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN8_HUMAN [view interactions] High throughput no yes
NEUFC_HUMAN [view interactions] High throughput no yes
FZD8_HUMAN [view interactions] High throughput no yes
EDEM3_HUMAN [view interactions] High throughput no yes
PLPL7_HUMAN [view interactions] High throughput no yes
TGFR1_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
CHPF2_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
TM9S2_HUMAN [view interactions] High throughput no yes
EXT2_HUMAN [view entry] [view interactions] High throughput yes no
ALG5_HUMAN [view interactions] High throughput no yes
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
GPHRA_HUMAN [view interactions] High throughput no no
DOPP1_HUMAN [view interactions] High throughput no yes
MPU1_HUMAN [view interactions] High throughput no yes
LGAT1_HUMAN [view interactions] High throughput no no
CC50A_HUMAN [view interactions] High throughput no yes
SELN_HUMAN [view interactions] High throughput no yes
TMTC3_HUMAN [view interactions] High throughput no yes
NOMO3_HUMAN [view interactions] High throughput no yes
SLIK5_HUMAN [view entry] [view interactions] High throughput yes no
CLGN_HUMAN [view interactions] High throughput no no
B3GA3_HUMAN [view entry] [view interactions] High throughput yes yes
ACSL1_HUMAN [view interactions] High throughput no no
MAN1_HUMAN [view interactions] High throughput no yes
GPI8_HUMAN [view entry] [view interactions] High throughput yes no
FDFT_HUMAN [view interactions] High throughput no yes
GLBL2_HUMAN [view interactions] High throughput no no
B3GL2_HUMAN [view interactions] High throughput no yes
MFS10_HUMAN [view interactions] High throughput no yes
NEMP1_HUMAN [view interactions] High throughput no no
ITAV_HUMAN [view interactions] High throughput no yes
ZDH13_HUMAN [view interactions] High throughput no no
LEMD2_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
CERS1_HUMAN [view interactions] High throughput no yes
ACATN_HUMAN [view interactions] High throughput no yes
RAB34_HUMAN [view interactions] High throughput no yes
MAGT1_HUMAN [view interactions] High throughput no yes
ERLEC_HUMAN [view interactions] High throughput no yes
4F2_HUMAN [view entry] [view interactions] High throughput yes no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
LAT1_HUMAN [view interactions] High throughput no yes
TTC13_HUMAN [view interactions] High throughput no no
ARMC6_HUMAN [view interactions] High throughput no yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
CNPY3_HUMAN [view interactions] High throughput no yes
NNRE_HUMAN [view interactions] High throughput no yes
EGFL7_HUMAN [view interactions] High throughput no yes
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
S38A7_HUMAN [view interactions] High throughput no yes
SUN2_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
PGPS1_HUMAN [view interactions] High throughput no yes
STIM1_HUMAN [view interactions] High throughput no yes
LMBD2_HUMAN [view interactions] High throughput no yes
GP1BB_HUMAN [view interactions] High throughput no no
SCAM2_HUMAN [view interactions] High throughput no no
ABD12_HUMAN [view interactions] High throughput no no
SCAM3_HUMAN [view interactions] High throughput no no
ITM2C_HUMAN [view interactions] High throughput no no
DIK2A_HUMAN [view interactions] High throughput no yes
PSME2_HUMAN [view interactions] High throughput no no
GANAB_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
DAAF5_HUMAN [view interactions] High throughput no no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
OS9_HUMAN [view interactions] High throughput no yes
LBR_HUMAN [view interactions] High throughput no yes
QSOX2_HUMAN [view interactions] High throughput no yes
EAA1_HUMAN [view entry] [view interactions] High throughput yes no
COX15_HUMAN [view interactions] High throughput no yes
ERG24_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
PDS5A_HUMAN [view interactions] High throughput no yes
HNRH2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
FADS1_HUMAN [view interactions] High throughput no yes
RSPRY_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
MON2_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
SURF4_HUMAN [view interactions] High throughput no yes
ECM29_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
SPNS1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RUFY1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
ERP44_HUMAN [view interactions] High throughput no yes
FUBP1_HUMAN [view interactions] High throughput no yes
NUDC1_HUMAN [view interactions] High throughput no no
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH3_HUMAN [view interactions] High throughput no no
DCMC_HUMAN [view interactions] High throughput no no
WWP1_HUMAN [view interactions] High throughput no yes
OTULL_HUMAN [view interactions] High throughput no no
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
DNJB5_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
DJC10_HUMAN [view interactions] High throughput no yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
T106B_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
B2CL1_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
LTN1_HUMAN [view interactions] High throughput no no
TYW3_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
CLK3_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
VGFR3_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes