CNIH3_HUMAN
Evidence for PS localization
Functions
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNIH3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 46.1538 | 4 | no |
| GO:0005261 | cation channel activity | 46.1538 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 46.1538 | 4 | no |
| GO:0015267 | channel activity | 46.1538 | 4 | no |
| GO:0022836 | gated channel activity | 46.1538 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 46.1538 | 4 | no |
| GO:0001540 | amyloid-beta binding | 30.7692 | 4 | no |
| GO:0004970 | ionotropic glutamate receptor activity | 30.7692 | 5 | no |
| GO:0004971 | AMPA glutamate receptor activity | 30.7692 | 6 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 30.7692 | 6 | no |
| GO:0008066 | glutamate receptor activity | 30.7692 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 30.7692 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 30.7692 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 30.7692 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 30.7692 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 30.7692 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNIH3_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | yes |
| GO:0051049 | regulation of transport | 53.8462 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.1538 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 46.1538 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 46.1538 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 46.1538 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 46.1538 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 46.1538 | 5 | yes |
| GO:0043269 | regulation of ion transport | 46.1538 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 46.1538 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 46.1538 | 6 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 38.4615 | 4 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 38.4615 | 5 | yes |
| GO:0006886 | intracellular protein transport | 30.7692 | 4 | no |
| GO:0008104 | protein localization | 30.7692 | 4 | no |
| GO:0015031 | protein transport | 30.7692 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.7692 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 30.7692 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:0071702 | organic substance transport | 30.7692 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 30.7692 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.7692 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.7692 | 4 | no |
| GO:0007215 | glutamate receptor signaling pathway | 23.0769 | 4 | no |
| GO:0006897 | endocytosis | 23.0769 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 23.0769 | 6 | no |
| GO:0031623 | receptor internalization | 23.0769 | 7 | no |
| GO:0033365 | protein localization to organelle | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0072594 | establishment of protein localization to organelle | 23.0769 | 4 | no |
| GO:0044057 | regulation of system process | 23.0769 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNIH3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMIM3_HUMAN | [view interactions] | High throughput | no | no |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIK_HUMAN | [view interactions] | High throughput | no | yes |
| CEAM3_HUMAN | [view interactions] | High throughput | no | no |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| CLD20_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM80_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP4_HUMAN | [view interactions] | High throughput | no | no |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| LEUTX_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| VISTA_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNN4_HUMAN | [view interactions] | High throughput | no | no |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC9_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT8_HUMAN | [view interactions] | High throughput | no | no |
| TM237_HUMAN | [view interactions] | High throughput | no | no |
| NEMP1_HUMAN | [view interactions] | High throughput | no | no |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SCFD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BET1_HUMAN | [view interactions] | Computational | no | no |
| STX17_HUMAN | [view interactions] | Computational | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |