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EAA1_HUMAN

GO
G2C
SynGO

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in EAA1_HUMAN
GO:0043168 anion binding 40.4255 4 yes
GO:0000166 nucleotide binding 34.0426 4 no
GO:0017076 purine nucleotide binding 34.0426 5 no
GO:0032555 purine ribonucleotide binding 34.0426 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.0426 4 no
GO:0043169 cation binding 25.5319 4 yes
GO:0046872 metal ion binding 25.5319 5 yes
GO:0003924 GTPase activity 25.5319 7 no
GO:0005525 GTP binding 25.5319 5 no
GO:0016462 pyrophosphatase activity 25.5319 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.5319 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.5319 6 no
GO:0019001 guanyl nucleotide binding 25.5319 6 no
GO:0032561 guanyl ribonucleotide binding 25.5319 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 8.5106 4 yes
GO:0015081 sodium ion transmembrane transporter activity 8.5106 6 yes
GO:0015291 secondary active transmembrane transporter activity 8.5106 4 yes
GO:0015293 symporter activity 8.5106 5 yes
GO:0015294 solute:monoatomic cation symporter activity 8.5106 5 yes
GO:0015370 solute:sodium symporter activity 8.5106 6 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 8.5106 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 8.5106 4 yes
GO:0046873 metal ion transmembrane transporter activity 8.5106 5 yes
GO:0005283 amino acid:sodium symporter activity 6.3830 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 6.3830 5 yes
GO:0005314 high-affinity L-glutamate transmembrane transporter activity 6.3830 6 yes
GO:0005343 organic acid:sodium symporter activity 6.3830 4 yes
GO:0005416 amino acid:monoatomic cation symporter activity 6.3830 4 yes
GO:0015172 acidic amino acid transmembrane transporter activity 6.3830 4 yes
GO:0015175 neutral L-amino acid transmembrane transporter activity 6.3830 4 yes
GO:0015179 L-amino acid transmembrane transporter activity 6.3830 4 yes
GO:0015501 glutamate:sodium symporter activity 6.3830 5 yes
GO:0031406 carboxylic acid binding 6.3830 4 yes
GO:0046943 carboxylic acid transmembrane transporter activity 6.3830 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EAA1_HUMAN
GO:0048522 positive regulation of cellular process 70.2128 4 yes
GO:0010646 regulation of cell communication 59.5745 4 yes
GO:0051128 regulation of cellular component organization 53.1915 4 no
GO:0048523 negative regulation of cellular process 48.9362 4 no
GO:0060255 regulation of macromolecule metabolic process 44.6809 4 no
GO:0009966 regulation of signal transduction 42.5532 4 no
GO:0031323 regulation of cellular metabolic process 42.5532 4 no
GO:0051049 regulation of transport 40.4255 4 no
GO:0010647 positive regulation of cell communication 38.2979 5 yes
GO:0023056 positive regulation of signaling 38.2979 4 yes
GO:0050804 modulation of chemical synaptic transmission 38.2979 5 yes
GO:0099177 regulation of trans-synaptic signaling 38.2979 4 yes
GO:0006996 organelle organization 38.2979 4 no
GO:0030030 cell projection organization 38.2979 4 no
GO:0080090 regulation of primary metabolic process 38.2979 4 no
GO:0071702 organic substance transport 36.1702 4 yes
GO:0031344 regulation of cell projection organization 36.1702 5 no
GO:0008104 protein localization 36.1702 4 no
GO:0071705 nitrogen compound transport 34.0426 4 yes
GO:0022607 cellular component assembly 34.0426 4 no
GO:0009893 positive regulation of metabolic process 34.0426 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.0426 5 no
GO:0051130 positive regulation of cellular component organization 34.0426 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.0426 6 no
GO:1902531 regulation of intracellular signal transduction 34.0426 5 no
GO:0009889 regulation of biosynthetic process 31.9149 4 no
GO:0010468 regulation of gene expression 31.9149 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.9149 5 no
GO:0031326 regulation of cellular biosynthetic process 31.9149 5 no
GO:0048584 positive regulation of response to stimulus 31.9149 4 no
GO:0044087 regulation of cellular component biogenesis 31.9149 4 no
GO:0031325 positive regulation of cellular metabolic process 29.7872 5 no
GO:0051246 regulation of protein metabolic process 29.7872 5 no
GO:0120036 plasma membrane bounded cell projection organization 29.7872 5 no
GO:0060341 regulation of cellular localization 29.7872 4 no
GO:0033043 regulation of organelle organization 29.7872 5 no
GO:0031399 regulation of protein modification process 27.6596 6 no
GO:0043067 regulation of programmed cell death 27.6596 4 no
GO:0032880 regulation of protein localization 27.6596 5 no
GO:0006915 apoptotic process 25.5319 4 no
GO:0009967 positive regulation of signal transduction 25.5319 5 no
GO:0019220 regulation of phosphate metabolic process 25.5319 6 no
GO:0042325 regulation of phosphorylation 25.5319 7 no
GO:0042981 regulation of apoptotic process 25.5319 5 no
GO:0051174 regulation of phosphorus metabolic process 25.5319 5 no
GO:0060627 regulation of vesicle-mediated transport 25.5319 4 no
GO:0141124 intracellular signaling cassette 25.5319 4 no
GO:1901701 cellular response to oxygen-containing compound 23.4043 4 yes
GO:0001932 regulation of protein phosphorylation 23.4043 7 no
GO:0009892 negative regulation of metabolic process 23.4043 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.4043 5 no
GO:0031175 neuron projection development 23.4043 6 no
GO:0031324 negative regulation of cellular metabolic process 23.4043 5 no
GO:0031346 positive regulation of cell projection organization 23.4043 6 no
GO:0042127 regulation of cell population proliferation 23.4043 4 no
GO:0051247 positive regulation of protein metabolic process 23.4043 6 no
GO:0051129 negative regulation of cellular component organization 23.4043 5 no
GO:0044089 positive regulation of cellular component biogenesis 23.4043 5 no
GO:0015031 protein transport 23.4043 4 no
GO:0071310 cellular response to organic substance 21.2766 4 yes
GO:0098657 import into cell 21.2766 4 yes
GO:0097435 supramolecular fiber organization 21.2766 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.2766 6 no
GO:0031401 positive regulation of protein modification process 21.2766 7 no
GO:0042327 positive regulation of phosphorylation 21.2766 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.2766 7 no
GO:0051240 positive regulation of multicellular organismal process 21.2766 4 no
GO:0007264 small GTPase-mediated signal transduction 21.2766 5 no
GO:0050890 cognition 21.2766 4 no
GO:1903829 positive regulation of protein localization 21.2766 5 no
GO:0009890 negative regulation of biosynthetic process 21.2766 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.2766 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.2766 6 no
GO:0050807 regulation of synapse organization 21.2766 5 no
GO:0010243 response to organonitrogen compound 19.1489 4 yes
GO:0050806 positive regulation of synaptic transmission 17.0213 5 yes
GO:0014070 response to organic cyclic compound 14.8936 4 yes
GO:0071417 cellular response to organonitrogen compound 14.8936 4 yes
GO:0099536 synaptic signaling 14.8936 4 yes
GO:0099537 trans-synaptic signaling 14.8936 5 yes
GO:1901699 cellular response to nitrogen compound 14.8936 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 12.7660 4 yes
GO:0007268 chemical synaptic transmission 12.7660 7 yes
GO:0030003 intracellular monoatomic cation homeostasis 12.7660 5 yes
GO:0055080 monoatomic cation homeostasis 12.7660 4 yes
GO:0098916 anterograde trans-synaptic signaling 12.7660 6 yes
GO:0006836 neurotransmitter transport 10.6383 4 yes
GO:0071407 cellular response to organic cyclic compound 10.6383 5 yes
GO:0001504 neurotransmitter uptake 8.5106 5 yes
GO:0003018 vascular process in circulatory system 8.5106 4 yes
GO:0006811 monoatomic ion transport 8.5106 4 yes
GO:0006812 monoatomic cation transport 8.5106 5 yes
GO:0009416 response to light stimulus 8.5106 4 yes
GO:0019752 carboxylic acid metabolic process 8.5106 5 yes
GO:0030001 metal ion transport 8.5106 6 yes
GO:0032787 monocarboxylic acid metabolic process 8.5106 6 yes
GO:0043279 response to alkaloid 8.5106 5 yes
GO:0043436 oxoacid metabolic process 8.5106 4 yes
GO:0050905 neuromuscular process 8.5106 4 yes
GO:0098655 monoatomic cation transmembrane transport 8.5106 4 yes
GO:0098662 inorganic cation transmembrane transport 8.5106 4 yes
GO:1901566 organonitrogen compound biosynthetic process 8.5106 4 yes
GO:0006820 monoatomic anion transport 6.3830 5 yes
GO:0006821 chloride transport 6.3830 5 yes
GO:0006835 dicarboxylic acid transport 6.3830 7 yes
GO:0006865 amino acid transport 6.3830 5 yes
GO:0010232 vascular transport 6.3830 4 yes
GO:0015698 inorganic anion transport 6.3830 4 yes
GO:0015711 organic anion transport 6.3830 5 yes
GO:0015740 C4-dicarboxylate transport 6.3830 8 yes
GO:0015800 acidic amino acid transport 6.3830 6 yes
GO:0015807 L-amino acid transport 6.3830 5 yes
GO:0015810 aspartate transmembrane transport 6.3830 4 yes
GO:0015813 L-glutamate transmembrane transport 6.3830 5 yes
GO:0015849 organic acid transport 6.3830 5 yes
GO:0016053 organic acid biosynthetic process 6.3830 4 yes
GO:0031223 auditory behavior 6.3830 4 yes
GO:0042220 response to cocaine 6.3830 4 yes
GO:0042940 D-amino acid transport 6.3830 5 yes
GO:0046394 carboxylic acid biosynthetic process 6.3830 5 yes
GO:0046942 carboxylic acid transport 6.3830 6 yes
GO:0050885 neuromuscular process controlling balance 6.3830 5 yes
GO:0051938 L-glutamate import 6.3830 6 yes
GO:0070633 transepithelial transport 6.3830 4 yes
GO:0070777 D-aspartate transmembrane transport 6.3830 5 yes
GO:0070778 L-aspartate transmembrane transport 6.3830 5 yes
GO:0070779 D-aspartate import across plasma membrane 6.3830 5 yes
GO:0071312 cellular response to alkaloid 6.3830 5 yes
GO:0071314 cellular response to cocaine 6.3830 5 yes
GO:0089718 amino acid import across plasma membrane 6.3830 4 yes
GO:0098656 monoatomic anion transmembrane transport 6.3830 4 yes
GO:0098661 inorganic anion transmembrane transport 6.3830 4 yes
GO:0098712 L-glutamate import across plasma membrane 6.3830 5 yes
GO:0140009 L-aspartate import across plasma membrane 6.3830 5 yes
GO:0150104 transport across blood-brain barrier 6.3830 5 yes
GO:1902475 L-alpha-amino acid transmembrane transport 6.3830 4 yes
GO:1902476 chloride transmembrane transport 6.3830 5 yes
GO:1905039 carboxylic acid transmembrane transport 6.3830 4 yes
GO:0006813 potassium ion transport 4.2553 7 yes
GO:0006883 intracellular sodium ion homeostasis 4.2553 5 yes
GO:0007600 sensory perception 4.2553 4 yes
GO:0007605 sensory perception of sound 4.2553 6 yes
GO:0008652 amino acid biosynthetic process 4.2553 4 yes
GO:0009448 gamma-aminobutyric acid metabolic process 4.2553 5 yes
GO:0009449 gamma-aminobutyric acid biosynthetic process 4.2553 5 yes
GO:0021545 cranial nerve development 4.2553 4 yes
GO:0048667 cell morphogenesis involved in neuron differentiation 4.2553 4 yes
GO:0050954 sensory perception of mechanical stimulus 4.2553 5 yes
GO:0055078 sodium ion homeostasis 4.2553 4 yes
GO:0071805 potassium ion transmembrane transport 4.2553 5 yes
GO:0170041 non-proteinogenic amino acid metabolic process 4.2553 4 yes
GO:0170043 non-proteinogenic amino acid biosynthetic process 4.2553 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EAA1_HUMAN [view entry] [view interactions] Low throughput yes no
SEPT4_HUMAN [view interactions] Low throughput no no
APR_HUMAN [view interactions] High throughput no yes
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
OBSCN_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
DYR2_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
RAMP3_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
CLC2D_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
PLD3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
CL16A_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
ETAA1_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
ATG9A_HUMAN [view interactions] High throughput no yes
BACD1_HUMAN [view interactions] High throughput no no
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PDZ1P_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SAFB1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR3_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
T120B_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
BT2A2_HUMAN [view interactions] High throughput no no
TNR1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TECT3_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
TM128_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LEG3_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
NHRF3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no