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EAA1_HUMAN

GO
G2C
SynGO

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in EAA1_HUMAN
GO:0017076 purine nucleotide binding 39.0244 4 no
GO:0032555 purine ribonucleotide binding 39.0244 4 no
GO:0035639 purine ribonucleoside triphosphate binding 39.0244 4 no
GO:0046872 metal ion binding 29.2683 4 yes
GO:0003924 GTPase activity 29.2683 7 no
GO:0005525 GTP binding 29.2683 5 no
GO:0016462 pyrophosphatase activity 29.2683 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 29.2683 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 29.2683 6 no
GO:0019001 guanyl nucleotide binding 29.2683 5 no
GO:0032561 guanyl ribonucleotide binding 29.2683 5 no
GO:0019900 kinase binding 24.3902 4 no
GO:0019901 protein kinase binding 24.3902 5 no
GO:0008324 cation transmembrane transporter activity 12.1951 4 yes
GO:0008509 anion transmembrane transporter activity 12.1951 4 yes
GO:0015081 sodium ion transmembrane transporter activity 12.1951 6 yes
GO:0015291 secondary active transmembrane transporter activity 12.1951 4 yes
GO:0015293 symporter activity 12.1951 5 yes
GO:0015294 solute:cation symporter activity 12.1951 5 yes
GO:0015370 solute:sodium symporter activity 12.1951 6 yes
GO:0022853 active ion transmembrane transporter activity 12.1951 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 12.1951 4 yes
GO:0046873 metal ion transmembrane transporter activity 12.1951 5 yes
GO:0005283 amino acid:sodium symporter activity 9.7561 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 9.7561 6 yes
GO:0005314 high-affinity L-glutamate transmembrane transporter activity 9.7561 7 yes
GO:0005343 organic acid:sodium symporter activity 9.7561 4 yes
GO:0005416 amino acid:cation symporter activity 9.7561 6 yes
GO:0008514 organic anion transmembrane transporter activity 9.7561 5 yes
GO:0015171 amino acid transmembrane transporter activity 9.7561 5 yes
GO:0015172 acidic amino acid transmembrane transporter activity 9.7561 6 yes
GO:0015175 neutral amino acid transmembrane transporter activity 9.7561 6 yes
GO:0015179 L-amino acid transmembrane transporter activity 9.7561 6 yes
GO:0015501 glutamate:sodium symporter activity 9.7561 6 yes
GO:0016595 glutamate binding 9.7561 5 yes
GO:0016597 amino acid binding 9.7561 4 yes
GO:0031406 carboxylic acid binding 9.7561 4 yes
GO:0046943 carboxylic acid transmembrane transporter activity 9.7561 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EAA1_HUMAN
GO:0048522 positive regulation of cellular process 73.1707 4 yes
GO:0010646 regulation of cell communication 60.9756 4 yes
GO:0051128 regulation of cellular component organization 56.0976 4 no
GO:0048523 negative regulation of cellular process 51.2195 4 no
GO:0051049 regulation of transport 46.3415 4 no
GO:0006996 organelle organization 46.3415 4 no
GO:0016192 vesicle-mediated transport 43.9024 4 no
GO:0031323 regulation of cellular metabolic process 43.9024 4 no
GO:0060255 regulation of macromolecule metabolic process 43.9024 4 no
GO:0009966 regulation of signal transduction 43.9024 4 no
GO:0050804 modulation of chemical synaptic transmission 41.4634 5 yes
GO:0071702 organic substance transport 41.4634 4 yes
GO:0071705 nitrogen compound transport 41.4634 4 yes
GO:0099177 regulation of trans-synaptic signaling 41.4634 4 yes
GO:0022607 cellular component assembly 41.4634 4 no
GO:0080090 regulation of primary metabolic process 41.4634 4 no
GO:0071310 cellular response to organic substance 39.0244 4 yes
GO:0008104 protein localization 39.0244 4 no
GO:0051171 regulation of nitrogen compound metabolic process 39.0244 4 no
GO:0030030 cell projection organization 39.0244 4 no
GO:0051130 positive regulation of cellular component organization 39.0244 5 no
GO:0010647 positive regulation of cell communication 39.0244 5 yes
GO:0023056 positive regulation of signaling 39.0244 4 yes
GO:0009893 positive regulation of metabolic process 36.5854 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.5854 5 no
GO:0031344 regulation of cell projection organization 36.5854 5 no
GO:0120036 plasma membrane bounded cell projection organization 36.5854 5 no
GO:1901701 cellular response to oxygen-containing compound 34.1463 4 yes
GO:0033043 regulation of organelle organization 34.1463 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.1463 6 no
GO:1902531 regulation of intracellular signal transduction 34.1463 5 no
GO:0031325 positive regulation of cellular metabolic process 31.7073 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.7073 5 no
GO:0051246 regulation of protein metabolic process 31.7073 5 no
GO:0010468 regulation of gene expression 31.7073 5 no
GO:0044087 regulation of cellular component biogenesis 31.7073 4 no
GO:0010562 positive regulation of phosphorus metabolic process 29.2683 6 no
GO:0019220 regulation of phosphate metabolic process 29.2683 6 no
GO:0031399 regulation of protein modification process 29.2683 6 no
GO:0042325 regulation of phosphorylation 29.2683 7 no
GO:0042327 positive regulation of phosphorylation 29.2683 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.2683 7 no
GO:0051174 regulation of phosphorus metabolic process 29.2683 5 no
GO:0022603 regulation of anatomical structure morphogenesis 29.2683 4 no
GO:0031175 neuron projection development 29.2683 6 no
GO:0051493 regulation of cytoskeleton organization 29.2683 6 no
GO:0051050 positive regulation of transport 29.2683 4 no
GO:0042127 regulation of cell population proliferation 29.2683 4 no
GO:0010941 regulation of cell death 26.8293 4 no
GO:0015031 protein transport 26.8293 4 no
GO:0036211 protein modification process 26.8293 4 no
GO:0043412 macromolecule modification 26.8293 4 no
GO:0051247 positive regulation of protein metabolic process 26.8293 6 no
GO:0044089 positive regulation of cellular component biogenesis 26.8293 5 no
GO:0045595 regulation of cell differentiation 26.8293 4 no
GO:0051094 positive regulation of developmental process 26.8293 4 no
GO:0048584 positive regulation of response to stimulus 26.8293 4 no
GO:0010243 response to organonitrogen compound 26.8293 4 yes
GO:0071417 cellular response to organonitrogen compound 24.3902 4 yes
GO:1901699 cellular response to nitrogen compound 24.3902 4 yes
GO:0097435 supramolecular fiber organization 24.3902 4 no
GO:0001932 regulation of protein phosphorylation 24.3902 7 no
GO:0031401 positive regulation of protein modification process 24.3902 7 no
GO:0032880 regulation of protein localization 24.3902 5 no
GO:0033674 positive regulation of kinase activity 24.3902 6 no
GO:0042981 regulation of apoptotic process 24.3902 6 no
GO:0043067 regulation of programmed cell death 24.3902 5 no
GO:0043085 positive regulation of catalytic activity 24.3902 4 no
GO:0043549 regulation of kinase activity 24.3902 5 no
GO:0050890 cognition 24.3902 4 no
GO:0051240 positive regulation of multicellular organismal process 24.3902 4 no
GO:0051338 regulation of transferase activity 24.3902 4 no
GO:0051347 positive regulation of transferase activity 24.3902 5 no
GO:0060341 regulation of cellular localization 24.3902 4 no
GO:0007010 cytoskeleton organization 24.3902 5 no
GO:0009892 negative regulation of metabolic process 24.3902 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.3902 5 no
GO:0031346 positive regulation of cell projection organization 24.3902 6 no
GO:0051129 negative regulation of cellular component organization 24.3902 5 no
GO:2000026 regulation of multicellular organismal development 24.3902 4 no
GO:0007264 small GTPase mediated signal transduction 24.3902 4 no
GO:0007265 Ras protein signal transduction 24.3902 5 no
GO:0032956 regulation of actin cytoskeleton organization 24.3902 5 no
GO:0032970 regulation of actin filament-based process 24.3902 4 no
GO:0050806 positive regulation of synaptic transmission 21.9512 5 yes
GO:0001934 positive regulation of protein phosphorylation 21.9512 8 no
GO:0034330 cell junction organization 21.9512 4 no
GO:0010638 positive regulation of organelle organization 21.9512 6 no
GO:0060284 regulation of cell development 21.9512 5 no
GO:1902903 regulation of supramolecular fiber organization 21.9512 5 no
GO:1903829 positive regulation of protein localization 21.9512 5 no
GO:0050807 regulation of synapse organization 21.9512 5 no
GO:0009967 positive regulation of signal transduction 21.9512 5 no
GO:0030334 regulation of cell migration 21.9512 5 no
GO:2000145 regulation of cell motility 21.9512 4 no
GO:0008284 positive regulation of cell population proliferation 21.9512 5 no
GO:0060627 regulation of vesicle-mediated transport 21.9512 4 no
GO:0014070 response to organic cyclic compound 19.5122 4 yes
GO:0071407 cellular response to organic cyclic compound 17.0732 5 yes
GO:0099537 trans-synaptic signaling 17.0732 4 yes
GO:0006811 ion transport 17.0732 4 yes
GO:0048878 chemical homeostasis 14.6341 4 yes
GO:0098657 import into cell 14.6341 4 yes
GO:0098916 anterograde trans-synaptic signaling 14.6341 5 yes
GO:1901566 organonitrogen compound biosynthetic process 14.6341 4 yes
GO:0006812 cation transport 14.6341 5 yes
GO:0006836 neurotransmitter transport 14.6341 4 yes
GO:0007268 chemical synaptic transmission 14.6341 6 yes
GO:0043436 oxoacid metabolic process 12.1951 4 yes
GO:0050801 ion homeostasis 12.1951 5 yes
GO:0055065 metal ion homeostasis 12.1951 7 yes
GO:0055080 cation homeostasis 12.1951 6 yes
GO:0098771 inorganic ion homeostasis 12.1951 6 yes
GO:0001504 neurotransmitter uptake 12.1951 4 yes
GO:0003018 vascular process in circulatory system 12.1951 4 yes
GO:0006873 cellular ion homeostasis 12.1951 4 yes
GO:0006875 cellular metal ion homeostasis 12.1951 6 yes
GO:0009416 response to light stimulus 12.1951 4 yes
GO:0019752 carboxylic acid metabolic process 12.1951 5 yes
GO:0030003 cellular cation homeostasis 12.1951 5 yes
GO:0042220 response to cocaine 9.7561 4 yes
GO:0042940 D-amino acid transport 9.7561 6 yes
GO:0043279 response to alkaloid 9.7561 5 yes
GO:0046394 carboxylic acid biosynthetic process 9.7561 5 yes
GO:0046942 carboxylic acid transport 9.7561 6 yes
GO:0051938 L-glutamate import 9.7561 6 yes
GO:0070633 transepithelial transport 9.7561 4 yes
GO:0070777 D-aspartate transport 9.7561 7 yes
GO:0070778 L-aspartate transmembrane transport 9.7561 5 yes
GO:0070779 D-aspartate import across plasma membrane 9.7561 5 yes
GO:0071312 cellular response to alkaloid 9.7561 5 yes
GO:0071314 cellular response to cocaine 9.7561 5 yes
GO:0089718 amino acid import across plasma membrane 9.7561 4 yes
GO:0098655 cation transmembrane transport 9.7561 4 yes
GO:0098656 anion transmembrane transport 9.7561 4 yes
GO:0098660 inorganic ion transmembrane transport 9.7561 4 yes
GO:0098662 inorganic cation transmembrane transport 9.7561 5 yes
GO:0098712 L-glutamate import across plasma membrane 9.7561 5 yes
GO:0150104 transport across blood-brain barrier 9.7561 5 yes
GO:1902475 L-alpha-amino acid transmembrane transport 9.7561 6 yes
GO:1905039 carboxylic acid transmembrane transport 9.7561 4 yes
GO:0000904 cell morphogenesis involved in differentiation 9.7561 4 yes
GO:0003333 amino acid transmembrane transport 9.7561 5 yes
GO:0006820 anion transport 9.7561 5 yes
GO:0006835 dicarboxylic acid transport 9.7561 7 yes
GO:0006865 amino acid transport 9.7561 5 yes
GO:0010232 vascular transport 9.7561 4 yes
GO:0015711 organic anion transport 9.7561 5 yes
GO:0015740 C4-dicarboxylate transport 9.7561 8 yes
GO:0015800 acidic amino acid transport 9.7561 6 yes
GO:0015807 L-amino acid transport 9.7561 5 yes
GO:0015813 L-glutamate transmembrane transport 9.7561 5 yes
GO:0015849 organic acid transport 9.7561 5 yes
GO:0016053 organic acid biosynthetic process 9.7561 4 yes
GO:0030001 metal ion transport 9.7561 6 yes
GO:0031223 auditory behavior 7.3171 4 yes
GO:0032787 monocarboxylic acid metabolic process 7.3171 6 yes
GO:0050885 neuromuscular process controlling balance 7.3171 5 yes
GO:0050905 neuromuscular process 7.3171 4 yes
GO:0098661 inorganic anion transmembrane transport 7.3171 5 yes
GO:0140009 L-aspartate import across plasma membrane 7.3171 5 yes
GO:1902476 chloride transmembrane transport 7.3171 6 yes
GO:0006821 chloride transport 7.3171 7 yes
GO:0008652 cellular amino acid biosynthetic process 7.3171 4 yes
GO:0015698 inorganic anion transport 7.3171 6 yes
GO:0048667 cell morphogenesis involved in neuron differentiation 4.8780 5 yes
GO:0050954 sensory perception of mechanical stimulus 4.8780 5 yes
GO:0055067 monovalent inorganic cation homeostasis 4.8780 7 yes
GO:0055078 sodium ion homeostasis 4.8780 8 yes
GO:0071805 potassium ion transmembrane transport 4.8780 6 yes
GO:0006813 potassium ion transport 4.8780 7 yes
GO:0006883 cellular sodium ion homeostasis 4.8780 7 yes
GO:0007600 sensory perception 4.8780 4 yes
GO:0007605 sensory perception of sound 4.8780 6 yes
GO:0009448 gamma-aminobutyric acid metabolic process 4.8780 4 yes
GO:0009449 gamma-aminobutyric acid biosynthetic process 4.8780 5 yes
GO:0021545 cranial nerve development 4.8780 4 yes
GO:0030004 cellular monovalent inorganic cation homeostasis 4.8780 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EAA1_HUMAN [view entry] [view interactions] Low throughput yes no
SEPT4_HUMAN [view interactions] Low throughput no no
KCTD5_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view interactions] High throughput no yes
NHRF3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
APR_HUMAN [view interactions] High throughput no yes
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
OBSCN_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
DYR2_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
RAMP3_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
CLC2D_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
ETAA1_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PDZ1P_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SAFB1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
APBB1_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR3_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
ZDH17_HUMAN [view interactions] High throughput no yes
T120B_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
BT2A2_HUMAN [view interactions] High throughput no no
TNR1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TECT3_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
TM128_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LEG3_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] Computational no no
GLNA_HUMAN [view entry] [view interactions] Computational yes yes
EAA2_HUMAN [view entry] [view interactions] Computational yes no