EAA1_HUMAN
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EAA1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 40.4255 | 4 | yes |
GO:0000166 | nucleotide binding | 34.0426 | 4 | no |
GO:0017076 | purine nucleotide binding | 34.0426 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 34.0426 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 34.0426 | 4 | no |
GO:0043169 | cation binding | 25.5319 | 4 | yes |
GO:0046872 | metal ion binding | 25.5319 | 5 | yes |
GO:0003924 | GTPase activity | 25.5319 | 7 | no |
GO:0005525 | GTP binding | 25.5319 | 5 | no |
GO:0016462 | pyrophosphatase activity | 25.5319 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.5319 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.5319 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 25.5319 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 25.5319 | 5 | no |
GO:0008324 | monoatomic cation transmembrane transporter activity | 8.5106 | 4 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 8.5106 | 6 | yes |
GO:0015291 | secondary active transmembrane transporter activity | 8.5106 | 4 | yes |
GO:0015293 | symporter activity | 8.5106 | 5 | yes |
GO:0015294 | solute:monoatomic cation symporter activity | 8.5106 | 5 | yes |
GO:0015370 | solute:sodium symporter activity | 8.5106 | 6 | yes |
GO:0022853 | active monoatomic ion transmembrane transporter activity | 8.5106 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 8.5106 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 8.5106 | 5 | yes |
GO:0005283 | amino acid:sodium symporter activity | 6.3830 | 5 | yes |
GO:0005313 | L-glutamate transmembrane transporter activity | 6.3830 | 5 | yes |
GO:0005314 | high-affinity L-glutamate transmembrane transporter activity | 6.3830 | 6 | yes |
GO:0005343 | organic acid:sodium symporter activity | 6.3830 | 4 | yes |
GO:0005416 | amino acid:monoatomic cation symporter activity | 6.3830 | 4 | yes |
GO:0015172 | acidic amino acid transmembrane transporter activity | 6.3830 | 4 | yes |
GO:0015175 | neutral L-amino acid transmembrane transporter activity | 6.3830 | 4 | yes |
GO:0015179 | L-amino acid transmembrane transporter activity | 6.3830 | 4 | yes |
GO:0015501 | glutamate:sodium symporter activity | 6.3830 | 5 | yes |
GO:0031406 | carboxylic acid binding | 6.3830 | 4 | yes |
GO:0046943 | carboxylic acid transmembrane transporter activity | 6.3830 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EAA1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.2128 | 4 | yes |
GO:0010646 | regulation of cell communication | 59.5745 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 53.1915 | 4 | no |
GO:0048523 | negative regulation of cellular process | 48.9362 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.6809 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.5532 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.5532 | 4 | no |
GO:0051049 | regulation of transport | 40.4255 | 4 | no |
GO:0010647 | positive regulation of cell communication | 38.2979 | 5 | yes |
GO:0023056 | positive regulation of signaling | 38.2979 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 38.2979 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 38.2979 | 4 | yes |
GO:0006996 | organelle organization | 38.2979 | 4 | no |
GO:0030030 | cell projection organization | 38.2979 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 38.2979 | 4 | no |
GO:0071702 | organic substance transport | 36.1702 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 36.1702 | 5 | no |
GO:0008104 | protein localization | 36.1702 | 4 | no |
GO:0071705 | nitrogen compound transport | 34.0426 | 4 | yes |
GO:0022607 | cellular component assembly | 34.0426 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 34.0426 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 34.0426 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 34.0426 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.0426 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 34.0426 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 31.9149 | 4 | no |
GO:0010468 | regulation of gene expression | 31.9149 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.9149 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 31.9149 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 31.9149 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.9149 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 29.7872 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 29.7872 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 29.7872 | 5 | no |
GO:0060341 | regulation of cellular localization | 29.7872 | 4 | no |
GO:0033043 | regulation of organelle organization | 29.7872 | 5 | no |
GO:0031399 | regulation of protein modification process | 27.6596 | 6 | no |
GO:0043067 | regulation of programmed cell death | 27.6596 | 4 | no |
GO:0032880 | regulation of protein localization | 27.6596 | 5 | no |
GO:0006915 | apoptotic process | 25.5319 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.5319 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.5319 | 7 | no |
GO:0042981 | regulation of apoptotic process | 25.5319 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.5319 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.5319 | 4 | no |
GO:0141124 | intracellular signaling cassette | 25.5319 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 23.4043 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 23.4043 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 23.4043 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.4043 | 5 | no |
GO:0031175 | neuron projection development | 23.4043 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.4043 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 23.4043 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 23.4043 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.4043 | 6 | no |
GO:0051129 | negative regulation of cellular component organization | 23.4043 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 23.4043 | 5 | no |
GO:0015031 | protein transport | 23.4043 | 4 | no |
GO:0071310 | cellular response to organic substance | 21.2766 | 4 | yes |
GO:0098657 | import into cell | 21.2766 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 21.2766 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 21.2766 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 21.2766 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 21.2766 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 21.2766 | 7 | no |
GO:0051240 | positive regulation of multicellular organismal process | 21.2766 | 4 | no |
GO:0007264 | small GTPase-mediated signal transduction | 21.2766 | 5 | no |
GO:0050890 | cognition | 21.2766 | 4 | no |
GO:1903829 | positive regulation of protein localization | 21.2766 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 21.2766 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.2766 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 21.2766 | 6 | no |
GO:0050807 | regulation of synapse organization | 21.2766 | 5 | no |
GO:0010243 | response to organonitrogen compound | 19.1489 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 17.0213 | 5 | yes |
GO:0014070 | response to organic cyclic compound | 14.8936 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 14.8936 | 4 | yes |
GO:0099536 | synaptic signaling | 14.8936 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 14.8936 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 14.8936 | 4 | yes |
GO:0006873 | intracellular monoatomic ion homeostasis | 12.7660 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 12.7660 | 7 | yes |
GO:0030003 | intracellular monoatomic cation homeostasis | 12.7660 | 5 | yes |
GO:0055080 | monoatomic cation homeostasis | 12.7660 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 12.7660 | 6 | yes |
GO:0006836 | neurotransmitter transport | 10.6383 | 4 | yes |
GO:0071407 | cellular response to organic cyclic compound | 10.6383 | 5 | yes |
GO:0001504 | neurotransmitter uptake | 8.5106 | 5 | yes |
GO:0003018 | vascular process in circulatory system | 8.5106 | 4 | yes |
GO:0006811 | monoatomic ion transport | 8.5106 | 4 | yes |
GO:0006812 | monoatomic cation transport | 8.5106 | 5 | yes |
GO:0009416 | response to light stimulus | 8.5106 | 4 | yes |
GO:0019752 | carboxylic acid metabolic process | 8.5106 | 5 | yes |
GO:0030001 | metal ion transport | 8.5106 | 6 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 8.5106 | 6 | yes |
GO:0043279 | response to alkaloid | 8.5106 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 8.5106 | 4 | yes |
GO:0050905 | neuromuscular process | 8.5106 | 4 | yes |
GO:0098655 | monoatomic cation transmembrane transport | 8.5106 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 8.5106 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 8.5106 | 4 | yes |
GO:0006820 | monoatomic anion transport | 6.3830 | 5 | yes |
GO:0006821 | chloride transport | 6.3830 | 5 | yes |
GO:0006835 | dicarboxylic acid transport | 6.3830 | 7 | yes |
GO:0006865 | amino acid transport | 6.3830 | 5 | yes |
GO:0010232 | vascular transport | 6.3830 | 4 | yes |
GO:0015698 | inorganic anion transport | 6.3830 | 4 | yes |
GO:0015711 | organic anion transport | 6.3830 | 5 | yes |
GO:0015740 | C4-dicarboxylate transport | 6.3830 | 8 | yes |
GO:0015800 | acidic amino acid transport | 6.3830 | 6 | yes |
GO:0015807 | L-amino acid transport | 6.3830 | 5 | yes |
GO:0015810 | aspartate transmembrane transport | 6.3830 | 4 | yes |
GO:0015813 | L-glutamate transmembrane transport | 6.3830 | 5 | yes |
GO:0015849 | organic acid transport | 6.3830 | 5 | yes |
GO:0016053 | organic acid biosynthetic process | 6.3830 | 4 | yes |
GO:0031223 | auditory behavior | 6.3830 | 4 | yes |
GO:0042220 | response to cocaine | 6.3830 | 4 | yes |
GO:0042940 | D-amino acid transport | 6.3830 | 5 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 6.3830 | 5 | yes |
GO:0046942 | carboxylic acid transport | 6.3830 | 6 | yes |
GO:0050885 | neuromuscular process controlling balance | 6.3830 | 5 | yes |
GO:0051938 | L-glutamate import | 6.3830 | 6 | yes |
GO:0070633 | transepithelial transport | 6.3830 | 4 | yes |
GO:0070777 | D-aspartate transmembrane transport | 6.3830 | 5 | yes |
GO:0070778 | L-aspartate transmembrane transport | 6.3830 | 5 | yes |
GO:0070779 | D-aspartate import across plasma membrane | 6.3830 | 5 | yes |
GO:0071312 | cellular response to alkaloid | 6.3830 | 5 | yes |
GO:0071314 | cellular response to cocaine | 6.3830 | 5 | yes |
GO:0089718 | amino acid import across plasma membrane | 6.3830 | 4 | yes |
GO:0098656 | monoatomic anion transmembrane transport | 6.3830 | 4 | yes |
GO:0098661 | inorganic anion transmembrane transport | 6.3830 | 4 | yes |
GO:0098712 | L-glutamate import across plasma membrane | 6.3830 | 5 | yes |
GO:0140009 | L-aspartate import across plasma membrane | 6.3830 | 5 | yes |
GO:0150104 | transport across blood-brain barrier | 6.3830 | 5 | yes |
GO:1902475 | L-alpha-amino acid transmembrane transport | 6.3830 | 4 | yes |
GO:1902476 | chloride transmembrane transport | 6.3830 | 5 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 6.3830 | 4 | yes |
GO:0006813 | potassium ion transport | 4.2553 | 7 | yes |
GO:0006883 | intracellular sodium ion homeostasis | 4.2553 | 5 | yes |
GO:0007600 | sensory perception | 4.2553 | 4 | yes |
GO:0007605 | sensory perception of sound | 4.2553 | 6 | yes |
GO:0008652 | amino acid biosynthetic process | 4.2553 | 4 | yes |
GO:0009448 | gamma-aminobutyric acid metabolic process | 4.2553 | 5 | yes |
GO:0009449 | gamma-aminobutyric acid biosynthetic process | 4.2553 | 5 | yes |
GO:0021545 | cranial nerve development | 4.2553 | 4 | yes |
GO:0048667 | cell morphogenesis involved in neuron differentiation | 4.2553 | 4 | yes |
GO:0050954 | sensory perception of mechanical stimulus | 4.2553 | 5 | yes |
GO:0055078 | sodium ion homeostasis | 4.2553 | 4 | yes |
GO:0071805 | potassium ion transmembrane transport | 4.2553 | 5 | yes |
GO:0170041 | non-proteinogenic amino acid metabolic process | 4.2553 | 4 | yes |
GO:0170043 | non-proteinogenic amino acid biosynthetic process | 4.2553 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EAA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SEPT4_HUMAN | [view interactions] | Low throughput | no | no |
APR_HUMAN | [view interactions] | High throughput | no | yes |
CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
DYR2_HUMAN | [view interactions] | High throughput | no | yes |
DBLOH_HUMAN | [view interactions] | High throughput | no | no |
RAMP3_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
KCD17_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
ETAA1_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
BACD1_HUMAN | [view interactions] | High throughput | no | no |
LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAST_HUMAN | [view interactions] | High throughput | no | yes |
SSR3_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDZ1P_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
T120B_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BT2A2_HUMAN | [view interactions] | High throughput | no | no |
TNR1B_HUMAN | [view interactions] | High throughput | no | no |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TECT3_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
TM128_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEG3_HUMAN | [view interactions] | High throughput | no | yes |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NHRF3_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |