Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPHB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
199 Arg His Prostatecancer(PC) -
279 Ala Ser Prostatecancer(PC) -
650 Val Ala Prostatecancer(PC) -
679 His Asn Prostatecancer(PC) -
883 Met Val Prostatecancer(PC) -
909 Ile Met Prostatecancer(PC) -
745 Arg Cys Bleedingdisorder,platelet-type,22(BDPLT22) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EPHB2_HUMAN
GO:0043168 anion binding 37.1134 4 yes
GO:0000166 nucleotide binding 31.9588 4 yes
GO:0017076 purine nucleotide binding 31.9588 5 yes
GO:0032555 purine ribonucleotide binding 31.9588 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.8969 4 yes
GO:0030554 adenyl nucleotide binding 24.7423 6 yes
GO:0032559 adenyl ribonucleotide binding 24.7423 5 yes
GO:0005524 ATP binding 22.6804 5 yes
GO:0043169 cation binding 20.6186 4 no
GO:0046872 metal ion binding 20.6186 5 no
GO:0016301 kinase activity 17.5258 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.5258 4 yes
GO:0004713 protein tyrosine kinase activity 11.3402 4 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 6.1856 5 yes
GO:0019199 transmembrane receptor protein kinase activity 6.1856 4 yes
GO:0005003 ephrin receptor activity 4.1237 6 yes
GO:0005005 transmembrane-ephrin receptor activity 4.1237 7 yes
GO:0008046 axon guidance receptor activity 3.0928 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPHB2_HUMAN
GO:0048522 positive regulation of cellular process 61.8557 4 yes
GO:0048523 negative regulation of cellular process 55.6701 4 yes
GO:0010646 regulation of cell communication 54.6392 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.5773 4 yes
GO:0031323 regulation of cellular metabolic process 50.5155 4 yes
GO:0051128 regulation of cellular component organization 46.3918 4 yes
GO:0009966 regulation of signal transduction 46.3918 4 yes
GO:0080090 regulation of primary metabolic process 45.3608 4 yes
GO:0009893 positive regulation of metabolic process 42.2680 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.2371 5 yes
GO:0022607 cellular component assembly 41.2371 4 yes
GO:0009889 regulation of biosynthetic process 39.1753 4 yes
GO:0010468 regulation of gene expression 39.1753 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 39.1753 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.1753 5 yes
GO:0051049 regulation of transport 38.1443 4 yes
GO:0008104 protein localization 36.0825 4 no
GO:0030030 cell projection organization 36.0825 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.0825 5 yes
GO:0051246 regulation of protein metabolic process 35.0515 5 yes
GO:1902531 regulation of intracellular signal transduction 35.0515 5 yes
GO:0120036 plasma membrane bounded cell projection organization 30.9278 5 yes
GO:0071310 cellular response to organic substance 29.8969 4 yes
GO:0048584 positive regulation of response to stimulus 29.8969 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.8969 4 yes
GO:0023056 positive regulation of signaling 28.8660 4 yes
GO:0031399 regulation of protein modification process 28.8660 6 yes
GO:0033043 regulation of organelle organization 28.8660 5 yes
GO:0044087 regulation of cellular component biogenesis 28.8660 4 yes
GO:0051130 positive regulation of cellular component organization 27.8351 5 yes
GO:0051240 positive regulation of multicellular organismal process 27.8351 4 yes
GO:0006796 phosphate-containing compound metabolic process 27.8351 4 yes
GO:0051247 positive regulation of protein metabolic process 27.8351 6 no
GO:0010647 positive regulation of cell communication 27.8351 5 yes
GO:0042127 regulation of cell population proliferation 26.8041 4 yes
GO:0009891 positive regulation of biosynthetic process 25.7732 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 25.7732 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.7732 6 yes
GO:0141124 intracellular signaling cassette 24.7423 4 no
GO:0006996 organelle organization 24.7423 4 no
GO:0009892 negative regulation of metabolic process 24.7423 4 yes
GO:2000026 regulation of multicellular organismal development 23.7113 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 23.7113 4 yes
GO:0009967 positive regulation of signal transduction 23.7113 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.7113 5 yes
GO:0031344 regulation of cell projection organization 23.7113 5 yes
GO:0045595 regulation of cell differentiation 23.7113 4 yes
GO:0051094 positive regulation of developmental process 22.6804 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.6804 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.6804 6 yes
GO:1901701 cellular response to oxygen-containing compound 22.6804 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.6804 5 yes
GO:0051493 regulation of cytoskeleton organization 22.6804 6 no
GO:0010243 response to organonitrogen compound 22.6804 4 yes
GO:0019220 regulation of phosphate metabolic process 22.6804 6 yes
GO:0051129 negative regulation of cellular component organization 21.6495 5 yes
GO:2000145 regulation of cell motility 21.6495 4 yes
GO:1902903 regulation of supramolecular fiber organization 21.6495 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.6495 5 no
GO:0042981 regulation of apoptotic process 21.6495 5 no
GO:0043067 regulation of programmed cell death 21.6495 4 no
GO:0030334 regulation of cell migration 21.6495 5 yes
GO:0031324 negative regulation of cellular metabolic process 21.6495 5 yes
GO:0042325 regulation of phosphorylation 21.6495 7 yes
GO:0048585 negative regulation of response to stimulus 21.6495 4 yes
GO:0060341 regulation of cellular localization 20.6186 4 yes
GO:0001932 regulation of protein phosphorylation 20.6186 7 yes
GO:0032970 regulation of actin filament-based process 20.6186 4 no
GO:0043933 protein-containing complex organization 20.6186 4 no
GO:0071702 organic substance transport 20.6186 4 no
GO:0071705 nitrogen compound transport 20.6186 4 no
GO:0010628 positive regulation of gene expression 20.6186 7 yes
GO:0031175 neuron projection development 20.6186 6 yes
GO:0034330 cell junction organization 20.6186 4 yes
GO:0060284 regulation of cell development 19.5876 5 yes
GO:0016310 phosphorylation 19.5876 5 yes
GO:0030155 regulation of cell adhesion 19.5876 4 yes
GO:0032101 regulation of response to external stimulus 19.5876 4 yes
GO:0032880 regulation of protein localization 19.5876 5 yes
GO:0080134 regulation of response to stress 18.5567 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.5567 4 yes
GO:0002684 positive regulation of immune system process 18.5567 4 yes
GO:0010648 negative regulation of cell communication 18.5567 5 yes
GO:0023057 negative regulation of signaling 18.5567 4 yes
GO:0036211 protein modification process 18.5567 4 yes
GO:0043412 macromolecule modification 18.5567 4 yes
GO:0044089 positive regulation of cellular component biogenesis 18.5567 5 yes
GO:0051050 positive regulation of transport 18.5567 4 yes
GO:0051248 negative regulation of protein metabolic process 17.5258 6 yes
GO:0010975 regulation of neuron projection development 17.5258 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 17.5258 6 yes
GO:0099177 regulation of trans-synaptic signaling 16.4948 4 yes
GO:2000147 positive regulation of cell motility 16.4948 5 yes
GO:0009968 negative regulation of signal transduction 16.4948 5 yes
GO:0022604 regulation of cell morphogenesis 16.4948 5 yes
GO:0030335 positive regulation of cell migration 16.4948 6 yes
GO:0040017 positive regulation of locomotion 16.4948 4 yes
GO:0043408 regulation of MAPK cascade 16.4948 6 yes
GO:0048812 neuron projection morphogenesis 16.4948 5 yes
GO:0050804 modulation of chemical synaptic transmission 16.4948 5 yes
GO:0051241 negative regulation of multicellular organismal process 15.4639 4 yes
GO:0051338 regulation of transferase activity 15.4639 4 yes
GO:0071417 cellular response to organonitrogen compound 15.4639 4 yes
GO:1901699 cellular response to nitrogen compound 15.4639 4 yes
GO:0008284 positive regulation of cell population proliferation 15.4639 5 yes
GO:0031346 positive regulation of cell projection organization 15.4639 6 yes
GO:0034762 regulation of transmembrane transport 15.4639 4 yes
GO:0045597 positive regulation of cell differentiation 15.4639 5 yes
GO:0050776 regulation of immune response 15.4639 4 yes
GO:0006468 protein phosphorylation 14.4330 5 yes
GO:0009890 negative regulation of biosynthetic process 14.4330 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 14.4330 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 14.4330 6 yes
GO:0043269 regulation of monoatomic ion transport 14.4330 5 yes
GO:0043549 regulation of kinase activity 14.4330 5 yes
GO:0045859 regulation of protein kinase activity 14.4330 6 yes
GO:0050807 regulation of synapse organization 14.4330 5 yes
GO:0051093 negative regulation of developmental process 13.4021 4 yes
GO:0051249 regulation of lymphocyte activation 13.4021 5 yes
GO:0002694 regulation of leukocyte activation 13.4021 4 yes
GO:0010629 negative regulation of gene expression 13.4021 7 yes
GO:0031347 regulation of defense response 13.4021 5 yes
GO:0033993 response to lipid 13.4021 4 yes
GO:0050865 regulation of cell activation 13.4021 4 yes
GO:0051960 regulation of nervous system development 12.3711 5 yes
GO:0061024 membrane organization 12.3711 4 yes
GO:0097485 neuron projection guidance 12.3711 7 yes
GO:0007411 axon guidance 12.3711 8 yes
GO:0031400 negative regulation of protein modification process 12.3711 7 yes
GO:0034329 cell junction assembly 12.3711 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 12.3711 5 yes
GO:0048013 ephrin receptor signaling pathway 12.3711 6 yes
GO:0050767 regulation of neurogenesis 12.3711 6 yes
GO:0051051 negative regulation of transport 12.3711 4 yes
GO:0071396 cellular response to lipid 11.3402 5 yes
GO:1901888 regulation of cell junction assembly 11.3402 5 yes
GO:1902532 negative regulation of intracellular signal transduction 11.3402 6 yes
GO:0010720 positive regulation of cell development 11.3402 6 yes
GO:0018193 peptidyl-amino acid modification 11.3402 5 yes
GO:0043270 positive regulation of monoatomic ion transport 11.3402 5 yes
GO:0050773 regulation of dendrite development 11.3402 4 yes
GO:0051251 positive regulation of lymphocyte activation 10.3093 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 10.3093 7 yes
GO:0001817 regulation of cytokine production 10.3093 4 yes
GO:1903829 positive regulation of protein localization 10.3093 5 yes
GO:0002696 positive regulation of leukocyte activation 10.3093 5 yes
GO:0007409 axonogenesis 10.3093 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 10.3093 6 yes
GO:0022898 regulation of transmembrane transporter activity 10.3093 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 10.3093 5 yes
GO:0034764 positive regulation of transmembrane transport 10.3093 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 10.3093 6 yes
GO:0045216 cell-cell junction organization 10.3093 5 yes
GO:0045596 negative regulation of cell differentiation 10.3093 5 yes
GO:0045936 negative regulation of phosphate metabolic process 10.3093 7 yes
GO:0050867 positive regulation of cell activation 10.3093 5 yes
GO:0051962 positive regulation of nervous system development 9.2784 5 yes
GO:0060491 regulation of cell projection assembly 9.2784 5 yes
GO:0007162 negative regulation of cell adhesion 9.2784 5 yes
GO:0010976 positive regulation of neuron projection development 9.2784 7 yes
GO:0018108 peptidyl-tyrosine phosphorylation 9.2784 6 yes
GO:0018212 peptidyl-tyrosine modification 9.2784 6 yes
GO:0042326 negative regulation of phosphorylation 9.2784 8 yes
GO:0050769 positive regulation of neurogenesis 9.2784 6 yes
GO:0050890 cognition 9.2784 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 8.2474 6 yes
GO:0001819 positive regulation of cytokine production 8.2474 5 yes
GO:0001933 negative regulation of protein phosphorylation 8.2474 8 yes
GO:0010977 negative regulation of neuron projection development 8.2474 7 yes
GO:0031345 negative regulation of cell projection organization 8.2474 6 yes
GO:0043086 negative regulation of catalytic activity 8.2474 4 yes
GO:0050770 regulation of axonogenesis 8.2474 5 yes
GO:0051963 regulation of synapse assembly 7.2165 6 yes
GO:0070663 regulation of leukocyte proliferation 7.2165 5 yes
GO:1902115 regulation of organelle assembly 7.2165 5 yes
GO:1905475 regulation of protein localization to membrane 7.2165 6 yes
GO:0007612 learning 7.2165 4 yes
GO:0010721 negative regulation of cell development 7.2165 6 yes
GO:0032410 negative regulation of transporter activity 7.2165 4 yes
GO:0032411 positive regulation of transporter activity 7.2165 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 7.2165 5 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 7.2165 5 yes
GO:0034763 negative regulation of transmembrane transport 7.2165 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 7.2165 6 yes
GO:0043271 negative regulation of monoatomic ion transport 7.2165 5 yes
GO:0051961 negative regulation of nervous system development 6.1856 5 yes
GO:0099175 regulation of postsynapse organization 6.1856 6 yes
GO:0099536 synaptic signaling 6.1856 4 yes
GO:0099537 trans-synaptic signaling 6.1856 5 yes
GO:1903034 regulation of response to wounding 6.1856 5 yes
GO:1905477 positive regulation of protein localization to membrane 6.1856 6 yes
GO:2000008 regulation of protein localization to cell surface 6.1856 6 yes
GO:0007043 cell-cell junction assembly 6.1856 6 yes
GO:0010770 positive regulation of cell morphogenesis 6.1856 6 yes
GO:0032944 regulation of mononuclear cell proliferation 6.1856 6 yes
GO:0048814 regulation of dendrite morphogenesis 6.1856 5 yes
GO:0050670 regulation of lymphocyte proliferation 6.1856 6 yes
GO:0050768 negative regulation of neurogenesis 6.1856 6 yes
GO:0051348 negative regulation of transferase activity 5.1546 5 yes
GO:0060998 regulation of dendritic spine development 5.1546 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 5.1546 5 yes
GO:0071219 cellular response to molecule of bacterial origin 5.1546 4 yes
GO:0071222 cellular response to lipopolysaccharide 5.1546 5 yes
GO:0071709 membrane assembly 5.1546 5 yes
GO:0106027 neuron projection organization 5.1546 6 yes
GO:1900271 regulation of long-term synaptic potentiation 5.1546 4 yes
GO:0002237 response to molecule of bacterial origin 5.1546 4 yes
GO:0007399 nervous system development 5.1546 4 yes
GO:0021952 central nervous system projection neuron axonogenesis 5.1546 8 yes
GO:0021955 central nervous system neuron axonogenesis 5.1546 7 yes
GO:0032496 response to lipopolysaccharide 5.1546 4 yes
GO:0042113 B cell activation 5.1546 4 yes
GO:0048168 regulation of neuronal synaptic plasticity 5.1546 4 yes
GO:0050771 negative regulation of axonogenesis 5.1546 6 yes
GO:0050775 positive regulation of dendrite morphogenesis 5.1546 6 yes
GO:0050806 positive regulation of synaptic transmission 5.1546 5 yes
GO:0060999 positive regulation of dendritic spine development 4.1237 5 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 4.1237 6 yes
GO:0061041 regulation of wound healing 4.1237 6 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 4.1237 8 yes
GO:0070665 positive regulation of leukocyte proliferation 4.1237 6 yes
GO:0097061 dendritic spine organization 4.1237 5 yes
GO:0099173 postsynapse organization 4.1237 4 yes
GO:1901890 positive regulation of cell junction assembly 4.1237 6 yes
GO:0001818 negative regulation of cytokine production 4.1237 5 yes
GO:1903076 regulation of protein localization to plasma membrane 4.1237 7 yes
GO:1904375 regulation of protein localization to cell periphery 4.1237 6 yes
GO:1904645 response to amyloid-beta 4.1237 4 yes
GO:1904646 cellular response to amyloid-beta 4.1237 5 yes
GO:1904892 regulation of receptor signaling pathway via STAT 4.1237 5 yes
GO:0043409 negative regulation of MAPK cascade 4.1237 7 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 4.1237 6 yes
GO:0046578 regulation of Ras protein signal transduction 4.1237 7 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 4.1237 5 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 3.0928 7 yes
GO:0051489 regulation of filopodium assembly 3.0928 7 yes
GO:0060997 dendritic spine morphogenesis 3.0928 6 yes
GO:0071679 commissural neuron axon guidance 3.0928 9 yes
GO:0099601 regulation of neurotransmitter receptor activity 3.0928 4 yes
GO:0106030 neuron projection fasciculation 3.0928 7 yes
GO:0120192 tight junction assembly 3.0928 7 yes
GO:0120193 tight junction organization 3.0928 6 yes
GO:1900273 positive regulation of long-term synaptic potentiation 3.0928 5 yes
GO:1903078 positive regulation of protein localization to plasma membrane 3.0928 7 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 3.0928 5 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 3.0928 6 yes
GO:1904377 positive regulation of protein localization to cell periphery 3.0928 6 yes
GO:0002697 regulation of immune effector process 3.0928 4 yes
GO:0006469 negative regulation of protein kinase activity 3.0928 7 yes
GO:2000310 regulation of NMDA receptor activity 3.0928 5 yes
GO:0007413 axonal fasciculation 3.0928 4 yes
GO:0031290 retinal ganglion cell axon guidance 3.0928 9 yes
GO:0032680 regulation of tumor necrosis factor production 3.0928 6 yes
GO:0032760 positive regulation of tumor necrosis factor production 3.0928 7 yes
GO:0032946 positive regulation of mononuclear cell proliferation 3.0928 7 yes
GO:0033673 negative regulation of kinase activity 3.0928 6 yes
GO:0050671 positive regulation of lymphocyte proliferation 3.0928 7 yes
GO:0050864 regulation of B cell activation 3.0928 6 yes
GO:0050871 positive regulation of B cell activation 3.0928 7 yes
GO:0051965 positive regulation of synapse assembly 2.0619 6 yes
GO:0090596 sensory organ morphogenesis 2.0619 4 yes
GO:0097104 postsynaptic membrane assembly 2.0619 6 yes
GO:0099545 trans-synaptic signaling by trans-synaptic complex 2.0619 6 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 2.0619 6 yes
GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission 2.0619 7 yes
GO:0106028 neuron projection retraction 2.0619 7 yes
GO:1900015 regulation of cytokine production involved in inflammatory response 2.0619 5 yes
GO:1900016 negative regulation of cytokine production involved in inflammatory response 2.0619 6 yes
GO:0001655 urogenital system development 2.0619 4 yes
GO:0001941 postsynaptic membrane organization 2.0619 5 yes
GO:1903365 regulation of fear response 2.0619 4 yes
GO:0002637 regulation of immunoglobulin production 2.0619 6 yes
GO:0002639 positive regulation of immunoglobulin production 2.0619 7 yes
GO:0002699 positive regulation of immune effector process 2.0619 5 yes
GO:1904782 negative regulation of NMDA glutamate receptor activity 2.0619 5 yes
GO:0002700 regulation of production of molecular mediator of immune response 2.0619 5 yes
GO:1904783 positive regulation of NMDA glutamate receptor activity 2.0619 5 yes
GO:0002702 positive regulation of production of molecular mediator of immune response 2.0619 6 yes
GO:0002819 regulation of adaptive immune response 2.0619 5 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2.0619 6 yes
GO:2000010 positive regulation of protein localization to cell surface 2.0619 6 yes
GO:2000272 negative regulation of signaling receptor activity 2.0619 4 yes
GO:2000273 positive regulation of signaling receptor activity 2.0619 4 yes
GO:2000316 regulation of T-helper 17 type immune response 2.0619 7 yes
GO:2000785 regulation of autophagosome assembly 2.0619 6 yes
GO:2000822 regulation of behavioral fear response 2.0619 5 yes
GO:0021535 cell migration in hindbrain 2.0619 4 yes
GO:0021631 optic nerve morphogenesis 2.0619 4 yes
GO:0021934 hindbrain tangential cell migration 2.0619 5 yes
GO:0030193 regulation of blood coagulation 2.0619 4 yes
GO:0030888 regulation of B cell proliferation 2.0619 7 yes
GO:0030890 positive regulation of B cell proliferation 2.0619 8 yes
GO:0031915 positive regulation of synaptic plasticity 2.0619 4 yes
GO:0042472 inner ear morphogenesis 2.0619 4 yes
GO:0044088 regulation of vacuole organization 2.0619 6 yes
GO:0046580 negative regulation of Ras protein signal transduction 2.0619 8 yes
GO:0048170 positive regulation of long-term neuronal synaptic plasticity 2.0619 6 yes
GO:0048592 eye morphogenesis 2.0619 5 yes
GO:0048593 camera-type eye morphogenesis 2.0619 6 yes
GO:0050795 regulation of behavior 2.0619 4 yes
GO:0050818 regulation of coagulation 2.0619 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPAC_HUMAN [view entry] [view interactions] Low throughput yes yes
RASA1_HUMAN [view interactions] Low throughput no yes
RYK_HUMAN [view entry] [view interactions] Low throughput yes no
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMMR_HUMAN [view interactions] Low throughput no yes
SPSB4_HUMAN [view interactions] Low throughput no no
SPSB1_HUMAN [view interactions] Low throughput no no
EPHA3_HUMAN [view interactions] Low throughput no yes
EPHB6_HUMAN [view interactions] Low throughput no no
TAB2_HUMAN [view interactions] Low throughput no yes
STK26_HUMAN [view interactions] Low throughput no no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
YES_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
KLDC2_HUMAN [view interactions] Low throughput no yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL2_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
NU153_HUMAN [view interactions] Low throughput no yes
EFNB2_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
RN186_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
EFNA5_HUMAN [view interactions] Low throughput no yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHA2_HUMAN [view interactions] Low throughput no no
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
RAPH1_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
SC24B_HUMAN [view interactions] High throughput no yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT8_HUMAN [view interactions] High throughput no no
ZFY16_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
YKT6_HUMAN [view interactions] High throughput no yes
PHAR4_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
FCHO2_HUMAN [view interactions] High throughput no yes
FERM2_HUMAN [view interactions] High throughput no yes
PKHA1_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
PTN13_HUMAN [view interactions] High throughput no yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
GRIN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT9_HUMAN [view interactions] High throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
LRBA_HUMAN [view interactions] High throughput no yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STIM1_HUMAN [view interactions] High throughput no yes
SEPT3_HUMAN [view interactions] High throughput no no
UACA_HUMAN [view interactions] High throughput no yes
DIP2A_HUMAN [view entry] [view interactions] High throughput yes no
M21D2_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
F1711_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
MERL_HUMAN [view interactions] High throughput no yes
SCAM1_HUMAN [view interactions] High throughput no no
US6NL_HUMAN [view interactions] High throughput no yes
ACOT2_HUMAN [view interactions] High throughput no yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP1_HUMAN [view interactions] High throughput no yes
TB10B_HUMAN [view interactions] High throughput no no
P4HA1_HUMAN [view interactions] High throughput no yes
SEP10_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
NUD19_HUMAN [view interactions] High throughput no no
SC23B_HUMAN [view interactions] High throughput no yes
GRIN3_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
PI4KA_HUMAN [view entry] [view interactions] High throughput yes yes
NISCH_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
SPSB2_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
EFNB1_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HECD1_HUMAN [view interactions] High throughput no yes
LRIQ1_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CLD4_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
EFNA1_HUMAN [view interactions] High throughput no no
EI2BA_HUMAN [view interactions] High throughput no yes
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
USE1_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
NEU1_HUMAN [view interactions] High throughput no no
B2CL1_HUMAN [view interactions] High throughput no yes
GPX1_HUMAN [view entry] [view interactions] High throughput yes yes
KITH_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
KPYR_HUMAN [view entry] [view interactions] High throughput yes no
ACY1_HUMAN [view interactions] High throughput no no
PA24C_HUMAN [view interactions] High throughput no yes
PA2GE_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
KDM4A_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
TSN15_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
CSF1R_HUMAN [view interactions] High throughput no yes
PSKH2_HUMAN [view interactions] High throughput no no
EPHA6_HUMAN [view interactions] High throughput no no
RS29_HUMAN [view interactions] High throughput no yes
DYH10_HUMAN [view interactions] High throughput no no
S39A7_HUMAN [view interactions] High throughput no yes
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
EAA1_HUMAN [view entry] [view interactions] High throughput yes no
PDIP3_HUMAN [view interactions] High throughput no no
PCAT1_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
NTPCR_HUMAN [view interactions] High throughput no yes
TRM2A_HUMAN [view interactions] High throughput no yes
HACD3_HUMAN [view interactions] High throughput no yes
MDN1_HUMAN [view interactions] High throughput no no
BAF_HUMAN [view entry] [view interactions] High throughput yes yes
FBSP1_HUMAN [view entry] [view interactions] High throughput yes no
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
OZF_HUMAN [view interactions] High throughput no yes
FANCI_HUMAN [view interactions] High throughput no yes
EPHB3_HUMAN [view interactions] High throughput no yes
RAE1L_HUMAN [view interactions] High throughput no no
ZDHC6_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
EPHB1_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
RBL1_HUMAN [view interactions] High throughput no yes
TP4A2_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MTMRE_HUMAN [view entry] [view interactions] High throughput yes yes
SNP29_HUMAN [view interactions] High throughput no yes
PDZ11_HUMAN [view interactions] High throughput no yes
NSUN2_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
CSKI2_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
EHBP1_HUMAN [view interactions] High throughput no yes
GAB1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
UNC5B_HUMAN [view interactions] High throughput no yes
SEPT6_HUMAN [view interactions] High throughput no yes
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
BI2L1_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PEAK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
NIBA2_HUMAN [view interactions] High throughput no no
MARK3_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
LSR_HUMAN [view interactions] High throughput no yes