Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PKHA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PKHA1_HUMAN
GO:0043168 anion binding 50.0000 4 yes
GO:0000166 nucleotide binding 48.0769 4 no
GO:0017076 purine nucleotide binding 48.0769 5 no
GO:0032555 purine ribonucleotide binding 48.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 48.0769 4 no
GO:0019900 kinase binding 34.6154 4 no
GO:0019901 protein kinase binding 34.6154 5 no
GO:0003924 GTPase activity 28.8462 7 no
GO:0005525 GTP binding 28.8462 5 no
GO:0016462 pyrophosphatase activity 28.8462 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.8462 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.8462 6 no
GO:0019001 guanyl nucleotide binding 28.8462 6 no
GO:0032561 guanyl ribonucleotide binding 28.8462 5 no
GO:0030165 PDZ domain binding 5.7692 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PKHA1_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 67.3077 4 no
GO:0051128 regulation of cellular component organization 65.3846 4 no
GO:0048523 negative regulation of cellular process 61.5385 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0010646 regulation of cell communication 59.6154 4 yes
GO:0080090 regulation of primary metabolic process 59.6154 4 no
GO:0008104 protein localization 53.8462 4 yes
GO:0009966 regulation of signal transduction 53.8462 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0010468 regulation of gene expression 48.0769 6 no
GO:0010556 regulation of macromolecule biosynthetic process 48.0769 5 no
GO:0006996 organelle organization 46.1538 4 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0051049 regulation of transport 46.1538 4 no
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:1902531 regulation of intracellular signal transduction 44.2308 5 yes
GO:0009892 negative regulation of metabolic process 44.2308 4 no
GO:0031325 positive regulation of cellular metabolic process 44.2308 5 no
GO:0031344 regulation of cell projection organization 42.3077 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.3077 6 no
GO:0030334 regulation of cell migration 40.3846 5 no
GO:0031324 negative regulation of cellular metabolic process 40.3846 5 no
GO:2000145 regulation of cell motility 40.3846 4 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0030030 cell projection organization 36.5385 4 yes
GO:0141124 intracellular signaling cassette 36.5385 4 yes
GO:0019220 regulation of phosphate metabolic process 36.5385 6 no
GO:0051174 regulation of phosphorus metabolic process 36.5385 5 no
GO:0120036 plasma membrane bounded cell projection organization 34.6154 5 yes
GO:0071702 organic substance transport 34.6154 4 no
GO:0071705 nitrogen compound transport 34.6154 4 no
GO:0060341 regulation of cellular localization 34.6154 4 no
GO:0001932 regulation of protein phosphorylation 32.6923 7 no
GO:0010647 positive regulation of cell communication 32.6923 5 no
GO:0023056 positive regulation of signaling 32.6923 4 no
GO:0042127 regulation of cell population proliferation 32.6923 4 no
GO:0042325 regulation of phosphorylation 32.6923 7 no
GO:0045595 regulation of cell differentiation 32.6923 4 no
GO:0051247 positive regulation of protein metabolic process 32.6923 6 no
GO:0032880 regulation of protein localization 32.6923 5 no
GO:0030335 positive regulation of cell migration 30.7692 6 no
GO:0040017 positive regulation of locomotion 30.7692 4 no
GO:2000147 positive regulation of cell motility 30.7692 5 no
GO:0044087 regulation of cellular component biogenesis 30.7692 4 no
GO:0010648 negative regulation of cell communication 28.8462 5 yes
GO:0023057 negative regulation of signaling 28.8462 4 yes
GO:0048585 negative regulation of response to stimulus 28.8462 4 yes
GO:0009967 positive regulation of signal transduction 28.8462 5 no
GO:0010975 regulation of neuron projection development 28.8462 7 no
GO:0042981 regulation of apoptotic process 28.8462 5 no
GO:0043067 regulation of programmed cell death 28.8462 4 no
GO:0051094 positive regulation of developmental process 28.8462 4 no
GO:2000026 regulation of multicellular organismal development 28.8462 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.8462 5 no
GO:0033043 regulation of organelle organization 28.8462 5 no
GO:0051050 positive regulation of transport 28.8462 4 no
GO:0009968 negative regulation of signal transduction 26.9231 5 yes
GO:0008284 positive regulation of cell population proliferation 26.9231 5 no
GO:0030155 regulation of cell adhesion 26.9231 4 no
GO:0031175 neuron projection development 26.9231 6 no
GO:0031401 positive regulation of protein modification process 26.9231 7 no
GO:0032101 regulation of response to external stimulus 26.9231 4 no
GO:0051130 positive regulation of cellular component organization 26.9231 5 no
GO:0051241 negative regulation of multicellular organismal process 26.9231 4 no
GO:0060627 regulation of vesicle-mediated transport 26.9231 4 no
GO:0071310 cellular response to organic substance 26.9231 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.9231 6 no
GO:0009891 positive regulation of biosynthetic process 26.9231 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.9231 6 no
GO:0009890 negative regulation of biosynthetic process 26.9231 5 no
GO:0022603 regulation of anatomical structure morphogenesis 26.9231 4 no
GO:0007264 small GTPase-mediated signal transduction 26.9231 5 no
GO:0015031 protein transport 26.9231 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0002684 positive regulation of immune system process 23.0769 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.0769 5 yes
GO:0050776 regulation of immune response 23.0769 4 yes
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 yes
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:0010563 negative regulation of phosphorus metabolic process 21.1538 6 no
GO:0016310 phosphorylation 21.1538 5 no
GO:0031346 positive regulation of cell projection organization 21.1538 6 no
GO:0036211 protein modification process 21.1538 4 no
GO:0043412 macromolecule modification 21.1538 4 no
GO:0043549 regulation of kinase activity 21.1538 5 no
GO:0045936 negative regulation of phosphate metabolic process 21.1538 7 no
GO:0051338 regulation of transferase activity 21.1538 4 no
GO:0080134 regulation of response to stress 21.1538 4 no
GO:0006886 intracellular protein transport 21.1538 4 no
GO:1902532 negative regulation of intracellular signal transduction 19.2308 6 yes
GO:0050778 positive regulation of immune response 15.3846 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 13.4615 6 yes
GO:0062197 cellular response to chemical stress 9.6154 4 yes
GO:0034599 cellular response to oxidative stress 7.6923 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 5.7692 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 5.7692 4 yes
GO:0008202 steroid metabolic process 5.7692 4 yes
GO:0031529 ruffle organization 5.7692 6 yes
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 5.7692 5 yes
GO:0048232 male gamete generation 5.7692 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 5.7692 5 yes
GO:0000302 response to reactive oxygen species 3.8462 4 yes
GO:0034614 cellular response to reactive oxygen species 3.8462 5 yes
GO:0042542 response to hydrogen peroxide 3.8462 4 yes
GO:0048705 skeletal system morphogenesis 3.8462 4 yes
GO:0050853 B cell receptor signaling pathway 3.8462 6 yes
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 3.8462 7 yes
GO:0070301 cellular response to hydrogen peroxide 3.8462 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SH3B4_HUMAN [view interactions] Low throughput no yes
PTN13_HUMAN [view interactions] Low throughput no yes
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PKHA2_HUMAN [view interactions] Low throughput no no
SNTG1_HUMAN [view interactions] Low throughput no no
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
PR15A_HUMAN [view interactions] High throughput no yes
PBX2_HUMAN [view interactions] High throughput no yes
WIPI3_HUMAN [view interactions] High throughput no no
MS3L1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
LATS2_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
CEP19_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB6_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CLD14_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
ZN610_HUMAN [view interactions] High throughput no yes
LRC61_HUMAN [view interactions] High throughput no yes
F131B_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes