Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PKHA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PKHA1_HUMAN
GO:0017076 purine nucleotide binding 59.4595 4 no
GO:0032555 purine ribonucleotide binding 59.4595 4 no
GO:0035639 purine ribonucleoside triphosphate binding 59.4595 4 no
GO:0019900 kinase binding 37.8378 4 no
GO:0019901 protein kinase binding 37.8378 5 no
GO:0003924 GTPase activity 37.8378 7 no
GO:0005525 GTP binding 37.8378 5 no
GO:0016462 pyrophosphatase activity 37.8378 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.8378 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.8378 6 no
GO:0019001 guanyl nucleotide binding 37.8378 5 no
GO:0032561 guanyl ribonucleotide binding 37.8378 5 no
GO:0019003 GDP binding 24.3243 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.6216 4 no
GO:0004713 protein tyrosine kinase activity 21.6216 4 no
GO:0005524 ATP binding 21.6216 5 no
GO:0016301 kinase activity 21.6216 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.6216 4 no
GO:0030554 adenyl nucleotide binding 21.6216 5 no
GO:0032559 adenyl ribonucleotide binding 21.6216 5 no
GO:0030165 PDZ domain binding 5.4054 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PKHA1_HUMAN
GO:0048522 positive regulation of cellular process 83.7838 4 no
GO:0051128 regulation of cellular component organization 70.2703 4 no
GO:0010646 regulation of cell communication 64.8649 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.8649 4 no
GO:0009893 positive regulation of metabolic process 62.1622 4 no
GO:0009966 regulation of signal transduction 59.4595 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 59.4595 5 no
GO:0080090 regulation of primary metabolic process 59.4595 4 no
GO:0048523 negative regulation of cellular process 56.7568 4 yes
GO:0031323 regulation of cellular metabolic process 56.7568 4 no
GO:0051171 regulation of nitrogen compound metabolic process 56.7568 4 no
GO:0030030 cell projection organization 54.0541 4 yes
GO:1902531 regulation of intracellular signal transduction 54.0541 5 yes
GO:0022607 cellular component assembly 54.0541 4 no
GO:0031325 positive regulation of cellular metabolic process 51.3514 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 51.3514 5 no
GO:0008104 protein localization 48.6486 4 yes
GO:0048584 positive regulation of response to stimulus 48.6486 4 yes
GO:0120036 plasma membrane bounded cell projection organization 48.6486 5 yes
GO:0030334 regulation of cell migration 48.6486 5 no
GO:0031344 regulation of cell projection organization 48.6486 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 48.6486 6 no
GO:2000145 regulation of cell motility 48.6486 4 no
GO:0010647 positive regulation of cell communication 45.9459 5 no
GO:0023056 positive regulation of signaling 45.9459 4 no
GO:0045595 regulation of cell differentiation 45.9459 4 no
GO:0051246 regulation of protein metabolic process 45.9459 5 no
GO:0006996 organelle organization 45.9459 4 no
GO:0010468 regulation of gene expression 45.9459 5 no
GO:0051049 regulation of transport 45.9459 4 no
GO:0019220 regulation of phosphate metabolic process 43.2432 6 no
GO:0042127 regulation of cell population proliferation 43.2432 4 no
GO:0042325 regulation of phosphorylation 43.2432 7 no
GO:0051094 positive regulation of developmental process 43.2432 4 no
GO:0051174 regulation of phosphorus metabolic process 43.2432 5 no
GO:0071310 cellular response to organic substance 43.2432 4 no
GO:0009967 positive regulation of signal transduction 40.5405 5 no
GO:0010562 positive regulation of phosphorus metabolic process 40.5405 6 no
GO:0042327 positive regulation of phosphorylation 40.5405 8 no
GO:0043085 positive regulation of catalytic activity 40.5405 4 no
GO:0045937 positive regulation of phosphate metabolic process 40.5405 7 no
GO:0051247 positive regulation of protein metabolic process 40.5405 6 no
GO:0071702 organic substance transport 40.5405 4 no
GO:0022603 regulation of anatomical structure morphogenesis 37.8378 4 no
GO:0030335 positive regulation of cell migration 37.8378 6 no
GO:0031175 neuron projection development 37.8378 6 no
GO:0040017 positive regulation of locomotion 37.8378 4 no
GO:1902533 positive regulation of intracellular signal transduction 37.8378 6 no
GO:2000147 positive regulation of cell motility 37.8378 5 no
GO:0016192 vesicle-mediated transport 37.8378 4 no
GO:0071705 nitrogen compound transport 37.8378 4 no
GO:0001932 regulation of protein phosphorylation 35.1351 7 no
GO:0008284 positive regulation of cell population proliferation 35.1351 5 no
GO:0009892 negative regulation of metabolic process 35.1351 4 no
GO:0010975 regulation of neuron projection development 35.1351 7 no
GO:0030155 regulation of cell adhesion 35.1351 4 no
GO:0031399 regulation of protein modification process 35.1351 6 no
GO:0043408 regulation of MAPK cascade 35.1351 6 no
GO:0051130 positive regulation of cellular component organization 35.1351 5 no
GO:0044087 regulation of cellular component biogenesis 35.1351 4 no
GO:1901701 cellular response to oxygen-containing compound 32.4324 4 yes
GO:0031401 positive regulation of protein modification process 32.4324 7 no
GO:0060284 regulation of cell development 32.4324 5 no
GO:2000026 regulation of multicellular organismal development 32.4324 4 no
GO:0007010 cytoskeleton organization 32.4324 5 no
GO:0007264 small GTPase mediated signal transduction 32.4324 4 no
GO:0033043 regulation of organelle organization 32.4324 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 29.7297 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 29.7297 5 yes
GO:0010648 negative regulation of cell communication 29.7297 5 yes
GO:0023057 negative regulation of signaling 29.7297 4 yes
GO:0001934 positive regulation of protein phosphorylation 29.7297 8 no
GO:0043549 regulation of kinase activity 29.7297 5 no
GO:0045597 positive regulation of cell differentiation 29.7297 5 no
GO:0051240 positive regulation of multicellular organismal process 29.7297 4 no
GO:0051241 negative regulation of multicellular organismal process 29.7297 4 no
GO:0051338 regulation of transferase activity 29.7297 4 no
GO:0051347 positive regulation of transferase activity 29.7297 5 no
GO:0009889 regulation of biosynthetic process 29.7297 4 no
GO:0010941 regulation of cell death 29.7297 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.7297 5 no
GO:0031326 regulation of cellular biosynthetic process 29.7297 5 no
GO:0015031 protein transport 29.7297 4 no
GO:0060627 regulation of vesicle-mediated transport 29.7297 4 no
GO:0009968 negative regulation of signal transduction 27.0270 5 yes
GO:0048585 negative regulation of response to stimulus 27.0270 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 27.0270 5 no
GO:0022604 regulation of cell morphogenesis 27.0270 5 no
GO:0031346 positive regulation of cell projection organization 27.0270 6 no
GO:0033674 positive regulation of kinase activity 27.0270 6 no
GO:0034330 cell junction organization 27.0270 4 no
GO:0007265 Ras protein signal transduction 27.0270 5 no
GO:0042981 regulation of apoptotic process 27.0270 6 no
GO:0043067 regulation of programmed cell death 27.0270 5 no
GO:0061024 membrane organization 27.0270 4 no
GO:0002684 positive regulation of immune system process 24.3243 4 yes
GO:0006796 phosphate-containing compound metabolic process 24.3243 4 no
GO:0010243 response to organonitrogen compound 24.3243 4 no
GO:0043410 positive regulation of MAPK cascade 24.3243 7 no
GO:0045785 positive regulation of cell adhesion 24.3243 5 no
GO:0050804 modulation of chemical synaptic transmission 24.3243 5 no
GO:0051093 negative regulation of developmental process 24.3243 4 no
GO:0051129 negative regulation of cellular component organization 24.3243 5 no
GO:0099177 regulation of trans-synaptic signaling 24.3243 4 no
GO:0097435 supramolecular fiber organization 24.3243 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.3243 5 no
GO:0010628 positive regulation of gene expression 24.3243 6 no
GO:0051252 regulation of RNA metabolic process 24.3243 5 no
GO:0051493 regulation of cytoskeleton organization 24.3243 6 no
GO:0051050 positive regulation of transport 24.3243 4 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0050776 regulation of immune response 21.6216 4 yes
GO:1902532 negative regulation of intracellular signal transduction 21.6216 6 yes
GO:0010720 positive regulation of cell development 21.6216 6 no
GO:0032101 regulation of response to external stimulus 21.6216 4 no
GO:0032990 cell part morphogenesis 21.6216 4 no
GO:0045596 negative regulation of cell differentiation 21.6216 5 no
GO:0048812 neuron projection morphogenesis 21.6216 7 no
GO:0048858 cell projection morphogenesis 21.6216 5 no
GO:0050767 regulation of neurogenesis 21.6216 6 no
GO:0050807 regulation of synapse organization 21.6216 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.6216 5 no
GO:0051336 regulation of hydrolase activity 21.6216 4 no
GO:0051960 regulation of nervous system development 21.6216 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.6216 6 no
GO:1901699 cellular response to nitrogen compound 21.6216 4 no
GO:0007015 actin filament organization 21.6216 5 no
GO:0006355 regulation of DNA-templated transcription 21.6216 6 no
GO:0031324 negative regulation of cellular metabolic process 21.6216 5 no
GO:0032956 regulation of actin cytoskeleton organization 21.6216 5 no
GO:0032970 regulation of actin filament-based process 21.6216 4 no
GO:0034329 cell junction assembly 21.6216 5 no
GO:1901888 regulation of cell junction assembly 21.6216 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.6216 7 no
GO:2001141 regulation of RNA biosynthetic process 21.6216 6 no
GO:0006886 intracellular protein transport 21.6216 4 no
GO:0050778 positive regulation of immune response 13.5135 5 yes
GO:0048015 phosphatidylinositol-mediated signaling 10.8108 5 yes
GO:0048017 inositol lipid-mediated signaling 10.8108 4 yes
GO:0051896 regulation of protein kinase B signaling 10.8108 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 8.1081 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 8.1081 4 yes
GO:0014065 phosphatidylinositol 3-kinase signaling 8.1081 6 yes
GO:0031529 ruffle organization 8.1081 6 yes
GO:0034599 cellular response to oxidative stress 8.1081 4 yes
GO:0048232 male gamete generation 8.1081 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 8.1081 5 yes
GO:0062197 cellular response to chemical stress 8.1081 4 yes
GO:0000302 response to reactive oxygen species 5.4054 4 yes
GO:0034614 cellular response to reactive oxygen species 5.4054 5 yes
GO:0042542 response to hydrogen peroxide 5.4054 4 yes
GO:0050853 B cell receptor signaling pathway 5.4054 6 yes
GO:0051898 negative regulation of protein kinase B signaling 5.4054 7 yes
GO:0070301 cellular response to hydrogen peroxide 5.4054 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PKHA1_HUMAN
DOID:0050686 organ system cancer 5.4054 3 no
DOID:10283 prostate cancer 5.4054 6 no
DOID:193 reproductive organ cancer 5.4054 4 no
DOID:3856 male reproductive organ cancer 5.4054 5 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SH3B4_HUMAN [view interactions] Low throughput no yes
PTN13_HUMAN [view interactions] Low throughput no yes
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PKHA2_HUMAN [view interactions] Low throughput no no
SNTG1_HUMAN [view interactions] Low throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
PR15A_HUMAN [view interactions] High throughput no yes
MS3L1_HUMAN [view interactions] High throughput no yes
WIPI3_HUMAN [view interactions] High throughput no no
PBX2_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
LATS2_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
CEP19_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB6_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
CLD14_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
ZN610_HUMAN [view interactions] High throughput no yes
LRC61_HUMAN [view interactions] High throughput no yes
F131B_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
FBX7_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LATS1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes