DOCK7_HUMAN
Evidence for PS localization
Functions
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 Ser-15 phosphorylation during axon formation and consequently for neuronal polarization (PubMed). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed). Has a role in pigmentation . Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003072 | DOC_MAPK_JIP1_4 | DOC | 885 | 891 | - |
| ELMI003072 | DOC_MAPK_JIP1_4 | DOC | 885 | 891 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DOCK7_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 35.8696 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.8696 | 5 | no |
| GO:0043168 | anion binding | 34.7826 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.6087 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.5217 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.1739 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.9130 | 5 | no |
| GO:0005524 | ATP binding | 22.8261 | 5 | no |
| GO:0019900 | kinase binding | 22.8261 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.7391 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.7391 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
| GO:0003723 | RNA binding | 21.7391 | 4 | no |
| GO:0031267 | small GTPase binding | 6.5217 | 5 | yes |
| GO:0051020 | GTPase binding | 6.5217 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.4348 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 4.3478 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DOCK7_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 68.4783 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 65.2174 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 64.1304 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 64.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 63.0435 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.5217 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.3478 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 51.0870 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.9130 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 48.9130 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 47.8261 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.7391 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.7391 | 6 | no |
| GO:0009966 | regulation of signal transduction | 45.6522 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.5652 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 44.5652 | 5 | no |
| GO:0006996 | organelle organization | 42.3913 | 4 | yes |
| GO:0008104 | protein localization | 40.2174 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0435 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 38.0435 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 38.0435 | 5 | no |
| GO:0022607 | cellular component assembly | 35.8696 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.8696 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 34.7826 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 33.6957 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 33.6957 | 5 | yes |
| GO:0051049 | regulation of transport | 31.5217 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.4348 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.4348 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.4348 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.4348 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.3478 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.2609 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.2609 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.2609 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.2609 | 6 | no |
| GO:0032880 | regulation of protein localization | 28.2609 | 5 | no |
| GO:0030030 | cell projection organization | 27.1739 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 27.1739 | 7 | yes |
| GO:0023056 | positive regulation of signaling | 27.1739 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.1739 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 27.1739 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.1739 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | yes |
| GO:0043412 | macromolecule modification | 26.0870 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.0870 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0071702 | organic substance transport | 26.0870 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | yes |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.9130 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 23.9130 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.9130 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.9130 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 23.9130 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.9130 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.9130 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.9130 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8261 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.8261 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.8261 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.7391 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.7391 | 7 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.7391 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 21.7391 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.7391 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 21.7391 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.6522 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.6522 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.6522 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.6522 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 19.5652 | 8 | yes |
| GO:0042327 | positive regulation of phosphorylation | 19.5652 | 8 | yes |
| GO:0043085 | positive regulation of catalytic activity | 17.3913 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.3043 | 4 | yes |
| GO:2000145 | regulation of cell motility | 16.3043 | 4 | yes |
| GO:0030334 | regulation of cell migration | 14.1304 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 14.1304 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 14.1304 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.1304 | 4 | yes |
| GO:0060284 | regulation of cell development | 14.1304 | 5 | yes |
| GO:2000147 | positive regulation of cell motility | 14.1304 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 13.0435 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 11.9565 | 5 | yes |
| GO:0031175 | neuron projection development | 10.8696 | 6 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 9.7826 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 8.6957 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 8.6957 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 7.6087 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.6087 | 4 | yes |
| GO:0007409 | axonogenesis | 4.3478 | 6 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 4.3478 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 4.3478 | 9 | yes |
| GO:0043087 | regulation of GTPase activity | 3.2609 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 3.2609 | 6 | yes |
| GO:0007097 | nuclear migration | 2.1739 | 4 | yes |
| GO:0090630 | activation of GTPase activity | 2.1739 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LRCH3_HUMAN | [view interactions] | Low throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | Low throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOD2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ISM2_HUMAN | [view interactions] | High throughput | no | no |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN10_HUMAN | [view interactions] | High throughput | no | yes |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| CIB2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC5_HUMAN | [view interactions] | High throughput | no | yes |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN8_HUMAN | [view interactions] | High throughput | no | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOB3B_HUMAN | [view interactions] | High throughput | no | no |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPP14_HUMAN | [view interactions] | High throughput | no | no |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| NSD3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASFA_HUMAN | [view interactions] | High throughput | no | no |
| CRLF3_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH2_HUMAN | [view interactions] | High throughput | no | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK6_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH1_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH4_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| CSAG1_HUMAN | [view interactions] | High throughput | no | no |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| SKAP1_HUMAN | [view interactions] | High throughput | no | no |
| PCAT1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRIP3_HUMAN | [view interactions] | High throughput | no | no |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| DS13A_HUMAN | [view interactions] | High throughput | no | no |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| AVIL_HUMAN | [view interactions] | High throughput | no | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| TGM5_HUMAN | [view interactions] | High throughput | no | no |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| IRF3_HUMAN | [view interactions] | High throughput | no | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| KLDC9_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RHG30_HUMAN | [view interactions] | High throughput | no | no |
| API5_HUMAN | [view interactions] | High throughput | no | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOSD1_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |