ANXA7_HUMAN
Evidence for PS localization
Functions
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002655 | LIG_EF_ALG2_ABM_1 | LIG | 4 | 12 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANXA7_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.3158 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.3158 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.3158 | 4 | no |
| GO:0046872 | metal ion binding | 22.8070 | 4 | yes |
| GO:0003723 | RNA binding | 21.0526 | 4 | yes |
| GO:0005509 | calcium ion binding | 10.5263 | 5 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 5.2632 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA7_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 57.8947 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.3860 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.3860 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 54.3860 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.6140 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.6140 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 43.8596 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.8596 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.1053 | 5 | no |
| GO:0010468 | regulation of gene expression | 38.5965 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.0877 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.0877 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.0877 | 5 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5789 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | yes |
| GO:0036211 | protein modification process | 29.8246 | 4 | no |
| GO:0043412 | macromolecule modification | 29.8246 | 4 | no |
| GO:0006996 | organelle organization | 29.8246 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.8246 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 28.0702 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0702 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.0702 | 5 | no |
| GO:0009966 | regulation of signal transduction | 28.0702 | 4 | no |
| GO:0010941 | regulation of cell death | 26.3158 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.3158 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.3158 | 6 | no |
| GO:0051049 | regulation of transport | 26.3158 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.3158 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.3158 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 24.5614 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.5614 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.5614 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.5614 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.5614 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.5614 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.8070 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.8070 | 6 | no |
| GO:0071310 | cellular response to organic substance | 22.8070 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.8070 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 22.8070 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.8070 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.8070 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.8070 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.8070 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.8070 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.0526 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.0526 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0008104 | protein localization | 21.0526 | 4 | no |
| GO:0022607 | cellular component assembly | 21.0526 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0010629 | negative regulation of gene expression | 14.0351 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA7_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 5.2632 | 4 | no |
| DOID:331 | central nervous system disease | 5.2632 | 3 | no |
| DOID:0050890 | synucleinopathy | 3.5088 | 5 | no |
| DOID:14330 | Parkinsons disease | 3.5088 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDCD6_HUMAN | [view interactions] | Low throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | Low throughput | no | no |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KGP1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| SEM5B_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| ASM_HUMAN | [view interactions] | High throughput | no | no |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TAF5L_HUMAN | [view interactions] | High throughput | no | no |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| TLE1_HUMAN | [view interactions] | High throughput | no | yes |
| TM108_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYB4_HUMAN | [view interactions] | High throughput | no | yes |
| CELF3_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR18_HUMAN | [view interactions] | High throughput | no | yes |
| WDR73_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| ZN135_HUMAN | [view interactions] | High throughput | no | yes |
| ZN431_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| JAZF1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX8_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CD14_HUMAN | [view interactions] | High throughput | no | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK08_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| FAN1_HUMAN | [view interactions] | High throughput | no | no |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KKCC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA4_HUMAN | [view interactions] | High throughput | no | no |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| S10AA_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| A1BG_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATS10_HUMAN | [view interactions] | High throughput | no | yes |
| ANGP2_HUMAN | [view interactions] | High throughput | no | no |
| APLP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM48_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| CENPB_HUMAN | [view interactions] | High throughput | no | yes |
| TETN_HUMAN | [view interactions] | High throughput | no | no |
| COBA2_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| CO4A5_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT11_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSAD_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F13A_HUMAN | [view interactions] | High throughput | no | no |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| FBN3_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAD1_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBP2_HUMAN | [view interactions] | High throughput | no | yes |
| GDF9_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGX3_HUMAN | [view interactions] | High throughput | no | no |
| HXD8_HUMAN | [view interactions] | High throughput | no | no |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| KLH23_HUMAN | [view interactions] | High throughput | no | no |
| MED31_HUMAN | [view interactions] | High throughput | no | yes |
| KMT2B_HUMAN | [view interactions] | High throughput | no | no |
| MPPD1_HUMAN | [view interactions] | High throughput | no | no |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VPS35_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LEG3_HUMAN | [view interactions] | Computational | no | yes |