Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CPNE6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CPNE6_HUMAN
GO:0005509 calcium ion binding 37.5000 6 yes
GO:0005544 calcium-dependent phospholipid binding 37.5000 4 yes
GO:0043169 cation binding 37.5000 4 yes
GO:0046872 metal ion binding 37.5000 5 yes
GO:0000166 nucleotide binding 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043168 anion binding 37.5000 4 no
GO:0003779 actin binding 25.0000 4 no
GO:0005216 monoatomic ion channel activity 25.0000 4 no
GO:0005261 monoatomic cation channel activity 25.0000 5 no
GO:0005262 calcium channel activity 25.0000 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 25.0000 4 no
GO:0015085 calcium ion transmembrane transporter activity 25.0000 6 no
GO:0015267 channel activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 25.0000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0003723 RNA binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CPNE6_HUMAN
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009890 negative regulation of biosynthetic process 37.5000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010629 negative regulation of gene expression 37.5000 7 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 37.5000 6 no
GO:0006996 organelle organization 37.5000 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 37.5000 4 yes
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0034330 cell junction organization 37.5000 4 no
GO:0036211 protein modification process 37.5000 4 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042327 positive regulation of phosphorylation 37.5000 8 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 no
GO:0050808 synapse organization 37.5000 5 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006974 DNA damage response 25.0000 4 no
GO:0007613 memory 25.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0048143 astrocyte activation 25.0000 4 no
GO:0048666 neuron development 25.0000 4 no
GO:0050767 regulation of neurogenesis 25.0000 6 no
GO:0050770 regulation of axonogenesis 25.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0001558 regulation of cell growth 25.0000 4 yes
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0010038 response to metal ion 25.0000 4 yes
GO:0030307 positive regulation of cell growth 25.0000 5 yes
GO:0045927 positive regulation of growth 25.0000 4 yes
GO:0048638 regulation of developmental growth 25.0000 4 yes
GO:0048639 positive regulation of developmental growth 25.0000 5 yes
GO:0006811 monoatomic ion transport 25.0000 4 no
GO:0006873 intracellular monoatomic ion homeostasis 25.0000 4 no
GO:0006874 intracellular calcium ion homeostasis 25.0000 5 no
GO:0030003 intracellular monoatomic cation homeostasis 25.0000 5 no
GO:0055074 calcium ion homeostasis 25.0000 4 no
GO:0055080 monoatomic cation homeostasis 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0030182 neuron differentiation 25.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032092 positive regulation of protein binding 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051099 positive regulation of binding 25.0000 4 no
GO:0051100 negative regulation of binding 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 25.0000 6 no
GO:1900180 regulation of protein localization to nucleus 25.0000 6 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRFE_HUMAN [view interactions] Low throughput no no
OS9_HUMAN [view interactions] Low throughput no yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
GRB7_HUMAN [view interactions] High throughput no no
MK11_HUMAN [view interactions] High throughput no yes
LTOR3_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SMN_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
KAD5_HUMAN [view entry] [view interactions] High throughput yes yes
CSAG2_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
CPNE4_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NOTC3_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes