KAD5_HUMAN
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KAD5_HUMAN |
---|---|---|---|---|
GO:0005524 | ATP binding | 54.5455 | 5 | yes |
GO:0017076 | purine nucleotide binding | 54.5455 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 54.5455 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 54.5455 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 54.5455 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 54.5455 | 4 | yes |
GO:0004550 | nucleoside diphosphate kinase activity | 36.3636 | 5 | yes |
GO:0016301 | kinase activity | 36.3636 | 4 | yes |
GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 36.3636 | 4 | yes |
GO:0019205 | nucleobase-containing compound kinase activity | 36.3636 | 5 | yes |
GO:0046872 | metal ion binding | 36.3636 | 4 | no |
GO:0004017 | adenylate kinase activity | 18.1818 | 6 | yes |
GO:0050145 | nucleoside monophosphate kinase activity | 18.1818 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KAD5_HUMAN |
---|---|---|---|---|
GO:0006796 | phosphate-containing compound metabolic process | 54.5455 | 4 | yes |
GO:0006753 | nucleoside phosphate metabolic process | 45.4545 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 45.4545 | 5 | yes |
GO:0009165 | nucleotide biosynthetic process | 45.4545 | 6 | yes |
GO:0018130 | heterocycle biosynthetic process | 45.4545 | 4 | yes |
GO:0019438 | aromatic compound biosynthetic process | 45.4545 | 4 | yes |
GO:0034654 | nucleobase-containing compound biosynthetic process | 45.4545 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 45.4545 | 4 | yes |
GO:0090407 | organophosphate biosynthetic process | 45.4545 | 4 | yes |
GO:1901137 | carbohydrate derivative biosynthetic process | 45.4545 | 4 | yes |
GO:1901293 | nucleoside phosphate biosynthetic process | 45.4545 | 5 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 45.4545 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
GO:0006163 | purine nucleotide metabolic process | 36.3636 | 5 | yes |
GO:0006164 | purine nucleotide biosynthetic process | 36.3636 | 6 | yes |
GO:0006220 | pyrimidine nucleotide metabolic process | 36.3636 | 5 | yes |
GO:0006221 | pyrimidine nucleotide biosynthetic process | 36.3636 | 6 | yes |
GO:0009141 | nucleoside triphosphate metabolic process | 36.3636 | 5 | yes |
GO:0009142 | nucleoside triphosphate biosynthetic process | 36.3636 | 6 | yes |
GO:0009144 | purine nucleoside triphosphate metabolic process | 36.3636 | 6 | yes |
GO:0009150 | purine ribonucleotide metabolic process | 36.3636 | 6 | yes |
GO:0009152 | purine ribonucleotide biosynthetic process | 36.3636 | 7 | yes |
GO:0009199 | ribonucleoside triphosphate metabolic process | 36.3636 | 6 | yes |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 36.3636 | 7 | yes |
GO:0009218 | pyrimidine ribonucleotide metabolic process | 36.3636 | 6 | yes |
GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 36.3636 | 7 | yes |
GO:0009259 | ribonucleotide metabolic process | 36.3636 | 5 | yes |
GO:0009260 | ribonucleotide biosynthetic process | 36.3636 | 6 | yes |
GO:0019693 | ribose phosphate metabolic process | 36.3636 | 4 | yes |
GO:0046390 | ribose phosphate biosynthetic process | 36.3636 | 5 | yes |
GO:0072521 | purine-containing compound metabolic process | 36.3636 | 4 | yes |
GO:0072522 | purine-containing compound biosynthetic process | 36.3636 | 5 | yes |
GO:0072527 | pyrimidine-containing compound metabolic process | 36.3636 | 4 | yes |
GO:0072528 | pyrimidine-containing compound biosynthetic process | 36.3636 | 5 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 36.3636 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
GO:0006996 | organelle organization | 36.3636 | 4 | no |
GO:0009132 | nucleoside diphosphate metabolic process | 27.2727 | 5 | yes |
GO:0009185 | ribonucleoside diphosphate metabolic process | 27.2727 | 6 | yes |
GO:0009262 | deoxyribonucleotide metabolic process | 27.2727 | 4 | yes |
GO:0009263 | deoxyribonucleotide biosynthetic process | 27.2727 | 5 | yes |
GO:0009265 | 2-deoxyribonucleotide biosynthetic process | 27.2727 | 6 | yes |
GO:0009394 | 2-deoxyribonucleotide metabolic process | 27.2727 | 5 | yes |
GO:0016310 | phosphorylation | 27.2727 | 5 | yes |
GO:0019692 | deoxyribose phosphate metabolic process | 27.2727 | 4 | yes |
GO:0046385 | deoxyribose phosphate biosynthetic process | 27.2727 | 5 | yes |
GO:0016192 | vesicle-mediated transport | 27.2727 | 4 | no |
GO:0010941 | regulation of cell death | 27.2727 | 4 | no |
GO:0042981 | regulation of apoptotic process | 27.2727 | 6 | no |
GO:0043067 | regulation of programmed cell death | 27.2727 | 5 | no |
GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
GO:0006165 | nucleoside diphosphate phosphorylation | 18.1818 | 6 | yes |
GO:0006172 | ADP biosynthetic process | 18.1818 | 8 | yes |
GO:0006173 | dADP biosynthetic process | 18.1818 | 8 | yes |
GO:0009133 | nucleoside diphosphate biosynthetic process | 18.1818 | 6 | yes |
GO:0009135 | purine nucleoside diphosphate metabolic process | 18.1818 | 6 | yes |
GO:0009136 | purine nucleoside diphosphate biosynthetic process | 18.1818 | 7 | yes |
GO:0009151 | purine deoxyribonucleotide metabolic process | 18.1818 | 6 | yes |
GO:0009153 | purine deoxyribonucleotide biosynthetic process | 18.1818 | 7 | yes |
GO:0009179 | purine ribonucleoside diphosphate metabolic process | 18.1818 | 7 | yes |
GO:0009180 | purine ribonucleoside diphosphate biosynthetic process | 18.1818 | 8 | yes |
GO:0009182 | purine deoxyribonucleoside diphosphate metabolic process | 18.1818 | 7 | yes |
GO:0009183 | purine deoxyribonucleoside diphosphate biosynthetic process | 18.1818 | 8 | yes |
GO:0009186 | deoxyribonucleoside diphosphate metabolic process | 18.1818 | 6 | yes |
GO:0009188 | ribonucleoside diphosphate biosynthetic process | 18.1818 | 7 | yes |
GO:0009189 | deoxyribonucleoside diphosphate biosynthetic process | 18.1818 | 7 | yes |
GO:0046031 | ADP metabolic process | 18.1818 | 7 | yes |
GO:0046034 | ATP metabolic process | 18.1818 | 7 | yes |
GO:0046056 | dADP metabolic process | 18.1818 | 7 | yes |
GO:0046939 | nucleotide phosphorylation | 18.1818 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KAD5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CG026_HUMAN | [view interactions] | High throughput | no | yes |
CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI46_HUMAN | [view interactions] | High throughput | no | no |
UGDH_HUMAN | [view interactions] | High throughput | no | no |
RN114_HUMAN | [view interactions] | High throughput | no | no |
CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
CEBPB_HUMAN | [view interactions] | High throughput | no | no |
DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
APT_HUMAN | [view interactions] | Computational | no | yes |
ENTP2_HUMAN | [view interactions] | Computational | no | yes |
NTPCR_HUMAN | [view interactions] | Computational | no | yes |
KAD9_HUMAN | [view interactions] | Computational | no | yes |
RIR2B_HUMAN | [view interactions] | Computational | no | yes |
NDKA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DCK_HUMAN | [view interactions] | Computational | no | no |
NDK5_HUMAN | [view interactions] | Computational | no | yes |
RIR2_HUMAN | [view interactions] | Computational | no | no |
NDK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TPK1_HUMAN | [view interactions] | Computational | no | yes |
NDK7_HUMAN | [view interactions] | Computational | no | yes |
PUR8_HUMAN | [view interactions] | Computational | no | yes |
NDKM_HUMAN | [view interactions] | Computational | no | yes |
KAD7_HUMAN | [view interactions] | Computational | no | no |
DGUOK_HUMAN | [view interactions] | Computational | no | yes |
RIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |