Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KAD5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KAD5_HUMAN
GO:0000166 nucleotide binding 44.4444 4 yes
GO:0005524 ATP binding 44.4444 5 yes
GO:0017076 purine nucleotide binding 44.4444 5 yes
GO:0030554 adenyl nucleotide binding 44.4444 6 yes
GO:0032555 purine ribonucleotide binding 44.4444 4 yes
GO:0032559 adenyl ribonucleotide binding 44.4444 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 yes
GO:0043168 anion binding 44.4444 4 yes
GO:0004550 nucleoside diphosphate kinase activity 33.3333 5 yes
GO:0016301 kinase activity 33.3333 4 yes
GO:0016776 phosphotransferase activity, phosphate group as acceptor 33.3333 4 yes
GO:0019205 nucleobase-containing compound kinase activity 33.3333 5 yes
GO:0050145 nucleoside monophosphate kinase activity 33.3333 5 yes
GO:0004017 adenylate kinase activity 22.2222 6 yes
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in KAD5_HUMAN
GO:0006996 organelle organization 55.5556 4 no
GO:0006796 phosphate-containing compound metabolic process 44.4444 4 yes
GO:0016310 phosphorylation 44.4444 5 yes
GO:0006220 pyrimidine nucleotide metabolic process 33.3333 5 yes
GO:0006221 pyrimidine nucleotide biosynthetic process 33.3333 6 yes
GO:0006753 nucleoside phosphate metabolic process 33.3333 4 yes
GO:0009117 nucleotide metabolic process 33.3333 5 yes
GO:0009132 nucleoside diphosphate metabolic process 33.3333 5 yes
GO:0009133 nucleoside diphosphate biosynthetic process 33.3333 6 yes
GO:0009165 nucleotide biosynthetic process 33.3333 6 yes
GO:0009185 ribonucleoside diphosphate metabolic process 33.3333 6 yes
GO:0009188 ribonucleoside diphosphate biosynthetic process 33.3333 7 yes
GO:0009218 pyrimidine ribonucleotide metabolic process 33.3333 6 yes
GO:0009220 pyrimidine ribonucleotide biosynthetic process 33.3333 7 yes
GO:0009259 ribonucleotide metabolic process 33.3333 5 yes
GO:0009260 ribonucleotide biosynthetic process 33.3333 6 yes
GO:0019693 ribose phosphate metabolic process 33.3333 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 33.3333 4 yes
GO:0046390 ribose phosphate biosynthetic process 33.3333 5 yes
GO:0072527 pyrimidine-containing compound metabolic process 33.3333 4 yes
GO:0072528 pyrimidine-containing compound biosynthetic process 33.3333 5 yes
GO:0090407 organophosphate biosynthetic process 33.3333 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 33.3333 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 33.3333 5 yes
GO:1901362 organic cyclic compound biosynthetic process 33.3333 4 yes
GO:1901566 organonitrogen compound biosynthetic process 33.3333 4 yes
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0006163 purine nucleotide metabolic process 22.2222 5 yes
GO:0006164 purine nucleotide biosynthetic process 22.2222 6 yes
GO:0006172 ADP biosynthetic process 22.2222 8 yes
GO:0006173 dADP biosynthetic process 22.2222 8 yes
GO:0009135 purine nucleoside diphosphate metabolic process 22.2222 6 yes
GO:0009136 purine nucleoside diphosphate biosynthetic process 22.2222 7 yes
GO:0009141 nucleoside triphosphate metabolic process 22.2222 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 22.2222 6 yes
GO:0009150 purine ribonucleotide metabolic process 22.2222 6 yes
GO:0009151 purine deoxyribonucleotide metabolic process 22.2222 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 22.2222 7 yes
GO:0009153 purine deoxyribonucleotide biosynthetic process 22.2222 7 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 22.2222 7 yes
GO:0009180 purine ribonucleoside diphosphate biosynthetic process 22.2222 8 yes
GO:0009182 purine deoxyribonucleoside diphosphate metabolic process 22.2222 7 yes
GO:0009183 purine deoxyribonucleoside diphosphate biosynthetic process 22.2222 8 yes
GO:0009186 deoxyribonucleoside diphosphate metabolic process 22.2222 6 yes
GO:0009189 deoxyribonucleoside diphosphate biosynthetic process 22.2222 7 yes
GO:0009199 ribonucleoside triphosphate metabolic process 22.2222 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 22.2222 7 yes
GO:0009262 deoxyribonucleotide metabolic process 22.2222 4 yes
GO:0009263 deoxyribonucleotide biosynthetic process 22.2222 5 yes
GO:0009265 2-deoxyribonucleotide biosynthetic process 22.2222 6 yes
GO:0009394 2-deoxyribonucleotide metabolic process 22.2222 5 yes
GO:0019692 deoxyribose phosphate metabolic process 22.2222 4 yes
GO:0046031 ADP metabolic process 22.2222 7 yes
GO:0046034 ATP metabolic process 22.2222 7 yes
GO:0046056 dADP metabolic process 22.2222 7 yes
GO:0046385 deoxyribose phosphate biosynthetic process 22.2222 5 yes
GO:0072521 purine-containing compound metabolic process 22.2222 4 yes
GO:0072522 purine-containing compound biosynthetic process 22.2222 5 yes
GO:0022607 cellular component assembly 22.2222 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0048523 negative regulation of cellular process 22.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAD5_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
INT15_HUMAN [view interactions] High throughput no yes
CPNE6_HUMAN [view entry] [view interactions] High throughput yes yes
NUCKS_HUMAN [view interactions] High throughput no yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
TRI46_HUMAN [view interactions] High throughput no no
UGDH_HUMAN [view interactions] High throughput no no
RN114_HUMAN [view interactions] High throughput no no
CEBPA_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
CEBPB_HUMAN [view interactions] High throughput no no
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no