HS12A_HUMAN
Evidence for PS localization
Functions
Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HS12A_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 30.6122 | 4 | no |
| GO:0043168 | anion binding | 26.5306 | 4 | yes |
| GO:0000166 | nucleotide binding | 24.4898 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 22.4490 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.4490 | 4 | yes |
| GO:0019901 | protein kinase binding | 22.4490 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.4082 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 12.2449 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 12.2449 | 5 | yes |
| GO:0005524 | ATP binding | 10.2041 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HS12A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.4286 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.1020 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.1020 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.0612 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 51.0204 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.0204 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 48.9796 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 48.9796 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.9796 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.9388 | 5 | no |
| GO:0006996 | organelle organization | 44.8980 | 4 | no |
| GO:0022607 | cellular component assembly | 44.8980 | 4 | no |
| GO:0008104 | protein localization | 42.8571 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.8163 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 38.7755 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.7755 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.7755 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.7755 | 5 | no |
| GO:0031399 | regulation of protein modification process | 38.7755 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.7347 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 36.7347 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.7347 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.6939 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.6939 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 34.6939 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 32.6531 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.6531 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.6531 | 4 | no |
| GO:0051049 | regulation of transport | 32.6531 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.6122 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.6122 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.6122 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.6122 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.6122 | 6 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 28.5714 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.5306 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.5306 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.5306 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 26.5306 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.5306 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 26.5306 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.5306 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.5306 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.5306 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.5306 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 26.5306 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.5306 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.5306 | 7 | no |
| GO:0043549 | regulation of kinase activity | 26.5306 | 5 | no |
| GO:0051338 | regulation of transferase activity | 26.5306 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4898 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.4898 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.4898 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.4898 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.4898 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.4898 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.4490 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.4490 | 5 | no |
| GO:0030030 | cell projection organization | 22.4490 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.4490 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.4490 | 5 | no |
| GO:0071705 | nitrogen compound transport | 22.4490 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.4490 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.4490 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.4490 | 6 | no |
| GO:0061024 | membrane organization | 22.4490 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.4490 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.4490 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.4490 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.4490 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 22.4490 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 22.4490 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.4082 | 5 | no |
| GO:0010038 | response to metal ion | 20.4082 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.4082 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 20.4082 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 20.4082 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.4082 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.4082 | 6 | no |
| GO:0044057 | regulation of system process | 20.4082 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.4082 | 5 | no |
| GO:0071702 | organic substance transport | 20.4082 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 20.4082 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.4082 | 6 | no |
| GO:0001817 | regulation of cytokine production | 20.4082 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.4082 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.4082 | 5 | no |
| GO:0051345 | positive regulation of hydrolase activity | 20.4082 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.4082 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SORL_HUMAN | [view interactions] | Low throughput | no | yes |
| MPRD_HUMAN | [view interactions] | Low throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRS11_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENY2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCOC_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP2_HUMAN | [view interactions] | High throughput | no | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBPZ_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRCAM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MEG10_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| ZNG1B_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| CCL22_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HS12B_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAR3_HUMAN | [view interactions] | High throughput | no | no |
| ZNG1A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PODXL_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYUB_HUMAN | [view interactions] | High throughput | no | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| PHAR4_HUMAN | [view interactions] | High throughput | no | yes |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| MACD2_HUMAN | [view interactions] | High throughput | no | yes |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| PRCC_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| LONP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFXL1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LFA3_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| AP5M1_HUMAN | [view interactions] | High throughput | no | no |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |