HS12A_HUMAN
Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in HS12A_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 37.0370 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 31.4815 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.6296 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 27.7778 | 5 | yes |
GO:0019900 | kinase binding | 27.7778 | 4 | no |
GO:0019901 | protein kinase binding | 24.0741 | 5 | no |
GO:0016462 | pyrophosphatase activity | 24.0741 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.0741 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.0741 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | yes |
GO:0005524 | ATP binding | 20.3704 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in HS12A_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 64.8148 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 59.2593 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 51.8519 | 4 | no |
GO:0051128 | regulation of cellular component organization | 51.8519 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 51.8519 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 48.1481 | 4 | no |
GO:0006996 | organelle organization | 48.1481 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 46.2963 | 5 | no |
GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
GO:0008104 | protein localization | 42.5926 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 40.7407 | 5 | no |
GO:0010468 | regulation of gene expression | 40.7407 | 5 | no |
GO:0009966 | regulation of signal transduction | 40.7407 | 4 | no |
GO:0022607 | cellular component assembly | 38.8889 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 38.8889 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 38.8889 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.0370 | 5 | no |
GO:0031399 | regulation of protein modification process | 37.0370 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.1852 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.4815 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 31.4815 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.4815 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.4815 | 4 | no |
GO:0042981 | regulation of apoptotic process | 29.6296 | 6 | no |
GO:0043067 | regulation of programmed cell death | 29.6296 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 29.6296 | 6 | no |
GO:0042325 | regulation of phosphorylation | 29.6296 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 29.6296 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.6296 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 29.6296 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
GO:0051049 | regulation of transport | 29.6296 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 29.6296 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.6296 | 5 | no |
GO:0010941 | regulation of cell death | 29.6296 | 4 | no |
GO:0051338 | regulation of transferase activity | 27.7778 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 27.7778 | 7 | no |
GO:0061024 | membrane organization | 27.7778 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 27.7778 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 27.7778 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 27.7778 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 25.9259 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 25.9259 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.9259 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.9259 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 24.0741 | 7 | no |
GO:0043549 | regulation of kinase activity | 24.0741 | 5 | no |
GO:0015031 | protein transport | 24.0741 | 4 | no |
GO:0032880 | regulation of protein localization | 24.0741 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.0741 | 4 | no |
GO:0071702 | organic substance transport | 24.0741 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 22.2222 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 22.2222 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | no |
GO:0060548 | negative regulation of cell death | 22.2222 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 22.2222 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 22.2222 | 4 | no |
GO:0010628 | positive regulation of gene expression | 22.2222 | 6 | no |
GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 20.3704 | 4 | no |
GO:0001817 | regulation of cytokine production | 20.3704 | 4 | no |
GO:0051094 | positive regulation of developmental process | 20.3704 | 4 | no |
GO:0051726 | regulation of cell cycle | 20.3704 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 20.3704 | 7 | no |
GO:0009891 | positive regulation of biosynthetic process | 20.3704 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.3704 | 6 | no |
GO:0010648 | negative regulation of cell communication | 20.3704 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 20.3704 | 4 | no |
GO:0023057 | negative regulation of signaling | 20.3704 | 4 | no |
GO:0033365 | protein localization to organelle | 20.3704 | 5 | no |
GO:0080134 | regulation of response to stress | 20.3704 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.3704 | 6 | no |
GO:2000026 | regulation of multicellular organismal development | 20.3704 | 4 | no |
GO:0007010 | cytoskeleton organization | 20.3704 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 20.3704 | 6 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in HS12A_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 7.4074 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 7.4074 | 5 | no |
DOID:114 | heart disease | 7.4074 | 3 | no |
DOID:2843 | long QT syndrome | 5.5556 | 6 | no |
DOID:10273 | heart conduction disease | 3.7037 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SORL_HUMAN | [view interactions] | Low throughput | no | yes |
MPRD_HUMAN | [view interactions] | Low throughput | no | yes |
SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
NRCAM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MEG10_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
DKKL1_HUMAN | [view interactions] | High throughput | no | no |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
CBWD2_HUMAN | [view interactions] | High throughput | no | no |
TMM51_HUMAN | [view interactions] | High throughput | no | yes |
UBP32_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
WBP1_HUMAN | [view interactions] | High throughput | no | yes |
MISP_HUMAN | [view interactions] | High throughput | no | no |
CCL22_HUMAN | [view interactions] | High throughput | no | no |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
HS12B_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
PTPRG_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NAR3_HUMAN | [view interactions] | High throughput | no | no |
CBWD1_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
PODXL_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
GLMP_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYUB_HUMAN | [view interactions] | High throughput | no | yes |
RHG35_HUMAN | [view interactions] | High throughput | no | yes |
PHAR4_HUMAN | [view interactions] | High throughput | no | yes |
BCOR_HUMAN | [view interactions] | High throughput | no | no |
ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
MACD2_HUMAN | [view interactions] | High throughput | no | yes |
PALLD_HUMAN | [view interactions] | High throughput | no | yes |
PRCC_HUMAN | [view interactions] | High throughput | no | yes |
NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
KT222_HUMAN | [view interactions] | High throughput | no | no |
LONP2_HUMAN | [view interactions] | High throughput | no | yes |
RBCC1_HUMAN | [view interactions] | High throughput | no | no |
CD80_HUMAN | [view interactions] | High throughput | no | no |
CSN1_HUMAN | [view interactions] | High throughput | no | no |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM263_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NFXL1_HUMAN | [view interactions] | High throughput | no | yes |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
NAAA_HUMAN | [view interactions] | High throughput | no | yes |
ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LFA3_HUMAN | [view interactions] | High throughput | no | no |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
CSN6_HUMAN | [view interactions] | High throughput | no | yes |
PKHG4_HUMAN | [view interactions] | High throughput | no | no |
CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
AP5M1_HUMAN | [view interactions] | High throughput | no | no |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
SLN11_HUMAN | [view interactions] | High throughput | no | yes |
DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ENY2_HUMAN | [view interactions] | High throughput | no | yes |
E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCOC_HUMAN | [view interactions] | High throughput | no | yes |
PI42C_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELP2_HUMAN | [view interactions] | High throughput | no | yes |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VANG1_HUMAN | [view interactions] | High throughput | no | no |
SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ELP1_HUMAN | [view interactions] | High throughput | no | yes |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUP62_HUMAN | [view interactions] | Computational | no | yes |
DNJB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HS105_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAE1L_HUMAN | [view interactions] | Computational | no | no |
BAG5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
HS71A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NUP50_HUMAN | [view interactions] | Computational | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DNJC2_HUMAN | [view interactions] | Computational | no | yes |
NDC1_HUMAN | [view interactions] | Computational | no | yes |
NU188_HUMAN | [view interactions] | Computational | no | yes |
AAAS_HUMAN | [view interactions] | Computational | no | yes |
TPR_HUMAN | [view interactions] | Computational | no | yes |
NUP58_HUMAN | [view interactions] | Computational | no | yes |
RBP2_HUMAN | [view interactions] | Computational | no | yes |
DNJB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NU155_HUMAN | [view interactions] | Computational | no | yes |
NU205_HUMAN | [view interactions] | Computational | no | no |
DNJC7_HUMAN | [view interactions] | Computational | no | yes |
GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NUP88_HUMAN | [view interactions] | Computational | no | yes |
SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NU214_HUMAN | [view interactions] | Computational | no | no |
NUP42_HUMAN | [view interactions] | Computational | no | no |
SEH1_HUMAN | [view interactions] | Computational | no | no |
NU107_HUMAN | [view interactions] | Computational | no | no |
NUP85_HUMAN | [view interactions] | Computational | no | yes |
NUP93_HUMAN | [view interactions] | Computational | no | yes |
HSP7E_HUMAN | [view interactions] | Computational | no | yes |
NUP35_HUMAN | [view interactions] | Computational | no | yes |
NU133_HUMAN | [view interactions] | Computational | no | yes |
P121A_HUMAN | [view interactions] | Computational | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
F10A1_HUMAN | [view interactions] | Computational | no | yes |
NU153_HUMAN | [view interactions] | Computational | no | yes |
NUP37_HUMAN | [view interactions] | Computational | no | yes |
BAG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
P121C_HUMAN | [view interactions] | Computational | no | yes |
BIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HS74L_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NUP98_HUMAN | [view interactions] | Computational | no | no |
NU160_HUMAN | [view interactions] | Computational | no | no |
NUP43_HUMAN | [view interactions] | Computational | no | yes |
HSP13_HUMAN | [view interactions] | Computational | no | yes |
PO210_HUMAN | [view interactions] | Computational | no | yes |
BAG4_HUMAN | [view interactions] | Computational | no | yes |
NUP54_HUMAN | [view interactions] | Computational | no | yes |