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CADM1_HUMAN

GO
G2C
SynaptomeDB

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed, PubMed). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner . Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed). In mast cells, may mediate attachment to and promote communication with nerves (PubMed). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node . Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells . Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells . Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons . May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa . Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed, PubMed). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CADM1_HUMAN
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0019900 kinase binding 23.3333 4 no
GO:0030165 PDZ domain binding 10.0000 4 yes
GO:0042803 protein homodimerization activity 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CADM1_HUMAN
GO:0048522 positive regulation of cellular process 70.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 yes
GO:0009893 positive regulation of metabolic process 46.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 yes
GO:0048523 negative regulation of cellular process 43.3333 4 no
GO:0051128 regulation of cellular component organization 43.3333 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 5 yes
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0009889 regulation of biosynthetic process 30.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0033043 regulation of organelle organization 30.0000 5 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0048584 positive regulation of response to stimulus 26.6667 4 yes
GO:0080134 regulation of response to stress 26.6667 4 yes
GO:0008104 protein localization 26.6667 4 no
GO:0009892 negative regulation of metabolic process 26.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 26.6667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0051130 positive regulation of cellular component organization 26.6667 5 no
GO:0019220 regulation of phosphate metabolic process 26.6667 6 no
GO:0022603 regulation of anatomical structure morphogenesis 26.6667 4 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0042127 regulation of cell population proliferation 26.6667 4 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 no
GO:0051246 regulation of protein metabolic process 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0010647 positive regulation of cell communication 23.3333 5 no
GO:0023056 positive regulation of signaling 23.3333 4 no
GO:0043933 protein-containing complex organization 23.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.3333 5 no
GO:0006355 regulation of DNA-templated transcription 23.3333 6 no
GO:0006357 regulation of transcription by RNA polymerase II 23.3333 7 no
GO:0010638 positive regulation of organelle organization 23.3333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 23.3333 5 no
GO:0051252 regulation of RNA metabolic process 23.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 23.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 23.3333 6 no
GO:0001932 regulation of protein phosphorylation 23.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 23.3333 8 no
GO:0008284 positive regulation of cell population proliferation 23.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.3333 6 no
GO:0030334 regulation of cell migration 23.3333 5 no
GO:0031401 positive regulation of protein modification process 23.3333 7 no
GO:0042325 regulation of phosphorylation 23.3333 7 no
GO:0042327 positive regulation of phosphorylation 23.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.3333 7 no
GO:0051493 regulation of cytoskeleton organization 23.3333 6 no
GO:2000145 regulation of cell motility 23.3333 4 no
GO:0031344 regulation of cell projection organization 23.3333 5 no
GO:0032880 regulation of protein localization 23.3333 5 no
GO:0051050 positive regulation of transport 23.3333 4 no
GO:0060341 regulation of cellular localization 23.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.3333 6 no
GO:0051240 positive regulation of multicellular organismal process 20.0000 4 yes
GO:0002684 positive regulation of immune system process 20.0000 4 yes
GO:0006915 apoptotic process 16.6667 4 yes
GO:0010628 positive regulation of gene expression 16.6667 6 yes
GO:0032101 regulation of response to external stimulus 16.6667 4 yes
GO:0048732 gland development 13.3333 4 yes
GO:0050776 regulation of immune response 13.3333 4 yes
GO:0050778 positive regulation of immune response 13.3333 5 yes
GO:0001817 regulation of cytokine production 13.3333 4 yes
GO:0001889 liver development 13.3333 5 yes
GO:0032103 positive regulation of response to external stimulus 13.3333 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 10.0000 4 yes
GO:0001819 positive regulation of cytokine production 10.0000 5 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 10.0000 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 10.0000 5 yes
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity 6.6667 8 yes
GO:0045088 regulation of innate immune response 6.6667 5 yes
GO:0045089 positive regulation of innate immune response 6.6667 6 yes
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 6.6667 7 yes
GO:0048232 male gamete generation 6.6667 4 yes
GO:0001910 regulation of leukocyte mediated cytotoxicity 6.6667 5 yes
GO:0001912 positive regulation of leukocyte mediated cytotoxicity 6.6667 6 yes
GO:0002697 regulation of immune effector process 6.6667 4 yes
GO:0002699 positive regulation of immune effector process 6.6667 5 yes
GO:0002703 regulation of leukocyte mediated immunity 6.6667 5 yes
GO:0002705 positive regulation of leukocyte mediated immunity 6.6667 6 yes
GO:0002706 regulation of lymphocyte mediated immunity 6.6667 6 yes
GO:0002708 positive regulation of lymphocyte mediated immunity 6.6667 7 yes
GO:0002715 regulation of natural killer cell mediated immunity 6.6667 6 yes
GO:0002717 positive regulation of natural killer cell mediated immunity 6.6667 7 yes
GO:0002831 regulation of response to biotic stimulus 6.6667 4 yes
GO:0002833 positive regulation of response to biotic stimulus 6.6667 5 yes
GO:0007420 brain development 6.6667 4 yes
GO:0031341 regulation of cell killing 6.6667 4 yes
GO:0031343 positive regulation of cell killing 6.6667 5 yes
GO:0031347 regulation of defense response 6.6667 5 yes
GO:0031349 positive regulation of defense response 6.6667 5 yes
GO:0042269 regulation of natural killer cell mediated cytotoxicity 6.6667 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
E41L3_HUMAN [view entry] [view interactions] Low throughput yes yes
CRTAM_HUMAN [view interactions] Low throughput no no
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
CADM1_HUMAN [view entry] [view interactions] Low throughput yes no
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
SIA8B_HUMAN [view interactions] Low throughput no yes
MPP3_HUMAN [view entry] [view interactions] Low throughput yes yes
FARP1_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MPP2_HUMAN [view entry] [view interactions] Low throughput yes yes
MCAF1_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
SPP2B_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
CNBP_HUMAN [view interactions] High throughput no no
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
DPY30_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
GCYB1_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
SCOC_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
PALS2_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
PTN13_HUMAN [view interactions] Computational no yes
CADM3_HUMAN [view interactions] Computational no no
NECT3_HUMAN [view entry] [view interactions] Computational yes yes
HAVR2_HUMAN [view interactions] Computational no no
TIAM1_HUMAN [view entry] [view interactions] Computational yes yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
ERBB3_HUMAN [view interactions] Computational no yes