Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CADM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed, PubMed). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner . Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed). In mast cells, may mediate attachment to and promote communication with nerves (PubMed). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node . Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells . Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells . Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons . May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa . Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed, PubMed). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CADM1_HUMAN
GO:0043168 anion binding 35.4839 4 no
GO:0000166 nucleotide binding 32.2581 4 no
GO:0017076 purine nucleotide binding 32.2581 5 no
GO:0032555 purine ribonucleotide binding 32.2581 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.2581 4 no
GO:0016462 pyrophosphatase activity 22.5806 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.5806 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.5806 6 no
GO:0030165 PDZ domain binding 9.6774 4 yes
GO:0042803 protein homodimerization activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CADM1_HUMAN
GO:0048522 positive regulation of cellular process 70.9677 4 yes
GO:0048523 negative regulation of cellular process 51.6129 4 yes
GO:0031323 regulation of cellular metabolic process 48.3871 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.3871 4 yes
GO:0080090 regulation of primary metabolic process 48.3871 4 yes
GO:0009893 positive regulation of metabolic process 45.1613 4 yes
GO:0010646 regulation of cell communication 45.1613 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.1613 5 yes
GO:0006996 organelle organization 45.1613 4 no
GO:0009889 regulation of biosynthetic process 41.9355 4 yes
GO:0010468 regulation of gene expression 41.9355 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 41.9355 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.9355 5 yes
GO:0031326 regulation of cellular biosynthetic process 41.9355 5 yes
GO:0022607 cellular component assembly 41.9355 4 no
GO:0009966 regulation of signal transduction 38.7097 4 yes
GO:0051128 regulation of cellular component organization 38.7097 4 no
GO:0009891 positive regulation of biosynthetic process 35.4839 5 yes
GO:0009892 negative regulation of metabolic process 35.4839 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 35.4839 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.4839 5 yes
GO:0031324 negative regulation of cellular metabolic process 35.4839 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 35.4839 6 yes
GO:0044087 regulation of cellular component biogenesis 35.4839 4 no
GO:0007010 cytoskeleton organization 32.2581 5 no
GO:0033043 regulation of organelle organization 32.2581 5 no
GO:0031399 regulation of protein modification process 29.0323 6 yes
GO:0048584 positive regulation of response to stimulus 29.0323 4 yes
GO:0051240 positive regulation of multicellular organismal process 29.0323 4 yes
GO:0051246 regulation of protein metabolic process 29.0323 5 yes
GO:0042127 regulation of cell population proliferation 29.0323 4 no
GO:1902531 regulation of intracellular signal transduction 29.0323 5 no
GO:0006355 regulation of DNA-templated transcription 29.0323 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.0323 5 no
GO:0051252 regulation of RNA metabolic process 29.0323 5 no
GO:2001141 regulation of RNA biosynthetic process 29.0323 6 no
GO:0019220 regulation of phosphate metabolic process 25.8065 6 yes
GO:0051174 regulation of phosphorus metabolic process 25.8065 5 yes
GO:0080134 regulation of response to stress 25.8065 4 yes
GO:0030030 cell projection organization 25.8065 4 no
GO:0010647 positive regulation of cell communication 25.8065 5 no
GO:0023056 positive regulation of signaling 25.8065 4 no
GO:0043933 protein-containing complex organization 25.8065 4 no
GO:0045595 regulation of cell differentiation 25.8065 4 no
GO:0051493 regulation of cytoskeleton organization 25.8065 6 no
GO:0009890 negative regulation of biosynthetic process 25.8065 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.8065 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.8065 6 no
GO:0044089 positive regulation of cellular component biogenesis 25.8065 5 no
GO:0051130 positive regulation of cellular component organization 25.8065 5 no
GO:0006357 regulation of transcription by RNA polymerase II 25.8065 8 no
GO:0002684 positive regulation of immune system process 22.5806 4 yes
GO:0006915 apoptotic process 22.5806 4 yes
GO:0010628 positive regulation of gene expression 22.5806 7 yes
GO:0042325 regulation of phosphorylation 22.5806 7 yes
GO:0048585 negative regulation of response to stimulus 22.5806 4 yes
GO:0032880 regulation of protein localization 22.5806 5 no
GO:0060341 regulation of cellular localization 22.5806 4 no
GO:0009967 positive regulation of signal transduction 22.5806 5 no
GO:0042981 regulation of apoptotic process 22.5806 5 no
GO:0043067 regulation of programmed cell death 22.5806 4 no
GO:0045597 positive regulation of cell differentiation 22.5806 5 no
GO:0051094 positive regulation of developmental process 22.5806 4 no
GO:0051247 positive regulation of protein metabolic process 22.5806 6 no
GO:0010638 positive regulation of organelle organization 22.5806 6 no
GO:0043254 regulation of protein-containing complex assembly 22.5806 5 no
GO:0051049 regulation of transport 22.5806 4 no
GO:0008104 protein localization 22.5806 4 no
GO:0001932 regulation of protein phosphorylation 19.3548 7 yes
GO:0009968 negative regulation of signal transduction 19.3548 5 yes
GO:0010648 negative regulation of cell communication 19.3548 5 yes
GO:0023057 negative regulation of signaling 19.3548 4 yes
GO:0031400 negative regulation of protein modification process 19.3548 7 yes
GO:0032101 regulation of response to external stimulus 19.3548 4 yes
GO:0050776 regulation of immune response 19.3548 4 yes
GO:0050778 positive regulation of immune response 19.3548 5 yes
GO:0051248 negative regulation of protein metabolic process 19.3548 6 yes
GO:0001817 regulation of cytokine production 16.1290 4 yes
GO:0001819 positive regulation of cytokine production 16.1290 5 yes
GO:0032103 positive regulation of response to external stimulus 16.1290 5 yes
GO:0048732 gland development 16.1290 4 yes
GO:0001889 liver development 12.9032 5 yes
GO:0002831 regulation of response to biotic stimulus 12.9032 4 yes
GO:0002833 positive regulation of response to biotic stimulus 12.9032 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 12.9032 6 yes
GO:0031347 regulation of defense response 12.9032 5 yes
GO:0031349 positive regulation of defense response 12.9032 5 yes
GO:0045088 regulation of innate immune response 12.9032 5 yes
GO:0045089 positive regulation of innate immune response 12.9032 6 yes
GO:0045936 negative regulation of phosphate metabolic process 12.9032 7 yes
GO:0001933 negative regulation of protein phosphorylation 9.6774 8 yes
GO:0042326 negative regulation of phosphorylation 9.6774 8 yes
GO:0001910 regulation of leukocyte mediated cytotoxicity 6.4516 5 yes
GO:0001912 positive regulation of leukocyte mediated cytotoxicity 6.4516 6 yes
GO:0002697 regulation of immune effector process 6.4516 4 yes
GO:0002699 positive regulation of immune effector process 6.4516 5 yes
GO:0002703 regulation of leukocyte mediated immunity 6.4516 5 yes
GO:0002705 positive regulation of leukocyte mediated immunity 6.4516 6 yes
GO:0002706 regulation of lymphocyte mediated immunity 6.4516 6 yes
GO:0002708 positive regulation of lymphocyte mediated immunity 6.4516 7 yes
GO:0002715 regulation of natural killer cell mediated immunity 6.4516 6 yes
GO:0002717 positive regulation of natural killer cell mediated immunity 6.4516 7 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 6.4516 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 6.4516 5 yes
GO:0031341 regulation of cell killing 6.4516 4 yes
GO:0031343 positive regulation of cell killing 6.4516 5 yes
GO:0042269 regulation of natural killer cell mediated cytotoxicity 6.4516 6 yes
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity 6.4516 8 yes
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 6.4516 7 yes
GO:0048232 male gamete generation 6.4516 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 6.4516 4 yes
GO:0120154 negative regulation of ERBB4 signaling pathway 6.4516 7 yes
GO:1901184 regulation of ERBB signaling pathway 6.4516 5 yes
GO:1901185 negative regulation of ERBB signaling pathway 6.4516 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
E41L3_HUMAN [view entry] [view interactions] Low throughput yes yes
CRTAM_HUMAN [view interactions] Low throughput no no
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
CADM1_HUMAN [view entry] [view interactions] Low throughput yes no
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
SIA8B_HUMAN [view interactions] Low throughput no yes
MPP3_HUMAN [view entry] [view interactions] Low throughput yes yes
FARP1_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MPP2_HUMAN [view entry] [view interactions] Low throughput yes yes
MCAF1_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
SPP2B_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
SPAG6_HUMAN [view interactions] High throughput no no
RSPH1_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
UBP10_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
CNBP_HUMAN [view interactions] High throughput no no
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
DPY30_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
GCYB1_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
SCOC_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
PALS2_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes