MCAF1_HUMAN
Evidence for PS localization
Functions
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3) (PubMed, PubMed). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002786 | LIG_SUMO_SIM_par_1 | LIG | 965 | 970 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCAF1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 35.2941 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCAF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.8235 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.9412 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 52.9412 | 5 | yes |
| GO:0010468 | regulation of gene expression | 47.0588 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.1765 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.1765 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.1765 | 4 | yes |
| GO:0006996 | organelle organization | 41.1765 | 4 | no |
| GO:0008104 | protein localization | 41.1765 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.1765 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.2941 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | yes |
| GO:0043412 | macromolecule modification | 35.2941 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 35.2941 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 35.2941 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.2941 | 5 | yes |
| GO:0022607 | cellular component assembly | 35.2941 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.4118 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 29.4118 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.4118 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 29.4118 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 29.4118 | 4 | no |
| GO:0036211 | protein modification process | 29.4118 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0080134 | regulation of response to stress | 29.4118 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 29.4118 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.5294 | 7 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 23.5294 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.5294 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.5294 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.5294 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 23.5294 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.5294 | 6 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.5294 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 23.5294 | 6 | yes |
| GO:0090304 | nucleic acid metabolic process | 23.5294 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.5294 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0051049 | regulation of transport | 23.5294 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.5294 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 23.5294 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.5294 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 23.5294 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.5294 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.5294 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 23.5294 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 23.5294 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.5294 | 5 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 17.6471 | 8 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 17.6471 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 17.6471 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 17.6471 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 17.6471 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 17.6471 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 17.6471 | 8 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 17.6471 | 8 | yes |
| GO:0006259 | DNA metabolic process | 11.7647 | 4 | yes |
| GO:0006304 | DNA modification | 11.7647 | 5 | yes |
| GO:0006305 | DNA alkylation | 11.7647 | 6 | yes |
| GO:0006306 | DNA methylation | 11.7647 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 11.7647 | 6 | yes |
| GO:0033044 | regulation of chromosome organization | 11.7647 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 11.7647 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 11.7647 | 5 | yes |
| GO:0044728 | DNA methylation or demethylation | 11.7647 | 6 | yes |
| GO:0050821 | protein stabilization | 11.7647 | 4 | yes |
| GO:2001252 | positive regulation of chromosome organization | 11.7647 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GT2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| MBD1_HUMAN | [view interactions] | Low throughput | no | yes |
| ERCC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ERCC2_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| T2EB_HUMAN | [view interactions] | Low throughput | no | yes |
| T2EA_HUMAN | [view interactions] | Low throughput | no | yes |
| SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF7_HUMAN | [view interactions] | Low throughput | no | no |
| TF2H1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK7_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNH_HUMAN | [view interactions] | Low throughput | no | yes |
| TF2H3_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB3_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB4_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB7_HUMAN | [view interactions] | Low throughput | no | yes |
| RPAB3_HUMAN | [view interactions] | Low throughput | no | yes |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| PAPP1_HUMAN | [view interactions] | High throughput | no | no |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| ANPRA_HUMAN | [view interactions] | High throughput | no | no |
| PCDH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMTF1_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVEP1_HUMAN | [view interactions] | High throughput | no | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMA4_HUMAN | [view interactions] | High throughput | no | no |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| MTNA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG3_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXXC5_HUMAN | [view interactions] | High throughput | no | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELF4_HUMAN | [view interactions] | High throughput | no | no |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| HNF1A_HUMAN | [view interactions] | High throughput | no | no |
| HNF1B_HUMAN | [view interactions] | High throughput | no | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| KLF12_HUMAN | [view interactions] | High throughput | no | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| HXA2_HUMAN | [view interactions] | High throughput | no | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TADA3_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| PR20E_HUMAN | [view interactions] | High throughput | no | no |
| SUV91_HUMAN | [view interactions] | High throughput | no | no |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CDY2_HUMAN | [view interactions] | High throughput | no | no |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN174_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| MCAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| TNNC2_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PIAS3_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPP2_HUMAN | [view interactions] | High throughput | no | no |
| HEYL_HUMAN | [view interactions] | High throughput | no | no |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN350_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB6_HUMAN | [view interactions] | High throughput | no | no |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| EPG5_HUMAN | [view interactions] | High throughput | no | yes |
| PKD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAD11_HUMAN | [view interactions] | High throughput | no | no |
| GMEB1_HUMAN | [view interactions] | High throughput | no | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD1_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
| KI13A_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |