MCAF1_HUMAN
Evidence for PS localization
Functions
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3) (PubMed, PubMed). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002786 | LIG_SUMO_SIM_par_1 | LIG | 965 | 970 | - |
| ELMI002786 | LIG_SUMO_SIM_par_1 | LIG | 965 | 970 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCAF1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 38.0952 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCAF1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 61.9048 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 57.1429 | 4 | yes |
| GO:0010468 | regulation of gene expression | 57.1429 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 57.1429 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 57.1429 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.3810 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 52.3810 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.6190 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 42.8571 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 42.8571 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 42.8571 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 42.8571 | 5 | yes |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 42.8571 | 4 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 38.0952 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 38.0952 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | no |
| GO:0010646 | regulation of cell communication | 38.0952 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 33.3333 | 8 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 28.5714 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.5714 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.5714 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 28.5714 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0036211 | protein modification process | 28.5714 | 4 | no |
| GO:0043412 | macromolecule modification | 28.5714 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.8095 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.8095 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 23.8095 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.8095 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.8095 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.8095 | 5 | no |
| GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 23.8095 | 8 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 23.8095 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.8095 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 23.8095 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 23.8095 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 23.8095 | 7 | yes |
| GO:0018193 | peptidyl-amino acid modification | 23.8095 | 5 | no |
| GO:0060284 | regulation of cell development | 23.8095 | 5 | no |
| GO:0030030 | cell projection organization | 23.8095 | 4 | no |
| GO:0072657 | protein localization to membrane | 23.8095 | 4 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 19.0476 | 9 | yes |
| GO:0033044 | regulation of chromosome organization | 14.2857 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 9.5238 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 9.5238 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 9.5238 | 5 | yes |
| GO:0050821 | protein stabilization | 9.5238 | 4 | yes |
| GO:2001252 | positive regulation of chromosome organization | 9.5238 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ERCC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ERCC2_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| T2EB_HUMAN | [view interactions] | Low throughput | no | yes |
| T2EA_HUMAN | [view interactions] | Low throughput | no | yes |
| SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF7_HUMAN | [view interactions] | Low throughput | no | no |
| TF2H1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK7_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNH_HUMAN | [view interactions] | Low throughput | no | yes |
| TF2H3_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB3_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB4_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB7_HUMAN | [view interactions] | Low throughput | no | yes |
| RPAB3_HUMAN | [view interactions] | Low throughput | no | yes |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| GT2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| MBD1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TADA3_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| PR20E_HUMAN | [view interactions] | High throughput | no | no |
| SUV91_HUMAN | [view interactions] | High throughput | no | no |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CDY2_HUMAN | [view interactions] | High throughput | no | no |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN174_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| MCAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| TNNC2_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPP2_HUMAN | [view interactions] | High throughput | no | no |
| HEYL_HUMAN | [view interactions] | High throughput | no | no |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN350_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB6_HUMAN | [view interactions] | High throughput | no | no |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| EPG5_HUMAN | [view interactions] | High throughput | no | yes |
| PKD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAD11_HUMAN | [view interactions] | High throughput | no | no |
| GMEB1_HUMAN | [view interactions] | High throughput | no | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD1_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
| KI13A_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| PAPP1_HUMAN | [view interactions] | High throughput | no | no |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| ANPRA_HUMAN | [view interactions] | High throughput | no | no |
| PCDH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMTF1_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVEP1_HUMAN | [view interactions] | High throughput | no | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMA4_HUMAN | [view interactions] | High throughput | no | no |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| MTNA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG3_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXXC5_HUMAN | [view interactions] | High throughput | no | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELF4_HUMAN | [view interactions] | High throughput | no | no |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| HNF1A_HUMAN | [view interactions] | High throughput | no | no |
| HNF1B_HUMAN | [view interactions] | High throughput | no | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| KLF12_HUMAN | [view interactions] | High throughput | no | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| HXA2_HUMAN | [view interactions] | High throughput | no | no |