NOMO1_HUMAN
Evidence for PS localization
Functions
Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NOMO1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 20.8333 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 20.8333 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 20.8333 | 4 | no |
| GO:0045296 | cadherin binding | 20.8333 | 4 | no |
| GO:0043022 | ribosome binding | 12.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NOMO1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 62.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 58.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.8333 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 41.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051049 | regulation of transport | 29.1667 | 4 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.1667 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 29.1667 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.1667 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 29.1667 | 5 | no |
| GO:0023057 | negative regulation of signaling | 29.1667 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0006996 | organelle organization | 29.1667 | 4 | no |
| GO:0043412 | macromolecule modification | 29.1667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.0000 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.8333 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.8333 | 4 | no |
| GO:0006811 | ion transport | 20.8333 | 4 | no |
| GO:0006812 | cation transport | 20.8333 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.8333 | 6 | no |
| GO:0043269 | regulation of ion transport | 20.8333 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 20.8333 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 20.8333 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.8333 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8333 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 20.8333 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.8333 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.8333 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.8333 | 8 | no |
| GO:0030030 | cell projection organization | 20.8333 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.8333 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 20.8333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.8333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.8333 | 6 | no |
| GO:0023056 | positive regulation of signaling | 20.8333 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.8333 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8333 | 7 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.8333 | 7 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NOMO1_HUMAN |
|---|---|---|---|---|
| DOID:37 | skin disease | 8.3333 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCLN_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR3_HUMAN | [view interactions] | High throughput | no | no |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| SGCZ_HUMAN | [view interactions] | High throughput | no | no |
| LYZL2_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| ZPBP2_HUMAN | [view interactions] | High throughput | no | no |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| EFNA2_HUMAN | [view interactions] | High throughput | no | no |
| PPB1_HUMAN | [view interactions] | High throughput | no | no |
| SIAT9_HUMAN | [view interactions] | High throughput | no | no |
| NCEH1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| ESPB1_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| ENPP7_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX2_HUMAN | [view interactions] | High throughput | no | no |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| LIPE_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
| CD1B_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| NNRD_HUMAN | [view interactions] | High throughput | no | yes |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| DPEP2_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPC6_HUMAN | [view interactions] | High throughput | no | no |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB2_HUMAN | [view interactions] | High throughput | no | no |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
| MCAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| REN3B_HUMAN | [view interactions] | High throughput | no | yes |
| CYH4_HUMAN | [view interactions] | High throughput | no | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| MRO2A_HUMAN | [view interactions] | High throughput | no | no |
| ZN492_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| TACAN_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| METL9_HUMAN | [view interactions] | High throughput | no | yes |
| SERC1_HUMAN | [view interactions] | High throughput | no | yes |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPC_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TACT_HUMAN | [view interactions] | High throughput | no | no |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| HEPS_HUMAN | [view interactions] | High throughput | no | yes |
| ANT3_HUMAN | [view interactions] | High throughput | no | no |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3C_HUMAN | [view interactions] | High throughput | no | no |
| GTR9_HUMAN | [view interactions] | High throughput | no | no |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNF10_HUMAN | [view interactions] | High throughput | no | no |
| S22A8_HUMAN | [view interactions] | High throughput | no | no |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| NOMO3_HUMAN | [view interactions] | High throughput | no | yes |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| SCAP_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| S6A15_HUMAN | [view interactions] | High throughput | no | yes |
| PCDG9_HUMAN | [view interactions] | High throughput | no | no |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| AT1B4_HUMAN | [view interactions] | High throughput | no | no |
| LCN9_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| PG12B_HUMAN | [view interactions] | High throughput | no | no |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| GINM1_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S39AC_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| PDXD1_HUMAN | [view interactions] | Computational | no | no |