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VMAT2_HUMAN

GO
G2C
SynaptomeDB

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed). Requisite for vesicular amine storage prior to secretion via exocytosis. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VMAT2_HUMAN
GO:0043168 anion binding 23.8095 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 14.2857 4 yes
GO:0015081 sodium ion transmembrane transporter activity 14.2857 6 yes
GO:0015291 secondary active transmembrane transporter activity 14.2857 4 yes
GO:0015293 symporter activity 14.2857 5 yes
GO:0015294 solute:monoatomic cation symporter activity 14.2857 5 yes
GO:0015370 solute:sodium symporter activity 14.2857 6 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 14.2857 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 14.2857 4 yes
GO:0046873 metal ion transmembrane transporter activity 14.2857 5 yes
GO:0008504 monoamine transmembrane transporter activity 9.5238 4 yes
GO:0008509 monoatomic anion transmembrane transporter activity 9.5238 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 9.5238 4 yes
GO:0015108 chloride transmembrane transporter activity 9.5238 5 yes
GO:0015296 monoatomic anion:monoatomic cation symporter activity 9.5238 5 yes
GO:0015373 monoatomic anion:sodium symporter activity 9.5238 6 yes
GO:0015377 chloride:monoatomic cation symporter activity 9.5238 6 yes
GO:0015378 sodium:chloride symporter activity 9.5238 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VMAT2_HUMAN
GO:0071702 organic substance transport 57.1429 4 yes
GO:0071705 nitrogen compound transport 52.3810 4 yes
GO:0008104 protein localization 52.3810 4 no
GO:0046903 secretion 47.6190 4 yes
GO:0061024 membrane organization 47.6190 4 no
GO:0015031 protein transport 38.0952 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0048522 positive regulation of cellular process 28.5714 4 no
GO:0007005 mitochondrion organization 28.5714 5 no
GO:0006836 neurotransmitter transport 23.8095 4 yes
GO:0048523 negative regulation of cellular process 23.8095 4 yes
GO:0098657 import into cell 23.8095 4 yes
GO:0010646 regulation of cell communication 23.8095 4 no
GO:0048278 vesicle docking 23.8095 4 no
GO:0051128 regulation of cellular component organization 23.8095 4 no
GO:0001504 neurotransmitter uptake 19.0476 5 yes
GO:0015850 organic hydroxy compound transport 19.0476 5 yes
GO:0009914 hormone transport 14.2857 4 yes
GO:0010243 response to organonitrogen compound 14.2857 4 yes
GO:0015844 monoamine transport 14.2857 5 yes
GO:0015872 dopamine transport 14.2857 7 yes
GO:0023061 signal release 14.2857 4 yes
GO:0046879 hormone secretion 14.2857 5 yes
GO:0051937 catecholamine transport 14.2857 6 yes
GO:0098810 neurotransmitter reuptake 14.2857 4 yes
GO:0007268 chemical synaptic transmission 9.5238 7 yes
GO:0009889 regulation of biosynthetic process 9.5238 4 yes
GO:0009890 negative regulation of biosynthetic process 9.5238 5 yes
GO:0009892 negative regulation of metabolic process 9.5238 4 yes
GO:0031323 regulation of cellular metabolic process 9.5238 4 yes
GO:0031324 negative regulation of cellular metabolic process 9.5238 5 yes
GO:0098916 anterograde trans-synaptic signaling 9.5238 6 yes
GO:0099536 synaptic signaling 9.5238 4 yes
GO:0099537 trans-synaptic signaling 9.5238 5 yes
GO:1903426 regulation of reactive oxygen species biosynthetic process 9.5238 5 yes
GO:1903427 negative regulation of reactive oxygen species biosynthetic process 9.5238 6 yes
GO:2000377 regulation of reactive oxygen species metabolic process 9.5238 5 yes
GO:2000378 negative regulation of reactive oxygen species metabolic process 9.5238 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
TY3H_HUMAN [view interactions] Low throughput no no
DDC_HUMAN [view interactions] Low throughput no no
DHB7_HUMAN [view interactions] High throughput no yes
RAB32_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
MITOS_HUMAN [view entry] [view interactions] High throughput yes yes
NEK6_HUMAN [view interactions] High throughput no yes
PM34_HUMAN [view interactions] High throughput no yes
YLAT2_HUMAN [view interactions] High throughput no no
TTK_HUMAN [view interactions] High throughput no yes
ATLA3_HUMAN [view interactions] High throughput no no
VPS50_HUMAN [view interactions] High throughput no yes
ECM29_HUMAN [view interactions] High throughput no no
EBP_HUMAN [view interactions] High throughput no no
TPPC5_HUMAN [view interactions] High throughput no yes
MTX1_HUMAN [view entry] [view interactions] High throughput yes yes
PXMP2_HUMAN [view interactions] High throughput no no
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
S2533_HUMAN [view interactions] High throughput no yes
COQ5_HUMAN [view interactions] High throughput no yes
HACD2_HUMAN [view interactions] High throughput no yes
PEX16_HUMAN [view interactions] High throughput no yes
DOLK_HUMAN [view interactions] High throughput no no
TFB2M_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
STML1_HUMAN [view interactions] High throughput no yes
OTUL_HUMAN [view interactions] High throughput no yes
AB17B_HUMAN [view entry] [view interactions] High throughput yes no
MCU_HUMAN [view interactions] High throughput no yes
TLCD4_HUMAN [view interactions] High throughput no no
RB39B_HUMAN [view interactions] High throughput no no
NDUC2_HUMAN [view interactions] High throughput no yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
COT2_HUMAN [view interactions] High throughput no no
ORC5_HUMAN [view interactions] High throughput no yes
APOB_HUMAN [view interactions] High throughput no no
RN5A_HUMAN [view interactions] High throughput no yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
SNG2_HUMAN [view interactions] High throughput no no
DAAF5_HUMAN [view interactions] High throughput no no
COG1_HUMAN [view interactions] High throughput no yes
S2552_HUMAN [view interactions] High throughput no no
PDXD1_HUMAN [view interactions] High throughput no no
COG2_HUMAN [view interactions] High throughput no no
MTFP1_HUMAN [view interactions] High throughput no no
EXOC2_HUMAN [view entry] [view interactions] High throughput yes no
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
SYRM_HUMAN [view interactions] High throughput no yes
SCMC2_HUMAN [view interactions] High throughput no yes
CL16A_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
GP151_HUMAN [view interactions] High throughput no no
MFSD5_HUMAN [view interactions] High throughput no yes
FHR5_HUMAN [view interactions] High throughput no no
NKG7_HUMAN [view interactions] High throughput no no
CXCR2_HUMAN [view interactions] High throughput no no
CTR1_HUMAN [view interactions] High throughput no no
TOM6_HUMAN [view interactions] High throughput no yes
TM109_HUMAN [view interactions] High throughput no yes
CKLF5_HUMAN [view interactions] High throughput no yes
BRID5_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
MZT2B_HUMAN [view interactions] High throughput no yes
TPC2A_HUMAN [view interactions] High throughput no yes
UBXN8_HUMAN [view interactions] High throughput no yes
KNTC1_HUMAN [view interactions] High throughput no no
MFSD8_HUMAN [view interactions] High throughput no yes
ADCK1_HUMAN [view interactions] High throughput no no
BTAF1_HUMAN [view interactions] High throughput no no
ORML3_HUMAN [view interactions] High throughput no no
DD19B_HUMAN [view interactions] High throughput no yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
GCP2_HUMAN [view interactions] High throughput no yes
ORML2_HUMAN [view interactions] High throughput no no
SERC1_HUMAN [view interactions] High throughput no yes
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
INT5_HUMAN [view interactions] High throughput no no
VPS52_HUMAN [view entry] [view interactions] High throughput yes no
DYM_HUMAN [view interactions] High throughput no yes
CD320_HUMAN [view interactions] High throughput no yes
STK39_HUMAN [view entry] [view interactions] High throughput yes yes
GCP4_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
T126B_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
NFIP1_HUMAN [view interactions] High throughput no yes
GET1_HUMAN [view interactions] High throughput no yes
MPC2_HUMAN [view interactions] High throughput no yes
TTI2_HUMAN [view interactions] High throughput no yes
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD4_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
MTX3_HUMAN [view interactions] High throughput no yes
ELOV4_HUMAN [view interactions] High throughput no no
S35B2_HUMAN [view interactions] High throughput no no