VMAT2_HUMAN
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed). Requisite for vesicular amine storage prior to secretion via exocytosis. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VMAT2_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 23.8095 | 4 | no |
GO:0008324 | monoatomic cation transmembrane transporter activity | 14.2857 | 4 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 14.2857 | 6 | yes |
GO:0015291 | secondary active transmembrane transporter activity | 14.2857 | 4 | yes |
GO:0015293 | symporter activity | 14.2857 | 5 | yes |
GO:0015294 | solute:monoatomic cation symporter activity | 14.2857 | 5 | yes |
GO:0015370 | solute:sodium symporter activity | 14.2857 | 6 | yes |
GO:0022853 | active monoatomic ion transmembrane transporter activity | 14.2857 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 14.2857 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 14.2857 | 5 | yes |
GO:0008504 | monoamine transmembrane transporter activity | 9.5238 | 4 | yes |
GO:0008509 | monoatomic anion transmembrane transporter activity | 9.5238 | 4 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 9.5238 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 9.5238 | 5 | yes |
GO:0015296 | monoatomic anion:monoatomic cation symporter activity | 9.5238 | 5 | yes |
GO:0015373 | monoatomic anion:sodium symporter activity | 9.5238 | 6 | yes |
GO:0015377 | chloride:monoatomic cation symporter activity | 9.5238 | 6 | yes |
GO:0015378 | sodium:chloride symporter activity | 9.5238 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VMAT2_HUMAN |
---|---|---|---|---|
GO:0071702 | organic substance transport | 57.1429 | 4 | yes |
GO:0071705 | nitrogen compound transport | 52.3810 | 4 | yes |
GO:0008104 | protein localization | 52.3810 | 4 | no |
GO:0046903 | secretion | 47.6190 | 4 | yes |
GO:0061024 | membrane organization | 47.6190 | 4 | no |
GO:0015031 | protein transport | 38.0952 | 4 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
GO:0007005 | mitochondrion organization | 28.5714 | 5 | no |
GO:0006836 | neurotransmitter transport | 23.8095 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 23.8095 | 4 | yes |
GO:0098657 | import into cell | 23.8095 | 4 | yes |
GO:0010646 | regulation of cell communication | 23.8095 | 4 | no |
GO:0048278 | vesicle docking | 23.8095 | 4 | no |
GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
GO:0001504 | neurotransmitter uptake | 19.0476 | 5 | yes |
GO:0015850 | organic hydroxy compound transport | 19.0476 | 5 | yes |
GO:0009914 | hormone transport | 14.2857 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 14.2857 | 4 | yes |
GO:0015844 | monoamine transport | 14.2857 | 5 | yes |
GO:0015872 | dopamine transport | 14.2857 | 7 | yes |
GO:0023061 | signal release | 14.2857 | 4 | yes |
GO:0046879 | hormone secretion | 14.2857 | 5 | yes |
GO:0051937 | catecholamine transport | 14.2857 | 6 | yes |
GO:0098810 | neurotransmitter reuptake | 14.2857 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 9.5238 | 7 | yes |
GO:0009889 | regulation of biosynthetic process | 9.5238 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 9.5238 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 9.5238 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 9.5238 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 9.5238 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 9.5238 | 6 | yes |
GO:0099536 | synaptic signaling | 9.5238 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 9.5238 | 5 | yes |
GO:1903426 | regulation of reactive oxygen species biosynthetic process | 9.5238 | 5 | yes |
GO:1903427 | negative regulation of reactive oxygen species biosynthetic process | 9.5238 | 6 | yes |
GO:2000377 | regulation of reactive oxygen species metabolic process | 9.5238 | 5 | yes |
GO:2000378 | negative regulation of reactive oxygen species metabolic process | 9.5238 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TY3H_HUMAN | [view interactions] | Low throughput | no | no |
DDC_HUMAN | [view interactions] | Low throughput | no | no |
DHB7_HUMAN | [view interactions] | High throughput | no | yes |
RAB32_HUMAN | [view interactions] | High throughput | no | yes |
GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEK6_HUMAN | [view interactions] | High throughput | no | yes |
PM34_HUMAN | [view interactions] | High throughput | no | yes |
YLAT2_HUMAN | [view interactions] | High throughput | no | no |
TTK_HUMAN | [view interactions] | High throughput | no | yes |
ATLA3_HUMAN | [view interactions] | High throughput | no | no |
VPS50_HUMAN | [view interactions] | High throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
EBP_HUMAN | [view interactions] | High throughput | no | no |
TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PXMP2_HUMAN | [view interactions] | High throughput | no | no |
HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S2533_HUMAN | [view interactions] | High throughput | no | yes |
COQ5_HUMAN | [view interactions] | High throughput | no | yes |
HACD2_HUMAN | [view interactions] | High throughput | no | yes |
PEX16_HUMAN | [view interactions] | High throughput | no | yes |
DOLK_HUMAN | [view interactions] | High throughput | no | no |
TFB2M_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STML1_HUMAN | [view interactions] | High throughput | no | yes |
OTUL_HUMAN | [view interactions] | High throughput | no | yes |
AB17B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MCU_HUMAN | [view interactions] | High throughput | no | yes |
TLCD4_HUMAN | [view interactions] | High throughput | no | no |
RB39B_HUMAN | [view interactions] | High throughput | no | no |
NDUC2_HUMAN | [view interactions] | High throughput | no | yes |
ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COT2_HUMAN | [view interactions] | High throughput | no | no |
ORC5_HUMAN | [view interactions] | High throughput | no | yes |
APOB_HUMAN | [view interactions] | High throughput | no | no |
RN5A_HUMAN | [view interactions] | High throughput | no | yes |
EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNG2_HUMAN | [view interactions] | High throughput | no | no |
DAAF5_HUMAN | [view interactions] | High throughput | no | no |
COG1_HUMAN | [view interactions] | High throughput | no | yes |
S2552_HUMAN | [view interactions] | High throughput | no | no |
PDXD1_HUMAN | [view interactions] | High throughput | no | no |
COG2_HUMAN | [view interactions] | High throughput | no | no |
MTFP1_HUMAN | [view interactions] | High throughput | no | no |
EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCMC1_HUMAN | [view interactions] | High throughput | no | no |
SYRM_HUMAN | [view interactions] | High throughput | no | yes |
SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
GP151_HUMAN | [view interactions] | High throughput | no | no |
MFSD5_HUMAN | [view interactions] | High throughput | no | yes |
FHR5_HUMAN | [view interactions] | High throughput | no | no |
NKG7_HUMAN | [view interactions] | High throughput | no | no |
CXCR2_HUMAN | [view interactions] | High throughput | no | no |
CTR1_HUMAN | [view interactions] | High throughput | no | no |
TOM6_HUMAN | [view interactions] | High throughput | no | yes |
TM109_HUMAN | [view interactions] | High throughput | no | yes |
CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
BRID5_HUMAN | [view interactions] | High throughput | no | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
MZT2B_HUMAN | [view interactions] | High throughput | no | yes |
TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
KNTC1_HUMAN | [view interactions] | High throughput | no | no |
MFSD8_HUMAN | [view interactions] | High throughput | no | yes |
ADCK1_HUMAN | [view interactions] | High throughput | no | no |
BTAF1_HUMAN | [view interactions] | High throughput | no | no |
ORML3_HUMAN | [view interactions] | High throughput | no | no |
DD19B_HUMAN | [view interactions] | High throughput | no | yes |
MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCP2_HUMAN | [view interactions] | High throughput | no | yes |
ORML2_HUMAN | [view interactions] | High throughput | no | no |
SERC1_HUMAN | [view interactions] | High throughput | no | yes |
S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INT5_HUMAN | [view interactions] | High throughput | no | no |
VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYM_HUMAN | [view interactions] | High throughput | no | yes |
CD320_HUMAN | [view interactions] | High throughput | no | yes |
STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCP4_HUMAN | [view interactions] | High throughput | no | yes |
FUND2_HUMAN | [view interactions] | High throughput | no | yes |
T126B_HUMAN | [view interactions] | High throughput | no | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
NFIP1_HUMAN | [view interactions] | High throughput | no | yes |
GET1_HUMAN | [view interactions] | High throughput | no | yes |
MPC2_HUMAN | [view interactions] | High throughput | no | yes |
TTI2_HUMAN | [view interactions] | High throughput | no | yes |
EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
JAK1_HUMAN | [view interactions] | High throughput | no | yes |
TELO2_HUMAN | [view interactions] | High throughput | no | yes |
MTX3_HUMAN | [view interactions] | High throughput | no | yes |
ELOV4_HUMAN | [view interactions] | High throughput | no | no |
S35B2_HUMAN | [view interactions] | High throughput | no | no |