VMAT2_HUMAN
Evidence for PS localization
Functions
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed). Requisite for vesicular amine storage prior to secretion via exocytosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VMAT2_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0008509 | anion transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0008504 | monoamine transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 9.5238 | 6 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 9.5238 | 5 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0015293 | symporter activity | 9.5238 | 5 | yes |
| GO:0015294 | solute:cation symporter activity | 9.5238 | 5 | yes |
| GO:0015296 | anion:cation symporter activity | 9.5238 | 5 | yes |
| GO:0015370 | solute:sodium symporter activity | 9.5238 | 6 | yes |
| GO:0015373 | anion:sodium symporter activity | 9.5238 | 6 | yes |
| GO:0015377 | cation:chloride symporter activity | 9.5238 | 6 | yes |
| GO:0015378 | sodium:chloride symporter activity | 9.5238 | 7 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 9.5238 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VMAT2_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 57.1429 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 57.1429 | 4 | yes |
| GO:0008104 | protein localization | 47.6190 | 4 | no |
| GO:0015031 | protein transport | 42.8571 | 4 | no |
| GO:0046903 | secretion | 42.8571 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 38.0952 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0007005 | mitochondrion organization | 28.5714 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
| GO:0061024 | membrane organization | 28.5714 | 4 | no |
| GO:0006836 | neurotransmitter transport | 23.8095 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 23.8095 | 4 | yes |
| GO:0010646 | regulation of cell communication | 23.8095 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 23.8095 | 5 | no |
| GO:0006887 | exocytosis | 23.8095 | 4 | no |
| GO:0006811 | ion transport | 19.0476 | 4 | yes |
| GO:0006812 | cation transport | 19.0476 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 14.2857 | 4 | yes |
| GO:0015844 | monoamine transport | 14.2857 | 5 | yes |
| GO:0015850 | organic hydroxy compound transport | 14.2857 | 5 | yes |
| GO:0015872 | dopamine transport | 14.2857 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 14.2857 | 4 | yes |
| GO:0051937 | catecholamine transport | 14.2857 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 9.5238 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 9.5238 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 9.5238 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 9.5238 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 9.5238 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 9.5238 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 9.5238 | 4 | yes |
| GO:1903426 | regulation of reactive oxygen species biosynthetic process | 9.5238 | 5 | yes |
| GO:1903427 | negative regulation of reactive oxygen species biosynthetic process | 9.5238 | 6 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 9.5238 | 5 | yes |
| GO:2000378 | negative regulation of reactive oxygen species metabolic process | 9.5238 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TY3H_HUMAN | [view interactions] | Low throughput | no | no |
| DDC_HUMAN | [view interactions] | Low throughput | no | no |
| COG2_HUMAN | [view interactions] | High throughput | no | no |
| MTFP1_HUMAN | [view interactions] | High throughput | no | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| GP151_HUMAN | [view interactions] | High throughput | no | no |
| MFSD5_HUMAN | [view interactions] | High throughput | no | yes |
| FHR5_HUMAN | [view interactions] | High throughput | no | no |
| NKG7_HUMAN | [view interactions] | High throughput | no | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| SL7A1_HUMAN | [view interactions] | High throughput | no | no |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| TM109_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| MZT2B_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| MFSD8_HUMAN | [view interactions] | High throughput | no | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| BTAF1_HUMAN | [view interactions] | High throughput | no | no |
| ORML3_HUMAN | [view interactions] | High throughput | no | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP2_HUMAN | [view interactions] | High throughput | no | yes |
| ORML2_HUMAN | [view interactions] | High throughput | no | no |
| SERC1_HUMAN | [view interactions] | High throughput | no | yes |
| S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| CD320_HUMAN | [view interactions] | High throughput | no | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| FUND2_HUMAN | [view interactions] | High throughput | no | yes |
| T126B_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| NFIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GET1_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| TTI2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| TELO2_HUMAN | [view interactions] | High throughput | no | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| DHB7_HUMAN | [view interactions] | High throughput | no | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| PM34_HUMAN | [view interactions] | High throughput | no | yes |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| VPS50_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2533_HUMAN | [view interactions] | High throughput | no | yes |
| COQ5_HUMAN | [view interactions] | High throughput | no | yes |
| HACD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX16_HUMAN | [view interactions] | High throughput | no | yes |
| DOLK_HUMAN | [view interactions] | High throughput | no | no |
| TFB2M_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STML1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| AB17B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| NDUC2_HUMAN | [view interactions] | High throughput | no | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COT2_HUMAN | [view interactions] | High throughput | no | no |
| ORC5_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| RN5A_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNG2_HUMAN | [view interactions] | High throughput | no | no |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| COG1_HUMAN | [view interactions] | High throughput | no | yes |
| S2552_HUMAN | [view interactions] | High throughput | no | no |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |