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RAB3A_HUMAN

Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane . Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane . Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed . Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells . Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed, PubMed). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT . Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB3A_HUMAN
GO:0017076 purine nucleotide binding 28.3784 4 yes
GO:0032555 purine ribonucleotide binding 28.3784 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.3784 4 yes
GO:0046872 metal ion binding 25.6757 4 no
GO:0005524 ATP binding 20.2703 5 no
GO:0030554 adenyl nucleotide binding 20.2703 5 no
GO:0032559 adenyl ribonucleotide binding 20.2703 5 no
GO:0016462 pyrophosphatase activity 14.8649 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 14.8649 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 14.8649 6 yes
GO:0005525 GTP binding 9.4595 5 yes
GO:0019001 guanyl nucleotide binding 9.4595 5 yes
GO:0032561 guanyl ribonucleotide binding 9.4595 5 yes
GO:0003924 GTPase activity 8.1081 7 yes
GO:0017022 myosin binding 4.0541 4 yes
GO:0031489 myosin V binding 2.7027 5 yes
GO:0051117 ATPase binding 2.7027 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAB3A_HUMAN
GO:0051049 regulation of transport 51.3514 4 yes
GO:0008104 protein localization 47.2973 4 yes
GO:0010646 regulation of cell communication 45.9459 4 yes
GO:0048522 positive regulation of cellular process 45.9459 4 yes
GO:0016192 vesicle-mediated transport 44.5946 4 yes
GO:0071702 organic substance transport 44.5946 4 yes
GO:0071705 nitrogen compound transport 44.5946 4 yes
GO:0051128 regulation of cellular component organization 41.8919 4 yes
GO:0015031 protein transport 40.5405 4 yes
GO:0046903 secretion 37.8378 4 yes
GO:0031323 regulation of cellular metabolic process 35.1351 4 no
GO:0060255 regulation of macromolecule metabolic process 35.1351 4 no
GO:0080090 regulation of primary metabolic process 35.1351 4 no
GO:0006996 organelle organization 33.7838 4 yes
GO:0048523 negative regulation of cellular process 33.7838 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.4324 4 no
GO:0050804 modulation of chemical synaptic transmission 31.0811 5 yes
GO:0099177 regulation of trans-synaptic signaling 31.0811 4 yes
GO:0022607 cellular component assembly 31.0811 4 no
GO:0009893 positive regulation of metabolic process 31.0811 4 no
GO:0023061 signal release 29.7297 4 yes
GO:0051046 regulation of secretion 29.7297 5 yes
GO:0060627 regulation of vesicle-mediated transport 29.7297 4 yes
GO:0023056 positive regulation of signaling 29.7297 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.7297 5 no
GO:1903530 regulation of secretion by cell 28.3784 4 yes
GO:0010647 positive regulation of cell communication 28.3784 5 no
GO:0009966 regulation of signal transduction 28.3784 4 no
GO:0043269 regulation of ion transport 27.0270 5 yes
GO:0099643 signal release from synapse 27.0270 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 27.0270 5 no
GO:0051246 regulation of protein metabolic process 27.0270 5 no
GO:0006887 exocytosis 25.6757 4 yes
GO:0031325 positive regulation of cellular metabolic process 25.6757 5 no
GO:0006836 neurotransmitter transport 24.3243 4 yes
GO:0017157 regulation of exocytosis 24.3243 5 yes
GO:0051050 positive regulation of transport 24.3243 4 yes
GO:0072657 protein localization to membrane 24.3243 4 yes
GO:0010468 regulation of gene expression 24.3243 5 no
GO:0048584 positive regulation of response to stimulus 24.3243 4 no
GO:0051247 positive regulation of protein metabolic process 24.3243 6 no
GO:0043933 protein-containing complex organization 22.9730 4 no
GO:0009892 negative regulation of metabolic process 22.9730 4 no
GO:0071310 cellular response to organic substance 22.9730 4 no
GO:0009889 regulation of biosynthetic process 21.6216 4 no
GO:0010941 regulation of cell death 21.6216 4 no
GO:0031324 negative regulation of cellular metabolic process 21.6216 5 no
GO:0007268 chemical synaptic transmission 20.2703 6 yes
GO:0045055 regulated exocytosis 20.2703 5 yes
GO:0098916 anterograde trans-synaptic signaling 20.2703 5 yes
GO:0099537 trans-synaptic signaling 20.2703 4 yes
GO:0065003 protein-containing complex assembly 20.2703 5 no
GO:0009967 positive regulation of signal transduction 20.2703 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.2703 5 no
GO:0031326 regulation of cellular biosynthetic process 20.2703 5 no
GO:0042981 regulation of apoptotic process 20.2703 6 no
GO:0043067 regulation of programmed cell death 20.2703 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.2703 5 no
GO:1902531 regulation of intracellular signal transduction 20.2703 5 no
GO:0044087 regulation of cellular component biogenesis 18.9189 4 yes
GO:0099003 vesicle-mediated transport in synapse 18.9189 5 yes
GO:0007269 neurotransmitter secretion 17.5676 4 yes
GO:0033043 regulation of organelle organization 17.5676 5 yes
GO:0061024 membrane organization 17.5676 4 yes
GO:0016079 synaptic vesicle exocytosis 16.2162 4 yes
GO:0030030 cell projection organization 16.2162 4 yes
GO:0046928 regulation of neurotransmitter secretion 16.2162 4 yes
GO:0051588 regulation of neurotransmitter transport 16.2162 5 yes
GO:0017156 calcium-ion regulated exocytosis 14.8649 6 yes
GO:0034330 cell junction organization 14.8649 4 yes
GO:0050808 synapse organization 14.8649 5 yes
GO:1990778 protein localization to cell periphery 14.8649 5 yes
GO:0048278 vesicle docking 13.5135 4 yes
GO:1903305 regulation of regulated secretory pathway 13.5135 6 yes
GO:0051952 regulation of amine transport 12.1622 5 yes
GO:0007005 mitochondrion organization 10.8108 5 yes
GO:0009306 protein secretion 10.8108 4 yes
GO:0035592 establishment of protein localization to extracellular region 10.8108 4 yes
GO:0043254 regulation of protein-containing complex assembly 10.8108 5 yes
GO:0071692 protein localization to extracellular region 10.8108 5 yes
GO:0072659 protein localization to plasma membrane 10.8108 5 yes
GO:0016050 vesicle organization 9.4595 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 9.4595 4 yes
GO:0051047 positive regulation of secretion 9.4595 5 yes
GO:0051650 establishment of vesicle localization 9.4595 4 yes
GO:0097479 synaptic vesicle localization 9.4595 4 yes
GO:1903532 positive regulation of secretion by cell 9.4595 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 9.4595 5 yes
GO:0031338 regulation of vesicle fusion 6.7568 5 yes
GO:0032990 cell part morphogenesis 6.7568 4 yes
GO:0045921 positive regulation of exocytosis 6.7568 6 yes
GO:0048812 neuron projection morphogenesis 6.7568 7 yes
GO:0048858 cell projection morphogenesis 6.7568 5 yes
GO:0050433 regulation of catecholamine secretion 6.7568 5 yes
GO:0097091 synaptic vesicle clustering 6.7568 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 6.7568 6 yes
GO:0007409 axonogenesis 5.4054 8 yes
GO:0014059 regulation of dopamine secretion 5.4054 6 yes
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane 5.4054 6 yes
GO:0048172 regulation of short-term neuronal synaptic plasticity 5.4054 5 yes
GO:1901632 regulation of synaptic vesicle membrane organization 5.4054 5 yes
GO:1903307 positive regulation of regulated secretory pathway 5.4054 7 yes
GO:0007009 plasma membrane organization 4.0541 5 yes
GO:0010807 regulation of synaptic vesicle priming 4.0541 6 yes
GO:0048489 synaptic vesicle transport 4.0541 4 yes
GO:1990709 presynaptic active zone organization 4.0541 4 yes
GO:0001778 plasma membrane repair 2.7027 6 yes
GO:0007274 neuromuscular synaptic transmission 2.7027 7 yes
GO:0007600 sensory perception 2.7027 4 yes
GO:0030324 lung development 2.7027 4 yes
GO:0032418 lysosome localization 2.7027 4 yes
GO:0034331 cell junction maintenance 2.7027 5 yes
GO:0043954 cellular component maintenance 2.7027 4 yes
GO:0099558 maintenance of synapse structure 2.7027 6 yes
GO:1903729 regulation of plasma membrane organization 2.7027 5 yes
GO:1905684 regulation of plasma membrane repair 2.7027 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in RAB3A_HUMAN
DOID:331 central nervous system disease 5.4054 3 no
DOID:0050700 cardiomyopathy 2.7027 4 no
DOID:0060036 intrinsic cardiomyopathy 2.7027 5 no
DOID:114 heart disease 2.7027 3 no
DOID:2843 long QT syndrome 2.7027 6 no
DOID:0050890 synucleinopathy 2.7027 5 no
DOID:1289 neurodegenerative disease 2.7027 4 no
DOID:14330 Parkinsons disease 2.7027 6 no
DOID:0050155 sensory system disease 2.7027 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB4B_HUMAN [view entry] [view interactions] Low throughput yes no
OCRL_HUMAN [view interactions] Low throughput no yes
PGTB2_HUMAN [view interactions] Low throughput no yes
SGSM2_HUMAN [view interactions] Low throughput no yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMS2_HUMAN [view entry] [view interactions] Low throughput yes no
RPH3L_HUMAN [view interactions] Low throughput no no
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
PRAF1_HUMAN [view interactions] Low throughput no yes
RAB3I_HUMAN [view interactions] Low throughput no no
SYTL5_HUMAN [view interactions] Low throughput no no
SYTL4_HUMAN [view interactions] Low throughput no yes
GDIA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAE2_HUMAN [view interactions] Low throughput no yes
RAE1_HUMAN [view interactions] Low throughput no yes
MELPH_HUMAN [view interactions] Low throughput no yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
MSS4_HUMAN [view interactions] Low throughput no yes
RAB12_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
ACM5_HUMAN [view entry] [view interactions] High throughput yes no
CRNL1_HUMAN [view interactions] High throughput no no
AT131_HUMAN [view entry] [view interactions] High throughput yes no
RUVB2_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
ATS7_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT4_HUMAN [view interactions] High throughput no yes
ATPMK_HUMAN [view interactions] High throughput no no
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
F227B_HUMAN [view interactions] High throughput no yes
XPOT_HUMAN [view interactions] High throughput no no
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
RU2A_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
A2MG_HUMAN [view interactions] High throughput no yes
AP1M2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ECSIT_HUMAN [view interactions] High throughput no yes
RNF32_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
CAF17_HUMAN [view interactions] High throughput no no
WIPI3_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
MTLR_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
VMAT2_HUMAN [view entry] [view interactions] High throughput yes no
EPHA8_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
GET4_HUMAN [view interactions] High throughput no yes
OST4_HUMAN [view interactions] High throughput no no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
APLP1_HUMAN [view interactions] High throughput no yes
CALB2_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
NEC2_HUMAN [view interactions] High throughput no no
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
NUFP1_HUMAN [view interactions] High throughput no yes
S15A1_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
VW5B2_HUMAN [view interactions] High throughput no yes
MOG1_HUMAN [view interactions] High throughput no yes
RB33B_HUMAN [view interactions] High throughput no no
MOCOS_HUMAN [view interactions] High throughput no no
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
BICL2_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TIMP2_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
ANGI_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CD177_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
MAST1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
KR108_HUMAN [view interactions] High throughput no no
R3GEF_HUMAN [view interactions] High throughput no yes
VRTN_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
ACM4_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3D_HUMAN [view interactions] High throughput no yes
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
SSRD_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
RB39B_HUMAN [view interactions] High throughput no no
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
CTCFL_HUMAN [view interactions] High throughput no no
MADD_HUMAN [view entry] [view interactions] Computational yes yes
VAMP2_HUMAN [view entry] [view interactions] Computational yes no
LIN7C_HUMAN [view entry] [view interactions] Computational yes yes
LIPA3_HUMAN [view entry] [view interactions] Computational yes yes
STX1A_HUMAN [view entry] [view interactions] Computational yes yes
VIAAT_HUMAN [view interactions] Computational no yes
RIMB1_HUMAN [view interactions] Computational no yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
MYH9_HUMAN [view entry] [view interactions] Computational yes no
SYT1_HUMAN [view entry] [view interactions] Computational yes no
LIN7B_HUMAN [view entry] [view interactions] Computational yes no
KIF1A_HUMAN [view entry] [view interactions] Computational yes no
VACHT_HUMAN [view interactions] Computational no no
PCLO_HUMAN [view entry] [view interactions] Computational yes yes
STXB1_HUMAN [view entry] [view interactions] Computational yes yes
SV2A_HUMAN [view entry] [view interactions] Computational yes yes
UN13B_HUMAN [view interactions] Computational no no
VGLU1_HUMAN [view entry] [view interactions] Computational yes no
DNJC5_HUMAN [view interactions] Computational no yes
SYN2_HUMAN [view entry] [view interactions] Computational yes no
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes
UN13A_HUMAN [view entry] [view interactions] Computational yes no
RB3GP_HUMAN [view entry] [view interactions] Computational yes yes
APBA1_HUMAN [view interactions] Computational no no
CPLX1_HUMAN [view entry] [view interactions] Computational yes yes
SYN3_HUMAN [view entry] [view interactions] Computational yes yes