Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RIMS2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RIMS2_HUMAN
GO:0000166 nucleotide binding 38.0952 4 no
GO:0017076 purine nucleotide binding 38.0952 5 no
GO:0032555 purine ribonucleotide binding 38.0952 4 no
GO:0043168 anion binding 38.0952 4 no
GO:0043169 cation binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 5 yes
GO:0031267 small GTPase binding 28.5714 5 yes
GO:0051020 GTPase binding 28.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0030554 adenyl nucleotide binding 23.8095 6 no
GO:0032559 adenyl ribonucleotide binding 23.8095 5 no
GO:0030695 GTPase regulator activity 23.8095 4 no
GO:0019900 kinase binding 23.8095 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RIMS2_HUMAN
GO:0008104 protein localization 71.4286 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0051049 regulation of transport 61.9048 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0046903 secretion 52.3810 4 yes
GO:0050804 modulation of chemical synaptic transmission 52.3810 5 yes
GO:0071702 organic substance transport 52.3810 4 yes
GO:0071705 nitrogen compound transport 52.3810 4 yes
GO:0099177 regulation of trans-synaptic signaling 52.3810 4 yes
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0015031 protein transport 47.6190 4 yes
GO:0060627 regulation of vesicle-mediated transport 47.6190 4 yes
GO:0006996 organelle organization 47.6190 4 no
GO:0017157 regulation of exocytosis 42.8571 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 42.8571 4 yes
GO:0051046 regulation of secretion 42.8571 5 yes
GO:1903530 regulation of secretion by cell 42.8571 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0023061 signal release 38.0952 4 yes
GO:0045055 regulated exocytosis 38.0952 4 yes
GO:0009893 positive regulation of metabolic process 38.0952 4 no
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 no
GO:0048523 negative regulation of cellular process 38.0952 4 no
GO:0080090 regulation of primary metabolic process 38.0952 4 no
GO:0009966 regulation of signal transduction 33.3333 4 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0009306 protein secretion 28.5714 4 yes
GO:0016079 synaptic vesicle exocytosis 28.5714 4 yes
GO:0017156 calcium-ion regulated exocytosis 28.5714 5 yes
GO:0035592 establishment of protein localization to extracellular region 28.5714 4 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0071692 protein localization to extracellular region 28.5714 5 yes
GO:0099643 signal release from synapse 28.5714 5 yes
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0009914 hormone transport 23.8095 4 yes
GO:0009967 positive regulation of signal transduction 23.8095 5 yes
GO:0022604 regulation of cell morphogenesis 23.8095 5 yes
GO:0046879 hormone secretion 23.8095 5 yes
GO:1903305 regulation of regulated secretory pathway 23.8095 6 yes
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0001934 positive regulation of protein phosphorylation 23.8095 8 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0009892 negative regulation of metabolic process 23.8095 4 no
GO:0010468 regulation of gene expression 23.8095 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.8095 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0034762 regulation of transmembrane transport 23.8095 4 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051247 positive regulation of protein metabolic process 23.8095 6 no
GO:0051248 negative regulation of protein metabolic process 23.8095 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:0048812 neuron projection morphogenesis 23.8095 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.8095 4 no
GO:0141124 intracellular signaling cassette 23.8095 4 no
GO:0016050 vesicle organization 23.8095 5 no
GO:0002790 peptide secretion 19.0476 5 yes
GO:0006886 intracellular protein transport 19.0476 4 yes
GO:0015833 peptide transport 19.0476 5 yes
GO:0030072 peptide hormone secretion 19.0476 6 yes
GO:0030073 insulin secretion 19.0476 5 yes
GO:0042886 amide transport 19.0476 5 yes
GO:0044057 regulation of system process 19.0476 4 yes
GO:0046928 regulation of neurotransmitter secretion 19.0476 5 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 19.0476 5 yes
GO:0050806 positive regulation of synaptic transmission 19.0476 5 yes
GO:0051240 positive regulation of multicellular organismal process 19.0476 4 yes
GO:0051588 regulation of neurotransmitter transport 19.0476 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 19.0476 6 yes
GO:0001558 regulation of cell growth 14.2857 4 yes
GO:0006836 neurotransmitter transport 14.2857 4 yes
GO:0007269 neurotransmitter secretion 14.2857 4 yes
GO:0030307 positive regulation of cell growth 14.2857 5 yes
GO:0031644 regulation of nervous system process 14.2857 5 yes
GO:0045927 positive regulation of growth 14.2857 4 yes
GO:0048638 regulation of developmental growth 14.2857 4 yes
GO:0048639 positive regulation of developmental growth 14.2857 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 14.2857 4 yes
GO:1903859 regulation of dendrite extension 14.2857 5 yes
GO:1903861 positive regulation of dendrite extension 14.2857 6 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 14.2857 5 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 9.5238 4 yes
GO:0031646 positive regulation of nervous system process 9.5238 5 yes
GO:0097151 positive regulation of inhibitory postsynaptic potential 9.5238 5 yes
GO:0098828 modulation of inhibitory postsynaptic potential 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RB6I2_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3C_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB3B_HUMAN [view interactions] High throughput no no
RAB3D_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
GBRL1_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
RIMS3_HUMAN [view entry] [view interactions] High throughput yes no
ZDH15_HUMAN [view entry] [view interactions] High throughput yes yes
ARSB_HUMAN [view interactions] High throughput no yes
MIPEP_HUMAN [view interactions] High throughput no yes
XDH_HUMAN [view interactions] High throughput no no