ZDH15_HUMAN
Evidence for PS localization
Functions
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed, PubMed). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA . Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis . Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon . Could also catalyze the palmitoylation of GAP43 . Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane . Could also palmitoylate FYN as shown in vitro (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZDH15_HUMAN |
|---|---|---|---|---|
| GO:0008270 | zinc ion binding | 18.1818 | 6 | yes |
| GO:0016409 | palmitoyltransferase activity | 18.1818 | 5 | yes |
| GO:0016417 | S-acyltransferase activity | 18.1818 | 5 | yes |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 18.1818 | 4 | yes |
| GO:0019107 | myristoyltransferase activity | 18.1818 | 5 | yes |
| GO:0019705 | protein-cysteine S-myristoyltransferase activity | 18.1818 | 4 | yes |
| GO:0019706 | protein-cysteine S-palmitoyltransferase activity | 18.1818 | 4 | yes |
| GO:0046872 | metal ion binding | 18.1818 | 4 | yes |
| GO:0046914 | transition metal ion binding | 18.1818 | 5 | yes |
| GO:0140439 | protein-cysteine S-stearoyltransferase activity | 18.1818 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZDH15_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 63.6364 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 63.6364 | 4 | yes |
| GO:0006996 | organelle organization | 54.5455 | 4 | yes |
| GO:0008104 | protein localization | 54.5455 | 4 | yes |
| GO:0015031 | protein transport | 54.5455 | 4 | yes |
| GO:0006886 | intracellular protein transport | 45.4545 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | yes |
| GO:0016050 | vesicle organization | 36.3636 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | yes |
| GO:0061024 | membrane organization | 36.3636 | 4 | no |
| GO:0006497 | protein lipidation | 27.2727 | 5 | yes |
| GO:0006605 | protein targeting | 27.2727 | 5 | yes |
| GO:0006612 | protein targeting to membrane | 27.2727 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 27.2727 | 5 | yes |
| GO:0018198 | peptidyl-cysteine modification | 27.2727 | 6 | yes |
| GO:0018230 | peptidyl-L-cysteine S-palmitoylation | 27.2727 | 7 | yes |
| GO:0018231 | peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine | 27.2727 | 7 | yes |
| GO:0018345 | protein palmitoylation | 27.2727 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.2727 | 4 | yes |
| GO:0033365 | protein localization to organelle | 27.2727 | 5 | yes |
| GO:0036211 | protein modification process | 27.2727 | 4 | yes |
| GO:0043412 | macromolecule modification | 27.2727 | 4 | yes |
| GO:0043543 | protein acylation | 27.2727 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 27.2727 | 4 | yes |
| GO:0072657 | protein localization to membrane | 27.2727 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 27.2727 | 4 | yes |
| GO:0006811 | ion transport | 27.2727 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0010976 | positive regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0031344 | regulation of cell projection organization | 18.1818 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 18.1818 | 6 | yes |
| GO:0034067 | protein localization to Golgi apparatus | 18.1818 | 6 | yes |
| GO:0035418 | protein localization to synapse | 18.1818 | 6 | yes |
| GO:0050773 | regulation of dendrite development | 18.1818 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 18.1818 | 5 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 18.1818 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 18.1818 | 7 | yes |
| GO:0099175 | regulation of postsynapse organization | 18.1818 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.1818 | 6 | yes |
| GO:0140450 | protein targeting to Golgi apparatus | 18.1818 | 5 | yes |
| GO:1900006 | positive regulation of dendrite development | 18.1818 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 18.1818 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ORML1_HUMAN | [view interactions] | High throughput | no | no |
| CP4F2_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACAN_HUMAN | [view interactions] | High throughput | no | no |
| C2C2L_HUMAN | [view interactions] | High throughput | no | yes |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| MCEM1_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC10_HUMAN | [view interactions] | High throughput | no | yes |
| LSME1_HUMAN | [view interactions] | High throughput | no | no |
| TR10B_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| CLRN1_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEFF2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| TM222_HUMAN | [view interactions] | High throughput | no | no |
| NRAC_HUMAN | [view interactions] | High throughput | no | no |
| LEMD1_HUMAN | [view interactions] | High throughput | no | no |
| TM14C_HUMAN | [view interactions] | High throughput | no | no |
| BNIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLLP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM42_HUMAN | [view interactions] | High throughput | no | no |
| SNORC_HUMAN | [view interactions] | High throughput | no | yes |
| PEX16_HUMAN | [view interactions] | High throughput | no | yes |
| ORML2_HUMAN | [view interactions] | High throughput | no | no |
| SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| DHRSX_HUMAN | [view interactions] | High throughput | no | yes |
| GIMA1_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| GT253_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| CEL2B_HUMAN | [view interactions] | High throughput | no | no |
| GOG7B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| TOX3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TA2R_HUMAN | [view interactions] | High throughput | no | no |
| PACR_HUMAN | [view interactions] | High throughput | no | no |
| TM128_HUMAN | [view interactions] | High throughput | no | yes |
| TSNA1_HUMAN | [view interactions] | High throughput | no | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |