Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BNIP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004487 LIG_LIR_Gen_1 LIG 82 88 -
ELMI004487 LIG_LIR_Gen_1 LIG 82 88 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BNIP3_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0008270 zinc ion binding 22.2222 7 no
GO:0046914 transition metal ion binding 22.2222 6 no
GO:0042803 protein homodimerization activity 11.1111 4 yes
GO:0051020 GTPase binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BNIP3_HUMAN
GO:0048522 positive regulation of cellular process 61.1111 4 yes
GO:0006996 organelle organization 61.1111 4 yes
GO:0042981 regulation of apoptotic process 50.0000 5 yes
GO:0043067 regulation of programmed cell death 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 yes
GO:0071702 organic substance transport 44.4444 4 no
GO:0071705 nitrogen compound transport 44.4444 4 no
GO:0007005 mitochondrion organization 44.4444 5 yes
GO:0031323 regulation of cellular metabolic process 44.4444 4 yes
GO:0048523 negative regulation of cellular process 38.8889 4 yes
GO:0061024 membrane organization 38.8889 4 yes
GO:0015031 protein transport 38.8889 4 no
GO:0006915 apoptotic process 38.8889 4 yes
GO:0009893 positive regulation of metabolic process 38.8889 4 yes
GO:0033043 regulation of organelle organization 33.3333 5 yes
GO:0043066 negative regulation of apoptotic process 33.3333 6 yes
GO:0043069 negative regulation of programmed cell death 33.3333 5 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0007006 mitochondrial membrane organization 33.3333 5 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0010821 regulation of mitochondrion organization 33.3333 6 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 yes
GO:0043065 positive regulation of apoptotic process 27.7778 6 yes
GO:0043068 positive regulation of programmed cell death 27.7778 5 yes
GO:0051129 negative regulation of cellular component organization 27.7778 5 yes
GO:0051130 positive regulation of cellular component organization 27.7778 5 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 27.7778 7 yes
GO:1901701 cellular response to oxygen-containing compound 27.7778 4 yes
GO:0072594 establishment of protein localization to organelle 27.7778 4 no
GO:0072657 protein localization to membrane 27.7778 4 no
GO:0009966 regulation of signal transduction 27.7778 4 no
GO:0010646 regulation of cell communication 27.7778 4 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0043933 protein-containing complex organization 27.7778 4 no
GO:0009894 regulation of catabolic process 27.7778 4 yes
GO:0010506 regulation of autophagy 27.7778 6 yes
GO:0010639 negative regulation of organelle organization 27.7778 6 yes
GO:0022411 cellular component disassembly 27.7778 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 27.7778 4 yes
GO:0031324 negative regulation of cellular metabolic process 27.7778 5 yes
GO:0031329 regulation of cellular catabolic process 27.7778 5 yes
GO:0034599 cellular response to oxidative stress 22.2222 4 yes
GO:0036293 response to decreased oxygen levels 22.2222 4 yes
GO:0036294 cellular response to decreased oxygen levels 22.2222 5 yes
GO:0062197 cellular response to chemical stress 22.2222 4 yes
GO:0071241 cellular response to inorganic substance 22.2222 4 yes
GO:0071248 cellular response to metal ion 22.2222 5 yes
GO:0071453 cellular response to oxygen levels 22.2222 4 yes
GO:1901565 organonitrogen compound catabolic process 22.2222 4 yes
GO:1903008 organelle disassembly 22.2222 5 yes
GO:2000377 regulation of reactive oxygen species metabolic process 22.2222 5 yes
GO:0006839 mitochondrial transport 22.2222 4 no
GO:0070585 protein localization to mitochondrion 22.2222 6 no
GO:0090150 establishment of protein localization to membrane 22.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no
GO:0000422 autophagy of mitochondrion 22.2222 4 yes
GO:0009057 macromolecule catabolic process 22.2222 4 yes
GO:0009896 positive regulation of catabolic process 22.2222 5 yes
GO:0010001 glial cell differentiation 22.2222 4 yes
GO:0010038 response to metal ion 22.2222 4 yes
GO:0010508 positive regulation of autophagy 22.2222 7 yes
GO:0010635 regulation of mitochondrial fusion 22.2222 5 yes
GO:0016241 regulation of macroautophagy 22.2222 7 yes
GO:0030163 protein catabolic process 22.2222 4 yes
GO:0031331 positive regulation of cellular catabolic process 22.2222 6 yes
GO:0034614 cellular response to reactive oxygen species 16.6667 5 yes
GO:0042542 response to hydrogen peroxide 16.6667 4 yes
GO:0048709 oligodendrocyte differentiation 16.6667 5 yes
GO:0051093 negative regulation of developmental process 16.6667 4 yes
GO:0051607 defense response to virus 16.6667 4 yes
GO:0051881 regulation of mitochondrial membrane potential 16.6667 4 yes
GO:0070301 cellular response to hydrogen peroxide 16.6667 5 yes
GO:0071260 cellular response to mechanical stimulus 16.6667 4 yes
GO:0071456 cellular response to hypoxia 16.6667 4 yes
GO:0090140 regulation of mitochondrial fission 16.6667 5 yes
GO:0090141 positive regulation of mitochondrial fission 16.6667 5 yes
GO:0140546 defense response to symbiont 16.6667 4 yes
GO:1903146 regulation of autophagy of mitochondrion 16.6667 7 yes
GO:1903599 positive regulation of autophagy of mitochondrion 16.6667 7 yes
GO:2000378 negative regulation of reactive oxygen species metabolic process 16.6667 6 yes
GO:0000302 response to reactive oxygen species 16.6667 4 yes
GO:0010637 negative regulation of mitochondrial fusion 16.6667 5 yes
GO:0010638 positive regulation of organelle organization 16.6667 6 yes
GO:0010657 muscle cell apoptotic process 16.6667 5 yes
GO:0010658 striated muscle cell apoptotic process 16.6667 6 yes
GO:0010660 regulation of muscle cell apoptotic process 16.6667 6 yes
GO:0010662 regulation of striated muscle cell apoptotic process 16.6667 7 yes
GO:0016239 positive regulation of macroautophagy 16.6667 8 yes
GO:0035694 mitochondrial protein catabolic process 11.1111 5 yes
GO:0035794 positive regulation of mitochondrial membrane permeability 11.1111 5 yes
GO:0035795 negative regulation of mitochondrial membrane permeability 11.1111 5 yes
GO:0036296 response to increased oxygen levels 11.1111 4 yes
GO:0043243 positive regulation of protein-containing complex disassembly 11.1111 6 yes
GO:0043244 regulation of protein-containing complex disassembly 11.1111 5 yes
GO:0043457 regulation of cellular respiration 11.1111 6 yes
GO:0043467 regulation of generation of precursor metabolites and energy 11.1111 5 yes
GO:0043653 mitochondrial fragmentation involved in apoptotic process 11.1111 7 yes
GO:0045444 fat cell differentiation 11.1111 4 yes
GO:0045837 negative regulation of membrane potential 11.1111 4 yes
GO:0046902 regulation of mitochondrial membrane permeability 11.1111 4 yes
GO:0048102 autophagic cell death 11.1111 4 yes
GO:0048678 response to axon injury 11.1111 4 yes
GO:0050873 brown fat cell differentiation 11.1111 5 yes
GO:0051402 neuron apoptotic process 11.1111 5 yes
GO:0051560 mitochondrial calcium ion homeostasis 11.1111 6 yes
GO:0051561 positive regulation of mitochondrial calcium ion concentration 11.1111 7 yes
GO:0055074 calcium ion homeostasis 11.1111 4 yes
GO:0055080 monoatomic cation homeostasis 11.1111 4 yes
GO:0071279 cellular response to cobalt ion 11.1111 6 yes
GO:0090200 positive regulation of release of cytochrome c from mitochondria 11.1111 7 yes
GO:0097193 intrinsic apoptotic signaling pathway 11.1111 4 yes
GO:0097345 mitochondrial outer membrane permeabilization 11.1111 7 yes
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 11.1111 5 yes
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process 11.1111 6 yes
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 11.1111 6 yes
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 11.1111 6 yes
GO:1903715 regulation of aerobic respiration 11.1111 7 yes
GO:1905709 negative regulation of membrane permeability 11.1111 4 yes
GO:1905710 positive regulation of membrane permeability 11.1111 4 yes
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia 11.1111 5 yes
GO:0006873 intracellular monoatomic ion homeostasis 11.1111 4 yes
GO:0006874 intracellular calcium ion homeostasis 11.1111 5 yes
GO:0008637 apoptotic mitochondrial changes 11.1111 6 yes
GO:0010659 cardiac muscle cell apoptotic process 11.1111 7 yes
GO:0010661 positive regulation of muscle cell apoptotic process 11.1111 7 yes
GO:0010663 positive regulation of striated muscle cell apoptotic process 11.1111 8 yes
GO:0010665 regulation of cardiac muscle cell apoptotic process 11.1111 8 yes
GO:0010666 positive regulation of cardiac muscle cell apoptotic process 11.1111 9 yes
GO:0010917 negative regulation of mitochondrial membrane potential 11.1111 5 yes
GO:0030003 intracellular monoatomic cation homeostasis 11.1111 5 yes
GO:0032025 response to cobalt ion 11.1111 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BNI3L_HUMAN [view interactions] Low throughput no yes
BCL2_HUMAN [view interactions] Low throughput no no
OPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
BNIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL1_HUMAN [view interactions] Low throughput no yes
NCBP1_HUMAN [view interactions] Low throughput no yes
CD47_HUMAN [view interactions] Low throughput no no
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC1_HUMAN [view interactions] Low throughput no no
MLP3B_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
BAG3_HUMAN [view entry] [view interactions] Low throughput yes no
MLP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
HIF1A_HUMAN [view interactions] Low throughput no no
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
CREB3_HUMAN [view interactions] High throughput no no
ZEP1_HUMAN [view interactions] High throughput no yes
TGM2_HUMAN [view interactions] High throughput no no
ALG3_HUMAN [view interactions] High throughput no yes
TMM11_HUMAN [view interactions] High throughput no no
PPTC7_HUMAN [view interactions] High throughput no yes
AMPE_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
LRAD1_HUMAN [view interactions] High throughput no no
FATE1_HUMAN [view interactions] High throughput no no
CLC7A_HUMAN [view interactions] High throughput no no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FAM3C_HUMAN [view interactions] High throughput no yes
SC22A_HUMAN [view interactions] High throughput no no
RPRM_HUMAN [view interactions] High throughput no no
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
BNIP2_HUMAN [view interactions] High throughput no yes
MALL_HUMAN [view interactions] High throughput no no
HEPS_HUMAN [view interactions] High throughput no yes
CR3L1_HUMAN [view interactions] High throughput no yes
MS4A3_HUMAN [view interactions] High throughput no no
BIK_HUMAN [view interactions] High throughput no yes
PLP2_HUMAN [view interactions] High throughput no yes
T106C_HUMAN [view interactions] High throughput no yes
SMIM3_HUMAN [view interactions] High throughput no no
CD3E_HUMAN [view interactions] High throughput no no
INGR2_HUMAN [view interactions] High throughput no yes
FFAR2_HUMAN [view interactions] High throughput no yes
JAGN1_HUMAN [view interactions] High throughput no no
F209A_HUMAN [view interactions] High throughput no no
TLCD4_HUMAN [view interactions] High throughput no no
RNK_HUMAN [view interactions] High throughput no yes
COPT2_HUMAN [view interactions] High throughput no yes
MF14B_HUMAN [view interactions] High throughput no no
SACA1_HUMAN [view interactions] High throughput no no
S6A17_HUMAN [view interactions] High throughput no yes
AMGO1_HUMAN [view interactions] High throughput no yes
SCN3B_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
AR13B_HUMAN [view interactions] High throughput no yes
S35B1_HUMAN [view interactions] High throughput no no
GP152_HUMAN [view interactions] High throughput no no
TM101_HUMAN [view interactions] High throughput no no
ZDH15_HUMAN [view entry] [view interactions] High throughput yes yes
REEP2_HUMAN [view interactions] High throughput no yes
ELOV4_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
TMX2_HUMAN [view interactions] High throughput no yes
T4S18_HUMAN [view interactions] High throughput no no
GPR42_HUMAN [view interactions] High throughput no no
TM205_HUMAN [view interactions] High throughput no yes
CLD9_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
GPR37_HUMAN [view interactions] High throughput no no
5HT2B_HUMAN [view interactions] High throughput no no
CLN8_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
B2CL2_HUMAN [view interactions] High throughput no yes
TNMD_HUMAN [view interactions] High throughput no no
RNF24_HUMAN [view interactions] High throughput no yes
CKLF5_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
FXYD6_HUMAN [view entry] [view interactions] High throughput yes yes
CC50A_HUMAN [view interactions] High throughput no yes
P4R3B_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
ATPMK_HUMAN [view interactions] High throughput no no
HTRA2_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
ABTB2_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RN149_HUMAN [view interactions] High throughput no no
FBXL4_HUMAN [view interactions] High throughput no yes
BAX_HUMAN [view interactions] High throughput no yes
BMF_HUMAN [view interactions] High throughput no yes
BID_HUMAN [view interactions] High throughput no no
B2L12_HUMAN [view interactions] High throughput no yes
HRK_HUMAN [view interactions] High throughput no no
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes