RHEB_HUMAN
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RHEB_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 32.0000 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 32.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | yes |
GO:0019900 | kinase binding | 20.0000 | 4 | yes |
GO:0019901 | protein kinase binding | 18.0000 | 5 | yes |
GO:0046872 | metal ion binding | 18.0000 | 4 | yes |
GO:0005525 | GTP binding | 16.0000 | 5 | yes |
GO:0016462 | pyrophosphatase activity | 16.0000 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.0000 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.0000 | 6 | yes |
GO:0019001 | guanyl nucleotide binding | 16.0000 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 16.0000 | 5 | yes |
GO:0003924 | GTPase activity | 14.0000 | 7 | yes |
GO:0019003 | GDP binding | 12.0000 | 4 | yes |
GO:0000287 | magnesium ion binding | 4.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RHEB_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 74.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 72.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 68.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 66.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 64.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 64.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 62.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 62.0000 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 54.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 52.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 50.0000 | 5 | no |
GO:0051128 | regulation of cellular component organization | 46.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 44.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 44.0000 | 4 | yes |
GO:0051049 | regulation of transport | 44.0000 | 4 | no |
GO:0006996 | organelle organization | 44.0000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 42.0000 | 5 | yes |
GO:0023056 | positive regulation of signaling | 42.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 42.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 42.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 38.0000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 38.0000 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 38.0000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 38.0000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 38.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 38.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 36.0000 | 7 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.0000 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 36.0000 | 5 | no |
GO:0008104 | protein localization | 36.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 36.0000 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 36.0000 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 34.0000 | 6 | no |
GO:0010648 | negative regulation of cell communication | 34.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 34.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 34.0000 | 5 | no |
GO:0060548 | negative regulation of cell death | 32.0000 | 5 | no |
GO:0009894 | regulation of catabolic process | 32.0000 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 32.0000 | 6 | yes |
GO:0071310 | cellular response to organic substance | 32.0000 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 32.0000 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 32.0000 | 4 | no |
GO:0071702 | organic substance transport | 32.0000 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 30.0000 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 30.0000 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 30.0000 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
GO:0006915 | apoptotic process | 30.0000 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 28.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 28.0000 | 4 | no |
GO:0015031 | protein transport | 28.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0000 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 26.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 26.0000 | 5 | no |
GO:0045595 | regulation of cell differentiation | 26.0000 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 26.0000 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 26.0000 | 7 | no |
GO:0033043 | regulation of organelle organization | 26.0000 | 5 | no |
GO:0036211 | protein modification process | 24.0000 | 4 | no |
GO:0043412 | macromolecule modification | 24.0000 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 24.0000 | 4 | no |
GO:0051338 | regulation of transferase activity | 24.0000 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.0000 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 24.0000 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | no |
GO:0022607 | cellular component assembly | 24.0000 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 24.0000 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 24.0000 | 4 | yes |
GO:0051726 | regulation of cell cycle | 24.0000 | 4 | yes |
GO:0051050 | positive regulation of transport | 24.0000 | 4 | no |
GO:2000145 | regulation of cell motility | 24.0000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 24.0000 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 22.0000 | 8 | no |
GO:0043549 | regulation of kinase activity | 22.0000 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 22.0000 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.0000 | 7 | no |
GO:0051129 | negative regulation of cellular component organization | 22.0000 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 22.0000 | 6 | no |
GO:0050804 | modulation of chemical synaptic transmission | 22.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 22.0000 | 4 | no |
GO:0030030 | cell projection organization | 22.0000 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 22.0000 | 5 | no |
GO:0051094 | positive regulation of developmental process | 22.0000 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 22.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 22.0000 | 6 | no |
GO:0030334 | regulation of cell migration | 22.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.0000 | 6 | no |
GO:0001934 | positive regulation of protein phosphorylation | 22.0000 | 8 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.0000 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.0000 | 6 | no |
GO:0010506 | regulation of autophagy | 16.0000 | 6 | yes |
GO:0016241 | regulation of macroautophagy | 16.0000 | 7 | yes |
GO:0007264 | small GTPase mediated signal transduction | 14.0000 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 14.0000 | 5 | yes |
GO:0060284 | regulation of cell development | 14.0000 | 5 | yes |
GO:0032006 | regulation of TOR signaling | 12.0000 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 12.0000 | 4 | yes |
GO:0051960 | regulation of nervous system development | 12.0000 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 12.0000 | 4 | yes |
GO:0050767 | regulation of neurogenesis | 10.0000 | 6 | yes |
GO:0010720 | positive regulation of cell development | 8.0000 | 6 | yes |
GO:0032008 | positive regulation of TOR signaling | 6.0000 | 7 | yes |
GO:0050769 | positive regulation of neurogenesis | 6.0000 | 6 | yes |
GO:0051962 | positive regulation of nervous system development | 6.0000 | 5 | yes |
GO:0014013 | regulation of gliogenesis | 4.0000 | 7 | yes |
GO:0014015 | positive regulation of gliogenesis | 4.0000 | 7 | yes |
GO:0045685 | regulation of glial cell differentiation | 4.0000 | 5 | yes |
GO:0045687 | positive regulation of glial cell differentiation | 4.0000 | 6 | yes |
GO:0048713 | regulation of oligodendrocyte differentiation | 4.0000 | 6 | yes |
GO:0048714 | positive regulation of oligodendrocyte differentiation | 4.0000 | 7 | yes |
GO:2000074 | regulation of type B pancreatic cell development | 4.0000 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in RHEB_HUMAN |
---|---|---|---|---|
DOID:0050686 | organ system cancer | 4.0000 | 3 | no |
DOID:6457 | Cowden syndrome | 4.0000 | 3 | no |
DOID:331 | central nervous system disease | 4.0000 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDE6D_HUMAN | [view interactions] | Low throughput | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TCTP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLD1_HUMAN | [view interactions] | Low throughput | no | no |
TSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TSC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RPTOR_HUMAN | [view interactions] | Low throughput | no | yes |
BNIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BNI3L_HUMAN | [view interactions] | Low throughput | no | yes |
PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATM_HUMAN | [view interactions] | Low throughput | no | yes |
ATR_HUMAN | [view interactions] | Low throughput | no | no |
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RN152_HUMAN | [view interactions] | Low throughput | no | no |
UBP4_HUMAN | [view interactions] | Low throughput | no | no |
ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | Low throughput | no | yes |
CREB1_HUMAN | [view interactions] | Low throughput | no | yes |
DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GO45_HUMAN | [view interactions] | High throughput | no | yes |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
CREB3_HUMAN | [view interactions] | High throughput | no | no |
S15A1_HUMAN | [view interactions] | High throughput | no | no |
I20RA_HUMAN | [view interactions] | High throughput | no | no |
NF2IP_HUMAN | [view interactions] | High throughput | no | no |
LEG7_HUMAN | [view interactions] | High throughput | no | no |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
CASL_HUMAN | [view interactions] | High throughput | no | yes |
RELL2_HUMAN | [view interactions] | High throughput | no | no |
SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPT19_HUMAN | [view interactions] | High throughput | no | no |
ENPP7_HUMAN | [view interactions] | High throughput | no | no |
KI67_HUMAN | [view interactions] | High throughput | no | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A2MG_HUMAN | [view interactions] | High throughput | no | yes |
ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARI2_HUMAN | [view interactions] | High throughput | no | no |
APBP2_HUMAN | [view interactions] | High throughput | no | yes |
CASP6_HUMAN | [view interactions] | High throughput | no | no |
CCKN_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
JMY_HUMAN | [view interactions] | High throughput | no | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
VPS4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITB8_HUMAN | [view interactions] | High throughput | no | no |
5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
DUS19_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
TM52B_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
SC5A5_HUMAN | [view interactions] | High throughput | no | no |
MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
VASH2_HUMAN | [view interactions] | High throughput | no | no |
LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPQM_HUMAN | [view interactions] | High throughput | no | no |
GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
PPBI_HUMAN | [view interactions] | High throughput | no | no |
STMN3_HUMAN | [view interactions] | High throughput | no | yes |
TGM3_HUMAN | [view interactions] | High throughput | no | no |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
API5_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SEH1_HUMAN | [view interactions] | Computational | no | no |
LST8_HUMAN | [view interactions] | Computational | no | yes |
WDR59_HUMAN | [view interactions] | Computational | no | yes |
DPTOR_HUMAN | [view interactions] | Computational | no | no |
TBCD7_HUMAN | [view interactions] | Computational | no | no |
RRAGB_HUMAN | [view interactions] | Computational | no | yes |
ULK1_HUMAN | [view interactions] | Computational | no | no |
NPRL2_HUMAN | [view interactions] | Computational | no | yes |
LTOR4_HUMAN | [view interactions] | Computational | no | yes |
RS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAKG1_HUMAN | [view interactions] | Computational | no | no |
AKTS1_HUMAN | [view interactions] | Computational | no | yes |
CAST1_HUMAN | [view interactions] | Computational | no | yes |
AAKB2_HUMAN | [view interactions] | Computational | no | yes |
KS6B2_HUMAN | [view interactions] | Computational | no | yes |
AAKB1_HUMAN | [view interactions] | Computational | no | yes |
LTOR3_HUMAN | [view interactions] | Computational | no | yes |
IF4E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAPK1_HUMAN | [view interactions] | Computational | no | no |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
WDR24_HUMAN | [view interactions] | Computational | no | yes |
MCRS1_HUMAN | [view interactions] | Computational | no | yes |
MAF1_HUMAN | [view interactions] | Computational | no | no |
4EBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RRAGC_HUMAN | [view interactions] | Computational | no | yes |
RRAGD_HUMAN | [view interactions] | Computational | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAKG3_HUMAN | [view interactions] | Computational | no | no |
AAPK2_HUMAN | [view interactions] | Computational | no | yes |
PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAKG2_HUMAN | [view interactions] | Computational | no | yes |
KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITFG2_HUMAN | [view interactions] | Computational | no | yes |
RBCC1_HUMAN | [view interactions] | Computational | no | no |
RICTR_HUMAN | [view interactions] | Computational | no | yes |
SAMTR_HUMAN | [view interactions] | Computational | no | yes |
PK3C3_HUMAN | [view interactions] | Computational | no | yes |
CAST2_HUMAN | [view interactions] | Computational | no | no |
G3P_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
S38A9_HUMAN | [view interactions] | Computational | no | yes |
ATG13_HUMAN | [view interactions] | Computational | no | no |
PDE4D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MIO_HUMAN | [view interactions] | Computational | no | yes |
SESN2_HUMAN | [view interactions] | Computational | no | no |
LTOR2_HUMAN | [view interactions] | Computational | no | yes |
SDCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SZT2_HUMAN | [view interactions] | Computational | no | yes |
SESN1_HUMAN | [view interactions] | Computational | no | no |
RRAGA_HUMAN | [view interactions] | Computational | no | yes |