HIP1_HUMAN
Evidence for PS localization
Functions
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed, PubMed, PubMed). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner . Regulates presynaptic nerve terminal activity . Enhances androgen receptor (AR)-mediated transcription (PubMed). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed). Binds 3-phosphoinositides (via ENTH domain) (PubMed). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed). May play a functional role in the cell filament networks (PubMed). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000454 | LIG_Clathr_ClatBox_1 | LIG | 332 | 336 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HIP1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 30.2326 | 4 | no |
| GO:0019901 | protein kinase binding | 27.9070 | 5 | no |
| GO:0046872 | metal ion binding | 23.2558 | 4 | no |
| GO:0003779 | actin binding | 20.9302 | 4 | yes |
| GO:0003723 | RNA binding | 20.9302 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.9302 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.9302 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.9302 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 16.2791 | 4 | yes |
| GO:0032051 | clathrin light chain binding | 9.3023 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 9.3023 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 9.3023 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 9.3023 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 9.3023 | 6 | yes |
| GO:0035254 | glutamate receptor binding | 6.9767 | 4 | yes |
| GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding | 6.9767 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 6.9767 | 4 | yes |
| GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding | 6.9767 | 4 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 4.6512 | 5 | yes |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | 4.6512 | 6 | yes |
| GO:0070851 | growth factor receptor binding | 4.6512 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HIP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.1395 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.8372 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.5116 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.5116 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.1860 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.1860 | 4 | yes |
| GO:0008104 | protein localization | 41.8605 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 41.8605 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.8605 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.5349 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.5349 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.2093 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2093 | 5 | yes |
| GO:0071702 | organic substance transport | 37.2093 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.2093 | 4 | yes |
| GO:0006996 | organelle organization | 37.2093 | 4 | no |
| GO:0006897 | endocytosis | 34.8837 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 34.8837 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 34.8837 | 4 | yes |
| GO:0051049 | regulation of transport | 34.8837 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.8837 | 5 | yes |
| GO:0015031 | protein transport | 32.5581 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 32.5581 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 32.5581 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.2326 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.2326 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 30.2326 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 27.9070 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9070 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 25.5814 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 25.5814 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 25.5814 | 4 | yes |
| GO:0051050 | positive regulation of transport | 25.5814 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.5814 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.5814 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.5814 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.5814 | 5 | no |
| GO:0010941 | regulation of cell death | 23.2558 | 4 | yes |
| GO:0006886 | intracellular protein transport | 23.2558 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.2558 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2558 | 5 | no |
| GO:0036211 | protein modification process | 23.2558 | 4 | no |
| GO:0043412 | macromolecule modification | 23.2558 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.2558 | 5 | no |
| GO:0030100 | regulation of endocytosis | 20.9302 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 20.9302 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 20.9302 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 20.9302 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.9302 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.9302 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.9302 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.9302 | 4 | no |
| GO:0031399 | regulation of protein modification process | 20.9302 | 6 | no |
| GO:0007015 | actin filament organization | 18.6047 | 5 | yes |
| GO:0048268 | clathrin coat assembly | 18.6047 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 18.6047 | 4 | yes |
| GO:0006915 | apoptotic process | 16.2791 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.2791 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 16.2791 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 13.9535 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.9535 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 9.3023 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 9.3023 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 9.3023 | 7 | yes |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 6.9767 | 10 | yes |
| GO:0010640 | regulation of platelet-derived growth factor receptor signaling pathway | 6.9767 | 5 | yes |
| GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway | 6.9767 | 6 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 6.9767 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 6.9767 | 6 | yes |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 6.9767 | 6 | yes |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 6.9767 | 9 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 6.9767 | 8 | yes |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 6.9767 | 7 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 6.9767 | 6 | yes |
| GO:0050821 | protein stabilization | 6.9767 | 4 | yes |
| GO:0052547 | regulation of peptidase activity | 6.9767 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 6.9767 | 6 | yes |
| GO:1901184 | regulation of ERBB signaling pathway | 6.9767 | 5 | yes |
| GO:1901186 | positive regulation of ERBB signaling pathway | 6.9767 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 6.9767 | 7 | yes |
| GO:2000586 | regulation of platelet-derived growth factor receptor-beta signaling pathway | 6.9767 | 6 | yes |
| GO:2000588 | positive regulation of platelet-derived growth factor receptor-beta signaling pathway | 6.9767 | 7 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 6.9767 | 8 | yes |
| GO:0051896 | regulation of protein kinase B signaling | 4.6512 | 6 | yes |
| GO:0051897 | positive regulation of protein kinase B signaling | 4.6512 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HIP1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.9767 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.9767 | 5 | no |
| DOID:114 | heart disease | 6.9767 | 3 | no |
| DOID:2843 | long QT syndrome | 6.9767 | 6 | no |
| DOID:10273 | heart conduction disease | 4.6512 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP1_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APAF_HUMAN | [view interactions] | Low throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | Low throughput | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP9_HUMAN | [view interactions] | Low throughput | no | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IFT57_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
| BFAR_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFP1_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| DEUP1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| GLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA53_HUMAN | [view interactions] | High throughput | no | no |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| SYT17_HUMAN | [view interactions] | High throughput | no | no |
| RPRM_HUMAN | [view interactions] | High throughput | no | no |
| C1D_HUMAN | [view interactions] | High throughput | no | yes |
| RNF10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM5_HUMAN | [view interactions] | High throughput | no | no |
| TELT_HUMAN | [view interactions] | High throughput | no | no |
| BSND_HUMAN | [view interactions] | High throughput | no | no |
| ZBT14_HUMAN | [view interactions] | High throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO2A1_HUMAN | [view interactions] | High throughput | no | no |
| CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
| BAAT_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| LHX5_HUMAN | [view interactions] | High throughput | no | no |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THEG_HUMAN | [view interactions] | High throughput | no | no |
| JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| SPART_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| ACL7B_HUMAN | [view interactions] | High throughput | no | no |
| CBWD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9A_HUMAN | [view interactions] | High throughput | no | no |
| KAD8_HUMAN | [view interactions] | High throughput | no | no |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| LRC56_HUMAN | [view interactions] | High throughput | no | no |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| SHP1L_HUMAN | [view interactions] | High throughput | no | no |
| LPAL2_HUMAN | [view interactions] | High throughput | no | no |
| SPSB1_HUMAN | [view interactions] | High throughput | no | no |
| CC036_HUMAN | [view interactions] | High throughput | no | no |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| CENPR_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| TEANC_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CASP3_HUMAN | [view interactions] | Computational | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |