GLSL_HUMAN
Evidence for PS localization
Functions
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GLSL_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.0000 | 4 | no |
| GO:0004359 | glutaminase activity | 30.0000 | 5 | yes |
| GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 30.0000 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 30.0000 | 4 | no |
| GO:0003779 | actin binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GLSL_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 40.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 40.0000 | 4 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 40.0000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | no |
| GO:0098657 | import into cell | 40.0000 | 4 | no |
| GO:0044057 | regulation of system process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 40.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0006536 | glutamate metabolic process | 30.0000 | 6 | yes |
| GO:0006537 | glutamate biosynthetic process | 30.0000 | 7 | yes |
| GO:0006541 | glutamine metabolic process | 30.0000 | 6 | yes |
| GO:0006543 | glutamine catabolic process | 30.0000 | 7 | yes |
| GO:0008652 | amino acid biosynthetic process | 30.0000 | 4 | yes |
| GO:0009063 | amino acid catabolic process | 30.0000 | 4 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 30.0000 | 5 | yes |
| GO:0009065 | glutamine family amino acid catabolic process | 30.0000 | 6 | yes |
| GO:0009084 | glutamine family amino acid biosynthetic process | 30.0000 | 6 | yes |
| GO:0016053 | organic acid biosynthetic process | 30.0000 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 30.0000 | 4 | yes |
| GO:0043650 | dicarboxylic acid biosynthetic process | 30.0000 | 6 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 30.0000 | 5 | yes |
| GO:0046395 | carboxylic acid catabolic process | 30.0000 | 5 | yes |
| GO:0170033 | L-amino acid metabolic process | 30.0000 | 5 | yes |
| GO:0170034 | L-amino acid biosynthetic process | 30.0000 | 6 | yes |
| GO:0170035 | L-amino acid catabolic process | 30.0000 | 6 | yes |
| GO:0170038 | proteinogenic amino acid biosynthetic process | 30.0000 | 5 | yes |
| GO:0170039 | proteinogenic amino acid metabolic process | 30.0000 | 4 | yes |
| GO:0170040 | proteinogenic amino acid catabolic process | 30.0000 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 30.0000 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 30.0000 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 30.0000 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 30.0000 | 5 | yes |
| GO:1901607 | alpha-amino acid biosynthetic process | 30.0000 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 30.0000 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 30.0000 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 30.0000 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 30.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 30.0000 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0030100 | regulation of endocytosis | 30.0000 | 5 | no |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 30.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | no |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 30.0000 | 7 | no |
| GO:0048259 | regulation of receptor-mediated endocytosis | 30.0000 | 6 | no |
| GO:0051046 | regulation of secretion | 30.0000 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | no |
| GO:1901184 | regulation of ERBB signaling pathway | 30.0000 | 5 | no |
| GO:1901186 | positive regulation of ERBB signaling pathway | 30.0000 | 6 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RALA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | Low throughput | no | no |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| GLSL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |