GRHPR_HUMAN
Evidence for PS localization
Functions
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRHPR_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0042803 | protein homodimerization activity | 24.2424 | 4 | yes |
| GO:0045296 | cadherin binding | 24.2424 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 24.2424 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.2424 | 4 | no |
| GO:0046872 | metal ion binding | 21.2121 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 15.1515 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 9.0909 | 4 | yes |
| GO:0051287 | NAD binding | 9.0909 | 4 | yes |
| GO:0008465 | glycerate dehydrogenase activity | 6.0606 | 5 | yes |
| GO:0016618 | hydroxypyruvate reductase activity | 6.0606 | 5 | yes |
| GO:0030267 | glyoxylate reductase (NADP+) activity | 6.0606 | 6 | yes |
| GO:0050661 | NADP binding | 6.0606 | 4 | yes |
| GO:0070402 | NADPH binding | 6.0606 | 4 | yes |
| GO:0106345 | glyoxylate reductase activity | 6.0606 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRHPR_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.4242 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.4242 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.4242 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 39.3939 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 39.3939 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 30.3030 | 6 | yes |
| GO:0010941 | regulation of cell death | 30.3030 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.3030 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.3030 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.3030 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.3030 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.3030 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.3030 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.2424 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.2424 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.2424 | 6 | no |
| GO:0023057 | negative regulation of signaling | 24.2424 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.2424 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.2424 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.2424 | 6 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 24.2424 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 24.2424 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.2121 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.2121 | 5 | no |
| GO:0008104 | protein localization | 21.2121 | 4 | no |
| GO:0006996 | organelle organization | 21.2121 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.2121 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.2121 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.2121 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 21.2121 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2121 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.2121 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.2121 | 5 | no |
| GO:0043648 | dicarboxylic acid metabolic process | 15.1515 | 6 | yes |
| GO:0046487 | glyoxylate metabolic process | 9.0909 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GRHPR_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.0606 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRHPR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S23A1_HUMAN | [view interactions] | Low throughput | no | no |
| CREG1_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGL_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| GLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| CDC7_HUMAN | [view interactions] | High throughput | no | yes |
| CC14B_HUMAN | [view interactions] | High throughput | no | no |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDM7_HUMAN | [view interactions] | High throughput | no | no |
| PRDM9_HUMAN | [view interactions] | High throughput | no | no |
| PYGO2_HUMAN | [view interactions] | High throughput | no | yes |
| SMBT2_HUMAN | [view interactions] | High throughput | no | yes |
| SLBP_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AK1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NNRD_HUMAN | [view interactions] | High throughput | no | yes |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| ALR_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIFK_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF2_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| AOFB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GLCTK_HUMAN | [view interactions] | Computational | no | yes |
| AOC2_HUMAN | [view interactions] | Computational | no | no |
| SPYA_HUMAN | [view interactions] | Computational | no | no |
| PGP_HUMAN | [view interactions] | Computational | no | yes |
| OXDA_HUMAN | [view interactions] | Computational | no | no |
| HAOX1_HUMAN | [view interactions] | Computational | no | no |
| HAOX2_HUMAN | [view interactions] | Computational | no | no |
| AGT2_HUMAN | [view interactions] | Computational | no | no |
| SDSL_HUMAN | [view interactions] | Computational | no | yes |
| SDHL_HUMAN | [view interactions] | Computational | no | yes |
| AOFA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HOGA1_HUMAN | [view interactions] | Computational | no | yes |
| AOC3_HUMAN | [view interactions] | Computational | no | no |