GDE_HUMAN
Evidence for PS localization
Functions
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDE_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 34.7826 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.4348 | 5 | no |
| GO:0043168 | anion binding | 30.4348 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0870 | 6 | no |
| GO:0043169 | cation binding | 26.0870 | 4 | no |
| GO:0046872 | metal ion binding | 26.0870 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.7391 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.7391 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0045296 | cadherin binding | 21.7391 | 4 | no |
| GO:0016758 | hexosyltransferase activity | 8.6957 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDE_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.8261 | 4 | no |
| GO:0071702 | organic substance transport | 47.8261 | 4 | no |
| GO:0008104 | protein localization | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 39.1304 | 4 | yes |
| GO:0036211 | protein modification process | 39.1304 | 4 | no |
| GO:0043412 | macromolecule modification | 39.1304 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 39.1304 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 39.1304 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
| GO:0071705 | nitrogen compound transport | 39.1304 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.7826 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.7826 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.7826 | 5 | no |
| GO:0015031 | protein transport | 34.7826 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.7826 | 5 | no |
| GO:0032880 | regulation of protein localization | 34.7826 | 5 | no |
| GO:0051049 | regulation of transport | 34.7826 | 4 | no |
| GO:0060341 | regulation of cellular localization | 34.7826 | 4 | no |
| GO:0006996 | organelle organization | 30.4348 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 30.4348 | 5 | no |
| GO:0023057 | negative regulation of signaling | 30.4348 | 4 | no |
| GO:0030162 | regulation of proteolysis | 30.4348 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 30.4348 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 26.0870 | 4 | yes |
| GO:0030163 | protein catabolic process | 26.0870 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 26.0870 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 26.0870 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 26.0870 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.0870 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.0870 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.0870 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.0870 | 6 | no |
| GO:0006508 | proteolysis | 21.7391 | 4 | no |
| GO:0032446 | protein modification by small protein conjugation | 21.7391 | 7 | no |
| GO:0043687 | post-translational protein modification | 21.7391 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.7391 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.7391 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | no |
| GO:0045861 | negative regulation of proteolysis | 21.7391 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0051051 | negative regulation of transport | 21.7391 | 4 | no |
| GO:0051223 | regulation of protein transport | 21.7391 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.7391 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.7391 | 5 | no |
| GO:1905475 | regulation of protein localization to membrane | 21.7391 | 6 | no |
| GO:0033365 | protein localization to organelle | 21.7391 | 5 | no |
| GO:0033993 | response to lipid | 17.3913 | 4 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 13.0435 | 4 | yes |
| GO:0048545 | response to steroid hormone | 13.0435 | 4 | yes |
| GO:0000272 | polysaccharide catabolic process | 8.6957 | 5 | yes |
| GO:0005976 | polysaccharide metabolic process | 8.6957 | 4 | yes |
| GO:0005977 | glycogen metabolic process | 8.6957 | 6 | yes |
| GO:0005980 | glycogen catabolic process | 8.6957 | 7 | yes |
| GO:0006112 | energy reserve metabolic process | 8.6957 | 5 | yes |
| GO:0009059 | macromolecule biosynthetic process | 8.6957 | 4 | yes |
| GO:0009251 | glucan catabolic process | 8.6957 | 6 | yes |
| GO:0016052 | carbohydrate catabolic process | 8.6957 | 4 | yes |
| GO:0031960 | response to corticosteroid | 8.6957 | 5 | yes |
| GO:0044042 | glucan metabolic process | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NHLC1_HUMAN | [view interactions] | Low throughput | no | no |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF5_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K6_HUMAN | [view interactions] | High throughput | no | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FASTK_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA2_HUMAN | [view interactions] | High throughput | no | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| ASB15_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN126_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLYG2_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| PUS1_HUMAN | [view interactions] | High throughput | no | yes |
| GDN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| DEOC_HUMAN | [view interactions] | High throughput | no | no |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| HXK4_HUMAN | [view interactions] | High throughput | no | yes |
| KHK_HUMAN | [view interactions] | High throughput | no | no |
| MA2B1_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| ST1E1_HUMAN | [view interactions] | High throughput | no | no |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| NNRD_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSH1_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XYLB_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| AMPB_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |