Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FKB1B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FKB1B_HUMAN
GO:0046872 metal ion binding 40.0000 4 no
GO:0008200 ion channel inhibitor activity 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005246 calcium channel regulator activity 20.0000 4 yes
GO:0019855 calcium channel inhibitor activity 20.0000 5 yes
GO:0030551 cyclic nucleotide binding 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FKB1B_HUMAN
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0048522 positive regulation of cellular process 65.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 yes
GO:0010646 regulation of cell communication 55.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.0000 4 yes
GO:0044057 regulation of system process 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 45.0000 5 yes
GO:0090257 regulation of muscle system process 45.0000 5 yes
GO:0006937 regulation of muscle contraction 45.0000 6 yes
GO:0009892 negative regulation of metabolic process 45.0000 4 yes
GO:0031324 negative regulation of cellular metabolic process 45.0000 5 yes
GO:0034762 regulation of transmembrane transport 45.0000 4 yes
GO:0051049 regulation of transport 45.0000 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 40.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 40.0000 5 yes
GO:0051282 regulation of sequestering of calcium ion 40.0000 4 yes
GO:0051336 regulation of hydrolase activity 40.0000 4 yes
GO:0051924 regulation of calcium ion transport 40.0000 7 yes
GO:0055117 regulation of cardiac muscle contraction 40.0000 7 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 40.0000 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 40.0000 7 yes
GO:1903522 regulation of blood circulation 40.0000 5 yes
GO:1904062 regulation of cation transmembrane transport 40.0000 6 yes
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0006942 regulation of striated muscle contraction 40.0000 7 yes
GO:0008016 regulation of heart contraction 40.0000 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 40.0000 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 40.0000 7 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 40.0000 6 yes
GO:0010959 regulation of metal ion transport 40.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 40.0000 6 yes
GO:0019722 calcium-mediated signaling 40.0000 5 yes
GO:0019932 second-messenger-mediated signaling 40.0000 4 yes
GO:0022898 regulation of transmembrane transporter activity 40.0000 4 yes
GO:0031399 regulation of protein modification process 40.0000 6 yes
GO:0032412 regulation of ion transmembrane transporter activity 40.0000 5 yes
GO:0034763 negative regulation of transmembrane transport 40.0000 5 yes
GO:0034765 regulation of ion transmembrane transport 40.0000 5 yes
GO:0043269 regulation of ion transport 40.0000 5 yes
GO:0051051 negative regulation of transport 40.0000 4 yes
GO:0051284 positive regulation of sequestering of calcium ion 35.0000 5 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 35.0000 6 yes
GO:1904063 negative regulation of cation transmembrane transport 35.0000 7 yes
GO:2001257 regulation of cation channel activity 35.0000 6 yes
GO:0016310 phosphorylation 35.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 35.0000 4 no
GO:0009966 regulation of signal transduction 35.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 35.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.0000 5 no
GO:0009889 regulation of biosynthetic process 35.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 35.0000 5 no
GO:0032410 negative regulation of transporter activity 35.0000 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 35.0000 5 yes
GO:0034766 negative regulation of ion transmembrane transport 35.0000 6 yes
GO:0035303 regulation of dephosphorylation 35.0000 7 yes
GO:0035304 regulation of protein dephosphorylation 35.0000 7 yes
GO:0043271 negative regulation of ion transport 35.0000 5 yes
GO:0043412 macromolecule modification 35.0000 4 yes
GO:0051128 regulation of cellular component organization 35.0000 4 yes
GO:0051248 negative regulation of protein metabolic process 30.0000 6 yes
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 30.0000 6 yes
GO:0051926 negative regulation of calcium ion transport 30.0000 6 yes
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 30.0000 7 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 30.0000 6 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 30.0000 7 yes
GO:2001258 negative regulation of cation channel activity 30.0000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0006355 regulation of DNA-templated transcription 30.0000 6 no
GO:0010468 regulation of gene expression 30.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 30.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0010921 regulation of phosphatase activity 30.0000 5 yes
GO:0014070 response to organic cyclic compound 30.0000 4 yes
GO:0036211 protein modification process 30.0000 4 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 30.0000 6 yes
GO:0019752 carboxylic acid metabolic process 25.0000 5 no
GO:0043436 oxoacid metabolic process 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0032411 positive regulation of transporter activity 25.0000 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0034764 positive regulation of transmembrane transport 25.0000 5 no
GO:0034767 positive regulation of ion transmembrane transport 25.0000 6 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051592 response to calcium ion 25.0000 5 no
GO:0051928 positive regulation of calcium ion transport 25.0000 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 25.0000 6 no
GO:1904064 positive regulation of cation transmembrane transport 25.0000 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 25.0000 7 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0035306 positive regulation of dephosphorylation 25.0000 8 no
GO:0035307 positive regulation of protein dephosphorylation 25.0000 8 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 yes
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0018193 peptidyl-amino acid modification 25.0000 5 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0031400 negative regulation of protein modification process 25.0000 7 yes
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 yes
GO:0048584 positive regulation of response to stimulus 25.0000 4 yes
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0048878 chemical homeostasis 25.0000 4 yes
GO:0055065 metal ion homeostasis 20.0000 7 yes
GO:0055074 calcium ion homeostasis 20.0000 8 yes
GO:0055080 cation homeostasis 20.0000 6 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0072503 cellular divalent inorganic cation homeostasis 20.0000 6 yes
GO:0072507 divalent inorganic cation homeostasis 20.0000 7 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:0080135 regulation of cellular response to stress 20.0000 4 yes
GO:0098655 cation transmembrane transport 20.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 20.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 20.0000 5 yes
GO:0098771 inorganic ion homeostasis 20.0000 6 yes
GO:0001508 action potential 20.0000 4 yes
GO:0006811 ion transport 20.0000 4 yes
GO:0006812 cation transport 20.0000 5 yes
GO:0006873 cellular ion homeostasis 20.0000 4 yes
GO:0006874 cellular calcium ion homeostasis 20.0000 7 yes
GO:0006875 cellular metal ion homeostasis 20.0000 6 yes
GO:0006936 muscle contraction 20.0000 4 yes
GO:0008104 protein localization 20.0000 4 yes
GO:0030001 metal ion transport 20.0000 6 yes
GO:0030003 cellular cation homeostasis 20.0000 5 yes
GO:0031667 response to nutrient levels 20.0000 4 yes
GO:0050801 ion homeostasis 20.0000 5 yes
GO:0051094 positive regulation of developmental process 20.0000 4 yes
GO:0051209 release of sequestered calcium ion into cytosol 15.0000 6 yes
GO:0051283 negative regulation of sequestering of calcium ion 15.0000 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 15.0000 8 yes
GO:0070588 calcium ion transmembrane transport 15.0000 6 yes
GO:0071702 organic substance transport 15.0000 4 yes
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 15.0000 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 15.0000 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 15.0000 6 yes
GO:1903034 regulation of response to wounding 15.0000 5 yes
GO:1903036 positive regulation of response to wounding 15.0000 5 yes
GO:1903530 regulation of secretion by cell 15.0000 4 yes
GO:0000413 protein peptidyl-prolyl isomerization 15.0000 7 yes
GO:0006816 calcium ion transport 15.0000 7 yes
GO:0018208 peptidyl-proline modification 15.0000 6 yes
GO:0031344 regulation of cell projection organization 15.0000 5 yes
GO:0031346 positive regulation of cell projection organization 15.0000 6 yes
GO:0032880 regulation of protein localization 15.0000 5 yes
GO:0035584 calcium-mediated signaling using intracellular calcium source 15.0000 6 yes
GO:0051046 regulation of secretion 15.0000 5 yes
GO:0051130 positive regulation of cellular component organization 15.0000 5 yes
GO:0051223 regulation of protein transport 10.0000 5 yes
GO:0051224 negative regulation of protein transport 10.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 10.0000 4 yes
GO:0051346 negative regulation of hydrolase activity 10.0000 5 yes
GO:0051604 protein maturation 10.0000 4 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 10.0000 7 yes
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 10.0000 5 yes
GO:0070201 regulation of establishment of protein localization 10.0000 6 yes
GO:0070570 regulation of neuron projection regeneration 10.0000 4 yes
GO:0070572 positive regulation of neuron projection regeneration 10.0000 5 yes
GO:0071692 protein localization to extracellular region 10.0000 5 yes
GO:0071705 nitrogen compound transport 10.0000 4 yes
GO:0090087 regulation of peptide transport 10.0000 5 yes
GO:0090276 regulation of peptide hormone secretion 10.0000 5 yes
GO:0090278 negative regulation of peptide hormone secretion 10.0000 6 yes
GO:0098870 action potential propagation 10.0000 5 yes
GO:1903523 negative regulation of blood circulation 10.0000 5 yes
GO:1903531 negative regulation of secretion by cell 10.0000 5 yes
GO:1903828 negative regulation of protein localization 10.0000 5 yes
GO:1904950 negative regulation of establishment of protein localization 10.0000 6 yes
GO:0000302 response to reactive oxygen species 10.0000 4 yes
GO:0002790 peptide secretion 10.0000 5 yes
GO:0002791 regulation of peptide secretion 10.0000 6 yes
GO:0002792 negative regulation of peptide secretion 10.0000 6 yes
GO:0006939 smooth muscle contraction 10.0000 5 yes
GO:0009306 protein secretion 10.0000 4 yes
GO:0009743 response to carbohydrate 10.0000 4 yes
GO:0009746 response to hexose 10.0000 6 yes
GO:0009749 response to glucose 10.0000 7 yes
GO:0009914 hormone transport 10.0000 4 yes
GO:0010459 negative regulation of heart rate 10.0000 4 yes
GO:0010923 negative regulation of phosphatase activity 10.0000 6 yes
GO:0010975 regulation of neuron projection development 10.0000 7 yes
GO:0010976 positive regulation of neuron projection development 10.0000 7 yes
GO:0015031 protein transport 10.0000 4 yes
GO:0015833 peptide transport 10.0000 5 yes
GO:0019227 neuronal action potential propagation 10.0000 4 yes
GO:0023061 signal release 10.0000 4 yes
GO:0030072 peptide hormone secretion 10.0000 6 yes
GO:0030073 insulin secretion 10.0000 5 yes
GO:0032101 regulation of response to external stimulus 10.0000 4 yes
GO:0032103 positive regulation of response to external stimulus 10.0000 5 yes
GO:0032515 negative regulation of phosphoprotein phosphatase activity 10.0000 7 yes
GO:0032943 mononuclear cell proliferation 10.0000 4 yes
GO:0033197 response to vitamin E 10.0000 4 yes
GO:0033273 response to vitamin 10.0000 4 yes
GO:0034284 response to monosaccharide 10.0000 5 yes
GO:0035305 negative regulation of dephosphorylation 10.0000 8 yes
GO:0035308 negative regulation of protein dephosphorylation 10.0000 8 yes
GO:0035592 establishment of protein localization to extracellular region 10.0000 4 yes
GO:0042098 T cell proliferation 10.0000 5 yes
GO:0042110 T cell activation 10.0000 4 yes
GO:0042542 response to hydrogen peroxide 10.0000 4 yes
GO:0042886 amide transport 10.0000 5 yes
GO:0043086 negative regulation of catalytic activity 10.0000 4 yes
GO:0045822 negative regulation of heart contraction 10.0000 6 yes
GO:0046651 lymphocyte proliferation 10.0000 4 yes
GO:0046676 negative regulation of insulin secretion 10.0000 7 yes
GO:0046879 hormone secretion 10.0000 5 yes
GO:0046883 regulation of hormone secretion 10.0000 4 yes
GO:0046888 negative regulation of hormone secretion 10.0000 5 yes
GO:0046903 secretion 10.0000 4 yes
GO:0048679 regulation of axon regeneration 10.0000 5 yes
GO:0048680 positive regulation of axon regeneration 10.0000 6 yes
GO:0050708 regulation of protein secretion 10.0000 5 yes
GO:0050709 negative regulation of protein secretion 10.0000 6 yes
GO:0050796 regulation of insulin secretion 10.0000 6 yes
GO:0051048 negative regulation of secretion 10.0000 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in FKB1B_HUMAN
DOID:0050700 cardiomyopathy 15.0000 4 no
DOID:0060036 intrinsic cardiomyopathy 15.0000 5 no
DOID:114 heart disease 15.0000 3 no
DOID:0060674 catecholaminergic polymorphic ventricular tachycardia 10.0000 5 no
DOID:10273 heart conduction disease 10.0000 4 no
DOID:2843 long QT syndrome 10.0000 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
FKB1A_HUMAN [view interactions] Low throughput no yes
BMR1A_HUMAN [view interactions] Low throughput no no
TGFR1_HUMAN [view interactions] Low throughput no no
RYR3_HUMAN [view interactions] Low throughput no no
FKB1B_HUMAN [view entry] [view interactions] Low throughput yes yes
ACVR1_HUMAN [view interactions] Low throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
TRI69_HUMAN [view interactions] High throughput no no
ATL4_HUMAN [view interactions] High throughput no yes
GMCL1_HUMAN [view interactions] High throughput no yes
KRA11_HUMAN [view interactions] High throughput no no
BMR1B_HUMAN [view interactions] High throughput no no
DDAH2_HUMAN [view interactions] High throughput no yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
ENOB_HUMAN [view entry] [view interactions] High throughput yes no
FABP5_HUMAN [view entry] [view interactions] High throughput yes no
GLOD4_HUMAN [view entry] [view interactions] High throughput yes yes
GMPPB_HUMAN [view interactions] High throughput no yes
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
ITPA_HUMAN [view interactions] High throughput no yes
AKAP6_HUMAN [view interactions] Computational no no
MTOR_HUMAN [view entry] [view interactions] Computational yes yes
RYR1_HUMAN [view interactions] Computational no no
ASPH_HUMAN [view interactions] Computational no yes