Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FKB1B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FKB1B_HUMAN
GO:0043169 cation binding 35.2941 4 no
GO:0046872 metal ion binding 35.2941 5 no
GO:0000166 nucleotide binding 23.5294 4 yes
GO:0008200 ion channel inhibitor activity 23.5294 5 yes
GO:0016248 channel inhibitor activity 23.5294 4 yes
GO:0099106 ion channel regulator activity 23.5294 4 yes
GO:0043168 anion binding 23.5294 4 no
GO:0005246 calcium channel regulator activity 17.6471 5 yes
GO:0019855 calcium channel inhibitor activity 17.6471 6 yes
GO:0030551 cyclic nucleotide binding 11.7647 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FKB1B_HUMAN
GO:0048523 negative regulation of cellular process 64.7059 4 yes
GO:0048522 positive regulation of cellular process 58.8235 4 yes
GO:0080090 regulation of primary metabolic process 52.9412 4 yes
GO:0031323 regulation of cellular metabolic process 52.9412 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 yes
GO:0010646 regulation of cell communication 47.0588 4 yes
GO:0044057 regulation of system process 47.0588 4 yes
GO:0051049 regulation of transport 41.1765 4 yes
GO:0090257 regulation of muscle system process 41.1765 5 yes
GO:0006937 regulation of muscle contraction 41.1765 6 yes
GO:0034762 regulation of transmembrane transport 41.1765 4 yes
GO:0051051 negative regulation of transport 35.2941 4 yes
GO:0051128 regulation of cellular component organization 35.2941 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 35.2941 5 yes
GO:0051282 regulation of sequestering of calcium ion 35.2941 4 yes
GO:0051924 regulation of calcium ion transport 35.2941 7 yes
GO:0055117 regulation of cardiac muscle contraction 35.2941 7 yes
GO:0141124 intracellular signaling cassette 35.2941 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 35.2941 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 35.2941 7 yes
GO:1903522 regulation of blood circulation 35.2941 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 35.2941 6 yes
GO:0009889 regulation of biosynthetic process 35.2941 4 no
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 no
GO:0006796 phosphate-containing compound metabolic process 35.2941 4 no
GO:0051240 positive regulation of multicellular organismal process 35.2941 4 no
GO:0006942 regulation of striated muscle contraction 35.2941 7 yes
GO:0008016 regulation of heart contraction 35.2941 6 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 35.2941 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 35.2941 7 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 35.2941 6 yes
GO:0010959 regulation of metal ion transport 35.2941 6 yes
GO:0019722 calcium-mediated signaling 35.2941 5 yes
GO:0022898 regulation of transmembrane transporter activity 35.2941 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 35.2941 5 yes
GO:0034763 negative regulation of transmembrane transport 35.2941 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 35.2941 5 yes
GO:0043269 regulation of monoatomic ion transport 35.2941 5 yes
GO:0048584 positive regulation of response to stimulus 29.4118 4 yes
GO:0051174 regulation of phosphorus metabolic process 29.4118 5 yes
GO:0051246 regulation of protein metabolic process 29.4118 5 yes
GO:0051284 positive regulation of sequestering of calcium ion 29.4118 5 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 29.4118 6 yes
GO:1904063 negative regulation of cation transmembrane transport 29.4118 7 yes
GO:2001257 regulation of cation channel activity 29.4118 6 yes
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0019752 carboxylic acid metabolic process 29.4118 5 no
GO:0043436 oxoacid metabolic process 29.4118 4 no
GO:0006355 regulation of DNA-templated transcription 29.4118 7 no
GO:0006357 regulation of transcription by RNA polymerase II 29.4118 8 no
GO:0010468 regulation of gene expression 29.4118 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.4118 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0051252 regulation of RNA metabolic process 29.4118 5 no
GO:2001141 regulation of RNA biosynthetic process 29.4118 6 no
GO:0019220 regulation of phosphate metabolic process 29.4118 6 yes
GO:0031324 negative regulation of cellular metabolic process 29.4118 5 yes
GO:0032410 negative regulation of transporter activity 29.4118 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 29.4118 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 29.4118 6 yes
GO:0043271 negative regulation of monoatomic ion transport 29.4118 5 yes
GO:0043412 macromolecule modification 29.4118 4 yes
GO:0048585 negative regulation of response to stimulus 23.5294 4 yes
GO:0051248 negative regulation of protein metabolic process 23.5294 6 yes
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 23.5294 6 yes
GO:0051336 regulation of hydrolase activity 23.5294 4 yes
GO:0051926 negative regulation of calcium ion transport 23.5294 6 yes
GO:0055074 calcium ion homeostasis 23.5294 4 yes
GO:0055080 monoatomic cation homeostasis 23.5294 4 yes
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 23.5294 7 yes
GO:0060341 regulation of cellular localization 23.5294 4 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 23.5294 6 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 23.5294 7 yes
GO:2001258 negative regulation of cation channel activity 23.5294 6 yes
GO:0009966 regulation of signal transduction 23.5294 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.5294 5 no
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0032787 monocarboxylic acid metabolic process 23.5294 6 no
GO:1901565 organonitrogen compound catabolic process 23.5294 4 no
GO:0016051 carbohydrate biosynthetic process 23.5294 4 no
GO:0016052 carbohydrate catabolic process 23.5294 4 no
GO:0006006 glucose metabolic process 23.5294 5 no
GO:0006163 purine nucleotide metabolic process 23.5294 5 no
GO:0006753 nucleoside phosphate metabolic process 23.5294 4 no
GO:0009117 nucleotide metabolic process 23.5294 5 no
GO:0009141 nucleoside triphosphate metabolic process 23.5294 5 no
GO:0009144 purine nucleoside triphosphate metabolic process 23.5294 6 no
GO:0009150 purine ribonucleotide metabolic process 23.5294 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 23.5294 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 23.5294 7 no
GO:0009259 ribonucleotide metabolic process 23.5294 5 no
GO:0019318 hexose metabolic process 23.5294 4 no
GO:0019693 ribose phosphate metabolic process 23.5294 4 no
GO:0072521 purine-containing compound metabolic process 23.5294 4 no
GO:0006873 intracellular monoatomic ion homeostasis 23.5294 4 yes
GO:0006874 intracellular calcium ion homeostasis 23.5294 5 yes
GO:0010648 negative regulation of cell communication 23.5294 5 yes
GO:0014070 response to organic cyclic compound 23.5294 4 yes
GO:0018193 peptidyl-amino acid modification 23.5294 5 yes
GO:0023057 negative regulation of signaling 23.5294 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 23.5294 5 yes
GO:0031399 regulation of protein modification process 23.5294 6 yes
GO:0035303 regulation of dephosphorylation 23.5294 7 yes
GO:0035304 regulation of protein dephosphorylation 23.5294 7 yes
GO:0036211 protein modification process 23.5294 4 yes
GO:0045936 negative regulation of phosphate metabolic process 17.6471 7 yes
GO:0051094 positive regulation of developmental process 17.6471 4 yes
GO:0051130 positive regulation of cellular component organization 17.6471 5 yes
GO:0051209 release of sequestered calcium ion into cytosol 17.6471 6 yes
GO:0051241 negative regulation of multicellular organismal process 17.6471 4 yes
GO:0051283 negative regulation of sequestering of calcium ion 17.6471 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 17.6471 6 yes
GO:0070588 calcium ion transmembrane transport 17.6471 5 yes
GO:0071702 organic substance transport 17.6471 4 yes
GO:0080134 regulation of response to stress 17.6471 4 yes
GO:0080135 regulation of cellular response to stress 17.6471 4 yes
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 17.6471 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 17.6471 6 yes
GO:0098655 monoatomic cation transmembrane transport 17.6471 4 yes
GO:0098662 inorganic cation transmembrane transport 17.6471 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 17.6471 6 yes
GO:0000413 protein peptidyl-prolyl isomerization 17.6471 7 yes
GO:0001508 action potential 17.6471 4 yes
GO:0006811 monoatomic ion transport 17.6471 4 yes
GO:0006812 monoatomic cation transport 17.6471 5 yes
GO:0006816 calcium ion transport 17.6471 7 yes
GO:0006936 muscle contraction 17.6471 4 yes
GO:0008104 protein localization 17.6471 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 17.6471 6 yes
GO:0010921 regulation of phosphatase activity 17.6471 5 yes
GO:0010975 regulation of neuron projection development 17.6471 7 yes
GO:0010976 positive regulation of neuron projection development 17.6471 7 yes
GO:0018208 peptidyl-proline modification 17.6471 6 yes
GO:0030001 metal ion transport 17.6471 6 yes
GO:0031344 regulation of cell projection organization 17.6471 5 yes
GO:0031346 positive regulation of cell projection organization 17.6471 6 yes
GO:0031400 negative regulation of protein modification process 17.6471 7 yes
GO:0032880 regulation of protein localization 17.6471 5 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 17.6471 6 yes
GO:0045822 negative regulation of heart contraction 11.7647 6 yes
GO:0046651 lymphocyte proliferation 11.7647 4 yes
GO:0046676 negative regulation of insulin secretion 11.7647 7 yes
GO:0046879 hormone secretion 11.7647 5 yes
GO:0046883 regulation of hormone secretion 11.7647 4 yes
GO:0046888 negative regulation of hormone secretion 11.7647 5 yes
GO:0046903 secretion 11.7647 4 yes
GO:0048679 regulation of axon regeneration 11.7647 5 yes
GO:0048680 positive regulation of axon regeneration 11.7647 6 yes
GO:0050708 regulation of protein secretion 11.7647 5 yes
GO:0050709 negative regulation of protein secretion 11.7647 6 yes
GO:0050796 regulation of insulin secretion 11.7647 6 yes
GO:0051046 regulation of secretion 11.7647 5 yes
GO:0051048 negative regulation of secretion 11.7647 5 yes
GO:0051223 regulation of protein transport 11.7647 5 yes
GO:0051224 negative regulation of protein transport 11.7647 5 yes
GO:0051346 negative regulation of hydrolase activity 11.7647 5 yes
GO:0051604 protein maturation 11.7647 4 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 11.7647 7 yes
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus 11.7647 5 yes
GO:0070201 regulation of establishment of protein localization 11.7647 6 yes
GO:0070570 regulation of neuron projection regeneration 11.7647 4 yes
GO:0070572 positive regulation of neuron projection regeneration 11.7647 5 yes
GO:0071692 protein localization to extracellular region 11.7647 5 yes
GO:0071705 nitrogen compound transport 11.7647 4 yes
GO:0090087 regulation of peptide transport 11.7647 5 yes
GO:0090276 regulation of peptide hormone secretion 11.7647 5 yes
GO:0090278 negative regulation of peptide hormone secretion 11.7647 6 yes
GO:0098870 action potential propagation 11.7647 5 yes
GO:1903034 regulation of response to wounding 11.7647 5 yes
GO:1903036 positive regulation of response to wounding 11.7647 5 yes
GO:1903523 negative regulation of blood circulation 11.7647 5 yes
GO:1903530 regulation of secretion by cell 11.7647 4 yes
GO:1903531 negative regulation of secretion by cell 11.7647 5 yes
GO:1903828 negative regulation of protein localization 11.7647 5 yes
GO:1904950 negative regulation of establishment of protein localization 11.7647 6 yes
GO:0000302 response to reactive oxygen species 11.7647 4 yes
GO:0002790 peptide secretion 11.7647 5 yes
GO:0002791 regulation of peptide secretion 11.7647 6 yes
GO:0002792 negative regulation of peptide secretion 11.7647 6 yes
GO:0006939 smooth muscle contraction 11.7647 5 yes
GO:0009306 protein secretion 11.7647 4 yes
GO:0009914 hormone transport 11.7647 4 yes
GO:0010459 negative regulation of heart rate 11.7647 4 yes
GO:0010923 negative regulation of phosphatase activity 11.7647 6 yes
GO:0015031 protein transport 11.7647 4 yes
GO:0015833 peptide transport 11.7647 5 yes
GO:0019227 neuronal action potential propagation 11.7647 4 yes
GO:0023061 signal release 11.7647 4 yes
GO:0030072 peptide hormone secretion 11.7647 6 yes
GO:0030073 insulin secretion 11.7647 5 yes
GO:0032101 regulation of response to external stimulus 11.7647 4 yes
GO:0032103 positive regulation of response to external stimulus 11.7647 5 yes
GO:0032515 negative regulation of phosphoprotein phosphatase activity 11.7647 7 yes
GO:0032943 mononuclear cell proliferation 11.7647 4 yes
GO:0033197 response to vitamin E 11.7647 4 yes
GO:0033273 response to vitamin 11.7647 4 yes
GO:0035305 negative regulation of dephosphorylation 11.7647 8 yes
GO:0035308 negative regulation of protein dephosphorylation 11.7647 8 yes
GO:0035592 establishment of protein localization to extracellular region 11.7647 4 yes
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 11.7647 4 yes
GO:0042098 T cell proliferation 11.7647 5 yes
GO:0042110 T cell activation 11.7647 4 yes
GO:0042542 response to hydrogen peroxide 11.7647 4 yes
GO:0042886 amide transport 11.7647 5 yes
GO:0043086 negative regulation of catalytic activity 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACVR1_HUMAN [view interactions] Low throughput no yes
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
FKB1A_HUMAN [view interactions] Low throughput no yes
BMR1A_HUMAN [view interactions] Low throughput no no
TGFR1_HUMAN [view interactions] Low throughput no no
RYR3_HUMAN [view interactions] Low throughput no no
FKB1B_HUMAN [view entry] [view interactions] Low throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
ITPA_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
K1H1_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
TRI69_HUMAN [view interactions] High throughput no no
ATL4_HUMAN [view interactions] High throughput no yes
GMCL1_HUMAN [view interactions] High throughput no yes
KRA11_HUMAN [view interactions] High throughput no no
BMR1B_HUMAN [view interactions] High throughput no no
DDAH2_HUMAN [view interactions] High throughput no yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
ENOB_HUMAN [view entry] [view interactions] High throughput yes no
FABP5_HUMAN [view entry] [view interactions] High throughput yes no
GLOD4_HUMAN [view entry] [view interactions] High throughput yes yes
GMPPB_HUMAN [view interactions] High throughput no yes
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes