FABP5_HUMAN
Evidence for PS localization
Functions
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed, PubMed). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation . May be involved in keratinocyte differentiation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FABP5_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 36.1111 | 4 | no |
| GO:0045296 | cadherin binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0046872 | metal ion binding | 22.2222 | 4 | no |
| GO:0001972 | retinoic acid binding | 5.5556 | 4 | yes |
| GO:0005501 | retinoid binding | 5.5556 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 5.5556 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 5.5556 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FABP5_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 52.7778 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.2222 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.2222 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.8889 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.1111 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.5556 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.5556 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.5556 | 5 | no |
| GO:0051049 | regulation of transport | 27.7778 | 4 | yes |
| GO:0006996 | organelle organization | 27.7778 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 27.7778 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 27.7778 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.7778 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.7778 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.7778 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.7778 | 5 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 25.0000 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.0000 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | yes |
| GO:0044057 | regulation of system process | 22.2222 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | yes |
| GO:0016310 | phosphorylation | 22.2222 | 5 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0008104 | protein localization | 22.2222 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 19.4444 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 19.4444 | 5 | yes |
| GO:0019318 | hexose metabolic process | 16.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 16.6667 | 4 | yes |
| GO:0051051 | negative regulation of transport | 13.8889 | 4 | yes |
| GO:0006006 | glucose metabolic process | 11.1111 | 5 | yes |
| GO:0008544 | epidermis development | 11.1111 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 11.1111 | 4 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 11.1111 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 11.1111 | 4 | yes |
| GO:0048878 | chemical homeostasis | 11.1111 | 4 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 11.1111 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 11.1111 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 11.1111 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 8.3333 | 4 | yes |
| GO:0006869 | lipid transport | 8.3333 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 8.3333 | 4 | yes |
| GO:0015849 | organic acid transport | 8.3333 | 5 | yes |
| GO:0015908 | fatty acid transport | 8.3333 | 6 | yes |
| GO:0006644 | phospholipid metabolic process | 5.5556 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 5.5556 | 5 | yes |
| GO:0006656 | phosphatidylcholine biosynthetic process | 5.5556 | 5 | yes |
| GO:0008654 | phospholipid biosynthetic process | 5.5556 | 4 | yes |
| GO:0010232 | vascular transport | 5.5556 | 4 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 5.5556 | 5 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 5.5556 | 5 | yes |
| GO:0010829 | negative regulation of glucose transmembrane transport | 5.5556 | 6 | yes |
| GO:0015909 | long-chain fatty acid transport | 5.5556 | 7 | yes |
| GO:0019216 | regulation of lipid metabolic process | 5.5556 | 5 | yes |
| GO:0019217 | regulation of fatty acid metabolic process | 5.5556 | 6 | yes |
| GO:0031392 | regulation of prostaglandin biosynthetic process | 5.5556 | 8 | yes |
| GO:0031644 | regulation of nervous system process | 5.5556 | 5 | yes |
| GO:0033500 | carbohydrate homeostasis | 5.5556 | 5 | yes |
| GO:0035358 | regulation of peroxisome proliferator activated receptor signaling pathway | 5.5556 | 5 | yes |
| GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway | 5.5556 | 6 | yes |
| GO:0042304 | regulation of fatty acid biosynthetic process | 5.5556 | 6 | yes |
| GO:0042593 | glucose homeostasis | 5.5556 | 6 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 5.5556 | 4 | yes |
| GO:0046470 | phosphatidylcholine metabolic process | 5.5556 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 5.5556 | 5 | yes |
| GO:0046890 | regulation of lipid biosynthetic process | 5.5556 | 5 | yes |
| GO:0051930 | regulation of sensory perception of pain | 5.5556 | 7 | yes |
| GO:0051931 | regulation of sensory perception | 5.5556 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 5.5556 | 4 | yes |
| GO:0099178 | regulation of retrograde trans-synaptic signaling by endocanabinoid | 5.5556 | 5 | yes |
| GO:0120162 | positive regulation of cold-induced thermogenesis | 5.5556 | 4 | yes |
| GO:0150104 | transport across blood-brain barrier | 5.5556 | 5 | yes |
| GO:1990379 | lipid transport across blood-brain barrier | 5.5556 | 6 | yes |
| GO:2001279 | regulation of unsaturated fatty acid biosynthetic process | 5.5556 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FABP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S10A7_HUMAN | [view interactions] | Low throughput | no | no |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ARM12_HUMAN | [view interactions] | High throughput | no | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| SPR1B_HUMAN | [view interactions] | High throughput | no | no |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| ARGI1_HUMAN | [view interactions] | High throughput | no | no |
| S10AE_HUMAN | [view interactions] | High throughput | no | no |
| DSC1_HUMAN | [view interactions] | High throughput | no | no |
| CDAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HIRA_HUMAN | [view interactions] | High throughput | no | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| CDIN1_HUMAN | [view interactions] | High throughput | no | yes |
| CABIN_HUMAN | [view interactions] | High throughput | no | yes |
| UBN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBN1_HUMAN | [view interactions] | High throughput | no | yes |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HORN_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HNF1A_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ASF1B_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| BAZ2A_HUMAN | [view interactions] | High throughput | no | no |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NELFB_HUMAN | [view interactions] | High throughput | no | no |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| NELFE_HUMAN | [view interactions] | High throughput | no | yes |
| PIWL4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD5_HUMAN | [view interactions] | High throughput | no | no |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| MITOK_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM3_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | Computational | no | yes |
| LIPS_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACBP_HUMAN | [view interactions] | Computational | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FAAH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |