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FABP5_HUMAN

Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed, PubMed). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation . May be involved in keratinocyte differentiation (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in FABP5_HUMAN
GO:0003723 RNA binding 36.5854 4 no
GO:0043169 cation binding 24.3902 4 no
GO:0046872 metal ion binding 24.3902 5 no
GO:0045296 cadherin binding 24.3902 4 no
GO:0043168 anion binding 21.9512 4 yes
GO:0019900 kinase binding 21.9512 4 no
GO:0019901 protein kinase binding 21.9512 5 no
GO:0001972 retinoic acid binding 4.8780 5 yes
GO:0005324 long-chain fatty acid transmembrane transporter activity 4.8780 5 yes
GO:0005501 retinoid binding 4.8780 4 yes
GO:0008028 monocarboxylic acid transmembrane transporter activity 4.8780 5 yes
GO:0015245 fatty acid transmembrane transporter activity 4.8780 4 yes
GO:0031406 carboxylic acid binding 4.8780 4 yes
GO:0033293 monocarboxylic acid binding 4.8780 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 4.8780 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FABP5_HUMAN
GO:0031323 regulation of cellular metabolic process 63.4146 4 yes
GO:0080090 regulation of primary metabolic process 63.4146 4 yes
GO:0048522 positive regulation of cellular process 58.5366 4 yes
GO:0009889 regulation of biosynthetic process 56.0976 4 yes
GO:0031326 regulation of cellular biosynthetic process 56.0976 5 yes
GO:0048523 negative regulation of cellular process 56.0976 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.0976 4 no
GO:0009893 positive regulation of metabolic process 51.2195 4 yes
GO:0010646 regulation of cell communication 51.2195 4 yes
GO:0010468 regulation of gene expression 51.2195 6 no
GO:0010556 regulation of macromolecule biosynthetic process 51.2195 5 no
GO:0009966 regulation of signal transduction 46.3415 4 yes
GO:0051128 regulation of cellular component organization 43.9024 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.9024 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 43.9024 5 no
GO:0051246 regulation of protein metabolic process 43.9024 5 no
GO:0006355 regulation of DNA-templated transcription 41.4634 7 no
GO:0009892 negative regulation of metabolic process 41.4634 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.4634 5 no
GO:0051252 regulation of RNA metabolic process 41.4634 5 no
GO:2001141 regulation of RNA biosynthetic process 41.4634 6 no
GO:0022607 cellular component assembly 39.0244 4 no
GO:0031324 negative regulation of cellular metabolic process 39.0244 5 no
GO:0051247 positive regulation of protein metabolic process 39.0244 6 no
GO:0048585 negative regulation of response to stimulus 36.5854 4 no
GO:0006796 phosphate-containing compound metabolic process 36.5854 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.5854 5 no
GO:1902531 regulation of intracellular signal transduction 36.5854 5 no
GO:0009894 regulation of catabolic process 34.1463 4 no
GO:0051049 regulation of transport 34.1463 4 yes
GO:0006996 organelle organization 34.1463 4 no
GO:0010648 negative regulation of cell communication 31.7073 5 no
GO:0023057 negative regulation of signaling 31.7073 4 no
GO:0048584 positive regulation of response to stimulus 31.7073 4 yes
GO:0009890 negative regulation of biosynthetic process 31.7073 5 no
GO:0009891 positive regulation of biosynthetic process 31.7073 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.7073 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.7073 6 no
GO:0031327 negative regulation of cellular biosynthetic process 31.7073 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.7073 6 no
GO:0009968 negative regulation of signal transduction 29.2683 5 no
GO:0033043 regulation of organelle organization 29.2683 5 no
GO:0023056 positive regulation of signaling 29.2683 4 yes
GO:0051240 positive regulation of multicellular organismal process 29.2683 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 29.2683 8 no
GO:0043412 macromolecule modification 29.2683 4 no
GO:0060341 regulation of cellular localization 26.8293 4 no
GO:0044087 regulation of cellular component biogenesis 26.8293 4 no
GO:0009967 positive regulation of signal transduction 26.8293 5 yes
GO:0010647 positive regulation of cell communication 26.8293 5 yes
GO:0036211 protein modification process 26.8293 4 no
GO:0080134 regulation of response to stress 26.8293 4 no
GO:0006163 purine nucleotide metabolic process 26.8293 5 no
GO:0006753 nucleoside phosphate metabolic process 26.8293 4 no
GO:0009117 nucleotide metabolic process 26.8293 5 no
GO:0072521 purine-containing compound metabolic process 26.8293 4 no
GO:0042176 regulation of protein catabolic process 24.3902 5 no
GO:1902532 negative regulation of intracellular signal transduction 24.3902 6 no
GO:0042981 regulation of apoptotic process 24.3902 5 no
GO:0043067 regulation of programmed cell death 24.3902 4 no
GO:1901565 organonitrogen compound catabolic process 24.3902 4 no
GO:0031344 regulation of cell projection organization 21.9512 5 no
GO:0032880 regulation of protein localization 21.9512 5 no
GO:0051130 positive regulation of cellular component organization 21.9512 5 no
GO:0051248 negative regulation of protein metabolic process 21.9512 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.9512 6 no
GO:0009896 positive regulation of catabolic process 21.9512 5 no
GO:0030162 regulation of proteolysis 21.9512 6 no
GO:0010629 negative regulation of gene expression 21.9512 7 no
GO:0051129 negative regulation of cellular component organization 21.9512 5 no
GO:0051726 regulation of cell cycle 21.9512 4 no
GO:0019318 hexose metabolic process 21.9512 4 yes
GO:0010628 positive regulation of gene expression 21.9512 7 no
GO:0031399 regulation of protein modification process 21.9512 6 no
GO:0032101 regulation of response to external stimulus 21.9512 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.9512 5 no
GO:0050776 regulation of immune response 21.9512 4 no
GO:0051094 positive regulation of developmental process 21.9512 4 no
GO:0071310 cellular response to organic substance 21.9512 4 no
GO:0019362 pyridine nucleotide metabolic process 21.9512 5 no
GO:0019752 carboxylic acid metabolic process 21.9512 5 no
GO:0043436 oxoacid metabolic process 21.9512 4 no
GO:0046496 nicotinamide nucleotide metabolic process 21.9512 6 no
GO:0072524 pyridine-containing compound metabolic process 21.9512 4 no
GO:0019693 ribose phosphate metabolic process 21.9512 4 no
GO:0006006 glucose metabolic process 19.5122 5 yes
GO:0044057 regulation of system process 19.5122 4 yes
GO:0051051 negative regulation of transport 17.0732 4 yes
GO:0034762 regulation of transmembrane transport 14.6341 4 yes
GO:0090407 organophosphate biosynthetic process 12.1951 4 yes
GO:0099177 regulation of trans-synaptic signaling 12.1951 4 yes
GO:0008544 epidermis development 9.7561 4 yes
GO:0008610 lipid biosynthetic process 9.7561 4 yes
GO:0034763 negative regulation of transmembrane transport 9.7561 5 yes
GO:0062012 regulation of small molecule metabolic process 9.7561 4 yes
GO:0071702 organic substance transport 9.7561 4 yes
GO:0003018 vascular process in circulatory system 7.3171 4 yes
GO:0006644 phospholipid metabolic process 7.3171 4 yes
GO:0006650 glycerophospholipid metabolic process 7.3171 5 yes
GO:0008654 phospholipid biosynthetic process 7.3171 5 yes
GO:0031644 regulation of nervous system process 7.3171 5 yes
GO:0045017 glycerolipid biosynthetic process 7.3171 4 yes
GO:0046474 glycerophospholipid biosynthetic process 7.3171 5 yes
GO:0046486 glycerolipid metabolic process 7.3171 4 yes
GO:1901566 organonitrogen compound biosynthetic process 7.3171 4 yes
GO:0006656 phosphatidylcholine biosynthetic process 4.8780 5 yes
GO:0006869 lipid transport 4.8780 5 yes
GO:0010232 vascular transport 4.8780 4 yes
GO:0010565 regulation of cellular ketone metabolic process 4.8780 5 yes
GO:0010827 regulation of glucose transmembrane transport 4.8780 5 yes
GO:0010829 negative regulation of glucose transmembrane transport 4.8780 6 yes
GO:0015711 organic anion transport 4.8780 5 yes
GO:0015718 monocarboxylic acid transport 4.8780 7 yes
GO:0015849 organic acid transport 4.8780 5 yes
GO:0015908 fatty acid transport 4.8780 6 yes
GO:0015909 long-chain fatty acid transport 4.8780 7 yes
GO:0019216 regulation of lipid metabolic process 4.8780 5 yes
GO:0019217 regulation of fatty acid metabolic process 4.8780 6 yes
GO:0031392 regulation of prostaglandin biosynthetic process 4.8780 8 yes
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 4.8780 5 yes
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway 4.8780 6 yes
GO:0042304 regulation of fatty acid biosynthetic process 4.8780 6 yes
GO:0042593 glucose homeostasis 4.8780 4 yes
GO:0046470 phosphatidylcholine metabolic process 4.8780 4 yes
GO:0046890 regulation of lipid biosynthetic process 4.8780 5 yes
GO:0046942 carboxylic acid transport 4.8780 6 yes
GO:0051930 regulation of sensory perception of pain 4.8780 7 yes
GO:0051931 regulation of sensory perception 4.8780 6 yes
GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid 4.8780 5 yes
GO:0120161 regulation of cold-induced thermogenesis 4.8780 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 4.8780 5 yes
GO:0150104 transport across blood-brain barrier 4.8780 5 yes
GO:1990379 lipid transport across blood-brain barrier 4.8780 6 yes
GO:2001279 regulation of unsaturated fatty acid biosynthetic process 4.8780 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S10A7_HUMAN [view interactions] Low throughput no no
PPARG_HUMAN [view interactions] Low throughput no yes
FABP5_HUMAN [view entry] [view interactions] Low throughput yes no
SLX4_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
MSH2_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
HNF1A_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
RIPK2_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
EIF1B_HUMAN [view interactions] High throughput no no
IKKE_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
SOMA_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ASF1B_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
BAZ2A_HUMAN [view interactions] High throughput no no
KDM3B_HUMAN [view interactions] High throughput no yes
KRR1_HUMAN [view interactions] High throughput no yes
NASP_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NELFB_HUMAN [view interactions] High throughput no yes
NELFD_HUMAN [view interactions] High throughput no yes
NELFE_HUMAN [view interactions] High throughput no yes
PIWL4_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
TDRD5_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
TIFAB_HUMAN [view interactions] High throughput no no
FHI2A_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
2ABA_HUMAN [view interactions] High throughput no yes
CEP57_HUMAN [view interactions] High throughput no yes
GCP3_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
MITOK_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
PCGF1_HUMAN [view interactions] High throughput no yes
PO5F1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
RBM3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
B2CL1_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
ARM12_HUMAN [view interactions] High throughput no no
GLUC_HUMAN [view interactions] High throughput no no
RARA_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
CYTA_HUMAN [view interactions] High throughput no no
KPRP_HUMAN [view interactions] High throughput no no
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
SPB12_HUMAN [view interactions] High throughput no no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
LEG7_HUMAN [view interactions] High throughput no no
SPR1B_HUMAN [view interactions] High throughput no no
DCD_HUMAN [view interactions] High throughput no no
ARGI1_HUMAN [view interactions] High throughput no no
S10AE_HUMAN [view interactions] High throughput no no
DSC1_HUMAN [view interactions] High throughput no no
CDAN1_HUMAN [view interactions] High throughput no yes
HIRA_HUMAN [view interactions] High throughput no yes
S10A8_HUMAN [view interactions] High throughput no no
SRSF1_HUMAN [view interactions] High throughput no yes
CDIN1_HUMAN [view interactions] High throughput no yes
CABIN_HUMAN [view interactions] High throughput no yes
UBN2_HUMAN [view interactions] High throughput no yes
UBN1_HUMAN [view interactions] High throughput no yes
TLK2_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
HORN_HUMAN [view interactions] High throughput no no
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
PD1L1_HUMAN [view interactions] High throughput no no
DX39B_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
RND1_HUMAN [view interactions] High throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
RNF8_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
DDX24_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
ALDR_HUMAN [view interactions] High throughput no no
ECI1_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5J_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
ENOB_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LGUL_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL_HUMAN [view interactions] High throughput no no
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
FKB1A_HUMAN [view interactions] High throughput no yes
FKB1B_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
NUD19_HUMAN [view interactions] High throughput no no
PMM2_HUMAN [view interactions] High throughput no no
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
LACB2_HUMAN [view interactions] High throughput no yes
RIFK_HUMAN [view interactions] High throughput no yes
MYDGF_HUMAN [view interactions] High throughput no yes
GALM_HUMAN [view interactions] High throughput no yes
CMBL_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
FOXO1_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
ERCC8_HUMAN [view interactions] High throughput no no
TP4AP_HUMAN [view interactions] High throughput no yes
WDR82_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes