Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DSG1_HUMAN

GO
G2C
SynGO

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

ELM instance Name Type Start End Partner
ELMI001927 CLV_C14_Caspase3-7 CLV 885 889 -
ELMI001927 CLV_C14_Caspase3-7 CLV 885 889 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DSG1_HUMAN
GO:0043168 anion binding 61.9048 4 no
GO:0000166 nucleotide binding 52.3810 4 no
GO:0017076 purine nucleotide binding 52.3810 5 no
GO:0030554 adenyl nucleotide binding 47.6190 6 no
GO:0032555 purine ribonucleotide binding 47.6190 4 no
GO:0035639 purine ribonucleoside triphosphate binding 47.6190 4 no
GO:0005524 ATP binding 42.8571 5 no
GO:0032559 adenyl ribonucleotide binding 42.8571 5 no
GO:0043169 cation binding 38.0952 4 yes
GO:0046872 metal ion binding 38.0952 5 yes
GO:0016301 kinase activity 30.9524 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 26.1905 4 no
GO:0019900 kinase binding 26.1905 4 no
GO:0003723 RNA binding 26.1905 4 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0005509 calcium ion binding 9.5238 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DSG1_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 no
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 no
GO:0080090 regulation of primary metabolic process 71.4286 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0010646 regulation of cell communication 64.2857 4 no
GO:0009966 regulation of signal transduction 61.9048 4 no
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0009889 regulation of biosynthetic process 52.3810 4 no
GO:0009893 positive regulation of metabolic process 52.3810 4 no
GO:0031326 regulation of cellular biosynthetic process 52.3810 5 no
GO:0051128 regulation of cellular component organization 52.3810 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0023056 positive regulation of signaling 47.6190 4 no
GO:0006796 phosphate-containing compound metabolic process 45.2381 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.2381 5 no
GO:0010647 positive regulation of cell communication 45.2381 5 no
GO:0031324 negative regulation of cellular metabolic process 45.2381 5 no
GO:0051246 regulation of protein metabolic process 45.2381 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 45.2381 5 no
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0051252 regulation of RNA metabolic process 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 40.4762 5 no
GO:0036211 protein modification process 40.4762 4 no
GO:0043412 macromolecule modification 40.4762 4 no
GO:0006355 regulation of DNA-templated transcription 40.4762 7 no
GO:0006996 organelle organization 40.4762 4 no
GO:2001141 regulation of RNA biosynthetic process 40.4762 6 no
GO:0048585 negative regulation of response to stimulus 38.0952 4 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 30.9524 7 no
GO:0016310 phosphorylation 30.9524 5 no
GO:0042325 regulation of phosphorylation 30.9524 7 no
GO:0042981 regulation of apoptotic process 30.9524 5 no
GO:0043067 regulation of programmed cell death 30.9524 4 no
GO:0080134 regulation of response to stress 30.9524 4 no
GO:0051726 regulation of cell cycle 30.9524 4 no
GO:0030162 regulation of proteolysis 28.5714 6 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0014070 response to organic cyclic compound 26.1905 4 yes
GO:0031401 positive regulation of protein modification process 26.1905 7 no
GO:0032101 regulation of response to external stimulus 26.1905 4 no
GO:0043085 positive regulation of catalytic activity 26.1905 4 no
GO:0043408 regulation of MAPK cascade 26.1905 6 no
GO:0051240 positive regulation of multicellular organismal process 26.1905 4 no
GO:0006357 regulation of transcription by RNA polymerase II 26.1905 8 no
GO:0033993 response to lipid 23.8095 4 yes
GO:0006468 protein phosphorylation 23.8095 5 no
GO:0043549 regulation of kinase activity 23.8095 5 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0071702 organic substance transport 23.8095 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.8095 6 no
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0051254 positive regulation of RNA metabolic process 23.8095 6 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045862 positive regulation of proteolysis 21.4286 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0045893 positive regulation of DNA-templated transcription 21.4286 8 no
GO:1902680 positive regulation of RNA biosynthetic process 21.4286 7 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0034330 cell junction organization 19.0476 4 yes
GO:0048545 response to steroid hormone 16.6667 4 yes
GO:0034329 cell junction assembly 14.2857 5 yes
GO:0050821 protein stabilization 14.2857 4 yes
GO:0045216 cell-cell junction organization 11.9048 5 yes
GO:1901654 response to ketone 9.5238 4 yes
GO:0007043 cell-cell junction assembly 7.1429 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PKP1_HUMAN [view interactions] Low throughput no no
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
DSC1_HUMAN [view interactions] Low throughput no no
DESP_HUMAN [view entry] [view interactions] Low throughput yes no
PKP3_HUMAN [view interactions] Low throughput no yes
PKP2_HUMAN [view interactions] Low throughput no yes
DSC2_HUMAN [view interactions] Low throughput no no
RN123_HUMAN [view interactions] Low throughput no yes
DDA1_HUMAN [view interactions] High throughput no yes
DET1_HUMAN [view interactions] High throughput no no
ERCC8_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes
POC1B_HUMAN [view interactions] High throughput no no
RBBP4_HUMAN [view interactions] High throughput no yes
COP1_HUMAN [view interactions] High throughput no no
SNR40_HUMAN [view interactions] High throughput no yes
WSB2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
UBP1_HUMAN [view interactions] High throughput no yes
UBP53_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
WIPI2_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
SAMD1_HUMAN [view interactions] High throughput no no
PI4KA_HUMAN [view entry] [view interactions] High throughput yes yes
TB22B_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
CF298_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
MET14_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARAF_HUMAN [view interactions] High throughput no yes
BLK_HUMAN [view interactions] High throughput no no
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
GAB1_HUMAN [view interactions] High throughput no yes
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
GAB2_HUMAN [view interactions] High throughput no yes
RHG18_HUMAN [view interactions] High throughput no yes
ARH40_HUMAN [view interactions] High throughput no no
SYDE1_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
COQ2_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
H2B1H_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
SIM26_HUMAN [view interactions] High throughput no no
RUVB1_HUMAN [view interactions] High throughput no yes
VRK3_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
KCNH2_HUMAN [view interactions] High throughput no no
CD9_HUMAN [view entry] [view interactions] High throughput yes no
HDAC5_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
MK07_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
KISSR_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
KHDR2_HUMAN [view interactions] High throughput no yes
PTPRQ_HUMAN [view interactions] High throughput no no
2ABA_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
CEP76_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC8_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
MCM5_HUMAN [view interactions] High throughput no no
UBXN1_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
TTC23_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
HIRA_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
NEK2_HUMAN [view interactions] High throughput no no
K1C17_HUMAN [view interactions] High throughput no no
ARM12_HUMAN [view interactions] High throughput no no
ATX3_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
NFIX_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH18_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
PKH4B_HUMAN [view interactions] High throughput no yes
SYDE2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SPB12_HUMAN [view interactions] High throughput no no
KPRP_HUMAN [view interactions] High throughput no no
FILA2_HUMAN [view interactions] High throughput no no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ARGI1_HUMAN [view interactions] High throughput no no
FABP5_HUMAN [view entry] [view interactions] High throughput yes no
KPLCE_HUMAN [view interactions] High throughput no no
HORN_HUMAN [view interactions] High throughput no no
CYTA_HUMAN [view interactions] High throughput no no
TGM3_HUMAN [view interactions] High throughput no no
CASPE_HUMAN [view interactions] High throughput no no
DCD_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
S10AE_HUMAN [view interactions] High throughput no no
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
FILA_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
DX39B_HUMAN [view interactions] High throughput no no
TSSP_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
OR2A4_HUMAN [view interactions] High throughput no no
RPAB5_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
ZC3C1_HUMAN [view interactions] High throughput no yes
ZDH19_HUMAN [view interactions] High throughput no no
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
RND1_HUMAN [view interactions] High throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
CDK4_HUMAN [view interactions] High throughput no no
PMVK_HUMAN [view entry] [view interactions] High throughput yes yes
LA_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
AIMP2_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF8_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TIF1A_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
R113A_HUMAN [view interactions] High throughput no yes
PRD14_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
FBW1A_HUMAN [view interactions] High throughput no yes
MBD5_HUMAN [view interactions] High throughput no no
FND3A_HUMAN [view interactions] High throughput no yes
DDX24_HUMAN [view interactions] High throughput no yes
HSF1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
GOLI_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
UBP20_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF4_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
DCAF7_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
DCA12_HUMAN [view interactions] High throughput no yes
DCA13_HUMAN [view interactions] High throughput no yes