DSG1_HUMAN
Evidence for PS localization
Functions
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001927 | CLV_C14_Caspase3-7 | CLV | 885 | 889 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DSG1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.4615 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 38.4615 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.4615 | 4 | no |
| GO:0046872 | metal ion binding | 35.8974 | 4 | yes |
| GO:0005524 | ATP binding | 33.3333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | no |
| GO:0019900 | kinase binding | 30.7692 | 4 | no |
| GO:0016301 | kinase activity | 28.2051 | 4 | no |
| GO:0019901 | protein kinase binding | 28.2051 | 5 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 23.0769 | 4 | no |
| GO:0045296 | cadherin binding | 20.5128 | 4 | no |
| GO:0005509 | calcium ion binding | 10.2564 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DSG1_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 64.1026 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 64.1026 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 64.1026 | 4 | no |
| GO:0010646 | regulation of cell communication | 61.5385 | 4 | no |
| GO:0009966 | regulation of signal transduction | 58.9744 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 58.9744 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 58.9744 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 48.7179 | 4 | no |
| GO:0022607 | cellular component assembly | 46.1538 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.1538 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.1538 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 46.1538 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 46.1538 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 43.5897 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 43.5897 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 41.0256 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.0256 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.0256 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 41.0256 | 5 | no |
| GO:0036211 | protein modification process | 41.0256 | 4 | no |
| GO:0043412 | macromolecule modification | 41.0256 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.4615 | 5 | no |
| GO:0023056 | positive regulation of signaling | 38.4615 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 38.4615 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 38.4615 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 35.8974 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 35.8974 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 35.8974 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 35.8974 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 35.8974 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 35.8974 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.8974 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0010941 | regulation of cell death | 30.7692 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 30.7692 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 30.7692 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 28.2051 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.2051 | 7 | no |
| GO:0008104 | protein localization | 28.2051 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 28.2051 | 7 | no |
| GO:0033043 | regulation of organelle organization | 28.2051 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 28.2051 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.2051 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.2051 | 5 | no |
| GO:0051726 | regulation of cell cycle | 28.2051 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.6410 | 4 | no |
| GO:0030162 | regulation of proteolysis | 25.6410 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.6410 | 6 | no |
| GO:0016310 | phosphorylation | 25.6410 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.6410 | 5 | no |
| GO:0051338 | regulation of transferase activity | 25.6410 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 25.6410 | 6 | no |
| GO:0034330 | cell junction organization | 23.0769 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.0769 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0006468 | protein phosphorylation | 23.0769 | 5 | no |
| GO:0043086 | negative regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.0769 | 5 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 20.5128 | 4 | yes |
| GO:0033993 | response to lipid | 20.5128 | 4 | yes |
| GO:0034329 | cell junction assembly | 20.5128 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 20.5128 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 20.5128 | 7 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.5128 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 20.5128 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.5128 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.5128 | 8 | no |
| GO:0007346 | regulation of mitotic cell cycle | 20.5128 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 20.5128 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 20.5128 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0051347 | positive regulation of transferase activity | 20.5128 | 5 | no |
| GO:0071705 | nitrogen compound transport | 20.5128 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 20.5128 | 4 | no |
| GO:0010942 | positive regulation of cell death | 20.5128 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.5128 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0007043 | cell-cell junction assembly | 15.3846 | 6 | yes |
| GO:0050821 | protein stabilization | 10.2564 | 4 | yes |
| GO:0048545 | response to steroid hormone | 7.6923 | 4 | yes |
| GO:1901654 | response to ketone | 7.6923 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DSG1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.6923 | 3 | no |
| DOID:0050686 | organ system cancer | 5.1282 | 3 | no |
| DOID:6457 | Cowden syndrome | 5.1282 | 3 | no |
| DOID:37 | skin disease | 5.1282 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 5.1282 | 5 | no |
| DOID:607 | paraplegia | 5.1282 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PKP1_HUMAN | [view interactions] | Low throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DSC1_HUMAN | [view interactions] | Low throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PKP3_HUMAN | [view interactions] | Low throughput | no | yes |
| PKP2_HUMAN | [view interactions] | Low throughput | no | yes |
| DSC2_HUMAN | [view interactions] | Low throughput | no | no |
| RN123_HUMAN | [view interactions] | Low throughput | no | yes |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| S10AE_HUMAN | [view interactions] | High throughput | no | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FILA_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| TSSP_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| RPAB5_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH19_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| ZMY11_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAMD1_HUMAN | [view interactions] | High throughput | no | no |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| CF298_HUMAN | [view interactions] | High throughput | no | yes |
| MITOK_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| ARH40_HUMAN | [view interactions] | High throughput | no | no |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| KCNH2_HUMAN | [view interactions] | High throughput | no | no |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| KISSR_HUMAN | [view interactions] | High throughput | no | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRQ_HUMAN | [view interactions] | High throughput | no | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| HIRA_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| ARM12_HUMAN | [view interactions] | High throughput | no | no |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKH4B_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| FILA2_HUMAN | [view interactions] | High throughput | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARGI1_HUMAN | [view interactions] | High throughput | no | no |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XP32_HUMAN | [view interactions] | High throughput | no | no |
| HORN_HUMAN | [view interactions] | High throughput | no | no |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| TGM3_HUMAN | [view interactions] | High throughput | no | no |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EVPL_HUMAN | [view interactions] | Computational | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PKP4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CASP3_HUMAN | [view interactions] | Computational | no | yes |