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TAOK2_HUMAN

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TAOK2_HUMAN
GO:0017076 purine nucleotide binding 58.3333 4 yes
GO:0032555 purine ribonucleotide binding 58.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0030554 adenyl nucleotide binding 45.8333 5 yes
GO:0032559 adenyl ribonucleotide binding 45.8333 5 yes
GO:0005524 ATP binding 37.5000 5 yes
GO:0016301 kinase activity 29.1667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 29.1667 4 yes
GO:0019900 kinase binding 25.0000 4 yes
GO:0019901 protein kinase binding 25.0000 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 20.8333 4 yes
GO:0003723 RNA binding 20.8333 4 no
GO:0019001 guanyl nucleotide binding 20.8333 5 no
GO:0032561 guanyl ribonucleotide binding 20.8333 5 no
GO:0004674 protein serine/threonine kinase activity 16.6667 4 yes
GO:0106310 protein serine kinase activity 16.6667 4 yes
GO:0048156 tau protein binding 12.5000 4 yes
GO:0019209 kinase activator activity 8.3333 4 yes
GO:0019887 protein kinase regulator activity 8.3333 4 yes
GO:0030295 protein kinase activator activity 8.3333 5 yes
GO:0043539 protein serine/threonine kinase activator activity 8.3333 6 yes
GO:0050321 tau-protein kinase activity 8.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TAOK2_HUMAN
GO:0048522 positive regulation of cellular process 70.8333 4 yes
GO:0048523 negative regulation of cellular process 70.8333 4 yes
GO:0051128 regulation of cellular component organization 70.8333 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0006996 organelle organization 62.5000 4 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 yes
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 54.1667 5 yes
GO:0033043 regulation of organelle organization 54.1667 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 54.1667 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.1667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 45.8333 6 yes
GO:0042325 regulation of phosphorylation 45.8333 7 yes
GO:0048584 positive regulation of response to stimulus 45.8333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 45.8333 5 yes
GO:0051174 regulation of phosphorus metabolic process 45.8333 5 yes
GO:1902531 regulation of intracellular signal transduction 45.8333 5 yes
GO:0009967 positive regulation of signal transduction 41.6667 5 yes
GO:0010647 positive regulation of cell communication 41.6667 5 yes
GO:0023056 positive regulation of signaling 41.6667 4 yes
GO:0044087 regulation of cellular component biogenesis 41.6667 4 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 yes
GO:0007010 cytoskeleton organization 37.5000 5 yes
GO:0008104 protein localization 37.5000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 yes
GO:0042327 positive regulation of phosphorylation 37.5000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 yes
GO:0051246 regulation of protein metabolic process 37.5000 5 yes
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0030030 cell projection organization 33.3333 4 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0043549 regulation of kinase activity 33.3333 5 yes
GO:0051247 positive regulation of protein metabolic process 33.3333 6 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0051493 regulation of cytoskeleton organization 33.3333 6 yes
GO:0080134 regulation of response to stress 33.3333 4 yes
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 29.1667 7 yes
GO:0001934 positive regulation of protein phosphorylation 29.1667 8 yes
GO:0043408 regulation of MAPK cascade 29.1667 6 yes
GO:0051726 regulation of cell cycle 29.1667 4 yes
GO:0080135 regulation of cellular response to stress 29.1667 4 yes
GO:1902903 regulation of supramolecular fiber organization 29.1667 5 no
GO:0010556 regulation of macromolecule biosynthetic process 29.1667 5 no
GO:0044089 positive regulation of cellular component biogenesis 29.1667 5 no
GO:0000165 MAPK cascade 25.0000 4 yes
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0032990 cell part morphogenesis 25.0000 4 yes
GO:0033674 positive regulation of kinase activity 25.0000 6 yes
GO:0036211 protein modification process 25.0000 4 yes
GO:0043085 positive regulation of catalytic activity 25.0000 4 yes
GO:0043410 positive regulation of MAPK cascade 25.0000 7 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0048812 neuron projection morphogenesis 25.0000 7 yes
GO:0048858 cell projection morphogenesis 25.0000 5 yes
GO:0051347 positive regulation of transferase activity 25.0000 5 yes
GO:0071702 organic substance transport 25.0000 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0006468 protein phosphorylation 20.8333 5 yes
GO:0016310 phosphorylation 20.8333 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 20.8333 6 yes
GO:0032956 regulation of actin cytoskeleton organization 20.8333 5 yes
GO:0032970 regulation of actin filament-based process 20.8333 4 yes
GO:0046328 regulation of JNK cascade 20.8333 7 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 20.8333 5 yes
GO:0071705 nitrogen compound transport 20.8333 4 yes
GO:0010639 negative regulation of organelle organization 20.8333 6 no
GO:0006355 regulation of DNA-templated transcription 20.8333 6 no
GO:0009891 positive regulation of biosynthetic process 20.8333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8333 6 no
GO:0033365 protein localization to organelle 20.8333 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.8333 6 no
GO:1903506 regulation of nucleic acid-templated transcription 20.8333 7 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.8333 5 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:0061024 membrane organization 20.8333 4 no
GO:1901214 regulation of neuron death 20.8333 5 no
GO:0016192 vesicle-mediated transport 20.8333 4 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0010638 positive regulation of organelle organization 20.8333 6 no
GO:0006605 protein targeting 16.6667 5 yes
GO:0006886 intracellular protein transport 16.6667 4 yes
GO:0006974 cellular response to DNA damage stimulus 16.6667 4 yes
GO:0007346 regulation of mitotic cell cycle 16.6667 5 yes
GO:0015031 protein transport 16.6667 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 16.6667 4 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 16.6667 7 yes
GO:0045859 regulation of protein kinase activity 16.6667 6 yes
GO:0045860 positive regulation of protein kinase activity 16.6667 7 yes
GO:0046330 positive regulation of JNK cascade 16.6667 8 yes
GO:0046777 protein autophosphorylation 16.6667 6 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 16.6667 6 yes
GO:0072657 protein localization to membrane 16.6667 4 yes
GO:0001558 regulation of cell growth 12.5000 4 yes
GO:0034329 cell junction assembly 12.5000 5 yes
GO:0034330 cell junction organization 12.5000 4 yes
GO:0042770 signal transduction in response to DNA damage 12.5000 4 yes
GO:1901987 regulation of cell cycle phase transition 12.5000 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 12.5000 6 yes
GO:0000075 cell cycle checkpoint signaling 8.3333 4 yes
GO:0000077 DNA damage checkpoint signaling 8.3333 5 yes
GO:0006612 protein targeting to membrane 8.3333 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 8.3333 4 yes
GO:0007095 mitotic G2 DNA damage checkpoint signaling 8.3333 6 yes
GO:0007409 axonogenesis 8.3333 8 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 8.3333 7 yes
GO:0010948 negative regulation of cell cycle process 8.3333 6 yes
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 8.3333 8 yes
GO:0022604 regulation of cell morphogenesis 8.3333 5 yes
GO:0031098 stress-activated protein kinase signaling cascade 8.3333 4 yes
GO:0031570 DNA integrity checkpoint signaling 8.3333 5 yes
GO:0044773 mitotic DNA damage checkpoint signaling 8.3333 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 8.3333 5 yes
GO:0044818 mitotic G2/M transition checkpoint 8.3333 5 yes
GO:0045786 negative regulation of cell cycle 8.3333 5 yes
GO:0045930 negative regulation of mitotic cell cycle 8.3333 6 yes
GO:0051403 stress-activated MAPK cascade 8.3333 5 yes
GO:0090150 establishment of protein localization to membrane 8.3333 4 yes
GO:1901988 negative regulation of cell cycle phase transition 8.3333 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 8.3333 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 8.3333 7 yes
GO:1902750 negative regulation of cell cycle G2/M phase transition 8.3333 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K6_HUMAN [view interactions] Low throughput no yes
M3K7_HUMAN [view interactions] Low throughput no yes
TNAP3_HUMAN [view interactions] Low throughput no yes
TBB5_HUMAN [view interactions] Low throughput no yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
USF1_HUMAN [view interactions] Low throughput no yes
MEG10_HUMAN [view interactions] High throughput no no
SCNAA_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
PPR18_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
ABITM_HUMAN [view interactions] High throughput no yes
TNR3_HUMAN [view interactions] High throughput no yes
KCNS3_HUMAN [view interactions] High throughput no yes
PCDBG_HUMAN [view interactions] High throughput no no
STK25_HUMAN [view interactions] High throughput no no
ZDHC1_HUMAN [view interactions] High throughput no no
NMUR2_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK3_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
KLH36_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
F172A_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
TAOK1_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
P5CS_HUMAN [view interactions] High throughput no yes
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
BGAL_HUMAN [view interactions] High throughput no yes
PPGB_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
AURKC_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
CIDEB_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TNKS2_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
RCOR3_HUMAN [view interactions] High throughput no yes
S39A8_HUMAN [view interactions] High throughput no yes
TY3H_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
BTNL9_HUMAN [view interactions] High throughput no no
BSCL2_HUMAN [view interactions] High throughput no yes
CD6_HUMAN [view interactions] High throughput no no
I17RA_HUMAN [view interactions] High throughput no yes
CLMN_HUMAN [view entry] [view interactions] High throughput yes no
MAGA9_HUMAN [view interactions] High throughput no no
PDE3A_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
FABD_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
H2A1J_HUMAN [view interactions] High throughput no yes
S10A7_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PIM1_HUMAN [view interactions] High throughput no yes
LTC4S_HUMAN [view interactions] High throughput no no
KCRM_HUMAN [view interactions] High throughput no no
EMD_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
ATM_HUMAN [view interactions] Computational no yes