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TAOK2_HUMAN

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TAOK2_HUMAN
GO:0043168 anion binding 27.5862 4 yes
GO:0000166 nucleotide binding 26.4368 4 yes
GO:0017076 purine nucleotide binding 26.4368 5 yes
GO:0032555 purine ribonucleotide binding 25.2874 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 22.9885 4 yes
GO:0003723 RNA binding 22.9885 4 no
GO:0030554 adenyl nucleotide binding 21.8391 6 yes
GO:0019900 kinase binding 20.6897 4 yes
GO:0032559 adenyl ribonucleotide binding 20.6897 5 yes
GO:0005524 ATP binding 18.3908 5 yes
GO:0019901 protein kinase binding 17.2414 5 yes
GO:0016301 kinase activity 13.7931 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 13.7931 4 yes
GO:0004674 protein serine/threonine kinase activity 9.1954 4 yes
GO:0106310 protein serine kinase activity 9.1954 4 yes
GO:0048156 tau protein binding 5.7471 4 yes
GO:0019887 protein kinase regulator activity 4.5977 4 yes
GO:0004709 MAP kinase kinase kinase activity 3.4483 5 yes
GO:0019209 kinase activator activity 3.4483 4 yes
GO:0030295 protein kinase activator activity 3.4483 5 yes
GO:0043539 protein serine/threonine kinase activator activity 3.4483 6 yes
GO:0050321 tau-protein kinase activity 3.4483 4 yes
GO:0031434 mitogen-activated protein kinase kinase binding 2.2989 6 yes
GO:0038191 neuropilin binding 2.2989 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TAOK2_HUMAN
GO:0048522 positive regulation of cellular process 50.5747 4 yes
GO:0048523 negative regulation of cellular process 49.4253 4 yes
GO:0010646 regulation of cell communication 45.9770 4 yes
GO:0051128 regulation of cellular component organization 44.8276 4 yes
GO:0009966 regulation of signal transduction 42.5287 4 yes
GO:0031323 regulation of cellular metabolic process 40.2299 4 yes
GO:0060255 regulation of macromolecule metabolic process 39.0805 4 yes
GO:0006996 organelle organization 39.0805 4 yes
GO:0022607 cellular component assembly 39.0805 4 yes
GO:0080090 regulation of primary metabolic process 37.9310 4 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0051246 regulation of protein metabolic process 29.8851 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.8851 5 yes
GO:1902531 regulation of intracellular signal transduction 28.7356 5 yes
GO:0030030 cell projection organization 27.5862 4 yes
GO:0031325 positive regulation of cellular metabolic process 27.5862 5 yes
GO:0048584 positive regulation of response to stimulus 26.4368 4 yes
GO:0009889 regulation of biosynthetic process 24.1379 4 no
GO:0031326 regulation of cellular biosynthetic process 24.1379 5 no
GO:0007010 cytoskeleton organization 24.1379 5 yes
GO:0010647 positive regulation of cell communication 24.1379 5 yes
GO:0023056 positive regulation of signaling 24.1379 4 yes
GO:0034330 cell junction organization 24.1379 4 yes
GO:0009892 negative regulation of metabolic process 22.9885 4 no
GO:0010468 regulation of gene expression 22.9885 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.9885 5 no
GO:0009967 positive regulation of signal transduction 22.9885 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 21.8391 5 no
GO:0031399 regulation of protein modification process 21.8391 6 yes
GO:0051247 positive regulation of protein metabolic process 20.6897 6 yes
GO:0141124 intracellular signaling cassette 20.6897 4 yes
GO:0006796 phosphate-containing compound metabolic process 20.6897 4 yes
GO:0033043 regulation of organelle organization 20.6897 5 yes
GO:0048812 neuron projection morphogenesis 19.5402 5 yes
GO:0051174 regulation of phosphorus metabolic process 19.5402 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.5402 4 yes
GO:0019220 regulation of phosphate metabolic process 19.5402 6 yes
GO:0001932 regulation of protein phosphorylation 18.3908 7 yes
GO:0031401 positive regulation of protein modification process 18.3908 7 yes
GO:0042325 regulation of phosphorylation 18.3908 7 yes
GO:1902533 positive regulation of intracellular signal transduction 16.0920 6 yes
GO:0034329 cell junction assembly 16.0920 5 yes
GO:0072657 protein localization to membrane 14.9425 4 yes
GO:0001934 positive regulation of protein phosphorylation 14.9425 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 14.9425 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 14.9425 4 yes
GO:0042327 positive regulation of phosphorylation 14.9425 8 yes
GO:0043085 positive regulation of catalytic activity 14.9425 4 yes
GO:0045937 positive regulation of phosphate metabolic process 14.9425 7 yes
GO:0051493 regulation of cytoskeleton organization 13.7931 6 yes
GO:0051726 regulation of cell cycle 13.7931 4 yes
GO:0043408 regulation of MAPK cascade 13.7931 6 yes
GO:0080134 regulation of response to stress 12.6437 4 yes
GO:0016310 phosphorylation 12.6437 5 yes
GO:0036211 protein modification process 12.6437 4 yes
GO:0043412 macromolecule modification 12.6437 4 yes
GO:0051338 regulation of transferase activity 11.4943 4 yes
GO:0006915 apoptotic process 11.4943 4 yes
GO:0043410 positive regulation of MAPK cascade 11.4943 7 yes
GO:0043549 regulation of kinase activity 11.4943 5 yes
GO:0045859 regulation of protein kinase activity 11.4943 6 yes
GO:0000165 MAPK cascade 10.3448 5 yes
GO:0032970 regulation of actin filament-based process 10.3448 4 yes
GO:0051347 positive regulation of transferase activity 9.1954 5 yes
GO:0001558 regulation of cell growth 9.1954 4 yes
GO:0006468 protein phosphorylation 9.1954 5 yes
GO:0010564 regulation of cell cycle process 9.1954 5 yes
GO:0032956 regulation of actin cytoskeleton organization 9.1954 5 yes
GO:0033674 positive regulation of kinase activity 9.1954 6 yes
GO:0045860 positive regulation of protein kinase activity 9.1954 7 yes
GO:0046328 regulation of JNK cascade 9.1954 7 yes
GO:0006605 protein targeting 8.0460 4 yes
GO:0007346 regulation of mitotic cell cycle 8.0460 5 yes
GO:0046330 positive regulation of JNK cascade 8.0460 8 yes
GO:0046777 protein autophosphorylation 6.8966 6 yes
GO:0048813 dendrite morphogenesis 6.8966 6 yes
GO:0080135 regulation of cellular response to stress 6.8966 4 yes
GO:0007409 axonogenesis 6.8966 6 yes
GO:0090150 establishment of protein localization to membrane 5.7471 4 yes
GO:1901987 regulation of cell cycle phase transition 5.7471 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 5.7471 6 yes
GO:0006974 DNA damage response 5.7471 4 yes
GO:0022604 regulation of cell morphogenesis 4.5977 5 yes
GO:0042770 signal transduction in response to DNA damage 4.5977 4 yes
GO:0048041 focal adhesion assembly 3.4483 7 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 3.4483 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 3.4483 6 yes
GO:0140058 neuron projection arborization 3.4483 6 yes
GO:0150115 cell-substrate junction organization 3.4483 5 yes
GO:1901988 negative regulation of cell cycle phase transition 3.4483 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 3.4483 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 3.4483 7 yes
GO:1902750 negative regulation of cell cycle G2/M phase transition 3.4483 8 yes
GO:0000075 cell cycle checkpoint signaling 3.4483 4 yes
GO:0000077 DNA damage checkpoint signaling 3.4483 5 yes
GO:0006612 protein targeting to membrane 3.4483 5 yes
GO:0007044 cell-substrate junction assembly 3.4483 6 yes
GO:0007093 mitotic cell cycle checkpoint signaling 3.4483 4 yes
GO:0007095 mitotic G2 DNA damage checkpoint signaling 3.4483 6 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 3.4483 7 yes
GO:0010948 negative regulation of cell cycle process 3.4483 6 yes
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 3.4483 8 yes
GO:0031098 stress-activated protein kinase signaling cascade 3.4483 4 yes
GO:0031570 DNA integrity checkpoint signaling 3.4483 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 3.4483 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 3.4483 7 yes
GO:0044773 mitotic DNA damage checkpoint signaling 3.4483 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 3.4483 5 yes
GO:0044818 mitotic G2/M transition checkpoint 3.4483 5 yes
GO:0045786 negative regulation of cell cycle 3.4483 5 yes
GO:0045930 negative regulation of mitotic cell cycle 3.4483 6 yes
GO:0051403 stress-activated MAPK cascade 2.2989 5 yes
GO:0140059 dendrite arborization 2.2989 7 yes
GO:0150019 basal dendrite morphogenesis 2.2989 7 yes
GO:0150020 basal dendrite arborization 2.2989 8 yes
GO:0031952 regulation of protein autophosphorylation 2.2989 8 yes
GO:0031954 positive regulation of protein autophosphorylation 2.2989 9 yes
GO:0032147 activation of protein kinase activity 2.2989 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K6_HUMAN [view interactions] Low throughput no yes
M3K7_HUMAN [view interactions] Low throughput no yes
TNAP3_HUMAN [view interactions] Low throughput no yes
TBB5_HUMAN [view interactions] Low throughput no yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
USF1_HUMAN [view interactions] Low throughput no yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TANC2_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
UBP2L_HUMAN [view interactions] High throughput no yes
SYWC_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
TEX2_HUMAN [view interactions] High throughput no yes
MEG10_HUMAN [view interactions] High throughput no no
SCNAA_HUMAN [view interactions] High throughput no no
PPR18_HUMAN [view interactions] High throughput no no
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
ABITM_HUMAN [view interactions] High throughput no yes
TNR3_HUMAN [view interactions] High throughput no yes
KCNS3_HUMAN [view interactions] High throughput no yes
PCDBG_HUMAN [view interactions] High throughput no no
STK25_HUMAN [view interactions] High throughput no no
ZDHC1_HUMAN [view interactions] High throughput no no
NMUR2_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK3_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
PPGB_HUMAN [view interactions] High throughput no yes
BGAL_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
P5CS_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
PLOD1_HUMAN [view interactions] High throughput no yes
TAOK1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH36_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
ARB2A_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
AURKC_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
KRA63_HUMAN [view interactions] High throughput no no
CIDEB_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TNKS2_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
RCOR3_HUMAN [view interactions] High throughput no yes
S39A8_HUMAN [view interactions] High throughput no yes
TY3H_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
BTNL9_HUMAN [view interactions] High throughput no no
BSCL2_HUMAN [view interactions] High throughput no yes
CD6_HUMAN [view interactions] High throughput no no
I17RA_HUMAN [view interactions] High throughput no yes
CLMN_HUMAN [view entry] [view interactions] High throughput yes no
MAGA9_HUMAN [view interactions] High throughput no no
PDE3A_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
FABD_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
H2A1J_HUMAN [view interactions] High throughput no yes
S10A7_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TOP3B_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PIM1_HUMAN [view interactions] High throughput no yes
LTC4S_HUMAN [view interactions] High throughput no no
KCRM_HUMAN [view interactions] High throughput no no
EMD_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
AGRL3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
ATLA1_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CNOT2_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
DHRS1_HUMAN [view interactions] High throughput no yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB2_HUMAN [view entry] [view interactions] High throughput yes yes
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
DVL2_HUMAN [view interactions] High throughput no yes
DVL3_HUMAN [view interactions] High throughput no yes
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G3_HUMAN [view interactions] High throughput no yes
ELAV4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX41_HUMAN [view entry] [view interactions] High throughput yes no
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
GBRB3_HUMAN [view entry] [view interactions] High throughput yes no
GBRG2_HUMAN [view entry] [view interactions] High throughput yes no
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
GASP1_HUMAN [view interactions] High throughput no yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
H3C_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
H2A2A_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
H2A1D_HUMAN [view interactions] High throughput no yes
H2AJ_HUMAN [view interactions] High throughput no yes
H2A1A_HUMAN [view interactions] High throughput no yes
H2A2B_HUMAN [view interactions] High throughput no yes
H2A3_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
H2A1C_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
H2A1H_HUMAN [view interactions] High throughput no yes
HMCS1_HUMAN [view interactions] High throughput no yes
HNRLL_HUMAN [view interactions] High throughput no yes
HSBP1_HUMAN [view interactions] High throughput no no
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNB2_HUMAN [view interactions] High throughput no no
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
JIP3_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
MCCB_HUMAN [view entry] [view interactions] High throughput yes yes
MIB2_HUMAN [view entry] [view interactions] High throughput yes yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
NAV1_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG3_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PLPR4_HUMAN [view entry] [view interactions] High throughput yes no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
RACK1_HUMAN [view interactions] High throughput no yes
RBP2_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM39_HUMAN [view interactions] High throughput no yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
RS21_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
SYUB_HUMAN [view interactions] High throughput no yes