TAOK2_HUMAN
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TAOK2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 58.3333 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 58.3333 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 45.8333 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 45.8333 | 5 | yes |
GO:0005524 | ATP binding | 37.5000 | 5 | yes |
GO:0016301 | kinase activity | 29.1667 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 29.1667 | 4 | yes |
GO:0019900 | kinase binding | 25.0000 | 4 | yes |
GO:0019901 | protein kinase binding | 25.0000 | 5 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 20.8333 | 4 | yes |
GO:0003723 | RNA binding | 20.8333 | 4 | no |
GO:0019001 | guanyl nucleotide binding | 20.8333 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 20.8333 | 5 | no |
GO:0004674 | protein serine/threonine kinase activity | 16.6667 | 4 | yes |
GO:0106310 | protein serine kinase activity | 16.6667 | 4 | yes |
GO:0048156 | tau protein binding | 12.5000 | 4 | yes |
GO:0019209 | kinase activator activity | 8.3333 | 4 | yes |
GO:0019887 | protein kinase regulator activity | 8.3333 | 4 | yes |
GO:0030295 | protein kinase activator activity | 8.3333 | 5 | yes |
GO:0043539 | protein serine/threonine kinase activator activity | 8.3333 | 6 | yes |
GO:0050321 | tau-protein kinase activity | 8.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TAOK2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.8333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 70.8333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 70.8333 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | yes |
GO:0006996 | organelle organization | 62.5000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 62.5000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 62.5000 | 4 | yes |
GO:0010646 | regulation of cell communication | 62.5000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 62.5000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 54.1667 | 5 | yes |
GO:0033043 | regulation of organelle organization | 54.1667 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 54.1667 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 45.8333 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 45.8333 | 7 | yes |
GO:0048584 | positive regulation of response to stimulus | 45.8333 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.8333 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 45.8333 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 45.8333 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 41.6667 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 41.6667 | 5 | yes |
GO:0023056 | positive regulation of signaling | 41.6667 | 4 | yes |
GO:0044087 | regulation of cellular component biogenesis | 41.6667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 37.5000 | 4 | yes |
GO:0007010 | cytoskeleton organization | 37.5000 | 5 | yes |
GO:0008104 | protein localization | 37.5000 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 37.5000 | 6 | yes |
GO:0042327 | positive regulation of phosphorylation | 37.5000 | 8 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 37.5000 | 7 | yes |
GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 37.5000 | 5 | no |
GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
GO:0030030 | cell projection organization | 33.3333 | 4 | yes |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | yes |
GO:0043549 | regulation of kinase activity | 33.3333 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | yes |
GO:0051338 | regulation of transferase activity | 33.3333 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 33.3333 | 6 | yes |
GO:0080134 | regulation of response to stress | 33.3333 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 33.3333 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 29.1667 | 7 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 29.1667 | 8 | yes |
GO:0043408 | regulation of MAPK cascade | 29.1667 | 6 | yes |
GO:0051726 | regulation of cell cycle | 29.1667 | 4 | yes |
GO:0080135 | regulation of cellular response to stress | 29.1667 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 29.1667 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.1667 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 29.1667 | 5 | no |
GO:0000165 | MAPK cascade | 25.0000 | 4 | yes |
GO:0010564 | regulation of cell cycle process | 25.0000 | 5 | yes |
GO:0032990 | cell part morphogenesis | 25.0000 | 4 | yes |
GO:0033674 | positive regulation of kinase activity | 25.0000 | 6 | yes |
GO:0036211 | protein modification process | 25.0000 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | yes |
GO:0043410 | positive regulation of MAPK cascade | 25.0000 | 7 | yes |
GO:0043412 | macromolecule modification | 25.0000 | 4 | yes |
GO:0048812 | neuron projection morphogenesis | 25.0000 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 25.0000 | 5 | yes |
GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | yes |
GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 25.0000 | 6 | yes |
GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 25.0000 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
GO:0006468 | protein phosphorylation | 20.8333 | 5 | yes |
GO:0016310 | phosphorylation | 20.8333 | 5 | yes |
GO:0032872 | regulation of stress-activated MAPK cascade | 20.8333 | 6 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 20.8333 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 20.8333 | 4 | yes |
GO:0046328 | regulation of JNK cascade | 20.8333 | 7 | yes |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 20.8333 | 5 | yes |
GO:0071705 | nitrogen compound transport | 20.8333 | 4 | yes |
GO:0010639 | negative regulation of organelle organization | 20.8333 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 6 | no |
GO:0009891 | positive regulation of biosynthetic process | 20.8333 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.8333 | 6 | no |
GO:0033365 | protein localization to organelle | 20.8333 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8333 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 20.8333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
GO:0060548 | negative regulation of cell death | 20.8333 | 5 | no |
GO:0061024 | membrane organization | 20.8333 | 4 | no |
GO:1901214 | regulation of neuron death | 20.8333 | 5 | no |
GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | no |
GO:0071310 | cellular response to organic substance | 20.8333 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 20.8333 | 6 | no |
GO:0006605 | protein targeting | 16.6667 | 5 | yes |
GO:0006886 | intracellular protein transport | 16.6667 | 4 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 16.6667 | 4 | yes |
GO:0007346 | regulation of mitotic cell cycle | 16.6667 | 5 | yes |
GO:0015031 | protein transport | 16.6667 | 4 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 16.6667 | 4 | yes |
GO:0032874 | positive regulation of stress-activated MAPK cascade | 16.6667 | 7 | yes |
GO:0045859 | regulation of protein kinase activity | 16.6667 | 6 | yes |
GO:0045860 | positive regulation of protein kinase activity | 16.6667 | 7 | yes |
GO:0046330 | positive regulation of JNK cascade | 16.6667 | 8 | yes |
GO:0046777 | protein autophosphorylation | 16.6667 | 6 | yes |
GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 16.6667 | 6 | yes |
GO:0072657 | protein localization to membrane | 16.6667 | 4 | yes |
GO:0001558 | regulation of cell growth | 12.5000 | 4 | yes |
GO:0034329 | cell junction assembly | 12.5000 | 5 | yes |
GO:0034330 | cell junction organization | 12.5000 | 4 | yes |
GO:0042770 | signal transduction in response to DNA damage | 12.5000 | 4 | yes |
GO:1901987 | regulation of cell cycle phase transition | 12.5000 | 6 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 12.5000 | 6 | yes |
GO:0000075 | cell cycle checkpoint signaling | 8.3333 | 4 | yes |
GO:0000077 | DNA damage checkpoint signaling | 8.3333 | 5 | yes |
GO:0006612 | protein targeting to membrane | 8.3333 | 5 | yes |
GO:0007093 | mitotic cell cycle checkpoint signaling | 8.3333 | 4 | yes |
GO:0007095 | mitotic G2 DNA damage checkpoint signaling | 8.3333 | 6 | yes |
GO:0007409 | axonogenesis | 8.3333 | 8 | yes |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 8.3333 | 7 | yes |
GO:0010948 | negative regulation of cell cycle process | 8.3333 | 6 | yes |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 8.3333 | 8 | yes |
GO:0022604 | regulation of cell morphogenesis | 8.3333 | 5 | yes |
GO:0031098 | stress-activated protein kinase signaling cascade | 8.3333 | 4 | yes |
GO:0031570 | DNA integrity checkpoint signaling | 8.3333 | 5 | yes |
GO:0044773 | mitotic DNA damage checkpoint signaling | 8.3333 | 6 | yes |
GO:0044774 | mitotic DNA integrity checkpoint signaling | 8.3333 | 5 | yes |
GO:0044818 | mitotic G2/M transition checkpoint | 8.3333 | 5 | yes |
GO:0045786 | negative regulation of cell cycle | 8.3333 | 5 | yes |
GO:0045930 | negative regulation of mitotic cell cycle | 8.3333 | 6 | yes |
GO:0051403 | stress-activated MAPK cascade | 8.3333 | 5 | yes |
GO:0090150 | establishment of protein localization to membrane | 8.3333 | 4 | yes |
GO:1901988 | negative regulation of cell cycle phase transition | 8.3333 | 7 | yes |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 8.3333 | 7 | yes |
GO:1902749 | regulation of cell cycle G2/M phase transition | 8.3333 | 7 | yes |
GO:1902750 | negative regulation of cell cycle G2/M phase transition | 8.3333 | 8 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MP2K3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MP2K6_HUMAN | [view interactions] | Low throughput | no | yes |
M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
USF1_HUMAN | [view interactions] | Low throughput | no | yes |
MEG10_HUMAN | [view interactions] | High throughput | no | no |
SCNAA_HUMAN | [view interactions] | High throughput | no | no |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPR18_HUMAN | [view interactions] | High throughput | no | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABITM_HUMAN | [view interactions] | High throughput | no | yes |
TNR3_HUMAN | [view interactions] | High throughput | no | yes |
KCNS3_HUMAN | [view interactions] | High throughput | no | yes |
PCDBG_HUMAN | [view interactions] | High throughput | no | no |
STK25_HUMAN | [view interactions] | High throughput | no | no |
ZDHC1_HUMAN | [view interactions] | High throughput | no | no |
NMUR2_HUMAN | [view interactions] | High throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
KLH36_HUMAN | [view interactions] | High throughput | no | yes |
STK24_HUMAN | [view interactions] | High throughput | no | yes |
PDC10_HUMAN | [view interactions] | High throughput | no | yes |
F172A_HUMAN | [view interactions] | High throughput | no | yes |
PI42C_HUMAN | [view interactions] | High throughput | no | yes |
TAOK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P5CS_HUMAN | [view interactions] | High throughput | no | yes |
PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BGAL_HUMAN | [view interactions] | High throughput | no | yes |
PPGB_HUMAN | [view interactions] | High throughput | no | yes |
AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AURKC_HUMAN | [view interactions] | High throughput | no | no |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
KLH12_HUMAN | [view interactions] | High throughput | no | no |
MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
TNKS2_HUMAN | [view interactions] | High throughput | no | no |
ZN363_HUMAN | [view interactions] | High throughput | no | yes |
CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCOR3_HUMAN | [view interactions] | High throughput | no | yes |
S39A8_HUMAN | [view interactions] | High throughput | no | yes |
TY3H_HUMAN | [view interactions] | High throughput | no | no |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
CIC_HUMAN | [view interactions] | High throughput | no | yes |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
CD6_HUMAN | [view interactions] | High throughput | no | no |
I17RA_HUMAN | [view interactions] | High throughput | no | yes |
CLMN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAGA9_HUMAN | [view interactions] | High throughput | no | no |
PDE3A_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
FABD_HUMAN | [view interactions] | High throughput | no | yes |
PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
S10A7_HUMAN | [view interactions] | High throughput | no | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIM1_HUMAN | [view interactions] | High throughput | no | yes |
LTC4S_HUMAN | [view interactions] | High throughput | no | no |
KCRM_HUMAN | [view interactions] | High throughput | no | no |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
SYNE3_HUMAN | [view interactions] | High throughput | no | no |
ATM_HUMAN | [view interactions] | Computational | no | yes |