Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLPR4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hydrolyzes lysophosphatidic acid (LPA) and participates to the axonal outgrowth during development by attenuating phospholipid-induced axon collapse in neuron. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLPR4_HUMAN
GO:0043168 anion binding 35.7143 4 no
GO:0043169 cation binding 28.5714 4 no
GO:0046872 metal ion binding 28.5714 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0016301 kinase activity 28.5714 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0008270 zinc ion binding 21.4286 7 no
GO:0046914 transition metal ion binding 21.4286 6 no
GO:0042803 protein homodimerization activity 21.4286 4 no
GO:0016791 phosphatase activity 14.2857 5 yes
GO:0042578 phosphoric ester hydrolase activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLPR4_HUMAN
GO:0010646 regulation of cell communication 85.7143 4 yes
GO:0050804 modulation of chemical synaptic transmission 71.4286 5 yes
GO:0099177 regulation of trans-synaptic signaling 71.4286 4 yes
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0010647 positive regulation of cell communication 57.1429 5 no
GO:0023056 positive regulation of signaling 57.1429 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0099536 synaptic signaling 42.8571 4 no
GO:0099537 trans-synaptic signaling 42.8571 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 no
GO:0036211 protein modification process 42.8571 4 no
GO:0043412 macromolecule modification 42.8571 4 no
GO:0022603 regulation of anatomical structure morphogenesis 42.8571 4 no
GO:0030030 cell projection organization 35.7143 4 yes
GO:0007268 chemical synaptic transmission 35.7143 7 no
GO:0031644 regulation of nervous system process 35.7143 5 no
GO:0043085 positive regulation of catalytic activity 35.7143 4 no
GO:0044057 regulation of system process 35.7143 4 no
GO:0050806 positive regulation of synaptic transmission 35.7143 5 no
GO:0050807 regulation of synapse organization 35.7143 5 no
GO:0050890 cognition 35.7143 4 no
GO:0098916 anterograde trans-synaptic signaling 35.7143 6 no
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0044087 regulation of cellular component biogenesis 35.7143 4 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0051094 positive regulation of developmental process 35.7143 4 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0048812 neuron projection morphogenesis 28.5714 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 yes
GO:0051049 regulation of transport 28.5714 4 no
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 28.5714 5 no
GO:0006996 organelle organization 28.5714 4 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0050770 regulation of axonogenesis 28.5714 5 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0007409 axonogenesis 21.4286 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 21.4286 6 yes
GO:0071702 organic substance transport 21.4286 4 yes
GO:0007215 glutamate receptor signaling pathway 21.4286 4 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0045862 positive regulation of proteolysis 21.4286 7 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0099175 regulation of postsynapse organization 21.4286 6 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0031175 neuron projection development 21.4286 6 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0034330 cell junction organization 21.4286 4 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0050767 regulation of neurogenesis 21.4286 6 no
GO:0051051 negative regulation of transport 21.4286 4 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:0060998 regulation of dendritic spine development 21.4286 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:1901888 regulation of cell junction assembly 21.4286 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:0006468 protein phosphorylation 21.4286 5 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0022604 regulation of cell morphogenesis 21.4286 5 no
GO:0046777 protein autophosphorylation 21.4286 6 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051962 positive regulation of nervous system development 21.4286 5 no
GO:0007612 learning 21.4286 4 no
GO:0008104 protein localization 21.4286 4 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:0006644 phospholipid metabolic process 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRI67_HUMAN [view interactions] Low throughput no no
GLU2B_HUMAN [view interactions] Low throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
F10C1_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
NDUF7_HUMAN [view interactions] High throughput no yes
F91A1_HUMAN [view interactions] High throughput no yes
NECT2_HUMAN [view interactions] High throughput no no
ZNRF3_HUMAN [view interactions] High throughput no no
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
NPAP1_HUMAN [view interactions] High throughput no no
MIB2_HUMAN [view entry] [view interactions] High throughput yes yes
DESI1_HUMAN [view interactions] High throughput no yes
PLPR1_HUMAN [view interactions] High throughput no no
OTU7A_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
CBPZ_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes