Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRX1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRX1A_HUMAN
GO:0046872 metal ion binding 22.2222 4 yes
GO:0005509 calcium ion binding 16.6667 5 yes
GO:0097109 neuroligin family protein binding 11.1111 4 yes
GO:0005246 calcium channel regulator activity 8.3333 4 yes
GO:0033130 acetylcholine receptor binding 8.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRX1A_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 55.5556 5 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0099177 regulation of trans-synaptic signaling 55.5556 4 yes
GO:0009966 regulation of signal transduction 52.7778 4 yes
GO:0051094 positive regulation of developmental process 52.7778 4 yes
GO:0099537 trans-synaptic signaling 47.2222 4 yes
GO:0007268 chemical synaptic transmission 44.4444 6 yes
GO:0022607 cellular component assembly 44.4444 4 yes
GO:0034330 cell junction organization 44.4444 4 yes
GO:0050808 synapse organization 44.4444 5 yes
GO:0098916 anterograde trans-synaptic signaling 44.4444 5 yes
GO:0048523 negative regulation of cellular process 44.4444 4 no
GO:0008104 protein localization 41.6667 4 yes
GO:0050807 regulation of synapse organization 41.6667 5 yes
GO:0051130 positive regulation of cellular component organization 41.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 41.6667 4 yes
GO:2000026 regulation of multicellular organismal development 41.6667 4 yes
GO:0010647 positive regulation of cell communication 38.8889 5 yes
GO:0023056 positive regulation of signaling 38.8889 4 yes
GO:0044057 regulation of system process 38.8889 4 yes
GO:0044087 regulation of cellular component biogenesis 38.8889 4 yes
GO:0051960 regulation of nervous system development 38.8889 5 yes
GO:0051962 positive regulation of nervous system development 38.8889 5 yes
GO:0051049 regulation of transport 38.8889 4 no
GO:0031644 regulation of nervous system process 36.1111 5 yes
GO:0044089 positive regulation of cellular component biogenesis 30.5556 5 yes
GO:0048584 positive regulation of response to stimulus 30.5556 4 yes
GO:0050806 positive regulation of synaptic transmission 30.5556 5 yes
GO:0072657 protein localization to membrane 30.5556 4 yes
GO:1901888 regulation of cell junction assembly 30.5556 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.5556 4 no
GO:0043269 regulation of ion transport 30.5556 5 no
GO:0007416 synapse assembly 27.7778 6 yes
GO:0007612 learning 27.7778 4 yes
GO:0009967 positive regulation of signal transduction 27.7778 5 yes
GO:0034329 cell junction assembly 27.7778 5 yes
GO:0050890 cognition 27.7778 4 yes
GO:0051963 regulation of synapse assembly 27.7778 6 yes
GO:0051965 positive regulation of synapse assembly 27.7778 6 yes
GO:0098815 modulation of excitatory postsynaptic potential 27.7778 4 yes
GO:1901890 positive regulation of cell junction assembly 27.7778 6 yes
GO:0035418 protein localization to synapse 25.0000 6 yes
GO:0043113 receptor clustering 25.0000 5 yes
GO:1902414 protein localization to cell junction 25.0000 5 yes
GO:0006996 organelle organization 25.0000 4 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0046903 secretion 22.2222 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 22.2222 6 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 22.2222 5 yes
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0051171 regulation of nitrogen compound metabolic process 22.2222 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no
GO:0099601 regulation of neurotransmitter receptor activity 22.2222 4 no
GO:0001941 postsynaptic membrane organization 19.4444 5 yes
GO:0007158 neuron cell-cell adhesion 19.4444 4 yes
GO:0030030 cell projection organization 19.4444 4 yes
GO:0031175 neuron projection development 19.4444 6 yes
GO:0061024 membrane organization 19.4444 4 yes
GO:0071709 membrane assembly 19.4444 5 yes
GO:0097104 postsynaptic membrane assembly 19.4444 6 yes
GO:0120036 plasma membrane bounded cell projection organization 19.4444 5 yes
GO:0023061 signal release 16.6667 4 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 16.6667 6 yes
GO:0099643 signal release from synapse 16.6667 5 yes
GO:0006836 neurotransmitter transport 13.8889 4 yes
GO:0007269 neurotransmitter secretion 13.8889 4 yes
GO:0050885 neuromuscular process controlling balance 13.8889 5 yes
GO:0050905 neuromuscular process 13.8889 4 yes
GO:0097119 postsynaptic density protein 95 clustering 13.8889 5 yes
GO:0031223 auditory behavior 11.1111 4 yes
GO:0042297 vocal learning 11.1111 5 yes
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 11.1111 7 yes
GO:0098596 imitative learning 11.1111 6 yes
GO:0098597 observational learning 11.1111 5 yes
GO:0098598 learned vocalization behavior or vocal learning 11.1111 4 yes
GO:0007411 axon guidance 8.3333 8 yes
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 8.3333 6 yes
GO:0097485 neuron projection guidance 8.3333 7 yes
GO:0090128 regulation of synapse maturation 5.5556 4 yes
GO:0090129 positive regulation of synapse maturation 5.5556 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
SYTL1_HUMAN [view interactions] Low throughput no yes
SYTL2_HUMAN [view interactions] Low throughput no no
SYTL3_HUMAN [view interactions] Low throughput no no
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAD_HUMAN [view interactions] Low throughput no yes
NLGN3_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT13_HUMAN [view interactions] Low throughput no no
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
APBA1_HUMAN [view interactions] Low throughput no no
APBA2_HUMAN [view interactions] Low throughput no yes
CBLN1_HUMAN [view entry] [view interactions] Low throughput yes no
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
NXPH1_HUMAN [view interactions] Low throughput no no
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO16_HUMAN [view interactions] High throughput no no
PDZD2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TULP1_HUMAN [view interactions] High throughput no no
RHG10_HUMAN [view interactions] High throughput no no
ELOA1_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
AT132_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
LNX2_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT2_HUMAN [view entry] [view interactions] Computational yes no
NXPH3_HUMAN [view interactions] Computational no no
DLG3_HUMAN [view entry] [view interactions] Computational yes yes
LRRT1_HUMAN [view entry] [view interactions] Computational yes yes
EPB41_HUMAN [view entry] [view interactions] Computational yes no
CSKI1_HUMAN [view entry] [view interactions] Computational yes yes
GRM5_HUMAN [view entry] [view interactions] Computational yes no
DLGP2_HUMAN [view entry] [view interactions] Computational yes no
DAG1_HUMAN [view entry] [view interactions] Computational yes no
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
NXPH2_HUMAN [view interactions] Computational no no
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
NXPH4_HUMAN [view interactions] Computational no no
SYT1_HUMAN [view entry] [view interactions] Computational yes no
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
LRRT4_HUMAN [view entry] [view interactions] Computational yes no
LRRT3_HUMAN [view entry] [view interactions] Computational yes no
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes
NLGNX_HUMAN [view entry] [view interactions] Computational yes yes