NRX1A_HUMAN
Evidence for PS localization
Functions
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NRX1A_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0043169 | cation binding | 18.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 18.6667 | 5 | yes |
| GO:0005509 | calcium ion binding | 12.0000 | 6 | yes |
| GO:0033130 | acetylcholine receptor binding | 4.0000 | 4 | yes |
| GO:0097109 | neuroligin family protein binding | 4.0000 | 4 | yes |
| GO:0005246 | calcium channel regulator activity | 2.6667 | 5 | yes |
| GO:0099106 | ion channel regulator activity | 2.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NRX1A_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 56.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.0000 | 4 | no |
| GO:0008104 | protein localization | 42.6667 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.3333 | 4 | yes |
| GO:0006996 | organelle organization | 34.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.6667 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 30.6667 | 4 | no |
| GO:0051049 | regulation of transport | 30.6667 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 29.3333 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 28.0000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 28.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 28.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.0000 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 28.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 28.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.3333 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.3333 | 5 | no |
| GO:0030030 | cell projection organization | 24.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.6667 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 22.6667 | 5 | yes |
| GO:0071702 | organic substance transport | 22.6667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.6667 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.6667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.3333 | 5 | no |
| GO:0071705 | nitrogen compound transport | 21.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.3333 | 5 | no |
| GO:0099536 | synaptic signaling | 20.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 20.0000 | 5 | yes |
| GO:0034330 | cell junction organization | 18.6667 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 18.6667 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 18.6667 | 5 | yes |
| GO:0061024 | membrane organization | 18.6667 | 4 | yes |
| GO:0072657 | protein localization to membrane | 18.6667 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 18.6667 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 18.6667 | 7 | yes |
| GO:0046903 | secretion | 17.3333 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 17.3333 | 5 | yes |
| GO:0031175 | neuron projection development | 16.0000 | 6 | yes |
| GO:0034329 | cell junction assembly | 16.0000 | 5 | yes |
| GO:0050808 | synapse organization | 16.0000 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 16.0000 | 5 | yes |
| GO:0044057 | regulation of system process | 14.6667 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 14.6667 | 6 | yes |
| GO:0031644 | regulation of nervous system process | 13.3333 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 13.3333 | 5 | yes |
| GO:0051965 | positive regulation of synapse assembly | 13.3333 | 6 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 13.3333 | 6 | yes |
| GO:0035418 | protein localization to synapse | 12.0000 | 6 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 12.0000 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 12.0000 | 5 | yes |
| GO:0007416 | synapse assembly | 12.0000 | 6 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 10.6667 | 5 | yes |
| GO:0043113 | receptor clustering | 9.3333 | 5 | yes |
| GO:0050890 | cognition | 9.3333 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 9.3333 | 6 | yes |
| GO:0023061 | signal release | 8.0000 | 4 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 8.0000 | 6 | yes |
| GO:0071709 | membrane assembly | 8.0000 | 5 | yes |
| GO:0007612 | learning | 8.0000 | 4 | yes |
| GO:0097104 | postsynaptic membrane assembly | 6.6667 | 6 | yes |
| GO:0099643 | signal release from synapse | 6.6667 | 5 | yes |
| GO:0001941 | postsynaptic membrane organization | 6.6667 | 5 | yes |
| GO:0006836 | neurotransmitter transport | 6.6667 | 4 | yes |
| GO:0007158 | neuron cell-cell adhesion | 6.6667 | 4 | yes |
| GO:0050885 | neuromuscular process controlling balance | 5.3333 | 5 | yes |
| GO:0050905 | neuromuscular process | 5.3333 | 4 | yes |
| GO:0097119 | postsynaptic density protein 95 clustering | 5.3333 | 5 | yes |
| GO:0097485 | neuron projection guidance | 5.3333 | 7 | yes |
| GO:0007269 | neurotransmitter secretion | 5.3333 | 4 | yes |
| GO:0007411 | axon guidance | 5.3333 | 8 | yes |
| GO:0031223 | auditory behavior | 4.0000 | 4 | yes |
| GO:0042297 | vocal learning | 4.0000 | 5 | yes |
| GO:0090128 | regulation of synapse maturation | 4.0000 | 4 | yes |
| GO:0097116 | gephyrin clustering involved in postsynaptic density assembly | 4.0000 | 7 | yes |
| GO:0098596 | imitative learning | 4.0000 | 6 | yes |
| GO:0098597 | observational learning | 4.0000 | 5 | yes |
| GO:0098598 | learned vocalization behavior or vocal learning | 4.0000 | 4 | yes |
| GO:0090129 | positive regulation of synapse maturation | 2.6667 | 5 | yes |
| GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly | 2.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYTL1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYTL2_HUMAN | [view interactions] | Low throughput | no | no |
| SYTL3_HUMAN | [view interactions] | Low throughput | no | no |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT13_HUMAN | [view interactions] | Low throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NXPH1_HUMAN | [view interactions] | Low throughput | no | no |
| CBLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP1_HUMAN | [view interactions] | High throughput | no | no |
| RHG10_HUMAN | [view interactions] | High throughput | no | no |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT132_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMER2_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AXA81_HUMAN | [view interactions] | High throughput | no | no |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| MGLYR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ3_HUMAN | [view interactions] | High throughput | no | yes |
| KCD16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PITM3_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| PLPR4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A6_HUMAN | [view interactions] | High throughput | no | yes |
| SLIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUB_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPKAP_HUMAN | [view interactions] | High throughput | no | yes |
| STAU2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| TEN4_HUMAN | [view interactions] | High throughput | no | no |
| NACHO_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |