Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRRT2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRRT2_HUMAN
GO:0046872 metal ion binding 50.0000 4 no
GO:0097109 neuroligin family protein binding 37.5000 4 no
GO:0042043 neurexin family protein binding 25.0000 4 yes
GO:0005246 calcium channel regulator activity 25.0000 4 no
GO:0005509 calcium ion binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRRT2_HUMAN
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 yes
GO:0051094 positive regulation of developmental process 62.5000 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0051130 positive regulation of cellular component organization 62.5000 5 yes
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 yes
GO:0022607 cellular component assembly 62.5000 4 no
GO:0099537 trans-synaptic signaling 62.5000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0034330 cell junction organization 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 50.0000 5 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0050806 positive regulation of synaptic transmission 50.0000 5 yes
GO:0050807 regulation of synapse organization 50.0000 5 yes
GO:0050808 synapse organization 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0051960 regulation of nervous system development 50.0000 5 yes
GO:0051962 positive regulation of nervous system development 50.0000 5 yes
GO:0051963 regulation of synapse assembly 50.0000 6 yes
GO:0051965 positive regulation of synapse assembly 50.0000 6 yes
GO:1901888 regulation of cell junction assembly 50.0000 5 yes
GO:1901890 positive regulation of cell junction assembly 50.0000 6 yes
GO:2000026 regulation of multicellular organismal development 50.0000 4 yes
GO:0061024 membrane organization 50.0000 4 no
GO:0071709 membrane assembly 50.0000 5 no
GO:0007158 neuron cell-cell adhesion 50.0000 4 no
GO:0007268 chemical synaptic transmission 50.0000 6 no
GO:0098916 anterograde trans-synaptic signaling 50.0000 5 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0051049 regulation of transport 37.5000 4 yes
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 yes
GO:0099175 regulation of postsynapse organization 37.5000 6 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 37.5000 4 no
GO:0007612 learning 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0031175 neuron projection development 37.5000 6 no
GO:0050890 cognition 37.5000 4 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0001941 postsynaptic membrane organization 37.5000 5 no
GO:0006836 neurotransmitter transport 37.5000 4 no
GO:0007269 neurotransmitter secretion 37.5000 4 no
GO:0007416 synapse assembly 37.5000 6 no
GO:0008104 protein localization 37.5000 4 no
GO:0023061 signal release 37.5000 4 no
GO:0034329 cell junction assembly 37.5000 5 no
GO:0035418 protein localization to synapse 37.5000 6 no
GO:0043113 receptor clustering 37.5000 5 no
GO:0046903 secretion 37.5000 4 no
GO:0072657 protein localization to membrane 37.5000 4 no
GO:0097104 postsynaptic membrane assembly 37.5000 6 no
GO:0097119 postsynaptic density protein 95 clustering 37.5000 5 no
GO:0099643 signal release from synapse 37.5000 5 no
GO:1902414 protein localization to cell junction 37.5000 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 37.5000 6 no
GO:0030100 regulation of endocytosis 25.0000 5 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:0099150 regulation of postsynaptic specialization assembly 25.0000 6 yes
GO:0099151 regulation of postsynaptic density assembly 25.0000 7 yes
GO:1902115 regulation of organelle assembly 25.0000 5 yes
GO:1904889 regulation of excitatory synapse assembly 25.0000 7 yes
GO:1905874 regulation of postsynaptic density organization 25.0000 6 yes
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0097090 presynaptic membrane organization 25.0000 5 no
GO:0097105 presynaptic membrane assembly 25.0000 6 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 25.0000 4 no
GO:0099560 synaptic membrane adhesion 25.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0007411 axon guidance 25.0000 8 no
GO:0097485 neuron projection guidance 25.0000 7 no
GO:0031223 auditory behavior 25.0000 4 no
GO:0042297 vocal learning 25.0000 5 no
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 25.0000 7 no
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 25.0000 6 no
GO:0098596 imitative learning 25.0000 6 no
GO:0098597 observational learning 25.0000 5 no
GO:0098598 learned vocalization behavior or vocal learning 25.0000 4 no
GO:0001956 positive regulation of neurotransmitter secretion 25.0000 5 no
GO:0006897 endocytosis 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0045921 positive regulation of exocytosis 25.0000 6 no
GO:0046928 regulation of neurotransmitter secretion 25.0000 4 no
GO:0048488 synaptic vesicle endocytosis 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051047 positive regulation of secretion 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051588 regulation of neurotransmitter transport 25.0000 5 no
GO:0051590 positive regulation of neurotransmitter transport 25.0000 5 no
GO:0051592 response to calcium ion 25.0000 5 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0071277 cellular response to calcium ion 25.0000 6 no
GO:0099003 vesicle-mediated transport in synapse 25.0000 5 no
GO:0140238 presynaptic endocytosis 25.0000 4 no
GO:1903305 regulation of regulated secretory pathway 25.0000 6 no
GO:1903307 positive regulation of regulated secretory pathway 25.0000 7 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:1903532 positive regulation of secretion by cell 25.0000 5 no
GO:2000300 regulation of synaptic vesicle exocytosis 25.0000 5 no
GO:2000302 positive regulation of synaptic vesicle exocytosis 25.0000 6 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 25.0000 6 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX2A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
TM38B_HUMAN [view interactions] High throughput no yes
LGR4_HUMAN [view interactions] High throughput no yes
CNPY3_HUMAN [view interactions] High throughput no yes
CNPY4_HUMAN [view interactions] High throughput no yes
DAD1_HUMAN [view entry] [view interactions] High throughput yes yes
GPC3_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
T120B_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
TYW1_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
PDE3B_HUMAN [view interactions] High throughput no no
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
ST7_HUMAN [view interactions] High throughput no yes
KCD15_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
TTI2_HUMAN [view interactions] High throughput no yes
KGP1_HUMAN [view interactions] High throughput no yes
CEIP2_HUMAN [view interactions] Computational no yes
NLGN1_HUMAN [view entry] [view interactions] Computational yes yes