Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRRT2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRRT2_HUMAN
GO:0043169 cation binding 57.1429 4 no
GO:0046872 metal ion binding 57.1429 5 no
GO:0097109 neuroligin family protein binding 42.8571 4 no
GO:0005509 calcium ion binding 28.5714 6 no
GO:0005246 calcium channel regulator activity 28.5714 5 no
GO:0099106 ion channel regulator activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRRT2_HUMAN
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 yes
GO:0051094 positive regulation of developmental process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0051130 positive regulation of cellular component organization 57.1429 5 yes
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 yes
GO:0022607 cellular component assembly 57.1429 4 no
GO:0099536 synaptic signaling 57.1429 4 no
GO:0099537 trans-synaptic signaling 57.1429 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 yes
GO:0023056 positive regulation of signaling 42.8571 4 yes
GO:0033043 regulation of organelle organization 42.8571 5 yes
GO:0034330 cell junction organization 42.8571 4 yes
GO:0044087 regulation of cellular component biogenesis 42.8571 4 yes
GO:0044089 positive regulation of cellular component biogenesis 42.8571 5 yes
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0050806 positive regulation of synaptic transmission 42.8571 5 yes
GO:0050807 regulation of synapse organization 42.8571 5 yes
GO:0050808 synapse organization 42.8571 5 yes
GO:0051240 positive regulation of multicellular organismal process 42.8571 4 yes
GO:0051960 regulation of nervous system development 42.8571 5 yes
GO:0051962 positive regulation of nervous system development 42.8571 5 yes
GO:0051963 regulation of synapse assembly 42.8571 6 yes
GO:0051965 positive regulation of synapse assembly 42.8571 6 yes
GO:1901888 regulation of cell junction assembly 42.8571 5 yes
GO:1901890 positive regulation of cell junction assembly 42.8571 6 yes
GO:2000026 regulation of multicellular organismal development 42.8571 4 yes
GO:0061024 membrane organization 42.8571 4 no
GO:0071709 membrane assembly 42.8571 5 no
GO:0006836 neurotransmitter transport 42.8571 4 no
GO:0007268 chemical synaptic transmission 42.8571 7 no
GO:0007269 neurotransmitter secretion 42.8571 4 no
GO:0023061 signal release 42.8571 4 no
GO:0046903 secretion 42.8571 4 no
GO:0098916 anterograde trans-synaptic signaling 42.8571 6 no
GO:0099643 signal release from synapse 42.8571 5 no
GO:0007158 neuron cell-cell adhesion 42.8571 4 no
GO:0007612 learning 42.8571 4 no
GO:0050890 cognition 42.8571 4 no
GO:0051049 regulation of transport 28.5714 4 yes
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 yes
GO:0099150 regulation of postsynaptic specialization assembly 28.5714 6 yes
GO:0099151 regulation of postsynaptic density assembly 28.5714 7 yes
GO:0099175 regulation of postsynapse organization 28.5714 6 yes
GO:1902115 regulation of organelle assembly 28.5714 5 yes
GO:1904889 regulation of excitatory synapse assembly 28.5714 7 yes
GO:1905874 regulation of postsynaptic density organization 28.5714 6 yes
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0022604 regulation of cell morphogenesis 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 28.5714 6 no
GO:0001941 postsynaptic membrane organization 28.5714 5 no
GO:0007411 axon guidance 28.5714 8 no
GO:0007416 synapse assembly 28.5714 6 no
GO:0008104 protein localization 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031223 auditory behavior 28.5714 4 no
GO:0034329 cell junction assembly 28.5714 5 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0042297 vocal learning 28.5714 5 no
GO:0043113 receptor clustering 28.5714 5 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0097104 postsynaptic membrane assembly 28.5714 6 no
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 28.5714 7 no
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 28.5714 6 no
GO:0097119 postsynaptic density protein 95 clustering 28.5714 5 no
GO:0097485 neuron projection guidance 28.5714 7 no
GO:0098596 imitative learning 28.5714 6 no
GO:0098597 observational learning 28.5714 5 no
GO:0098598 learned vocalization behavior or vocal learning 28.5714 4 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:1902414 protein localization to cell junction 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX2A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
KCD15_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
TTI2_HUMAN [view interactions] High throughput no yes
KGP1_HUMAN [view interactions] High throughput no yes
GPC3_HUMAN [view interactions] High throughput no no
DAD1_HUMAN [view entry] [view interactions] High throughput yes yes
CNPY4_HUMAN [view interactions] High throughput no yes
CNPY3_HUMAN [view interactions] High throughput no yes
LGR4_HUMAN [view interactions] High throughput no yes
TM38B_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
T120B_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
TYW1_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
PDE3B_HUMAN [view interactions] High throughput no no
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
ST7_HUMAN [view interactions] High throughput no yes