Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRX3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002288 LIG_PDZ_Class_2 LIG 1638 1643 -
ELMI002288 LIG_PDZ_Class_2 LIG 1638 1643 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRX3A_HUMAN
GO:0000166 nucleotide binding 25.0000 4 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0106310 protein serine kinase activity 25.0000 4 no
GO:0042043 neurexin family protein binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NRX3A_HUMAN
GO:0048523 negative regulation of cellular process 87.5000 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 50.0000 4 no
GO:2000145 regulation of cell motility 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0030334 regulation of cell migration 50.0000 5 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0030155 regulation of cell adhesion 37.5000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0043270 positive regulation of monoatomic ion transport 25.0000 5 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050678 regulation of epithelial cell proliferation 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0051928 positive regulation of calcium ion transport 25.0000 6 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 25.0000 4 no
GO:1903305 regulation of regulated secretory pathway 25.0000 6 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0030336 negative regulation of cell migration 25.0000 6 no
GO:0040013 negative regulation of locomotion 25.0000 4 no
GO:2000146 negative regulation of cell motility 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0002064 epithelial cell development 25.0000 4 no
GO:0006469 negative regulation of protein kinase activity 25.0000 7 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022407 regulation of cell-cell adhesion 25.0000 5 no
GO:0022409 positive regulation of cell-cell adhesion 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
RPB2_HUMAN [view interactions] High throughput no yes