Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in both signal transduction and cellular adhesion in the CNS. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRT_HUMAN
GO:0019902 phosphatase binding 31.2500 4 yes
GO:0019903 protein phosphatase binding 31.2500 5 yes
GO:0000166 nucleotide binding 31.2500 4 no
GO:0005524 ATP binding 31.2500 5 no
GO:0017076 purine nucleotide binding 31.2500 5 no
GO:0030554 adenyl nucleotide binding 31.2500 6 no
GO:0032555 purine ribonucleotide binding 31.2500 4 no
GO:0032559 adenyl ribonucleotide binding 31.2500 5 no
GO:0035639 purine ribonucleoside triphosphate binding 31.2500 4 no
GO:0043168 anion binding 31.2500 4 no
GO:0043169 cation binding 31.2500 4 no
GO:0046872 metal ion binding 31.2500 5 no
GO:0042803 protein homodimerization activity 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 18.7500 5 yes
GO:0140297 DNA-binding transcription factor binding 18.7500 4 yes
GO:0004725 protein tyrosine phosphatase activity 12.5000 4 yes
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 12.5000 5 yes
GO:0016790 thiolester hydrolase activity 12.5000 4 yes
GO:0016791 phosphatase activity 12.5000 5 yes
GO:0019198 transmembrane receptor protein phosphatase activity 12.5000 4 yes
GO:0042578 phosphoric ester hydrolase activity 12.5000 4 yes
GO:0042805 actinin binding 12.5000 4 yes
GO:0045296 cadherin binding 12.5000 4 yes
GO:0051393 alpha-actinin binding 12.5000 5 yes
GO:0097677 STAT family protein binding 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRT_HUMAN
GO:0010646 regulation of cell communication 81.2500 4 yes
GO:0009966 regulation of signal transduction 75.0000 4 yes
GO:0051128 regulation of cellular component organization 68.7500 4 yes
GO:0048522 positive regulation of cellular process 68.7500 4 no
GO:0048584 positive regulation of response to stimulus 62.5000 4 no
GO:0048523 negative regulation of cellular process 56.2500 4 yes
GO:0009967 positive regulation of signal transduction 56.2500 5 no
GO:0010647 positive regulation of cell communication 56.2500 5 no
GO:0023056 positive regulation of signaling 56.2500 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 43.7500 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 43.7500 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 43.7500 5 yes
GO:0072657 protein localization to membrane 43.7500 4 no
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0022607 cellular component assembly 43.7500 4 no
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0051240 positive regulation of multicellular organismal process 43.7500 4 no
GO:0051130 positive regulation of cellular component organization 43.7500 5 no
GO:0030030 cell projection organization 43.7500 4 no
GO:0036211 protein modification process 37.5000 4 yes
GO:0043412 macromolecule modification 37.5000 4 yes
GO:0050807 regulation of synapse organization 37.5000 5 yes
GO:0034330 cell junction organization 37.5000 4 no
GO:0050808 synapse organization 37.5000 5 no
GO:0006996 organelle organization 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0035418 protein localization to synapse 37.5000 6 no
GO:0051094 positive regulation of developmental process 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:1902414 protein localization to cell junction 37.5000 5 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:2000026 regulation of multicellular organismal development 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0031175 neuron projection development 37.5000 6 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0048585 negative regulation of response to stimulus 31.2500 4 yes
GO:0043113 receptor clustering 31.2500 5 no
GO:0008284 positive regulation of cell population proliferation 31.2500 5 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0010468 regulation of gene expression 31.2500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0031401 positive regulation of protein modification process 31.2500 7 no
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:1902533 positive regulation of intracellular signal transduction 31.2500 6 no
GO:0007268 chemical synaptic transmission 31.2500 7 no
GO:0098916 anterograde trans-synaptic signaling 31.2500 6 no
GO:0099536 synaptic signaling 31.2500 4 no
GO:0099537 trans-synaptic signaling 31.2500 5 no
GO:0141124 intracellular signaling cassette 31.2500 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 no
GO:0044057 regulation of system process 31.2500 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 yes
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0030334 regulation of cell migration 25.0000 5 yes
GO:0071310 cellular response to organic substance 25.0000 4 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0072578 neurotransmitter-gated ion channel clustering 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0007399 nervous system development 25.0000 4 no
GO:0007416 synapse assembly 25.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0007612 learning 25.0000 4 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0050806 positive regulation of synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no
GO:0007411 axon guidance 25.0000 8 no
GO:0097485 neuron projection guidance 25.0000 7 no
GO:0007158 neuron cell-cell adhesion 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0030336 negative regulation of cell migration 18.7500 6 yes
GO:0034097 response to cytokine 18.7500 4 yes
GO:0040013 negative regulation of locomotion 18.7500 4 yes
GO:0071345 cellular response to cytokine stimulus 18.7500 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 18.7500 4 yes
GO:1904892 regulation of receptor signaling pathway via STAT 18.7500 5 yes
GO:2000146 negative regulation of cell motility 18.7500 5 yes
GO:0006470 protein dephosphorylation 12.5000 5 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 12.5000 5 yes
GO:0016311 dephosphorylation 12.5000 5 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 12.5000 6 yes
GO:0070741 response to interleukin-6 12.5000 5 yes
GO:0071354 cellular response to interleukin-6 12.5000 6 yes
GO:1904893 negative regulation of receptor signaling pathway via STAT 12.5000 6 yes
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 12.5000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRN_HUMAN [view interactions] Low throughput no yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX3A_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
VGLU1_HUMAN [view entry] [view interactions] High throughput yes no
VIAAT_HUMAN [view interactions] High throughput no yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
KPB1_HUMAN [view interactions] High throughput no yes
KPBB_HUMAN [view interactions] High throughput no no
AAKG3_HUMAN [view interactions] High throughput no no
RMND1_HUMAN [view interactions] High throughput no yes