Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in both signal transduction and cellular adhesion in the CNS. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRT_HUMAN
GO:0019902 phosphatase binding 31.8182 4 yes
GO:0019903 protein phosphatase binding 27.2727 5 yes
GO:0005524 ATP binding 27.2727 5 no
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0030554 adenyl nucleotide binding 27.2727 5 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0046872 metal ion binding 27.2727 4 no
GO:0042803 protein homodimerization activity 18.1818 4 yes
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 13.6364 5 yes
GO:0140297 DNA-binding transcription factor binding 13.6364 4 yes
GO:0004725 protein tyrosine phosphatase activity 9.0909 4 yes
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 9.0909 5 yes
GO:0016790 thiolester hydrolase activity 9.0909 4 yes
GO:0016791 phosphatase activity 9.0909 5 yes
GO:0019198 transmembrane receptor protein phosphatase activity 9.0909 4 yes
GO:0042578 phosphoric ester hydrolase activity 9.0909 4 yes
GO:0042805 actinin binding 9.0909 4 yes
GO:0045296 cadherin binding 9.0909 4 yes
GO:0051393 alpha-actinin binding 9.0909 5 yes
GO:0097677 STAT family protein binding 9.0909 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRT_HUMAN
GO:0010646 regulation of cell communication 77.2727 4 yes
GO:0009966 regulation of signal transduction 63.6364 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0048523 negative regulation of cellular process 59.0909 4 yes
GO:0051049 regulation of transport 54.5455 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0031323 regulation of cellular metabolic process 45.4545 4 no
GO:0006996 organelle organization 40.9091 4 no
GO:0050804 modulation of chemical synaptic transmission 40.9091 5 no
GO:0099177 regulation of trans-synaptic signaling 40.9091 4 no
GO:0030030 cell projection organization 40.9091 4 no
GO:0008104 protein localization 40.9091 4 no
GO:0009893 positive regulation of metabolic process 40.9091 4 no
GO:0010647 positive regulation of cell communication 40.9091 5 no
GO:0023056 positive regulation of signaling 40.9091 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.9091 4 no
GO:0060255 regulation of macromolecule metabolic process 40.9091 4 no
GO:0080090 regulation of primary metabolic process 40.9091 4 no
GO:0071310 cellular response to organic substance 36.3636 4 yes
GO:0022607 cellular component assembly 36.3636 4 no
GO:0031175 neuron projection development 36.3636 6 no
GO:0120036 plasma membrane bounded cell projection organization 36.3636 5 no
GO:2000026 regulation of multicellular organismal development 36.3636 4 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0042127 regulation of cell population proliferation 36.3636 4 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0051130 positive regulation of cellular component organization 36.3636 5 no
GO:0006796 phosphate-containing compound metabolic process 31.8182 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 31.8182 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 31.8182 5 yes
GO:0036211 protein modification process 31.8182 4 yes
GO:0043412 macromolecule modification 31.8182 4 yes
GO:0051240 positive regulation of multicellular organismal process 31.8182 4 no
GO:0060627 regulation of vesicle-mediated transport 31.8182 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.8182 4 no
GO:0051050 positive regulation of transport 31.8182 4 no
GO:0051094 positive regulation of developmental process 31.8182 4 no
GO:0051247 positive regulation of protein metabolic process 31.8182 6 no
GO:0034330 cell junction organization 31.8182 4 no
GO:0050808 synapse organization 31.8182 5 no
GO:1902531 regulation of intracellular signal transduction 31.8182 5 no
GO:0043113 receptor clustering 31.8182 5 no
GO:0072657 protein localization to membrane 31.8182 4 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 yes
GO:0061024 membrane organization 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0008284 positive regulation of cell population proliferation 27.2727 5 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 5 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0031401 positive regulation of protein modification process 27.2727 7 no
GO:0007268 chemical synaptic transmission 27.2727 6 no
GO:0098916 anterograde trans-synaptic signaling 27.2727 5 no
GO:0099537 trans-synaptic signaling 27.2727 4 no
GO:0030334 regulation of cell migration 22.7273 5 yes
GO:2000145 regulation of cell motility 22.7273 4 yes
GO:0006811 ion transport 22.7273 4 no
GO:0044057 regulation of system process 22.7273 4 no
GO:0051046 regulation of secretion 22.7273 5 no
GO:0051588 regulation of neurotransmitter transport 22.7273 5 no
GO:1903530 regulation of secretion by cell 22.7273 4 no
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0010975 regulation of neuron projection development 22.7273 7 no
GO:0045595 regulation of cell differentiation 22.7273 4 no
GO:0051129 negative regulation of cellular component organization 22.7273 5 no
GO:0051960 regulation of nervous system development 22.7273 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.7273 6 no
GO:0006355 regulation of DNA-templated transcription 22.7273 6 no
GO:0007399 nervous system development 22.7273 4 no
GO:0008285 negative regulation of cell population proliferation 22.7273 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.7273 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:0042325 regulation of phosphorylation 22.7273 7 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.7273 7 no
GO:2001141 regulation of RNA biosynthetic process 22.7273 6 no
GO:0050806 positive regulation of synaptic transmission 22.7273 5 no
GO:0007416 synapse assembly 22.7273 6 no
GO:0010562 positive regulation of phosphorus metabolic process 22.7273 6 no
GO:0034329 cell junction assembly 22.7273 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.7273 7 no
GO:1903829 positive regulation of protein localization 22.7273 5 no
GO:0007158 neuron cell-cell adhesion 22.7273 4 no
GO:0007612 learning 22.7273 4 no
GO:0050890 cognition 22.7273 4 no
GO:0016192 vesicle-mediated transport 22.7273 4 no
GO:0035418 protein localization to synapse 22.7273 6 no
GO:0043269 regulation of ion transport 22.7273 5 no
GO:1902414 protein localization to cell junction 22.7273 5 no
GO:0009968 negative regulation of signal transduction 18.1818 5 yes
GO:0010648 negative regulation of cell communication 18.1818 5 yes
GO:0023057 negative regulation of signaling 18.1818 4 yes
GO:0030336 negative regulation of cell migration 18.1818 6 yes
GO:0040013 negative regulation of locomotion 18.1818 4 yes
GO:2000146 negative regulation of cell motility 18.1818 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 13.6364 4 yes
GO:1904892 regulation of receptor signaling pathway via STAT 13.6364 5 yes
GO:0006470 protein dephosphorylation 9.0909 5 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 9.0909 5 yes
GO:0016311 dephosphorylation 9.0909 5 yes
GO:0034097 response to cytokine 9.0909 4 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 9.0909 6 yes
GO:0070741 response to interleukin-6 9.0909 5 yes
GO:0071345 cellular response to cytokine stimulus 9.0909 5 yes
GO:0071354 cellular response to interleukin-6 9.0909 6 yes
GO:1904893 negative regulation of receptor signaling pathway via STAT 9.0909 6 yes
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 9.0909 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in PTPRT_HUMAN
DOID:331 central nervous system disease 9.0909 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRN_HUMAN [view interactions] Low throughput no yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX3A_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
NRX2A_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
VGLU1_HUMAN [view entry] [view interactions] High throughput yes no
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
VIAAT_HUMAN [view interactions] High throughput no yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
KPBB_HUMAN [view interactions] High throughput no no
KPB1_HUMAN [view interactions] High throughput no yes
AAKG3_HUMAN [view interactions] High throughput no no
RMND1_HUMAN [view interactions] High throughput no yes