Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NLGN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep . The protein is involved in nervous system development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
89 Pro Leu Autism20(AUTS20) -
309 Leu Pro Autism20(AUTS20) -
337 Gly Glu Autism20(AUTS20) -
835 His Tyr Autism20(AUTS20) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI004103 LIG_WRC_WIRS_1 LIG 837 842 -
ELMI004103 LIG_WRC_WIRS_1 LIG 837 842 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NLGN1_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0019900 kinase binding 28.5714 4 no
GO:0000166 nucleotide binding 23.8095 4 no
GO:0017076 purine nucleotide binding 23.8095 5 no
GO:0030695 GTPase regulator activity 23.8095 4 no
GO:0032555 purine ribonucleotide binding 23.8095 4 no
GO:0043168 anion binding 23.8095 4 no
GO:0030165 PDZ domain binding 14.2857 4 yes
GO:0042043 neurexin family protein binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NLGN1_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0008104 protein localization 61.9048 4 yes
GO:0009966 regulation of signal transduction 61.9048 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0050804 modulation of chemical synaptic transmission 52.3810 5 yes
GO:0099177 regulation of trans-synaptic signaling 52.3810 4 yes
GO:0043113 receptor clustering 47.6190 5 yes
GO:0051049 regulation of transport 47.6190 4 yes
GO:0072657 protein localization to membrane 47.6190 4 yes
GO:0010647 positive regulation of cell communication 42.8571 5 yes
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0023056 positive regulation of signaling 42.8571 4 yes
GO:0030030 cell projection organization 42.8571 4 yes
GO:0051130 positive regulation of cellular component organization 42.8571 5 yes
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 yes
GO:0006996 organelle organization 38.0952 4 yes
GO:0007268 chemical synaptic transmission 38.0952 7 yes
GO:0009967 positive regulation of signal transduction 38.0952 5 yes
GO:0031175 neuron projection development 38.0952 6 yes
GO:0034330 cell junction organization 38.0952 4 yes
GO:0048584 positive regulation of response to stimulus 38.0952 4 yes
GO:0050807 regulation of synapse organization 38.0952 5 yes
GO:0051050 positive regulation of transport 38.0952 4 yes
GO:0051094 positive regulation of developmental process 38.0952 4 yes
GO:0098916 anterograde trans-synaptic signaling 38.0952 6 yes
GO:0099536 synaptic signaling 38.0952 4 yes
GO:0099537 trans-synaptic signaling 38.0952 5 yes
GO:0031344 regulation of cell projection organization 33.3333 5 yes
GO:0031644 regulation of nervous system process 33.3333 5 yes
GO:0034329 cell junction assembly 33.3333 5 yes
GO:0035418 protein localization to synapse 33.3333 6 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0050808 synapse organization 33.3333 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 33.3333 4 yes
GO:1902414 protein localization to cell junction 33.3333 5 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 33.3333 5 yes
GO:0007612 learning 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0007399 nervous system development 28.5714 4 yes
GO:0007416 synapse assembly 28.5714 6 yes
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 yes
GO:0022898 regulation of transmembrane transporter activity 28.5714 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 28.5714 5 yes
GO:0034762 regulation of transmembrane transport 28.5714 4 yes
GO:0048812 neuron projection morphogenesis 28.5714 5 yes
GO:0050806 positive regulation of synaptic transmission 28.5714 5 yes
GO:0051129 negative regulation of cellular component organization 28.5714 5 yes
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 yes
GO:0051960 regulation of nervous system development 28.5714 5 yes
GO:0051962 positive regulation of nervous system development 28.5714 5 yes
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 yes
GO:0061024 membrane organization 28.5714 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 28.5714 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0001941 postsynaptic membrane organization 23.8095 5 yes
GO:0007158 neuron cell-cell adhesion 23.8095 4 yes
GO:0030100 regulation of endocytosis 23.8095 5 yes
GO:0031346 positive regulation of cell projection organization 23.8095 6 yes
GO:0044089 positive regulation of cellular component biogenesis 23.8095 5 yes
GO:0045595 regulation of cell differentiation 23.8095 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 23.8095 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 23.8095 6 yes
GO:0061001 regulation of dendritic spine morphogenesis 23.8095 5 yes
GO:0071709 membrane assembly 23.8095 5 yes
GO:0097104 postsynaptic membrane assembly 23.8095 6 yes
GO:0099175 regulation of postsynapse organization 23.8095 6 yes
GO:2000311 regulation of AMPA receptor activity 23.8095 5 yes
GO:0009893 positive regulation of metabolic process 23.8095 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.8095 5 no
GO:0019220 regulation of phosphate metabolic process 23.8095 6 no
GO:0031325 positive regulation of cellular metabolic process 23.8095 5 no
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0051174 regulation of phosphorus metabolic process 23.8095 5 no
GO:0051246 regulation of protein metabolic process 23.8095 5 no
GO:0051247 positive regulation of protein metabolic process 23.8095 6 no
GO:0080090 regulation of primary metabolic process 23.8095 4 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0141124 intracellular signaling cassette 23.8095 4 no
GO:0010038 response to metal ion 19.0476 4 yes
GO:0045807 positive regulation of endocytosis 19.0476 5 yes
GO:0051046 regulation of secretion 19.0476 5 yes
GO:0051093 negative regulation of developmental process 19.0476 4 yes
GO:0051963 regulation of synapse assembly 19.0476 6 yes
GO:0051965 positive regulation of synapse assembly 19.0476 6 yes
GO:0060998 regulation of dendritic spine development 19.0476 4 yes
GO:0060999 positive regulation of dendritic spine development 19.0476 5 yes
GO:0071241 cellular response to inorganic substance 19.0476 4 yes
GO:0071248 cellular response to metal ion 19.0476 5 yes
GO:0072578 neurotransmitter-gated ion channel clustering 19.0476 6 yes
GO:0097113 AMPA glutamate receptor clustering 19.0476 8 yes
GO:0097119 postsynaptic density protein 95 clustering 19.0476 5 yes
GO:0097688 glutamate receptor clustering 19.0476 7 yes
GO:0098657 import into cell 19.0476 4 yes
GO:1901888 regulation of cell junction assembly 19.0476 5 yes
GO:1901890 positive regulation of cell junction assembly 19.0476 6 yes
GO:1903530 regulation of secretion by cell 19.0476 4 yes
GO:0010976 positive regulation of neuron projection development 14.2857 7 yes
GO:0017157 regulation of exocytosis 14.2857 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 14.2857 6 yes
GO:0043954 cellular component maintenance 14.2857 4 yes
GO:0048488 synaptic vesicle endocytosis 14.2857 5 yes
GO:0050795 regulation of behavior 14.2857 4 yes
GO:0051047 positive regulation of secretion 14.2857 5 yes
GO:0060491 regulation of cell projection assembly 14.2857 5 yes
GO:0097090 presynaptic membrane organization 14.2857 5 yes
GO:0097105 presynaptic membrane assembly 14.2857 6 yes
GO:0097114 NMDA glutamate receptor clustering 14.2857 7 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 14.2857 4 yes
GO:0099054 presynapse assembly 14.2857 5 yes
GO:0099172 presynapse organization 14.2857 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 14.2857 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 14.2857 6 yes
GO:0140238 presynaptic endocytosis 14.2857 4 yes
GO:1902533 positive regulation of intracellular signal transduction 14.2857 6 yes
GO:1903532 positive regulation of secretion by cell 14.2857 5 yes
GO:2000310 regulation of NMDA receptor activity 14.2857 5 yes
GO:0001956 positive regulation of neurotransmitter secretion 9.5238 6 yes
GO:0006605 protein targeting 9.5238 4 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 9.5238 5 yes
GO:0010840 regulation of circadian sleep/wake cycle, wakefulness 9.5238 5 yes
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness 9.5238 5 yes
GO:0010977 negative regulation of neuron projection development 9.5238 7 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 9.5238 5 yes
GO:0030865 cortical cytoskeleton organization 9.5238 6 yes
GO:0031345 negative regulation of cell projection organization 9.5238 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 9.5238 6 yes
GO:0034331 cell junction maintenance 9.5238 5 yes
GO:0042749 regulation of circadian sleep/wake cycle 9.5238 4 yes
GO:0042753 positive regulation of circadian rhythm 9.5238 4 yes
GO:0045664 regulation of neuron differentiation 9.5238 5 yes
GO:0045921 positive regulation of exocytosis 9.5238 6 yes
GO:0046928 regulation of neurotransmitter secretion 9.5238 5 yes
GO:0048520 positive regulation of behavior 9.5238 5 yes
GO:0048789 cytoskeletal matrix organization at active zone 9.5238 7 yes
GO:0051489 regulation of filopodium assembly 9.5238 7 yes
GO:0051491 positive regulation of filopodium assembly 9.5238 7 yes
GO:0051588 regulation of neurotransmitter transport 9.5238 5 yes
GO:0051590 positive regulation of neurotransmitter transport 9.5238 5 yes
GO:0051592 response to calcium ion 9.5238 5 yes
GO:0061000 negative regulation of dendritic spine development 9.5238 5 yes
GO:0061002 negative regulation of dendritic spine morphogenesis 9.5238 6 yes
GO:0071277 cellular response to calcium ion 9.5238 6 yes
GO:0072553 terminal button organization 9.5238 5 yes
GO:0090125 cell-cell adhesion involved in synapse maturation 9.5238 4 yes
GO:0097091 synaptic vesicle clustering 9.5238 5 yes
GO:0097115 neurexin clustering involved in presynaptic membrane assembly 9.5238 6 yes
GO:0097479 synaptic vesicle localization 9.5238 4 yes
GO:0099558 maintenance of synapse structure 9.5238 6 yes
GO:0140058 neuron projection arborization 9.5238 6 yes
GO:1900027 regulation of ruffle assembly 9.5238 7 yes
GO:1900029 positive regulation of ruffle assembly 9.5238 7 yes
GO:1900073 regulation of neuromuscular synaptic transmission 9.5238 6 yes
GO:1900075 positive regulation of neuromuscular synaptic transmission 9.5238 6 yes
GO:1900242 regulation of synaptic vesicle endocytosis 9.5238 6 yes
GO:1900244 positive regulation of synaptic vesicle endocytosis 9.5238 6 yes
GO:1903305 regulation of regulated secretory pathway 9.5238 6 yes
GO:1903307 positive regulation of regulated secretory pathway 9.5238 7 yes
GO:1903421 regulation of synaptic vesicle recycling 9.5238 5 yes
GO:1903423 positive regulation of synaptic vesicle recycling 9.5238 5 yes
GO:1904861 excitatory synapse assembly 9.5238 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 9.5238 6 yes
GO:2000302 positive regulation of synaptic vesicle exocytosis 9.5238 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
KALRN_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX2A_HUMAN [view entry] [view interactions] Low throughput yes no
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
BRK1_HUMAN [view interactions] High throughput no no
CD3Z_HUMAN [view interactions] High throughput no no
ARI1B_HUMAN [view interactions] High throughput no yes
TLK2_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
TRADD_HUMAN [view interactions] High throughput no yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI1_HUMAN [view interactions] High throughput no no
MAGI3_HUMAN [view interactions] High throughput no no
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA3_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ADCY9_HUMAN [view interactions] High throughput no yes
EP3A_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
LCFC1_HUMAN [view interactions] High throughput no no
TNF18_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes