Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NLGN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep . The protein is involved in nervous system development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
89 Pro Leu Autism20(AUTS20) -
309 Leu Pro Autism20(AUTS20) -
337 Gly Glu Autism20(AUTS20) -
835 His Tyr Autism20(AUTS20) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI004103 LIG_WRC_WIRS_1 LIG 837 842 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NLGN1_HUMAN
GO:0046872 metal ion binding 34.6154 4 no
GO:0019900 kinase binding 23.0769 4 no
GO:0042043 neurexin family protein binding 15.3846 4 yes
GO:0001540 amyloid-beta binding 11.5385 4 yes
GO:0030165 PDZ domain binding 11.5385 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NLGN1_HUMAN
GO:0010646 regulation of cell communication 69.2308 4 yes
GO:0048522 positive regulation of cellular process 65.3846 4 yes
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:0048523 negative regulation of cellular process 53.8462 4 yes
GO:0050804 modulation of chemical synaptic transmission 53.8462 5 yes
GO:0099177 regulation of trans-synaptic signaling 53.8462 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 yes
GO:0051049 regulation of transport 46.1538 4 yes
GO:0010647 positive regulation of cell communication 42.3077 5 yes
GO:0022607 cellular component assembly 42.3077 4 yes
GO:0023056 positive regulation of signaling 42.3077 4 yes
GO:0034330 cell junction organization 38.4615 4 yes
GO:0043113 receptor clustering 38.4615 5 yes
GO:0051130 positive regulation of cellular component organization 38.4615 5 yes
GO:0072657 protein localization to membrane 38.4615 4 yes
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 yes
GO:0007612 learning 38.4615 4 no
GO:0050890 cognition 38.4615 4 no
GO:0030030 cell projection organization 38.4615 4 yes
GO:0044057 regulation of system process 34.6154 4 yes
GO:0048584 positive regulation of response to stimulus 34.6154 4 yes
GO:0050807 regulation of synapse organization 34.6154 5 yes
GO:0050808 synapse organization 34.6154 5 yes
GO:0098916 anterograde trans-synaptic signaling 34.6154 5 yes
GO:0099537 trans-synaptic signaling 34.6154 4 yes
GO:0007268 chemical synaptic transmission 34.6154 6 yes
GO:0009967 positive regulation of signal transduction 34.6154 5 yes
GO:0031175 neuron projection development 34.6154 6 yes
GO:0031644 regulation of nervous system process 34.6154 5 yes
GO:0034329 cell junction assembly 30.7692 5 yes
GO:0044087 regulation of cellular component biogenesis 30.7692 4 yes
GO:0050806 positive regulation of synaptic transmission 30.7692 5 yes
GO:0051050 positive regulation of transport 30.7692 4 yes
GO:0051094 positive regulation of developmental process 30.7692 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 30.7692 4 yes
GO:1902531 regulation of intracellular signal transduction 30.7692 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 30.7692 5 yes
GO:0006996 organelle organization 30.7692 4 yes
GO:0034762 regulation of transmembrane transport 26.9231 4 yes
GO:0034765 regulation of ion transmembrane transport 26.9231 5 yes
GO:0035418 protein localization to synapse 26.9231 6 yes
GO:0043269 regulation of ion transport 26.9231 5 yes
GO:0051129 negative regulation of cellular component organization 26.9231 5 yes
GO:0060627 regulation of vesicle-mediated transport 26.9231 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 26.9231 4 yes
GO:1902414 protein localization to cell junction 26.9231 5 yes
GO:1904062 regulation of cation transmembrane transport 26.9231 6 yes
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0007416 synapse assembly 26.9231 6 yes
GO:0016192 vesicle-mediated transport 26.9231 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.9231 4 yes
GO:0031344 regulation of cell projection organization 26.9231 5 yes
GO:0032412 regulation of ion transmembrane transporter activity 23.0769 5 yes
GO:0032990 cell part morphogenesis 23.0769 4 yes
GO:0044089 positive regulation of cellular component biogenesis 23.0769 5 yes
GO:0048812 neuron projection morphogenesis 23.0769 7 yes
GO:0048858 cell projection morphogenesis 23.0769 5 yes
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 yes
GO:0051960 regulation of nervous system development 23.0769 5 yes
GO:0051962 positive regulation of nervous system development 23.0769 5 yes
GO:0061024 membrane organization 23.0769 4 yes
GO:0071702 organic substance transport 23.0769 4 yes
GO:0071705 nitrogen compound transport 23.0769 4 yes
GO:0099175 regulation of postsynapse organization 23.0769 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.0769 6 yes
GO:2000026 regulation of multicellular organismal development 23.0769 4 yes
GO:2001257 regulation of cation channel activity 23.0769 6 yes
GO:0009893 positive regulation of metabolic process 23.0769 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 no
GO:0031323 regulation of cellular metabolic process 23.0769 4 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0051171 regulation of nitrogen compound metabolic process 23.0769 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0060255 regulation of macromolecule metabolic process 23.0769 4 no
GO:0080090 regulation of primary metabolic process 23.0769 4 no
GO:0007010 cytoskeleton organization 23.0769 5 yes
GO:0007158 neuron cell-cell adhesion 23.0769 4 yes
GO:0007399 nervous system development 23.0769 4 yes
GO:0010975 regulation of neuron projection development 23.0769 7 yes
GO:0015031 protein transport 23.0769 4 yes
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 yes
GO:0030100 regulation of endocytosis 23.0769 5 yes
GO:0045595 regulation of cell differentiation 19.2308 4 yes
GO:0051963 regulation of synapse assembly 19.2308 6 yes
GO:0051965 positive regulation of synapse assembly 19.2308 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 19.2308 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 19.2308 6 yes
GO:0061001 regulation of dendritic spine morphogenesis 19.2308 5 yes
GO:0071709 membrane assembly 19.2308 5 yes
GO:0097104 postsynaptic membrane assembly 19.2308 6 yes
GO:1901888 regulation of cell junction assembly 19.2308 5 yes
GO:1901890 positive regulation of cell junction assembly 19.2308 6 yes
GO:2000311 regulation of AMPA receptor activity 19.2308 5 yes
GO:0001941 postsynaptic membrane organization 19.2308 5 yes
GO:0031346 positive regulation of cell projection organization 19.2308 6 yes
GO:0045807 positive regulation of endocytosis 15.3846 5 yes
GO:0051046 regulation of secretion 15.3846 5 yes
GO:0051093 negative regulation of developmental process 15.3846 4 yes
GO:0060998 regulation of dendritic spine development 15.3846 4 yes
GO:0060999 positive regulation of dendritic spine development 15.3846 5 yes
GO:0071241 cellular response to inorganic substance 15.3846 4 yes
GO:0071248 cellular response to metal ion 15.3846 5 yes
GO:0072578 neurotransmitter-gated ion channel clustering 15.3846 6 yes
GO:0097113 AMPA glutamate receptor clustering 15.3846 8 yes
GO:0097119 postsynaptic density protein 95 clustering 15.3846 5 yes
GO:0097688 glutamate receptor clustering 15.3846 7 yes
GO:1903530 regulation of secretion by cell 15.3846 4 yes
GO:0006886 intracellular protein transport 15.3846 4 yes
GO:0010038 response to metal ion 15.3846 4 yes
GO:0043576 regulation of respiratory gaseous exchange 11.5385 4 yes
GO:0044065 regulation of respiratory system process 11.5385 5 yes
GO:0048488 synaptic vesicle endocytosis 11.5385 5 yes
GO:0050795 regulation of behavior 11.5385 4 yes
GO:0060491 regulation of cell projection assembly 11.5385 5 yes
GO:0070925 organelle assembly 11.5385 5 yes
GO:0097090 presynaptic membrane organization 11.5385 5 yes
GO:0097105 presynaptic membrane assembly 11.5385 6 yes
GO:0097114 NMDA glutamate receptor clustering 11.5385 7 yes
GO:0098698 postsynaptic specialization assembly 11.5385 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 11.5385 4 yes
GO:0099003 vesicle-mediated transport in synapse 11.5385 5 yes
GO:0099054 presynapse assembly 11.5385 5 yes
GO:0099084 postsynaptic specialization organization 11.5385 5 yes
GO:0099172 presynapse organization 11.5385 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 11.5385 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 11.5385 6 yes
GO:0140238 presynaptic endocytosis 11.5385 4 yes
GO:1902533 positive regulation of intracellular signal transduction 11.5385 6 yes
GO:2000310 regulation of NMDA receptor activity 11.5385 5 yes
GO:0002087 regulation of respiratory gaseous exchange by nervous system process 11.5385 4 yes
GO:0006897 endocytosis 11.5385 5 yes
GO:0017157 regulation of exocytosis 11.5385 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 11.5385 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 7.6923 6 yes
GO:0042749 regulation of circadian sleep/wake cycle 7.6923 4 yes
GO:0042753 positive regulation of circadian rhythm 7.6923 4 yes
GO:0045664 regulation of neuron differentiation 7.6923 5 yes
GO:0045921 positive regulation of exocytosis 7.6923 6 yes
GO:0046928 regulation of neurotransmitter secretion 7.6923 4 yes
GO:0048520 positive regulation of behavior 7.6923 5 yes
GO:0048789 cytoskeletal matrix organization at active zone 7.6923 7 yes
GO:0051047 positive regulation of secretion 7.6923 5 yes
GO:0051489 regulation of filopodium assembly 7.6923 7 yes
GO:0051491 positive regulation of filopodium assembly 7.6923 7 yes
GO:0051588 regulation of neurotransmitter transport 7.6923 5 yes
GO:0051590 positive regulation of neurotransmitter transport 7.6923 5 yes
GO:0051592 response to calcium ion 7.6923 5 yes
GO:0061000 negative regulation of dendritic spine development 7.6923 5 yes
GO:0061002 negative regulation of dendritic spine morphogenesis 7.6923 6 yes
GO:0071277 cellular response to calcium ion 7.6923 6 yes
GO:0072553 terminal button organization 7.6923 5 yes
GO:0097091 synaptic vesicle clustering 7.6923 5 yes
GO:0097115 neurexin clustering involved in presynaptic membrane assembly 7.6923 6 yes
GO:0097479 synaptic vesicle localization 7.6923 4 yes
GO:0099560 synaptic membrane adhesion 7.6923 5 yes
GO:0140058 neuron projection arborization 7.6923 8 yes
GO:1900027 regulation of ruffle assembly 7.6923 7 yes
GO:1900029 positive regulation of ruffle assembly 7.6923 7 yes
GO:1900242 regulation of synaptic vesicle endocytosis 7.6923 6 yes
GO:1900244 positive regulation of synaptic vesicle endocytosis 7.6923 6 yes
GO:1903305 regulation of regulated secretory pathway 7.6923 6 yes
GO:1903307 positive regulation of regulated secretory pathway 7.6923 7 yes
GO:1903421 regulation of synaptic vesicle recycling 7.6923 5 yes
GO:1903423 positive regulation of synaptic vesicle recycling 7.6923 5 yes
GO:1903532 positive regulation of secretion by cell 7.6923 5 yes
GO:1904861 excitatory synapse assembly 7.6923 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 7.6923 5 yes
GO:2000302 positive regulation of synaptic vesicle exocytosis 7.6923 6 yes
GO:2000807 regulation of synaptic vesicle clustering 7.6923 4 yes
GO:2000809 positive regulation of synaptic vesicle clustering 7.6923 5 yes
GO:0001956 positive regulation of neurotransmitter secretion 7.6923 5 yes
GO:0006605 protein targeting 7.6923 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 7.6923 5 yes
GO:0010840 regulation of circadian sleep/wake cycle, wakefulness 7.6923 5 yes
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness 7.6923 5 yes
GO:0010977 negative regulation of neuron projection development 7.6923 7 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 7.6923 5 yes
GO:0030865 cortical cytoskeleton organization 7.6923 6 yes
GO:0031345 negative regulation of cell projection organization 7.6923 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRT_HUMAN [view entry] [view interactions] Low throughput yes yes
KALRN_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] Low throughput yes no
NRX2A_HUMAN [view entry] [view interactions] Low throughput yes no
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
CD3Z_HUMAN [view interactions] High throughput no no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
TRADD_HUMAN [view interactions] High throughput no yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI1_HUMAN [view interactions] High throughput no no
MAGI3_HUMAN [view interactions] High throughput no no
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA3_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ADCY9_HUMAN [view interactions] High throughput no yes
EP3A_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
LCFC1_HUMAN [view interactions] High throughput no no
TNF18_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
DLGP1_HUMAN [view entry] [view interactions] Computational yes no
TSP1_HUMAN [view interactions] Computational no no
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
NXN_HUMAN [view interactions] Computational no no
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
LRRT2_HUMAN [view entry] [view interactions] Computational yes no