Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRX2A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRX2A_HUMAN
GO:0042043 neurexin family protein binding 36.3636 4 no
GO:0043169 cation binding 18.1818 4 yes
GO:0046872 metal ion binding 18.1818 5 yes
GO:0097109 neuroligin family protein binding 18.1818 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRX2A_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 no
GO:0008104 protein localization 63.6364 4 yes
GO:0072657 protein localization to membrane 63.6364 4 yes
GO:0010646 regulation of cell communication 63.6364 4 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0051049 regulation of transport 54.5455 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0051130 positive regulation of cellular component organization 54.5455 5 no
GO:0022607 cellular component assembly 45.4545 4 yes
GO:0034330 cell junction organization 45.4545 4 yes
GO:0043113 receptor clustering 45.4545 5 yes
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0010647 positive regulation of cell communication 45.4545 5 no
GO:0023056 positive regulation of signaling 45.4545 4 no
GO:0050804 modulation of chemical synaptic transmission 45.4545 5 no
GO:0051094 positive regulation of developmental process 45.4545 4 no
GO:0060627 regulation of vesicle-mediated transport 45.4545 4 no
GO:0099177 regulation of trans-synaptic signaling 45.4545 4 no
GO:0007268 chemical synaptic transmission 36.3636 7 yes
GO:0034329 cell junction assembly 36.3636 5 yes
GO:0035418 protein localization to synapse 36.3636 6 yes
GO:0050808 synapse organization 36.3636 5 yes
GO:0098916 anterograde trans-synaptic signaling 36.3636 6 yes
GO:0099536 synaptic signaling 36.3636 4 yes
GO:0099537 trans-synaptic signaling 36.3636 5 yes
GO:1902414 protein localization to cell junction 36.3636 5 yes
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0030100 regulation of endocytosis 36.3636 5 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0031344 regulation of cell projection organization 36.3636 5 no
GO:0031346 positive regulation of cell projection organization 36.3636 6 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:0050806 positive regulation of synaptic transmission 36.3636 5 no
GO:0060255 regulation of macromolecule metabolic process 36.3636 4 no
GO:0051050 positive regulation of transport 36.3636 4 no
GO:0044087 regulation of cellular component biogenesis 36.3636 4 no
GO:0051240 positive regulation of multicellular organismal process 36.3636 4 no
GO:0051960 regulation of nervous system development 36.3636 5 no
GO:0051962 positive regulation of nervous system development 36.3636 5 no
GO:1901888 regulation of cell junction assembly 36.3636 5 no
GO:2000026 regulation of multicellular organismal development 36.3636 4 no
GO:0001941 postsynaptic membrane organization 27.2727 5 yes
GO:0007158 neuron cell-cell adhesion 27.2727 4 yes
GO:0007416 synapse assembly 27.2727 6 yes
GO:0061024 membrane organization 27.2727 4 yes
GO:0071709 membrane assembly 27.2727 5 yes
GO:0097104 postsynaptic membrane assembly 27.2727 6 yes
GO:0097119 postsynaptic density protein 95 clustering 27.2727 5 yes
GO:0002090 regulation of receptor internalization 27.2727 7 no
GO:0006996 organelle organization 27.2727 4 no
GO:0007399 nervous system development 27.2727 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0022898 regulation of transmembrane transporter activity 27.2727 4 no
GO:0031644 regulation of nervous system process 27.2727 5 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 27.2727 5 no
GO:0034762 regulation of transmembrane transport 27.2727 4 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0048259 regulation of receptor-mediated endocytosis 27.2727 6 no
GO:0051129 negative regulation of cellular component organization 27.2727 5 no
GO:0072578 neurotransmitter-gated ion channel clustering 27.2727 6 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0098815 modulation of excitatory postsynaptic potential 27.2727 4 no
GO:0099601 regulation of neurotransmitter receptor activity 27.2727 4 no
GO:1990778 protein localization to cell periphery 27.2727 5 no
GO:2000463 positive regulation of excitatory postsynaptic potential 27.2727 5 no
GO:0030155 regulation of cell adhesion 27.2727 4 no
GO:0042127 regulation of cell population proliferation 27.2727 4 no
GO:0051046 regulation of secretion 27.2727 5 no
GO:1903530 regulation of secretion by cell 27.2727 4 no
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0050807 regulation of synapse organization 27.2727 5 no
GO:0051963 regulation of synapse assembly 27.2727 6 no
GO:0051965 positive regulation of synapse assembly 27.2727 6 no
GO:0098657 import into cell 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:1901890 positive regulation of cell junction assembly 27.2727 6 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:0007612 learning 18.1818 4 yes
GO:0050890 cognition 18.1818 4 yes
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 18.1818 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DDX24_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes