Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRX2A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRX2A_HUMAN
GO:0042043 neurexin family protein binding 21.4286 4 no
GO:0046872 metal ion binding 14.2857 4 yes
GO:0097109 neuroligin family protein binding 10.7143 4 yes
GO:0005246 calcium channel regulator activity 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRX2A_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 no
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 60.7143 5 no
GO:0051128 regulation of cellular component organization 60.7143 4 no
GO:0099177 regulation of trans-synaptic signaling 60.7143 4 no
GO:0051094 positive regulation of developmental process 53.5714 4 no
GO:0007268 chemical synaptic transmission 50.0000 6 yes
GO:0008104 protein localization 50.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 5 yes
GO:0099537 trans-synaptic signaling 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0022607 cellular component assembly 46.4286 4 yes
GO:0034330 cell junction organization 46.4286 4 yes
GO:0050808 synapse organization 46.4286 5 yes
GO:0010647 positive regulation of cell communication 46.4286 5 no
GO:0023056 positive regulation of signaling 46.4286 4 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0050807 regulation of synapse organization 39.2857 5 no
GO:0051240 positive regulation of multicellular organismal process 39.2857 4 no
GO:0051960 regulation of nervous system development 39.2857 5 no
GO:0051962 positive regulation of nervous system development 39.2857 5 no
GO:2000026 regulation of multicellular organismal development 39.2857 4 no
GO:0072657 protein localization to membrane 35.7143 4 yes
GO:1901888 regulation of cell junction assembly 35.7143 5 no
GO:0050806 positive regulation of synaptic transmission 35.7143 5 no
GO:0031644 regulation of nervous system process 32.1429 5 no
GO:0044057 regulation of system process 32.1429 4 no
GO:0044089 positive regulation of cellular component biogenesis 32.1429 5 no
GO:0051963 regulation of synapse assembly 32.1429 6 no
GO:0051965 positive regulation of synapse assembly 32.1429 6 no
GO:1901890 positive regulation of cell junction assembly 32.1429 6 no
GO:0043269 regulation of ion transport 32.1429 5 no
GO:0048584 positive regulation of response to stimulus 32.1429 4 no
GO:0007612 learning 28.5714 4 yes
GO:0035418 protein localization to synapse 28.5714 6 yes
GO:0043113 receptor clustering 28.5714 5 yes
GO:0050890 cognition 28.5714 4 yes
GO:1902414 protein localization to cell junction 28.5714 5 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0007416 synapse assembly 25.0000 6 yes
GO:0034329 cell junction assembly 25.0000 5 yes
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 25.0000 6 no
GO:0001941 postsynaptic membrane organization 21.4286 5 yes
GO:0007158 neuron cell-cell adhesion 21.4286 4 yes
GO:0061024 membrane organization 21.4286 4 yes
GO:0071709 membrane assembly 21.4286 5 yes
GO:0097104 postsynaptic membrane assembly 21.4286 6 yes
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0009893 positive regulation of metabolic process 21.4286 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.4286 5 no
GO:0031323 regulation of cellular metabolic process 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0051171 regulation of nitrogen compound metabolic process 21.4286 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0060255 regulation of macromolecule metabolic process 21.4286 4 no
GO:0080090 regulation of primary metabolic process 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0032412 regulation of ion transmembrane transporter activity 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of ion transmembrane transport 21.4286 5 no
GO:0099003 vesicle-mediated transport in synapse 21.4286 5 no
GO:0099601 regulation of neurotransmitter receptor activity 21.4286 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 21.4286 5 no
GO:0046903 secretion 17.8571 4 yes
GO:0006836 neurotransmitter transport 14.2857 4 yes
GO:0007269 neurotransmitter secretion 14.2857 4 yes
GO:0023061 signal release 14.2857 4 yes
GO:0097119 postsynaptic density protein 95 clustering 14.2857 5 yes
GO:0099643 signal release from synapse 14.2857 5 yes
GO:0097116 gephyrin clustering involved in postsynaptic density assembly 10.7143 7 yes
GO:0031223 auditory behavior 7.1429 4 yes
GO:0042297 vocal learning 7.1429 5 yes
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 7.1429 6 yes
GO:0098596 imitative learning 7.1429 6 yes
GO:0098597 observational learning 7.1429 5 yes
GO:0098598 learned vocalization behavior or vocal learning 7.1429 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
AFAD_HUMAN [view interactions] Low throughput no yes
PTPRT_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX24_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGNX_HUMAN [view entry] [view interactions] Computational yes yes
LRRT3_HUMAN [view entry] [view interactions] Computational yes no
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes
NLGN3_HUMAN [view entry] [view interactions] Computational yes yes
LRRT4_HUMAN [view entry] [view interactions] Computational yes no
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
SYT1_HUMAN [view entry] [view interactions] Computational yes no
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
DLGP2_HUMAN [view entry] [view interactions] Computational yes no
APBA1_HUMAN [view interactions] Computational no no
GRM5_HUMAN [view entry] [view interactions] Computational yes no
NXPH3_HUMAN [view interactions] Computational no no
LRRT1_HUMAN [view entry] [view interactions] Computational yes yes
DLG3_HUMAN [view entry] [view interactions] Computational yes yes
STXB1_HUMAN [view entry] [view interactions] Computational yes yes
GRID2_HUMAN [view entry] [view interactions] Computational yes no
APBA2_HUMAN [view interactions] Computational no yes
CBLN1_HUMAN [view entry] [view interactions] Computational yes no
NXPH1_HUMAN [view interactions] Computational no no
AGRL1_HUMAN [view entry] [view interactions] Computational yes no
CBLN2_HUMAN [view interactions] Computational no no
NRX1A_HUMAN [view entry] [view interactions] Computational yes no