NLGN2_HUMAN
Evidence for PS localization
Functions
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 . Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NLGN2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 21.7391 | 4 | no |
| GO:0042043 | neurexin family protein binding | 6.5217 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NLGN2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 54.3478 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.4783 | 4 | yes |
| GO:0030030 | cell projection organization | 39.1304 | 4 | no |
| GO:0022607 | cellular component assembly | 39.1304 | 4 | yes |
| GO:0051049 | regulation of transport | 36.9565 | 4 | yes |
| GO:0072657 | protein localization to membrane | 34.7826 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 32.6087 | 5 | no |
| GO:0034330 | cell junction organization | 32.6087 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 32.6087 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 32.6087 | 4 | yes |
| GO:0043113 | receptor clustering | 30.4348 | 5 | yes |
| GO:0050808 | synapse organization | 30.4348 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 28.2609 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.2609 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 28.2609 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.2609 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 26.0870 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 26.0870 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 26.0870 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 26.0870 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 23.9130 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.9130 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.9130 | 4 | no |
| GO:0031175 | neuron projection development | 23.9130 | 6 | no |
| GO:0050890 | cognition | 23.9130 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.9130 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.7391 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:0006996 | organelle organization | 21.7391 | 4 | no |
| GO:0007612 | learning | 21.7391 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 21.7391 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 21.7391 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 19.5652 | 4 | yes |
| GO:0034329 | cell junction assembly | 19.5652 | 5 | yes |
| GO:0043269 | regulation of ion transport | 19.5652 | 5 | yes |
| GO:0044057 | regulation of system process | 19.5652 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 19.5652 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 19.5652 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 19.5652 | 4 | yes |
| GO:0061024 | membrane organization | 19.5652 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 17.3913 | 4 | yes |
| GO:0007416 | synapse assembly | 17.3913 | 6 | yes |
| GO:0031644 | regulation of nervous system process | 17.3913 | 5 | yes |
| GO:0032880 | regulation of protein localization | 17.3913 | 5 | yes |
| GO:0035418 | protein localization to synapse | 17.3913 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 17.3913 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 17.3913 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 17.3913 | 5 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 15.2174 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 15.2174 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 15.2174 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.2174 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 15.2174 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 15.2174 | 5 | yes |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 15.2174 | 6 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 15.2174 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 15.2174 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 13.0435 | 6 | yes |
| GO:0007158 | neuron cell-cell adhesion | 13.0435 | 4 | yes |
| GO:0051046 | regulation of secretion | 13.0435 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 13.0435 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 13.0435 | 6 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 13.0435 | 6 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 13.0435 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 13.0435 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 13.0435 | 4 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 10.8696 | 5 | yes |
| GO:0001941 | postsynaptic membrane organization | 10.8696 | 5 | yes |
| GO:0007600 | sensory perception | 10.8696 | 4 | yes |
| GO:0050885 | neuromuscular process controlling balance | 10.8696 | 5 | yes |
| GO:0050905 | neuromuscular process | 10.8696 | 4 | yes |
| GO:0051965 | positive regulation of synapse assembly | 10.8696 | 6 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 10.8696 | 6 | yes |
| GO:0071709 | membrane assembly | 10.8696 | 5 | yes |
| GO:0097104 | postsynaptic membrane assembly | 10.8696 | 6 | yes |
| GO:0097116 | gephyrin clustering involved in postsynaptic density assembly | 10.8696 | 7 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 10.8696 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 10.8696 | 5 | yes |
| GO:0006897 | endocytosis | 8.6957 | 5 | yes |
| GO:0007420 | brain development | 8.6957 | 4 | yes |
| GO:0008344 | adult locomotory behavior | 8.6957 | 4 | yes |
| GO:0043954 | cellular component maintenance | 8.6957 | 4 | yes |
| GO:0051223 | regulation of protein transport | 8.6957 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 8.6957 | 7 | yes |
| GO:0060998 | regulation of dendritic spine development | 8.6957 | 4 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 8.6957 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 8.6957 | 6 | yes |
| GO:0097119 | postsynaptic density protein 95 clustering | 8.6957 | 5 | yes |
| GO:0099172 | presynapse organization | 8.6957 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.6957 | 6 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 8.6957 | 6 | yes |
| GO:0002087 | regulation of respiratory gaseous exchange by nervous system process | 6.5217 | 4 | yes |
| GO:0002791 | regulation of peptide secretion | 6.5217 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 6.5217 | 5 | yes |
| GO:0019233 | sensory perception of pain | 6.5217 | 5 | yes |
| GO:0034331 | cell junction maintenance | 6.5217 | 5 | yes |
| GO:0035641 | locomotory exploration behavior | 6.5217 | 4 | yes |
| GO:0043576 | regulation of respiratory gaseous exchange | 6.5217 | 4 | yes |
| GO:0044065 | regulation of respiratory system process | 6.5217 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 6.5217 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 6.5217 | 4 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 6.5217 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 6.5217 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 6.5217 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 6.5217 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 6.5217 | 5 | yes |
| GO:0072553 | terminal button organization | 6.5217 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 6.5217 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 6.5217 | 5 | yes |
| GO:0097090 | presynaptic membrane organization | 6.5217 | 5 | yes |
| GO:0097105 | presynaptic membrane assembly | 6.5217 | 6 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 6.5217 | 5 | yes |
| GO:0099054 | presynapse assembly | 6.5217 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 6.5217 | 6 | yes |
| GO:0140238 | presynaptic endocytosis | 6.5217 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 6.5217 | 5 | yes |
| GO:1904862 | inhibitory synapse assembly | 6.5217 | 7 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 6.5217 | 6 | yes |
| GO:1905606 | regulation of presynapse assembly | 6.5217 | 7 | yes |
| GO:2000807 | regulation of synaptic vesicle clustering | 4.3478 | 4 | yes |
| GO:2000809 | positive regulation of synaptic vesicle clustering | 4.3478 | 5 | yes |
| GO:0002793 | positive regulation of peptide secretion | 4.3478 | 6 | yes |
| GO:0007630 | jump response | 4.3478 | 5 | yes |
| GO:0031646 | positive regulation of nervous system process | 4.3478 | 5 | yes |
| GO:0032024 | positive regulation of insulin secretion | 4.3478 | 7 | yes |
| GO:0032228 | regulation of synaptic transmission, GABAergic | 4.3478 | 6 | yes |
| GO:0032230 | positive regulation of synaptic transmission, GABAergic | 4.3478 | 6 | yes |
| GO:0034394 | protein localization to cell surface | 4.3478 | 5 | yes |
| GO:0045217 | cell-cell junction maintenance | 4.3478 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 4.3478 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 4.3478 | 6 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 4.3478 | 6 | yes |
| GO:0097151 | positive regulation of inhibitory postsynaptic potential | 4.3478 | 5 | yes |
| GO:0098828 | modulation of inhibitory postsynaptic potential | 4.3478 | 4 | yes |
| GO:1901142 | insulin metabolic process | 4.3478 | 4 | yes |
| GO:1902473 | regulation of protein localization to synapse | 4.3478 | 6 | yes |
| GO:1902474 | positive regulation of protein localization to synapse | 4.3478 | 6 | yes |
| GO:1904032 | regulation of t-SNARE clustering | 4.3478 | 7 | yes |
| GO:1904034 | positive regulation of t-SNARE clustering | 4.3478 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NRX2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MDGA1_HUMAN | [view interactions] | Low throughput | no | no |
| PCDGC_HUMAN | [view interactions] | Low throughput | no | yes |
| PCDGD_HUMAN | [view interactions] | Low throughput | no | no |
| PCDGM_HUMAN | [view interactions] | Low throughput | no | yes |
| PCDG3_HUMAN | [view interactions] | Low throughput | no | no |
| RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| CRIS2_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| MAGI3_HUMAN | [view interactions] | High throughput | no | no |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYZL2_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMS_HUMAN | [view interactions] | High throughput | no | no |
| TAFA2_HUMAN | [view interactions] | High throughput | no | no |
| REL1_HUMAN | [view interactions] | High throughput | no | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| ADCY9_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| TNF18_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| PATE1_HUMAN | [view interactions] | High throughput | no | no |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| PRTN3_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| UD17_HUMAN | [view interactions] | High throughput | no | no |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| CD1B_HUMAN | [view interactions] | High throughput | no | yes |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| B3GA2_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGLU1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| APBB3_HUMAN | [view interactions] | High throughput | no | no |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SLIK3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LHPL4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ARHG9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |