C1QB_HUMAN
Evidence for PS localization
Functions
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 42 | Gly | Asp | C1qdeficiency2(C1QD2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C1QB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6190 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 38.0952 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.0952 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 38.0952 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 28.5714 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
| GO:0051960 | regulation of nervous system development | 28.5714 | 5 | no |
| GO:0051962 | positive regulation of nervous system development | 28.5714 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 28.5714 | 4 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 23.8095 | 4 | yes |
| GO:0034330 | cell junction organization | 23.8095 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | yes |
| GO:0050808 | synapse organization | 23.8095 | 5 | yes |
| GO:0140546 | defense response to symbiont | 23.8095 | 4 | yes |
| GO:0030334 | regulation of cell migration | 23.8095 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 23.8095 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.8095 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.8095 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0050807 | regulation of synapse organization | 23.8095 | 5 | no |
| GO:0051963 | regulation of synapse assembly | 23.8095 | 6 | no |
| GO:1901888 | regulation of cell junction assembly | 23.8095 | 5 | no |
| GO:0022411 | cellular component disassembly | 19.0476 | 4 | yes |
| GO:0050776 | regulation of immune response | 19.0476 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 19.0476 | 5 | yes |
| GO:0006958 | complement activation, classical pathway | 14.2857 | 4 | yes |
| GO:0098883 | synapse pruning | 14.2857 | 6 | yes |
| GO:0150146 | cell junction disassembly | 14.2857 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| C1QC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| CO6A2_HUMAN | [view interactions] | High throughput | no | no |
| NAR5_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA2B2_HUMAN | [view interactions] | High throughput | no | no |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| GT253_HUMAN | [view interactions] | High throughput | no | yes |
| NAGAB_HUMAN | [view interactions] | High throughput | no | yes |
| ANAG_HUMAN | [view interactions] | High throughput | no | no |
| CHSTE_HUMAN | [view interactions] | High throughput | no | no |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| BDNF_HUMAN | [view interactions] | High throughput | no | yes |
| VWDE_HUMAN | [view interactions] | High throughput | no | no |
| PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
| TRHDE_HUMAN | [view interactions] | High throughput | no | no |
| CHPF2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COCA1_HUMAN | [view interactions] | High throughput | no | yes |
| MGT5A_HUMAN | [view interactions] | High throughput | no | yes |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| SEM6B_HUMAN | [view interactions] | High throughput | no | yes |
| BGLR_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIR2_HUMAN | [view interactions] | High throughput | no | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP30_HUMAN | [view interactions] | High throughput | no | yes |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR27_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| MYOC_HUMAN | [view interactions] | High throughput | no | no |
| IL32_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GT252_HUMAN | [view interactions] | High throughput | no | yes |
| SC65_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CF120_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| PCSK6_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CELR1_HUMAN | [view interactions] | High throughput | no | no |
| ZNG1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| GAS6_HUMAN | [view interactions] | High throughput | no | no |
| MA2B1_HUMAN | [view interactions] | High throughput | no | yes |
| MANBA_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| ACHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| METRL_HUMAN | [view interactions] | High throughput | no | no |
| ATS7_HUMAN | [view interactions] | High throughput | no | no |
| BMP8A_HUMAN | [view interactions] | High throughput | no | no |
| HYAL2_HUMAN | [view interactions] | High throughput | no | no |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METRN_HUMAN | [view interactions] | High throughput | no | yes |