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PLXA1_HUMAN

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PLXA1_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0019900 kinase binding 34.2105 4 no
GO:0019901 protein kinase binding 34.2105 5 no
GO:0003924 GTPase activity 34.2105 7 no
GO:0005525 GTP binding 34.2105 5 no
GO:0016462 pyrophosphatase activity 34.2105 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 34.2105 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 34.2105 6 no
GO:0019001 guanyl nucleotide binding 34.2105 5 no
GO:0032561 guanyl ribonucleotide binding 34.2105 5 no
GO:0016301 kinase activity 21.0526 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.0526 4 no
GO:0019003 GDP binding 21.0526 4 no
GO:0017154 semaphorin receptor activity 18.4211 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLXA1_HUMAN
GO:0048522 positive regulation of cellular process 92.1053 4 yes
GO:0051128 regulation of cellular component organization 73.6842 4 yes
GO:0048523 negative regulation of cellular process 65.7895 4 yes
GO:0031344 regulation of cell projection organization 60.5263 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 60.5263 6 yes
GO:0045595 regulation of cell differentiation 55.2632 4 yes
GO:0030030 cell projection organization 55.2632 4 no
GO:0022603 regulation of anatomical structure morphogenesis 52.6316 4 yes
GO:0120036 plasma membrane bounded cell projection organization 52.6316 5 no
GO:2000145 regulation of cell motility 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031175 neuron projection development 50.0000 6 no
GO:0010975 regulation of neuron projection development 47.3684 7 yes
GO:0030334 regulation of cell migration 47.3684 5 yes
GO:0051094 positive regulation of developmental process 47.3684 4 yes
GO:0009966 regulation of signal transduction 47.3684 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 no
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0080090 regulation of primary metabolic process 47.3684 4 no
GO:0030155 regulation of cell adhesion 44.7368 4 yes
GO:0045597 positive regulation of cell differentiation 44.7368 5 yes
GO:0051130 positive regulation of cellular component organization 44.7368 5 yes
GO:0009893 positive regulation of metabolic process 44.7368 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.7368 5 no
GO:0031323 regulation of cellular metabolic process 44.7368 4 no
GO:0051049 regulation of transport 44.7368 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.7368 5 no
GO:0051336 regulation of hydrolase activity 42.1053 4 yes
GO:0060284 regulation of cell development 42.1053 5 yes
GO:2000026 regulation of multicellular organismal development 42.1053 4 yes
GO:0031325 positive regulation of cellular metabolic process 42.1053 5 no
GO:0022604 regulation of cell morphogenesis 39.4737 5 yes
GO:0031346 positive regulation of cell projection organization 39.4737 6 yes
GO:0006996 organelle organization 39.4737 4 no
GO:0033043 regulation of organelle organization 39.4737 5 no
GO:0051246 regulation of protein metabolic process 39.4737 5 no
GO:1902531 regulation of intracellular signal transduction 39.4737 5 no
GO:0019220 regulation of phosphate metabolic process 36.8421 6 no
GO:0031399 regulation of protein modification process 36.8421 6 no
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 no
GO:0051247 positive regulation of protein metabolic process 36.8421 6 no
GO:0007411 axon guidance 36.8421 8 no
GO:0097485 neuron projection guidance 36.8421 7 no
GO:0008360 regulation of cell shape 34.2105 6 yes
GO:0051240 positive regulation of multicellular organismal process 34.2105 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 34.2105 6 no
GO:0010941 regulation of cell death 34.2105 4 no
GO:0042127 regulation of cell population proliferation 34.2105 4 no
GO:0042325 regulation of phosphorylation 34.2105 7 no
GO:0042327 positive regulation of phosphorylation 34.2105 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.2105 7 no
GO:0051129 negative regulation of cellular component organization 34.2105 5 no
GO:0071310 cellular response to organic substance 34.2105 4 no
GO:0051493 regulation of cytoskeleton organization 34.2105 6 no
GO:0051960 regulation of nervous system development 31.5789 5 yes
GO:0001558 regulation of cell growth 31.5789 4 no
GO:0001932 regulation of protein phosphorylation 31.5789 7 no
GO:0001934 positive regulation of protein phosphorylation 31.5789 8 no
GO:0030335 positive regulation of cell migration 31.5789 6 no
GO:0031401 positive regulation of protein modification process 31.5789 7 no
GO:0040017 positive regulation of locomotion 31.5789 4 no
GO:0042981 regulation of apoptotic process 31.5789 6 no
GO:0043067 regulation of programmed cell death 31.5789 5 no
GO:0043085 positive regulation of catalytic activity 31.5789 4 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:2000147 positive regulation of cell motility 31.5789 5 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0010720 positive regulation of cell development 28.9474 6 yes
GO:0050767 regulation of neurogenesis 28.9474 6 yes
GO:0050770 regulation of axonogenesis 28.9474 5 yes
GO:0009892 negative regulation of metabolic process 28.9474 4 no
GO:0048585 negative regulation of response to stimulus 28.9474 4 no
GO:0048638 regulation of developmental growth 28.9474 4 no
GO:0051093 negative regulation of developmental process 28.9474 4 no
GO:0007010 cytoskeleton organization 28.9474 5 no
GO:0007264 small GTPase mediated signal transduction 28.9474 4 no
GO:0022607 cellular component assembly 28.9474 4 no
GO:0032956 regulation of actin cytoskeleton organization 28.9474 5 no
GO:0032970 regulation of actin filament-based process 28.9474 4 no
GO:0071526 semaphorin-plexin signaling pathway 26.3158 4 yes
GO:0008104 protein localization 26.3158 4 no
GO:0008284 positive regulation of cell population proliferation 26.3158 5 no
GO:0010468 regulation of gene expression 26.3158 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.3158 5 no
GO:0051338 regulation of transferase activity 26.3158 4 no
GO:0051345 positive regulation of hydrolase activity 26.3158 5 no
GO:0061024 membrane organization 26.3158 4 no
GO:0045596 negative regulation of cell differentiation 26.3158 5 no
GO:0051241 negative regulation of multicellular organismal process 26.3158 4 no
GO:0007265 Ras protein signal transduction 26.3158 5 no
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0044089 positive regulation of cellular component biogenesis 26.3158 5 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:0006796 phosphate-containing compound metabolic process 23.6842 4 no
GO:0031324 negative regulation of cellular metabolic process 23.6842 5 no
GO:0032880 regulation of protein localization 23.6842 5 no
GO:0033674 positive regulation of kinase activity 23.6842 6 no
GO:0043549 regulation of kinase activity 23.6842 5 no
GO:0045785 positive regulation of cell adhesion 23.6842 5 no
GO:0051347 positive regulation of transferase activity 23.6842 5 no
GO:0051726 regulation of cell cycle 23.6842 4 no
GO:0060341 regulation of cellular localization 23.6842 4 no
GO:1901214 regulation of neuron death 23.6842 5 no
GO:0032101 regulation of response to external stimulus 23.6842 4 no
GO:0061387 regulation of extent of cell growth 23.6842 5 no
GO:0009967 positive regulation of signal transduction 23.6842 5 no
GO:0010638 positive regulation of organelle organization 23.6842 6 no
GO:0010942 positive regulation of cell death 23.6842 5 no
GO:0002009 morphogenesis of an epithelium 21.0526 4 yes
GO:0043087 regulation of GTPase activity 21.0526 5 yes
GO:0050769 positive regulation of neurogenesis 21.0526 6 yes
GO:0051962 positive regulation of nervous system development 21.0526 5 yes
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 21.0526 5 yes
GO:0002684 positive regulation of immune system process 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 21.0526 5 no
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0016310 phosphorylation 21.0526 5 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0036211 protein modification process 21.0526 4 no
GO:0040013 negative regulation of locomotion 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.0526 5 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:1903829 positive regulation of protein localization 21.0526 5 no
GO:0030516 regulation of axon extension 21.0526 5 no
GO:0031345 negative regulation of cell projection organization 21.0526 6 no
GO:0050920 regulation of chemotaxis 21.0526 4 no
GO:0050807 regulation of synapse organization 21.0526 5 no
GO:0051495 positive regulation of cytoskeleton organization 21.0526 7 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:0060491 regulation of cell projection assembly 21.0526 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 21.0526 6 no
GO:0007162 negative regulation of cell adhesion 18.4211 5 yes
GO:0050772 positive regulation of axonogenesis 18.4211 6 yes
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 18.4211 6 yes
GO:1990138 neuron projection extension 15.7895 4 yes
GO:0014910 regulation of smooth muscle cell migration 10.5263 6 yes
GO:0060600 dichotomous subdivision of an epithelial terminal unit 7.8947 5 yes
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching 7.8947 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PLXA1_HUMAN
DOID:0050700 cardiomyopathy 5.2632 4 no
DOID:0060036 intrinsic cardiomyopathy 5.2632 5 no
DOID:114 heart disease 5.2632 3 no
DOID:2843 long QT syndrome 5.2632 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TYOBP_HUMAN [view interactions] Low throughput no no
TREM2_HUMAN [view interactions] Low throughput no yes
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR2_HUMAN [view interactions] Low throughput no no
ANPRA_HUMAN [view interactions] Low throughput no no
RHOD_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
MGT4C_HUMAN [view interactions] High throughput no yes
SG1D1_HUMAN [view interactions] High throughput no no
DEF5_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
SIA8D_HUMAN [view interactions] High throughput no yes
TAFA4_HUMAN [view interactions] High throughput no no
CCDC7_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PLXB1_HUMAN [view interactions] High throughput no yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
DRA_HUMAN [view interactions] High throughput no no
TAZ_HUMAN [view interactions] High throughput no yes
SUSD4_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
TMM25_HUMAN [view interactions] High throughput no yes
CANT1_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRK_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
NKG2A_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
MSMB_HUMAN [view interactions] High throughput no no
TECT2_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CL12B_HUMAN [view interactions] High throughput no no
IN35_HUMAN [view interactions] High throughput no yes
CRIS2_HUMAN [view interactions] High throughput no no
C1QB_HUMAN [view interactions] High throughput no no
MFAP4_HUMAN [view interactions] High throughput no no
PCDB3_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
TDGF1_HUMAN [view interactions] High throughput no no
CAH6_HUMAN [view interactions] High throughput no no
CLC4M_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
EFNA2_HUMAN [view interactions] High throughput no no
DQA1_HUMAN [view interactions] High throughput no yes
BRID5_HUMAN [view interactions] High throughput no no
TM87A_HUMAN [view interactions] High throughput no yes
KLK15_HUMAN [view interactions] High throughput no no
SIA8E_HUMAN [view interactions] High throughput no yes
PSPC_HUMAN [view interactions] High throughput no no
ECEL1_HUMAN [view interactions] High throughput no yes
KLRD1_HUMAN [view interactions] High throughput no no
ISLR_HUMAN [view interactions] High throughput no no
TAFA1_HUMAN [view interactions] High throughput no no
CNTP3_HUMAN [view interactions] High throughput no yes
CFC1_HUMAN [view interactions] High throughput no no
LYZL1_HUMAN [view interactions] High throughput no no
T106A_HUMAN [view interactions] High throughput no no
WDR25_HUMAN [view interactions] High throughput no yes
DNSL1_HUMAN [view interactions] High throughput no yes
ANTR1_HUMAN [view interactions] High throughput no no
SIRPD_HUMAN [view interactions] High throughput no no
LY6H_HUMAN [view entry] [view interactions] High throughput yes no
SLUR1_HUMAN [view interactions] High throughput no no
CA054_HUMAN [view interactions] High throughput no yes
GGH_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
DPB1_HUMAN [view interactions] High throughput no no
PI15_HUMAN [view interactions] High throughput no no
BTNL2_HUMAN [view interactions] High throughput no no
HLAG_HUMAN [view interactions] High throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
FIBIN_HUMAN [view interactions] High throughput no yes
C1T9B_HUMAN [view interactions] High throughput no no
LIRA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
NCTR3_HUMAN [view interactions] High throughput no no
IL5RA_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RND1_HUMAN [view interactions] High throughput no no
SEM5B_HUMAN [view interactions] High throughput no yes
SEM6A_HUMAN [view interactions] High throughput no yes
SEM6C_HUMAN [view interactions] High throughput no no
SEM6D_HUMAN [view interactions] High throughput no no
PLXD1_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SEM3D_HUMAN [view interactions] Computational no no
SEM3C_HUMAN [view interactions] Computational no no
FES_HUMAN [view entry] [view interactions] Computational yes no
PLXA2_HUMAN [view entry] [view interactions] Computational yes yes
RRAS_HUMAN [view interactions] Computational no yes
NPHN_HUMAN [view interactions] Computational no no
PLXA3_HUMAN [view entry] [view interactions] Computational yes no
SEM3G_HUMAN [view interactions] Computational no no
FYN_HUMAN [view entry] [view interactions] Computational yes no
FARP2_HUMAN [view interactions] Computational no yes
NRCAM_HUMAN [view entry] [view interactions] Computational yes no
SEM3A_HUMAN [view interactions] Computational no no
SEM4D_HUMAN [view interactions] Computational no yes
SEM7A_HUMAN [view interactions] Computational no yes
SEM4F_HUMAN [view entry] [view interactions] Computational yes no
SEM3F_HUMAN [view entry] [view interactions] Computational yes no
LIMK1_HUMAN [view interactions] Computational no yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
PLXA4_HUMAN [view entry] [view interactions] Computational yes no
SEM6B_HUMAN [view interactions] Computational no yes