PLXA1_HUMAN
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLXA1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0019900 | kinase binding | 34.2105 | 4 | no |
GO:0019901 | protein kinase binding | 34.2105 | 5 | no |
GO:0003924 | GTPase activity | 34.2105 | 7 | no |
GO:0005525 | GTP binding | 34.2105 | 5 | no |
GO:0016462 | pyrophosphatase activity | 34.2105 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.2105 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.2105 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 34.2105 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 34.2105 | 5 | no |
GO:0016301 | kinase activity | 21.0526 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.0526 | 4 | no |
GO:0019003 | GDP binding | 21.0526 | 4 | no |
GO:0017154 | semaphorin receptor activity | 18.4211 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLXA1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 92.1053 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 73.6842 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 65.7895 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 60.5263 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 60.5263 | 6 | yes |
GO:0045595 | regulation of cell differentiation | 55.2632 | 4 | yes |
GO:0030030 | cell projection organization | 55.2632 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 52.6316 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 52.6316 | 5 | no |
GO:2000145 | regulation of cell motility | 50.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0031175 | neuron projection development | 50.0000 | 6 | no |
GO:0010975 | regulation of neuron projection development | 47.3684 | 7 | yes |
GO:0030334 | regulation of cell migration | 47.3684 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 47.3684 | 4 | yes |
GO:0009966 | regulation of signal transduction | 47.3684 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.3684 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 47.3684 | 4 | no |
GO:0030155 | regulation of cell adhesion | 44.7368 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 44.7368 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 44.7368 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 44.7368 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 44.7368 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 44.7368 | 4 | no |
GO:0051049 | regulation of transport | 44.7368 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.7368 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 42.1053 | 4 | yes |
GO:0060284 | regulation of cell development | 42.1053 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 42.1053 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 42.1053 | 5 | no |
GO:0022604 | regulation of cell morphogenesis | 39.4737 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 39.4737 | 6 | yes |
GO:0006996 | organelle organization | 39.4737 | 4 | no |
GO:0033043 | regulation of organelle organization | 39.4737 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 39.4737 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 39.4737 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 36.8421 | 6 | no |
GO:0031399 | regulation of protein modification process | 36.8421 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 36.8421 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 36.8421 | 6 | no |
GO:0007411 | axon guidance | 36.8421 | 8 | no |
GO:0097485 | neuron projection guidance | 36.8421 | 7 | no |
GO:0008360 | regulation of cell shape | 34.2105 | 6 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 34.2105 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 34.2105 | 6 | no |
GO:0010941 | regulation of cell death | 34.2105 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 34.2105 | 4 | no |
GO:0042325 | regulation of phosphorylation | 34.2105 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 34.2105 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 34.2105 | 7 | no |
GO:0051129 | negative regulation of cellular component organization | 34.2105 | 5 | no |
GO:0071310 | cellular response to organic substance | 34.2105 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 34.2105 | 6 | no |
GO:0051960 | regulation of nervous system development | 31.5789 | 5 | yes |
GO:0001558 | regulation of cell growth | 31.5789 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 31.5789 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 31.5789 | 8 | no |
GO:0030335 | positive regulation of cell migration | 31.5789 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 31.5789 | 7 | no |
GO:0040017 | positive regulation of locomotion | 31.5789 | 4 | no |
GO:0042981 | regulation of apoptotic process | 31.5789 | 6 | no |
GO:0043067 | regulation of programmed cell death | 31.5789 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 31.5789 | 4 | no |
GO:0051050 | positive regulation of transport | 31.5789 | 4 | no |
GO:2000147 | positive regulation of cell motility | 31.5789 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.5789 | 4 | no |
GO:0010720 | positive regulation of cell development | 28.9474 | 6 | yes |
GO:0050767 | regulation of neurogenesis | 28.9474 | 6 | yes |
GO:0050770 | regulation of axonogenesis | 28.9474 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 28.9474 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 28.9474 | 4 | no |
GO:0048638 | regulation of developmental growth | 28.9474 | 4 | no |
GO:0051093 | negative regulation of developmental process | 28.9474 | 4 | no |
GO:0007010 | cytoskeleton organization | 28.9474 | 5 | no |
GO:0007264 | small GTPase mediated signal transduction | 28.9474 | 4 | no |
GO:0022607 | cellular component assembly | 28.9474 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 28.9474 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 28.9474 | 4 | no |
GO:0071526 | semaphorin-plexin signaling pathway | 26.3158 | 4 | yes |
GO:0008104 | protein localization | 26.3158 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 26.3158 | 5 | no |
GO:0010468 | regulation of gene expression | 26.3158 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
GO:0051338 | regulation of transferase activity | 26.3158 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 26.3158 | 5 | no |
GO:0061024 | membrane organization | 26.3158 | 4 | no |
GO:0045596 | negative regulation of cell differentiation | 26.3158 | 5 | no |
GO:0051241 | negative regulation of multicellular organismal process | 26.3158 | 4 | no |
GO:0007265 | Ras protein signal transduction | 26.3158 | 5 | no |
GO:0010647 | positive regulation of cell communication | 26.3158 | 5 | no |
GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 26.3158 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 26.3158 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.6842 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.6842 | 5 | no |
GO:0032880 | regulation of protein localization | 23.6842 | 5 | no |
GO:0033674 | positive regulation of kinase activity | 23.6842 | 6 | no |
GO:0043549 | regulation of kinase activity | 23.6842 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 23.6842 | 5 | no |
GO:0051347 | positive regulation of transferase activity | 23.6842 | 5 | no |
GO:0051726 | regulation of cell cycle | 23.6842 | 4 | no |
GO:0060341 | regulation of cellular localization | 23.6842 | 4 | no |
GO:1901214 | regulation of neuron death | 23.6842 | 5 | no |
GO:0032101 | regulation of response to external stimulus | 23.6842 | 4 | no |
GO:0061387 | regulation of extent of cell growth | 23.6842 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 23.6842 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 23.6842 | 6 | no |
GO:0010942 | positive regulation of cell death | 23.6842 | 5 | no |
GO:0002009 | morphogenesis of an epithelium | 21.0526 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 21.0526 | 5 | yes |
GO:0050769 | positive regulation of neurogenesis | 21.0526 | 6 | yes |
GO:0051962 | positive regulation of nervous system development | 21.0526 | 5 | yes |
GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 21.0526 | 5 | yes |
GO:0002684 | positive regulation of immune system process | 21.0526 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.0526 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 21.0526 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 21.0526 | 4 | no |
GO:0016310 | phosphorylation | 21.0526 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.0526 | 5 | no |
GO:0036211 | protein modification process | 21.0526 | 4 | no |
GO:0040013 | negative regulation of locomotion | 21.0526 | 4 | no |
GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 21.0526 | 4 | no |
GO:1903829 | positive regulation of protein localization | 21.0526 | 5 | no |
GO:0030516 | regulation of axon extension | 21.0526 | 5 | no |
GO:0031345 | negative regulation of cell projection organization | 21.0526 | 6 | no |
GO:0050920 | regulation of chemotaxis | 21.0526 | 4 | no |
GO:0050807 | regulation of synapse organization | 21.0526 | 5 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 21.0526 | 7 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.0526 | 6 | no |
GO:0060491 | regulation of cell projection assembly | 21.0526 | 5 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 21.0526 | 6 | no |
GO:0007162 | negative regulation of cell adhesion | 18.4211 | 5 | yes |
GO:0050772 | positive regulation of axonogenesis | 18.4211 | 6 | yes |
GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 18.4211 | 6 | yes |
GO:1990138 | neuron projection extension | 15.7895 | 4 | yes |
GO:0014910 | regulation of smooth muscle cell migration | 10.5263 | 6 | yes |
GO:0060600 | dichotomous subdivision of an epithelial terminal unit | 7.8947 | 5 | yes |
GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching | 7.8947 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PLXA1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 5.2632 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 5.2632 | 5 | no |
DOID:114 | heart disease | 5.2632 | 3 | no |
DOID:2843 | long QT syndrome | 5.2632 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TYOBP_HUMAN | [view interactions] | Low throughput | no | no |
TREM2_HUMAN | [view interactions] | Low throughput | no | yes |
NRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NRP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
ANPRA_HUMAN | [view interactions] | Low throughput | no | no |
RHOD_HUMAN | [view interactions] | Low throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGT4C_HUMAN | [view interactions] | High throughput | no | yes |
SG1D1_HUMAN | [view interactions] | High throughput | no | no |
DEF5_HUMAN | [view interactions] | High throughput | no | no |
DEF1_HUMAN | [view interactions] | High throughput | no | no |
OS9_HUMAN | [view interactions] | High throughput | no | yes |
SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
TAFA4_HUMAN | [view interactions] | High throughput | no | no |
CCDC7_HUMAN | [view interactions] | High throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLXB1_HUMAN | [view interactions] | High throughput | no | yes |
L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
DRA_HUMAN | [view interactions] | High throughput | no | no |
TAZ_HUMAN | [view interactions] | High throughput | no | yes |
SUSD4_HUMAN | [view interactions] | High throughput | no | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
TMM25_HUMAN | [view interactions] | High throughput | no | yes |
CANT1_HUMAN | [view interactions] | High throughput | no | yes |
PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRK_HUMAN | [view interactions] | High throughput | no | no |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
NKG2A_HUMAN | [view interactions] | High throughput | no | no |
LEG1_HUMAN | [view interactions] | High throughput | no | yes |
MSMB_HUMAN | [view interactions] | High throughput | no | no |
TECT2_HUMAN | [view interactions] | High throughput | no | yes |
FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CL12B_HUMAN | [view interactions] | High throughput | no | no |
IN35_HUMAN | [view interactions] | High throughput | no | yes |
CRIS2_HUMAN | [view interactions] | High throughput | no | no |
C1QB_HUMAN | [view interactions] | High throughput | no | no |
MFAP4_HUMAN | [view interactions] | High throughput | no | no |
PCDB3_HUMAN | [view interactions] | High throughput | no | no |
LY86_HUMAN | [view interactions] | High throughput | no | no |
PRG2_HUMAN | [view interactions] | High throughput | no | no |
TDGF1_HUMAN | [view interactions] | High throughput | no | no |
CAH6_HUMAN | [view interactions] | High throughput | no | no |
CLC4M_HUMAN | [view interactions] | High throughput | no | no |
SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
EFNA2_HUMAN | [view interactions] | High throughput | no | no |
DQA1_HUMAN | [view interactions] | High throughput | no | yes |
BRID5_HUMAN | [view interactions] | High throughput | no | no |
TM87A_HUMAN | [view interactions] | High throughput | no | yes |
KLK15_HUMAN | [view interactions] | High throughput | no | no |
SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
PSPC_HUMAN | [view interactions] | High throughput | no | no |
ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
KLRD1_HUMAN | [view interactions] | High throughput | no | no |
ISLR_HUMAN | [view interactions] | High throughput | no | no |
TAFA1_HUMAN | [view interactions] | High throughput | no | no |
CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
CFC1_HUMAN | [view interactions] | High throughput | no | no |
LYZL1_HUMAN | [view interactions] | High throughput | no | no |
T106A_HUMAN | [view interactions] | High throughput | no | no |
WDR25_HUMAN | [view interactions] | High throughput | no | yes |
DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
ANTR1_HUMAN | [view interactions] | High throughput | no | no |
SIRPD_HUMAN | [view interactions] | High throughput | no | no |
LY6H_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SLUR1_HUMAN | [view interactions] | High throughput | no | no |
CA054_HUMAN | [view interactions] | High throughput | no | yes |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
DPB1_HUMAN | [view interactions] | High throughput | no | no |
PI15_HUMAN | [view interactions] | High throughput | no | no |
BTNL2_HUMAN | [view interactions] | High throughput | no | no |
HLAG_HUMAN | [view interactions] | High throughput | no | no |
CBLN4_HUMAN | [view interactions] | High throughput | no | no |
FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
C1T9B_HUMAN | [view interactions] | High throughput | no | no |
LIRA5_HUMAN | [view interactions] | High throughput | no | no |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCTR3_HUMAN | [view interactions] | High throughput | no | no |
IL5RA_HUMAN | [view interactions] | High throughput | no | no |
TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RND1_HUMAN | [view interactions] | High throughput | no | no |
SEM5B_HUMAN | [view interactions] | High throughput | no | yes |
SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
SEM6C_HUMAN | [view interactions] | High throughput | no | no |
SEM6D_HUMAN | [view interactions] | High throughput | no | no |
PLXD1_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEM3D_HUMAN | [view interactions] | Computational | no | no |
SEM3C_HUMAN | [view interactions] | Computational | no | no |
FES_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PLXA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RRAS_HUMAN | [view interactions] | Computational | no | yes |
NPHN_HUMAN | [view interactions] | Computational | no | no |
PLXA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SEM3G_HUMAN | [view interactions] | Computational | no | no |
FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FARP2_HUMAN | [view interactions] | Computational | no | yes |
NRCAM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SEM3A_HUMAN | [view interactions] | Computational | no | no |
SEM4D_HUMAN | [view interactions] | Computational | no | yes |
SEM7A_HUMAN | [view interactions] | Computational | no | yes |
SEM4F_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SEM3F_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LIMK1_HUMAN | [view interactions] | Computational | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLXA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SEM6B_HUMAN | [view interactions] | Computational | no | yes |