Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLXB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for SEMA4D (PubMed, PubMed, PubMed). Plays a role in GABAergic synapse development . Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development . Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed, PubMed). Plays a role in axon guidance, invasive growth and cell migration (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLXB1_HUMAN
GO:0019900 kinase binding 35.0000 4 no
GO:0019901 protein kinase binding 35.0000 5 no
GO:0030215 semaphorin receptor binding 30.0000 4 yes
GO:0000166 nucleotide binding 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 5 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0043168 anion binding 30.0000 4 no
GO:0017154 semaphorin receptor activity 25.0000 4 yes
GO:0030695 GTPase regulator activity 25.0000 4 yes
GO:0005096 GTPase activator activity 15.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLXB1_HUMAN
GO:0048522 positive regulation of cellular process 90.0000 4 yes
GO:0051128 regulation of cellular component organization 85.0000 4 yes
GO:0030334 regulation of cell migration 70.0000 5 yes
GO:0048523 negative regulation of cellular process 70.0000 4 yes
GO:2000145 regulation of cell motility 70.0000 4 yes
GO:0031344 regulation of cell projection organization 65.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 65.0000 6 yes
GO:2000026 regulation of multicellular organismal development 65.0000 4 yes
GO:0010646 regulation of cell communication 60.0000 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 60.0000 4 yes
GO:0045595 regulation of cell differentiation 60.0000 4 yes
GO:0048584 positive regulation of response to stimulus 60.0000 4 yes
GO:0060284 regulation of cell development 60.0000 5 yes
GO:0071526 semaphorin-plexin signaling pathway 60.0000 4 yes
GO:0009966 regulation of signal transduction 55.0000 4 yes
GO:0010975 regulation of neuron projection development 55.0000 7 yes
GO:0030030 cell projection organization 55.0000 4 yes
GO:0051130 positive regulation of cellular component organization 55.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 55.0000 5 yes
GO:0030335 positive regulation of cell migration 55.0000 6 no
GO:0040017 positive regulation of locomotion 55.0000 4 no
GO:2000147 positive regulation of cell motility 55.0000 5 no
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0051960 regulation of nervous system development 50.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 yes
GO:0030155 regulation of cell adhesion 45.0000 4 yes
GO:0033043 regulation of organelle organization 45.0000 5 yes
GO:0042127 regulation of cell population proliferation 45.0000 4 yes
GO:0050767 regulation of neurogenesis 45.0000 6 yes
GO:0050770 regulation of axonogenesis 45.0000 5 yes
GO:0051094 positive regulation of developmental process 45.0000 4 yes
GO:0007411 axon guidance 45.0000 8 no
GO:0009893 positive regulation of metabolic process 45.0000 4 no
GO:0031175 neuron projection development 45.0000 6 no
GO:0031323 regulation of cellular metabolic process 45.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 45.0000 5 no
GO:0097485 neuron projection guidance 45.0000 7 no
GO:0120036 plasma membrane bounded cell projection organization 45.0000 5 no
GO:0031346 positive regulation of cell projection organization 40.0000 6 yes
GO:0043085 positive regulation of catalytic activity 40.0000 4 yes
GO:0045597 positive regulation of cell differentiation 40.0000 5 yes
GO:0001558 regulation of cell growth 40.0000 4 no
GO:0001667 ameboidal-type cell migration 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0032101 regulation of response to external stimulus 40.0000 4 no
GO:0040013 negative regulation of locomotion 40.0000 4 no
GO:0048585 negative regulation of response to stimulus 40.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 40.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0141124 intracellular signaling cassette 40.0000 4 no
GO:0007162 negative regulation of cell adhesion 35.0000 5 yes
GO:0010720 positive regulation of cell development 35.0000 6 yes
GO:0051493 regulation of cytoskeleton organization 35.0000 6 yes
GO:0001932 regulation of protein phosphorylation 35.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 35.0000 8 no
GO:0009889 regulation of biosynthetic process 35.0000 4 no
GO:0010468 regulation of gene expression 35.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 35.0000 6 no
GO:0019220 regulation of phosphate metabolic process 35.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 35.0000 5 no
GO:0031399 regulation of protein modification process 35.0000 6 no
GO:0031401 positive regulation of protein modification process 35.0000 7 no
GO:0042325 regulation of phosphorylation 35.0000 7 no
GO:0042327 positive regulation of phosphorylation 35.0000 8 no
GO:0042981 regulation of apoptotic process 35.0000 5 no
GO:0043067 regulation of programmed cell death 35.0000 4 no
GO:0044087 regulation of cellular component biogenesis 35.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 35.0000 7 no
GO:0048638 regulation of developmental growth 35.0000 4 no
GO:0051129 negative regulation of cellular component organization 35.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 35.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 35.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 35.0000 5 no
GO:0035023 regulation of Rho protein signal transduction 30.0000 7 yes
GO:0050769 positive regulation of neurogenesis 30.0000 6 yes
GO:0050772 positive regulation of axonogenesis 30.0000 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 30.0000 6 yes
GO:0051336 regulation of hydrolase activity 30.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 30.0000 5 yes
GO:0051962 positive regulation of nervous system development 30.0000 5 yes
GO:0001755 neural crest cell migration 30.0000 6 no
GO:0006355 regulation of DNA-templated transcription 30.0000 7 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0010721 negative regulation of cell development 30.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0030516 regulation of axon extension 30.0000 5 no
GO:0031345 negative regulation of cell projection organization 30.0000 6 no
GO:0032102 negative regulation of response to external stimulus 30.0000 5 no
GO:0043066 negative regulation of apoptotic process 30.0000 6 no
GO:0043069 negative regulation of programmed cell death 30.0000 5 no
GO:0044089 positive regulation of cellular component biogenesis 30.0000 5 no
GO:0045596 negative regulation of cell differentiation 30.0000 5 no
GO:0050919 negative chemotaxis 30.0000 4 no
GO:0050920 regulation of chemotaxis 30.0000 4 no
GO:0051093 negative regulation of developmental process 30.0000 4 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:0061387 regulation of extent of cell growth 30.0000 5 no
GO:0090497 mesenchymal cell migration 30.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0002684 positive regulation of immune system process 30.0000 4 no
GO:0010594 regulation of endothelial cell migration 30.0000 5 no
GO:0010632 regulation of epithelial cell migration 30.0000 4 no
GO:0008284 positive regulation of cell population proliferation 30.0000 5 no
GO:0050678 regulation of epithelial cell proliferation 30.0000 5 no
GO:0050679 positive regulation of epithelial cell proliferation 30.0000 6 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 yes
GO:0022607 cellular component assembly 25.0000 4 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0035025 positive regulation of Rho protein signal transduction 25.0000 8 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 25.0000 7 yes
GO:0001764 neuron migration 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010977 negative regulation of neuron projection development 25.0000 7 no
GO:0030307 positive regulation of cell growth 25.0000 5 no
GO:0030308 negative regulation of cell growth 25.0000 5 no
GO:0030517 negative regulation of axon extension 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0045926 negative regulation of growth 25.0000 4 no
GO:0045927 positive regulation of growth 25.0000 4 no
GO:0048640 negative regulation of developmental growth 25.0000 5 no
GO:0048841 regulation of axon extension involved in axon guidance 25.0000 6 no
GO:0048843 negative regulation of axon extension involved in axon guidance 25.0000 6 no
GO:0050768 negative regulation of neurogenesis 25.0000 6 no
GO:0050771 negative regulation of axonogenesis 25.0000 6 no
GO:0050922 negative regulation of chemotaxis 25.0000 5 no
GO:0051961 negative regulation of nervous system development 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007264 small GTPase-mediated signal transduction 25.0000 5 no
GO:0010595 positive regulation of endothelial cell migration 25.0000 6 no
GO:0010634 positive regulation of epithelial cell migration 25.0000 5 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0008285 negative regulation of cell population proliferation 20.0000 5 yes
GO:0043087 regulation of GTPase activity 20.0000 5 yes
GO:0043547 positive regulation of GTPase activity 20.0000 6 yes
GO:0050808 synapse organization 20.0000 5 yes
GO:0033688 regulation of osteoblast proliferation 15.0000 5 yes
GO:0034329 cell junction assembly 15.0000 5 yes
GO:0048812 neuron projection morphogenesis 15.0000 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.0000 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.0000 7 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 15.0000 4 yes
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 15.0000 5 yes
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 15.0000 6 yes
GO:0007416 synapse assembly 10.0000 6 yes
GO:0033689 negative regulation of osteoblast proliferation 10.0000 6 yes
GO:1904862 inhibitory synapse assembly 10.0000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RND1_HUMAN [view interactions] Low throughput no no
MET_HUMAN [view interactions] Low throughput no yes
ARHGB_HUMAN [view interactions] Low throughput no yes
ARHGC_HUMAN [view interactions] Low throughput no yes
RASM_HUMAN [view entry] [view interactions] Low throughput yes yes
RON_HUMAN [view interactions] Low throughput no yes
SEM4D_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
SEM4A_HUMAN [view interactions] Low throughput no no
RHOD_HUMAN [view interactions] Low throughput no no
RND3_HUMAN [view interactions] Low throughput no no
RND2_HUMAN [view interactions] Low throughput no no
PLXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
UTER_HUMAN [view interactions] Low throughput no no
SOX4_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP2_HUMAN [view entry] [view interactions] High throughput yes yes
PLXA1_HUMAN [view entry] [view interactions] High throughput yes yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCG2_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
SGTB_HUMAN [view interactions] High throughput no yes
CF298_HUMAN [view interactions] High throughput no yes
CENPO_HUMAN [view interactions] High throughput no no
CENPU_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
SMPX_HUMAN [view interactions] High throughput no no
HBB_HUMAN [view interactions] High throughput no no
HBA_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
ISG20_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
SEM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
SEM4F_HUMAN [view entry] [view interactions] High throughput yes no
SEM4G_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes