Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEM4F_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probable cell surface receptor that regulates oligodendroglial precursor cell migration . Might also regulate differentiation of oligodendroglial precursor cells . Has growth cone collapse activity against retinal ganglion-cell axons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SEM4F_HUMAN
GO:0005216 monoatomic ion channel activity 36.3636 4 no
GO:0015267 channel activity 36.3636 4 no
GO:0022836 gated channel activity 36.3636 5 no
GO:0043169 cation binding 36.3636 4 no
GO:0005261 monoatomic cation channel activity 27.2727 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 27.2727 4 no
GO:0046872 metal ion binding 27.2727 5 no
GO:0017154 semaphorin receptor activity 27.2727 4 no
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 27.2727 6 no
GO:0015276 ligand-gated monoatomic ion channel activity 27.2727 5 no
GO:0022824 transmitter-gated monoatomic ion channel activity 27.2727 5 no
GO:0022834 ligand-gated channel activity 27.2727 6 no
GO:0022835 transmitter-gated channel activity 27.2727 4 no
GO:0098960 postsynaptic neurotransmitter receptor activity 27.2727 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 27.2727 5 no
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 27.2727 6 no
GO:0030215 semaphorin receptor binding 18.1818 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SEM4F_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0030030 cell projection organization 54.5455 4 yes
GO:0051049 regulation of transport 54.5455 4 no
GO:0010646 regulation of cell communication 54.5455 4 no
GO:0031175 neuron projection development 45.4545 6 yes
GO:0048523 negative regulation of cellular process 45.4545 4 yes
GO:0051128 regulation of cellular component organization 45.4545 4 yes
GO:0120036 plasma membrane bounded cell projection organization 45.4545 5 yes
GO:0007411 axon guidance 36.3636 8 yes
GO:0022603 regulation of anatomical structure morphogenesis 36.3636 4 yes
GO:0030334 regulation of cell migration 36.3636 5 yes
GO:0031344 regulation of cell projection organization 36.3636 5 yes
GO:0045595 regulation of cell differentiation 36.3636 4 yes
GO:0071526 semaphorin-plexin signaling pathway 36.3636 4 yes
GO:0097485 neuron projection guidance 36.3636 7 yes
GO:2000026 regulation of multicellular organismal development 36.3636 4 yes
GO:2000145 regulation of cell motility 36.3636 4 yes
GO:0008104 protein localization 36.3636 4 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0042127 regulation of cell population proliferation 36.3636 4 no
GO:0051094 positive regulation of developmental process 36.3636 4 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0007268 chemical synaptic transmission 36.3636 7 no
GO:0098916 anterograde trans-synaptic signaling 36.3636 6 no
GO:0099536 synaptic signaling 36.3636 4 no
GO:0099537 trans-synaptic signaling 36.3636 5 no
GO:0001667 ameboidal-type cell migration 27.2727 4 yes
GO:0001755 neural crest cell migration 27.2727 6 yes
GO:0010975 regulation of neuron projection development 27.2727 7 yes
GO:0030335 positive regulation of cell migration 27.2727 6 yes
GO:0040017 positive regulation of locomotion 27.2727 4 yes
GO:0045596 negative regulation of cell differentiation 27.2727 5 yes
GO:0045926 negative regulation of growth 27.2727 4 yes
GO:0048585 negative regulation of response to stimulus 27.2727 4 yes
GO:0048638 regulation of developmental growth 27.2727 4 yes
GO:0048640 negative regulation of developmental growth 27.2727 5 yes
GO:0050767 regulation of neurogenesis 27.2727 6 yes
GO:0050770 regulation of axonogenesis 27.2727 5 yes
GO:0051093 negative regulation of developmental process 27.2727 4 yes
GO:0051129 negative regulation of cellular component organization 27.2727 5 yes
GO:0051241 negative regulation of multicellular organismal process 27.2727 4 yes
GO:0051960 regulation of nervous system development 27.2727 5 yes
GO:0060284 regulation of cell development 27.2727 5 yes
GO:0090497 mesenchymal cell migration 27.2727 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 yes
GO:2000147 positive regulation of cell motility 27.2727 5 yes
GO:0001508 action potential 27.2727 4 no
GO:0006811 monoatomic ion transport 27.2727 4 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 no
GO:0045597 positive regulation of cell differentiation 27.2727 5 no
GO:0050678 regulation of epithelial cell proliferation 27.2727 5 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0031346 positive regulation of cell projection organization 27.2727 6 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0048812 neuron projection morphogenesis 27.2727 5 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.2727 4 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 no
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 no
GO:0001558 regulation of cell growth 18.1818 4 yes
GO:0007399 nervous system development 18.1818 4 yes
GO:0010721 negative regulation of cell development 18.1818 6 yes
GO:0010977 negative regulation of neuron projection development 18.1818 7 yes
GO:0030308 negative regulation of cell growth 18.1818 5 yes
GO:0030516 regulation of axon extension 18.1818 5 yes
GO:0030517 negative regulation of axon extension 18.1818 6 yes
GO:0031290 retinal ganglion cell axon guidance 18.1818 9 yes
GO:0031345 negative regulation of cell projection organization 18.1818 6 yes
GO:0032101 regulation of response to external stimulus 18.1818 4 yes
GO:0032102 negative regulation of response to external stimulus 18.1818 5 yes
GO:0040013 negative regulation of locomotion 18.1818 4 yes
GO:0048841 regulation of axon extension involved in axon guidance 18.1818 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 18.1818 6 yes
GO:0050768 negative regulation of neurogenesis 18.1818 6 yes
GO:0050771 negative regulation of axonogenesis 18.1818 6 yes
GO:0050919 negative chemotaxis 18.1818 4 yes
GO:0050920 regulation of chemotaxis 18.1818 4 yes
GO:0050922 negative regulation of chemotaxis 18.1818 5 yes
GO:0051961 negative regulation of nervous system development 18.1818 5 yes
GO:0061387 regulation of extent of cell growth 18.1818 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPC_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
DRB3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
TMM25_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
TM11B_HUMAN [view interactions] High throughput no no
GRIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CD1E_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
DRB1_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
ADA33_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
GLT10_HUMAN [view interactions] High throughput no no
DB135_HUMAN [view interactions] High throughput no no
T106A_HUMAN [view interactions] High throughput no no
SG1D1_HUMAN [view interactions] High throughput no no
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
DQA1_HUMAN [view interactions] High throughput no yes
ACHB4_HUMAN [view entry] [view interactions] High throughput yes no
CRLF2_HUMAN [view interactions] High throughput no no
CLC2D_HUMAN [view interactions] High throughput no yes
DQB1_HUMAN [view interactions] High throughput no no
CL12B_HUMAN [view interactions] High throughput no no
ARSL_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP2_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB1_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB3_HUMAN [view interactions] High throughput no yes