SEM4F_HUMAN
Evidence for PS localization
Functions
Probable cell surface receptor that regulates oligodendroglial precursor cell migration . Might also regulate differentiation of oligodendroglial precursor cells . Has growth cone collapse activity against retinal ganglion-cell axons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SEM4F_HUMAN |
|---|---|---|---|---|
| GO:0017154 | semaphorin receptor activity | 41.6667 | 4 | no |
| GO:0005216 | ion channel activity | 25.0000 | 4 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 25.0000 | 6 | no |
| GO:0005261 | cation channel activity | 25.0000 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0015267 | channel activity | 25.0000 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 25.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 25.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 25.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 25.0000 | 4 | no |
| GO:0022836 | gated channel activity | 25.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 25.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 25.0000 | 6 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 25.0000 | 5 | no |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 25.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SEM4F_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 50.0000 | 4 | yes |
| GO:0030334 | regulation of cell migration | 50.0000 | 5 | yes |
| GO:0031175 | neuron projection development | 50.0000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | yes |
| GO:0071526 | semaphorin-plexin signaling pathway | 50.0000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 50.0000 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 50.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 50.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 50.0000 | 4 | no |
| GO:0007411 | axon guidance | 41.6667 | 8 | yes |
| GO:0010975 | regulation of neuron projection development | 41.6667 | 7 | yes |
| GO:0050767 | regulation of neurogenesis | 41.6667 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 41.6667 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 41.6667 | 5 | yes |
| GO:0060284 | regulation of cell development | 41.6667 | 5 | yes |
| GO:0097485 | neuron projection guidance | 41.6667 | 7 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 41.6667 | 6 | yes |
| GO:0051049 | regulation of transport | 41.6667 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 41.6667 | 4 | no |
| GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 41.6667 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 41.6667 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 41.6667 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 41.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 41.6667 | 5 | no |
| GO:0045596 | negative regulation of cell differentiation | 33.3333 | 5 | yes |
| GO:0045926 | negative regulation of growth | 33.3333 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 33.3333 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 33.3333 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 33.3333 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 33.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:1990138 | neuron projection extension | 33.3333 | 4 | no |
| GO:0010720 | positive regulation of cell development | 33.3333 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 33.3333 | 4 | no |
| GO:0050769 | positive regulation of neurogenesis | 33.3333 | 6 | no |
| GO:0050772 | positive regulation of axonogenesis | 33.3333 | 6 | no |
| GO:0051962 | positive regulation of nervous system development | 33.3333 | 5 | no |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 33.3333 | 6 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0001755 | neural crest cell migration | 25.0000 | 6 | yes |
| GO:0010721 | negative regulation of cell development | 25.0000 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 25.0000 | 7 | yes |
| GO:0030308 | negative regulation of cell growth | 25.0000 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | yes |
| GO:0030516 | regulation of axon extension | 25.0000 | 5 | yes |
| GO:0030517 | negative regulation of axon extension | 25.0000 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 25.0000 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 25.0000 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 25.0000 | 5 | yes |
| GO:0040013 | negative regulation of locomotion | 25.0000 | 4 | yes |
| GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | yes |
| GO:0048841 | regulation of axon extension involved in axon guidance | 25.0000 | 6 | yes |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | 25.0000 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 25.0000 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 25.0000 | 6 | yes |
| GO:0050919 | negative chemotaxis | 25.0000 | 4 | yes |
| GO:0050920 | regulation of chemotaxis | 25.0000 | 4 | yes |
| GO:0050922 | negative regulation of chemotaxis | 25.0000 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 25.0000 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 25.0000 | 5 | yes |
| GO:0090497 | mesenchymal cell migration | 25.0000 | 5 | yes |
| GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 25.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 25.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0021612 | facial nerve structural organization | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0050678 | regulation of epithelial cell proliferation | 25.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0007162 | negative regulation of cell adhesion | 25.0000 | 5 | no |
| GO:0008360 | regulation of cell shape | 25.0000 | 6 | no |
| GO:0043087 | regulation of GTPase activity | 25.0000 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0002009 | morphogenesis of an epithelium | 25.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 25.0000 | 4 | yes |
| GO:0001667 | ameboidal-type cell migration | 25.0000 | 4 | yes |
| GO:0007399 | nervous system development | 16.6667 | 4 | yes |
| GO:0031290 | retinal ganglion cell axon guidance | 16.6667 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| DRB3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| GRIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD1E_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| ADA33_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| GLT10_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRLF2_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| ARSL_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXB1_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB3_HUMAN | [view interactions] | High throughput | no | yes |
| PLXA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLXA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLXA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLXB2_HUMAN | [view interactions] | Computational | no | yes |
| PLXD1_HUMAN | [view interactions] | Computational | no | yes |